YBR110W / ALG1

Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR110W / ALG1

Click on Significant Values for Screen Details ID:SGTC_138|Compound:0850-0259|FD-Score:-2.97|P-value:7.63E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:2.94|P-value:8.54E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:2.97|P-value:7.65E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.90|P-value:1.61E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-2.95|P-value:8.33E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.51|P-value:7.41E-7 ID:SGTC_376|Compound:3970-0862|FD-Score:4.15|P-value:4.66E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.85|P-value:2.02E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.86|P-value:1.07E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.83|P-value:2.47E-10 ID:SGTC_502|Compound:l-744,832|FD-Score:5.09|P-value:2.87E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:-7.51|P-value:5.76E-16 ID:SGTC_521|Compound:r062-0005|FD-Score:-5.39|P-value:4.39E-9 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.19|P-value:3.37E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.02|P-value:6.38E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.85|P-value:1.99E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:4.92|P-value:7.54E-8 ID:SGTC_852|Compound:0418-0143|FD-Score:4.22|P-value:3.29E-6 ID:SGTC_894|Compound:0960-0238|FD-Score:3.22|P-value:2.92E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.08|P-value:5.15E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.18|P-value:3.49E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:2.99|P-value:7.05E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.37|P-value:1.59E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:5.81|P-value:2.80E-10 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.46|P-value:9.73E-7 ID:SGTC_1642|Compound:st009582|FD-Score:3.26|P-value:2.52E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.58|P-value:6.71E-5 ID:SGTC_1813|Compound:st051246|FD-Score:3.18|P-value:3.51E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.17|P-value:3.55E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.16|P-value:3.79E-4 ID:SGTC_2064|Compound:5220758|FD-Score:2.94|P-value:8.65E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.49|P-value:1.01E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.12|P-value:4.39E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.13|P-value:4.23E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-2.94|P-value:8.51E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.20|P-value:3.25E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.15|P-value:3.91E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.77|P-value:2.96E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.50|P-value:1.29E-29 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.16|P-value:4.59E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:4.26|P-value:2.69E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.01|P-value:6.72E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.08|P-value:6.62E-6 ID:SGTC_2851|Compound:9015922|FD-Score:5.39|P-value:4.51E-9 ID:SGTC_2852|Compound:9023854|FD-Score:3.04|P-value:5.92E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.02|P-value:6.33E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-2.97|P-value:7.63E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:2.94|P-value:8.54E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:2.97|P-value:7.65E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.90|P-value:1.61E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-2.95|P-value:8.33E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.51|P-value:7.41E-7 ID:SGTC_376|Compound:3970-0862|FD-Score:4.15|P-value:4.66E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.85|P-value:2.02E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.86|P-value:1.07E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.83|P-value:2.47E-10 ID:SGTC_502|Compound:l-744,832|FD-Score:5.09|P-value:2.87E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:-7.51|P-value:5.76E-16 ID:SGTC_521|Compound:r062-0005|FD-Score:-5.39|P-value:4.39E-9 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.19|P-value:3.37E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.02|P-value:6.38E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.85|P-value:1.99E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:4.92|P-value:7.54E-8 ID:SGTC_852|Compound:0418-0143|FD-Score:4.22|P-value:3.29E-6 ID:SGTC_894|Compound:0960-0238|FD-Score:3.22|P-value:2.92E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.08|P-value:5.15E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.18|P-value:3.49E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:2.99|P-value:7.05E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.37|P-value:1.59E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:5.81|P-value:2.80E-10 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.46|P-value:9.73E-7 ID:SGTC_1642|Compound:st009582|FD-Score:3.26|P-value:2.52E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.58|P-value:6.71E-5 ID:SGTC_1813|Compound:st051246|FD-Score:3.18|P-value:3.51E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.17|P-value:3.55E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.16|P-value:3.79E-4 ID:SGTC_2064|Compound:5220758|FD-Score:2.94|P-value:8.65E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.49|P-value:1.01E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.12|P-value:4.39E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.13|P-value:4.23E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-2.94|P-value:8.51E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.20|P-value:3.25E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.15|P-value:3.91E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.77|P-value:2.96E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.50|P-value:1.29E-29 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.16|P-value:4.59E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:4.26|P-value:2.69E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.01|P-value:6.72E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.08|P-value:6.62E-6 ID:SGTC_2851|Compound:9015922|FD-Score:5.39|P-value:4.51E-9 ID:SGTC_2852|Compound:9023854|FD-Score:3.04|P-value:5.92E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.02|P-value:6.33E-4

Top fitness defect scores for YBR110W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2567 aureobasidin a 10.50 60.0 nM 1.29E-29 11 2.94E-26 0.11
2 SGTC_453 enantio-paf c16 5.83 10.0 µM 2.47E-10 6 2.76E-9 0.35
3 SGTC_1568 digitonin 5.81 820.0 nM 2.80E-10 sphingolipid biosynthesis & PDR1 4 3.09E-9 0.54
4 SGTC_2851 9015922 5.39 71.4 µM 4.51E-9 4 3.58E-8 0.65
5 SGTC_502 l-744,832 5.09 89.3 µM 2.87E-8 calcium & mitochondrial duress 3 1.83E-7 0.05
6 SGTC_770 0389-1121 4.92 67.2 µM 7.54E-8 RPP1 & pyrimidine depletion 3 4.29E-7 0.13
7 SGTC_243 5hr heat shock (37°C) + splitomicin 4.51 1.0 µM 7.41E-7 heat shock/prefoldin 3 3.22E-6 0.36
8 SGTC_1597 7-benzyloxygramine 4.46 47.5 µM 9.73E-7 calcium & mitochondrial duress 47 4.10E-6 0.12
9 SGTC_2756 carbadox 4.26 75.1 µM 2.69E-6 18 1.01E-5 0.05
10 SGTC_852 0418-0143 4.22 439.0 µM 3.29E-6 calcium & mitochondrial duress 11 1.20E-5 0.17
11 SGTC_2688 kanamycin b 4.16 96.7 µM 4.59E-6 calcium & mitochondrial duress 18 1.61E-5 0.16
12 SGTC_376 3970-0862 4.15 59.1 µM 4.66E-6 7 1.63E-5 0.02
13 SGTC_2810 7959871 4.08 45.5 µM 6.62E-6 copper-dependent oxidative stress 16 2.23E-5 0.03
14 SGTC_224 benfluorex 3.90 43.9 µM 1.61E-5 5 4.90E-5 0.03
15 SGTC_743 1275-0778 3.85 158.0 µM 1.99E-5 excess fatty acid 16 5.91E-5 0.09
16 SGTC_1702 st027038 3.58 51.0 µM 6.71E-5 3 1.73E-4 0.03
17 SGTC_1355 1499-0035 3.37 1.7 µM 1.59E-4 7 3.72E-4 0.07
18 SGTC_1642 st009582 3.26 77.7 µM 2.52E-4 RPP1 & pyrimidine depletion 11 5.58E-4 0.03
19 SGTC_894 0960-0238 3.22 55.9 µM 2.92E-4 14 6.34E-4 0.10
20 SGTC_2248 tofa 3.20 1.1 µM 3.25E-4 sphingolipid biosynthesis & PDR1 45 6.98E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.360 2.33E-103 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.222 9.85E-39 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.194 7.06E-30 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.184 7.50E-27 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.169 8.12E-23 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.153 4.15E-19 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.152 1.05E-18 YBR078W ECM33 hom GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
0.151 1.08E-18 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.150 2.51E-18 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.150 2.74E-18 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.149 3.81E-18 YBR056W YBR056W hom Putative glycoside hydrolase of the mitochondrial intermembrane space
0.144 4.57E-17 YPR004C AIM45 hom Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response
0.141 1.79E-16 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.141 2.42E-16 YPL220W RPL1A hom Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.138 1.18E-15 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching