YBR109C / CMD1

Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR109C / CMD1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:-3.64|P-value:2.97E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:4.36|P-value:2.16E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:18.70|P-value:1.42E-69 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.58|P-value:3.62E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:7.01|P-value:2.33E-11 ID:SGTC_81|Compound:0411-0046|FD-Score:15.80|P-value:2.41E-50 ID:SGTC_117|Compound:lucigenin|FD-Score:5.79|P-value:2.77E-8 ID:SGTC_121|Compound:0557-0495|FD-Score:7.05|P-value:1.89E-11 ID:SGTC_173|Compound:1273-0061|FD-Score:3.44|P-value:6.37E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.38|P-value:7.72E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:5.57|P-value:8.95E-8 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.71|P-value:2.53E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.61|P-value:7.24E-8 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.34|P-value:8.07E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.49|P-value:1.29E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:6.77|P-value:1.04E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:3.30|P-value:9.97E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:3.38|P-value:7.79E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.10|P-value:5.98E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:13.80|P-value:1.30E-38 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.88|P-value:1.40E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.64|P-value:3.30E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.30|P-value:9.91E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:14.10|P-value:2.08E-40 ID:SGTC_502|Compound:l-744,832|FD-Score:6.90|P-value:4.82E-11 ID:SGTC_513|Compound:4245-1575|FD-Score:3.95|P-value:1.06E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.07|P-value:6.08E-9 ID:SGTC_582|Compound:0987-0078|FD-Score:13.70|P-value:4.64E-38 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.90|P-value:1.14E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.87|P-value:1.41E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.47|P-value:1.39E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.38|P-value:2.05E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.88|P-value:2.11E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.44|P-value:6.36E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.87|P-value:1.32E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.55|P-value:3.99E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.79|P-value:1.73E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.54|P-value:9.41E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:4.80|P-value:3.39E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:5.64|P-value:5.96E-8 ID:SGTC_992|Compound:3909-8734|FD-Score:3.92|P-value:1.21E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.74|P-value:2.06E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.89|P-value:2.26E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.15|P-value:4.93E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:-3.98|P-value:8.76E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.32|P-value:2.55E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.83|P-value:1.69E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.34|P-value:8.96E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.41|P-value:6.38E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-5.56|P-value:7.88E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.20|P-value:6.83E-12 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.60|P-value:3.42E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:15.40|P-value:6.12E-48 ID:SGTC_1615|Compound:st002656|FD-Score:3.39|P-value:7.61E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.45|P-value:6.21E-4 ID:SGTC_1666|Compound:st014829|FD-Score:5.16|P-value:6.51E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-3.76|P-value:1.94E-4 ID:SGTC_1712|Compound:st032288|FD-Score:8.20|P-value:7.03E-15 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.30|P-value:3.38E-7 ID:SGTC_1800|Compound:st050079|FD-Score:4.83|P-value:2.98E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.34|P-value:2.41E-5 ID:SGTC_1831|Compound:st055328|FD-Score:5.32|P-value:3.02E-7 ID:SGTC_1841|Compound:st054148|FD-Score:4.22|P-value:3.87E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-7.71|P-value:1.86E-13 ID:SGTC_2021|Compound:4019055|FD-Score:6.13|P-value:4.51E-9 ID:SGTC_2036|Compound:5160441|FD-Score:5.16|P-value:6.53E-7 ID:SGTC_2225|Compound:6654152|FD-Score:3.95|P-value:1.05E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.42|P-value:6.15E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.53|P-value:1.07E-7 ID:SGTC_2326|Compound:6164455|FD-Score:4.08|P-value:6.46E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.15|P-value:4.97E-5 ID:SGTC_2459|Compound:5811157|FD-Score:5.05|P-value:1.09E-6 ID:SGTC_2475|Compound:5812728|FD-Score:4.36|P-value:2.21E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.97|P-value:9.92E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.35|P-value:8.52E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.14|P-value:4.70E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.40|P-value:2.03E-7 ID:SGTC_2981|Compound:9013952|FD-Score:-3.39|P-value:6.87E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.48|P-value:1.32E-5 ID:SGTC_3055|Compound:9094636|FD-Score:4.14|P-value:5.13E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-8.65|P-value:1.86E-16 ID:SGTC_3131|Compound:9127911|FD-Score:-3.44|P-value:5.89E-4 ID:SGTC_3196|Compound:9111891|FD-Score:4.29|P-value:2.90E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.40|P-value:6.64E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.63|P-value:3.35E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.64|P-value:2.97E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:4.36|P-value:2.16E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:18.70|P-value:1.42E-69 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.58|P-value:3.62E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:7.01|P-value:2.33E-11 ID:SGTC_81|Compound:0411-0046|FD-Score:15.80|P-value:2.41E-50 ID:SGTC_117|Compound:lucigenin|FD-Score:5.79|P-value:2.77E-8 ID:SGTC_121|Compound:0557-0495|FD-Score:7.05|P-value:1.89E-11 ID:SGTC_173|Compound:1273-0061|FD-Score:3.44|P-value:6.37E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.38|P-value:7.72E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:5.57|P-value:8.95E-8 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.71|P-value:2.53E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.61|P-value:7.24E-8 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.34|P-value:8.07E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.49|P-value:1.29E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:6.77|P-value:1.04E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:3.30|P-value:9.97E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:3.38|P-value:7.79E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.10|P-value:5.98E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:13.80|P-value:1.30E-38 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.88|P-value:1.40E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.64|P-value:3.30E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.30|P-value:9.91E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:14.10|P-value:2.08E-40 ID:SGTC_502|Compound:l-744,832|FD-Score:6.90|P-value:4.82E-11 ID:SGTC_513|Compound:4245-1575|FD-Score:3.95|P-value:1.06E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.07|P-value:6.08E-9 ID:SGTC_582|Compound:0987-0078|FD-Score:13.70|P-value:4.64E-38 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.90|P-value:1.14E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.87|P-value:1.41E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.47|P-value:1.39E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.38|P-value:2.05E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.88|P-value:2.11E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.44|P-value:6.36E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.87|P-value:1.32E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.55|P-value:3.99E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.79|P-value:1.73E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.54|P-value:9.41E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:4.80|P-value:3.39E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:5.64|P-value:5.96E-8 ID:SGTC_992|Compound:3909-8734|FD-Score:3.92|P-value:1.21E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.74|P-value:2.06E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.89|P-value:2.26E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.15|P-value:4.93E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:-3.98|P-value:8.76E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.32|P-value:2.55E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.83|P-value:1.69E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.34|P-value:8.96E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.41|P-value:6.38E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-5.56|P-value:7.88E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.20|P-value:6.83E-12 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.60|P-value:3.42E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:15.40|P-value:6.12E-48 ID:SGTC_1615|Compound:st002656|FD-Score:3.39|P-value:7.61E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.45|P-value:6.21E-4 ID:SGTC_1666|Compound:st014829|FD-Score:5.16|P-value:6.51E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-3.76|P-value:1.94E-4 ID:SGTC_1712|Compound:st032288|FD-Score:8.20|P-value:7.03E-15 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.30|P-value:3.38E-7 ID:SGTC_1800|Compound:st050079|FD-Score:4.83|P-value:2.98E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.34|P-value:2.41E-5 ID:SGTC_1831|Compound:st055328|FD-Score:5.32|P-value:3.02E-7 ID:SGTC_1841|Compound:st054148|FD-Score:4.22|P-value:3.87E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-7.71|P-value:1.86E-13 ID:SGTC_2021|Compound:4019055|FD-Score:6.13|P-value:4.51E-9 ID:SGTC_2036|Compound:5160441|FD-Score:5.16|P-value:6.53E-7 ID:SGTC_2225|Compound:6654152|FD-Score:3.95|P-value:1.05E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.42|P-value:6.15E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.53|P-value:1.07E-7 ID:SGTC_2326|Compound:6164455|FD-Score:4.08|P-value:6.46E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.15|P-value:4.97E-5 ID:SGTC_2459|Compound:5811157|FD-Score:5.05|P-value:1.09E-6 ID:SGTC_2475|Compound:5812728|FD-Score:4.36|P-value:2.21E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.97|P-value:9.92E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.35|P-value:8.52E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.14|P-value:4.70E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.40|P-value:2.03E-7 ID:SGTC_2981|Compound:9013952|FD-Score:-3.39|P-value:6.87E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.48|P-value:1.32E-5 ID:SGTC_3055|Compound:9094636|FD-Score:4.14|P-value:5.13E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-8.65|P-value:1.86E-16 ID:SGTC_3131|Compound:9127911|FD-Score:-3.44|P-value:5.89E-4 ID:SGTC_3196|Compound:9111891|FD-Score:4.29|P-value:2.90E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.40|P-value:6.64E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.63|P-value:3.35E-4

Top fitness defect scores for YBR109C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_39 0986-0283 18.70 58.4 µM 1.42E-69 calcium & mitochondrial duress 2 1.62E-78 6.38
2 SGTC_81 0411-0046 15.80 10.0 µM 2.41E-50 1 9.29E-57 2.84
3 SGTC_1597 7-benzyloxygramine 15.40 47.5 µM 6.12E-48 calcium & mitochondrial duress 7 4.87E-54 0.38
4 SGTC_467 ro 31-8220 14.10 72.8 µM 2.08E-40 calcium & mitochondrial duress 2 1.61E-45 6.09
5 SGTC_390 dec-rvkr-cmk 13.80 16.7 µM 1.30E-38 calcium & mitochondrial duress 1 1.74E-43 9.34
6 SGTC_582 0987-0078 13.70 156.0 µM 4.64E-38 calcium & mitochondrial duress 1 7.33E-43 5.58
7 SGTC_1712 st032288 8.20 53.4 µM 7.03E-15 calcium & mitochondrial duress 6 1.22E-16 0.19
8 SGTC_1317 1273-0028 7.20 910.0 nM 6.83E-12 azole & statin 5 2.91E-13 0.48
9 SGTC_121 0557-0495 7.05 61.3 µM 1.89E-11 calcium & mitochondrial duress 3 9.19E-13 0.71
10 SGTC_65 0798-0905 7.01 35.0 µM 2.33E-11 calcium & mitochondrial duress 1 1.16E-12 1.68
11 SGTC_502 l-744,832 6.90 89.3 µM 4.82E-11 calcium & mitochondrial duress 1 2.65E-12 1.66
12 SGTC_314 1671-0008 6.77 2.7 µM 1.04E-10 2 6.35E-12 1.39
13 SGTC_2021 4019055 6.13 173.0 µM 4.51E-9 endomembrane recycling 18 4.48E-10 0.29
14 SGTC_528 3492-0019 6.07 172.0 µM 6.08E-9 calcium & mitochondrial duress 7 6.27E-10 0.26
15 SGTC_117 lucigenin 5.79 22.1 µM 2.77E-8 redox potentiating 6 3.48E-9 0.07
16 SGTC_851 0394-0702 5.64 453.0 µM 5.96E-8 mitochondrial processes 13 8.27E-9 0.85
17 SGTC_266 formosanin C 5.61 406.0 nM 7.24E-8 sphingolipid biosynthesis & PDR1 11 1.03E-8 0.39
18 SGTC_193 1273-0060 5.57 1.6 µM 8.95E-8 ergosterol biosynthesis 3 1.31E-8 0.69
19 SGTC_2289 7946404 5.53 165.1 µM 1.07E-7 9 1.59E-8 0.04
20 SGTC_2896 9052656 5.40 71.4 µM 2.03E-7 endomembrane recycling 14 3.30E-8 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.381 6.49E-116 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.370 2.77E-109 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.342 1.33E-92 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.339 5.37E-91 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.323 3.74E-82 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.265 4.12E-55 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
0.263 4.71E-54 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.229 3.82E-41 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.224 3.00E-39 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.221 1.90E-38 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.194 1.03E-29 YER120W SCS2 hom Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
0.191 9.11E-29 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.185 2.60E-27 YCR008W SAT4 hom Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
0.182 1.92E-26 YER133W GLC7 het Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
0.181 4.54E-26 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication