YBR111W-A / SUS1

Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR111W-A / SUS1

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:5.79|P-value:4.22E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:5.51|P-value:1.75E-7 ID:SGTC_62|Compound:0180-0423|FD-Score:6.31|P-value:2.39E-9 ID:SGTC_108|Compound:0509-0257|FD-Score:4.37|P-value:3.13E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.38|P-value:2.98E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:3.68|P-value:4.07E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.06|P-value:1.04E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.66|P-value:8.38E-8 ID:SGTC_252|Compound:miconazole|FD-Score:-3.42|P-value:3.22E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.20|P-value:6.06E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.32|P-value:8.97E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.50|P-value:8.27E-17 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.34|P-value:9.26E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.40|P-value:7.07E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.50|P-value:2.51E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.67|P-value:2.16E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.41|P-value:3.37E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.50|P-value:2.47E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.09|P-value:8.22E-9 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.12|P-value:9.05E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.15|P-value:1.04E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.65|P-value:4.56E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.66|P-value:1.38E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.42|P-value:9.57E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.63|P-value:3.62E-10 ID:SGTC_802|Compound:4112-3352|FD-Score:3.61|P-value:5.22E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.13|P-value:7.94E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:4.26|P-value:4.74E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:5.14|P-value:1.09E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.48|P-value:7.88E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.89|P-value:7.64E-7 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.52|P-value:7.00E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.74|P-value:3.29E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.76|P-value:3.07E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.21|P-value:6.70E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.44|P-value:9.16E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.46|P-value:8.40E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.42|P-value:2.53E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.82|P-value:4.60E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.63|P-value:4.74E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.31|P-value:4.84E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.46|P-value:2.86E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.48|P-value:8.00E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.47|P-value:8.11E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.51|P-value:7.10E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.05|P-value:1.06E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.66|P-value:4.28E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.69|P-value:2.63E-10 ID:SGTC_1712|Compound:st032288|FD-Score:5.13|P-value:1.11E-6 ID:SGTC_1760|Compound:st045453|FD-Score:3.96|P-value:1.48E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.46|P-value:2.12E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.33|P-value:4.44E-7 ID:SGTC_1922|Compound:5578187|FD-Score:-3.29|P-value:5.15E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.44|P-value:3.05E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.40|P-value:6.99E-6 ID:SGTC_2008|Compound:4012253|FD-Score:4.48|P-value:1.93E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.27|P-value:4.63E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.59|P-value:5.54E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.12|P-value:8.14E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.77|P-value:2.98E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.70|P-value:1.17E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.98|P-value:4.12E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.33|P-value:4.53E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.45|P-value:8.70E-4 ID:SGTC_2534|Compound:helenine|FD-Score:3.63|P-value:4.83E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.31|P-value:9.54E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.74|P-value:1.95E-10 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.98|P-value:1.42E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:4.19|P-value:6.38E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.51|P-value:7.10E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.51|P-value:7.16E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.92|P-value:1.75E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.28|P-value:4.49E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.70|P-value:3.72E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.76|P-value:9.55E-5 ID:SGTC_2985|Compound:9022375|FD-Score:5.64|P-value:9.38E-8 ID:SGTC_2986|Compound:9022445|FD-Score:3.68|P-value:4.04E-4 ID:SGTC_3116|Compound:9124943|FD-Score:4.15|P-value:7.38E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.49|P-value:7.78E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:5.79|P-value:4.22E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:5.51|P-value:1.75E-7 ID:SGTC_62|Compound:0180-0423|FD-Score:6.31|P-value:2.39E-9 ID:SGTC_108|Compound:0509-0257|FD-Score:4.37|P-value:3.13E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.38|P-value:2.98E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:3.68|P-value:4.07E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.06|P-value:1.04E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.66|P-value:8.38E-8 ID:SGTC_252|Compound:miconazole|FD-Score:-3.42|P-value:3.22E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.20|P-value:6.06E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.32|P-value:8.97E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.50|P-value:8.27E-17 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.34|P-value:9.26E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.40|P-value:7.07E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.50|P-value:2.51E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.67|P-value:2.16E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.41|P-value:3.37E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.50|P-value:2.47E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.09|P-value:8.22E-9 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.12|P-value:9.05E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.15|P-value:1.04E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.65|P-value:4.56E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.66|P-value:1.38E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.42|P-value:9.57E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.63|P-value:3.62E-10 ID:SGTC_802|Compound:4112-3352|FD-Score:3.61|P-value:5.22E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.13|P-value:7.94E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:4.26|P-value:4.74E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:5.14|P-value:1.09E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.48|P-value:7.88E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.89|P-value:7.64E-7 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.52|P-value:7.00E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.74|P-value:3.29E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.76|P-value:3.07E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.21|P-value:6.70E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.44|P-value:9.16E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.46|P-value:8.40E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.42|P-value:2.53E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.82|P-value:4.60E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.63|P-value:4.74E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.31|P-value:4.84E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.46|P-value:2.86E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.48|P-value:8.00E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.47|P-value:8.11E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.51|P-value:7.10E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.05|P-value:1.06E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.66|P-value:4.28E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.69|P-value:2.63E-10 ID:SGTC_1712|Compound:st032288|FD-Score:5.13|P-value:1.11E-6 ID:SGTC_1760|Compound:st045453|FD-Score:3.96|P-value:1.48E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.46|P-value:2.12E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.33|P-value:4.44E-7 ID:SGTC_1922|Compound:5578187|FD-Score:-3.29|P-value:5.15E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.44|P-value:3.05E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.40|P-value:6.99E-6 ID:SGTC_2008|Compound:4012253|FD-Score:4.48|P-value:1.93E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.27|P-value:4.63E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.59|P-value:5.54E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.12|P-value:8.14E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.77|P-value:2.98E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.70|P-value:1.17E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.98|P-value:4.12E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.33|P-value:4.53E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.45|P-value:8.70E-4 ID:SGTC_2534|Compound:helenine|FD-Score:3.63|P-value:4.83E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.31|P-value:9.54E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.74|P-value:1.95E-10 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.98|P-value:1.42E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:4.19|P-value:6.38E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.51|P-value:7.10E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.51|P-value:7.16E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.92|P-value:1.75E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.28|P-value:4.49E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.70|P-value:3.72E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.76|P-value:9.55E-5 ID:SGTC_2985|Compound:9022375|FD-Score:5.64|P-value:9.38E-8 ID:SGTC_2986|Compound:9022445|FD-Score:3.68|P-value:4.04E-4 ID:SGTC_3116|Compound:9124943|FD-Score:4.15|P-value:7.38E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.49|P-value:7.78E-4

Top fitness defect scores for YBR111W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2679 rapamycin 6.74 1.0 nM 1.95E-10 65 8.14E-12
2 SGTC_1687 st020778 6.69 55.4 µM 2.63E-10 92 1.14E-11
3 SGTC_800 3448-7362 6.63 155.0 µM 3.62E-10 translation 33 1.63E-11
4 SGTC_62 0180-0423 6.31 3.2 µM 2.39E-9 60S ribosome export 5 1.37E-10
5 SGTC_528 3492-0019 6.09 172.0 µM 8.22E-9 calcium & mitochondrial duress 120 5.54E-10
6 SGTC_45 0kpi-0036 5.79 14.9 µM 4.22E-8 excess fatty acid 6 3.51E-9
7 SGTC_221 trifluoperazine 5.66 10.3 µM 8.38E-8 NEO1-PIK1 135 7.64E-9
8 SGTC_2985 9022375 5.64 71.4 µM 9.38E-8 RPP1 & pyrimidine depletion 8 8.68E-9
9 SGTC_58 0957-0393 5.51 9.0 µM 1.75E-7 cell wall 242 1.75E-8
10 SGTC_1844 rapamycin 5.33 4.0 nM 4.44E-7 105 5.04E-8
11 SGTC_778 3456-2434 5.15 196.0 µM 1.04E-6 mitochondrial response to ROS 41 1.32E-7
12 SGTC_1028 k015-0029 5.14 4.8 µM 1.09E-6 4 1.40E-7
13 SGTC_1712 st032288 5.13 53.4 µM 1.11E-6 calcium & mitochondrial duress 110 1.42E-7
14 SGTC_1171 0368-0077 4.82 21.4 µM 4.60E-6 12 7.14E-7
15 SGTC_2008 4012253 4.48 172.0 µM 1.93E-5 14 3.65E-6
16 SGTC_1781 st038725 4.46 66.3 µM 2.12E-5 NEO1 83 4.06E-6
17 SGTC_1167 k781-0610 4.42 148.0 µM 2.53E-5 RNA processing & uracil transport 15 4.95E-6
18 SGTC_118 0083-0097 4.38 135.3 µM 2.98E-5 translation 94 5.95E-6
19 SGTC_108 0509-0257 4.37 621.1 µM 3.13E-5 37 6.31E-6
20 SGTC_2927 9011802 4.28 47.9 µM 4.49E-5 20 9.50E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.226 3.85E-40 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.205 3.37E-33 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.191 5.89E-29 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.190 1.21E-28 YGL072C_d YGL072C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.186 2.38E-27 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.182 3.64E-26 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.179 1.71E-25 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.178 3.84E-25 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.176 1.37E-24 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.175 1.99E-24 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.175 2.05E-24 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.173 4.67E-24 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.171 1.92E-23 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.171 2.26E-23 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.169 8.05E-23 YDL041W_d YDL041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C