YBR113W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR113W / YBR113W

Click on Significant Values for Screen Details ID:SGTC_205|Compound:1486-1330|FD-Score:3.10|P-value:2.75E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.15|P-value:2.29E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.07|P-value:4.21E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.23|P-value:1.61E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:-3.25|P-value:2.03E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.64|P-value:1.30E-7 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.15|P-value:3.17E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:2.79|P-value:9.30E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.94|P-value:6.01E-6 ID:SGTC_385|Compound:1494-0393|FD-Score:2.92|P-value:5.73E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.21|P-value:2.46E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.20|P-value:1.83E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.08|P-value:4.32E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.08|P-value:4.15E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-2.94|P-value:7.18E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.24|P-value:2.12E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.11|P-value:3.64E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.78|P-value:9.73E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:-2.91|P-value:7.95E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-2.89|P-value:8.54E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:2.92|P-value:5.67E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.09|P-value:4.00E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.16|P-value:2.16E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:2.81|P-value:8.47E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.08|P-value:3.04E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.20|P-value:2.54E-4 ID:SGTC_1765|Compound:st044815|FD-Score:5.61|P-value:2.51E-10 ID:SGTC_1767|Compound:st044992|FD-Score:-3.07|P-value:4.30E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.45|P-value:6.08E-5 ID:SGTC_1830|Compound:st055982|FD-Score:3.72|P-value:1.79E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.07|P-value:3.11E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.29|P-value:9.66E-7 ID:SGTC_1895|Compound:st058434|FD-Score:3.47|P-value:5.71E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.38|P-value:8.37E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.29|P-value:1.25E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-3.05|P-value:4.69E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.80|P-value:9.08E-4 ID:SGTC_2188|Compound:6126565|FD-Score:2.83|P-value:7.92E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.56|P-value:3.58E-10 ID:SGTC_2447|Compound:5741742|FD-Score:3.39|P-value:7.98E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.97|P-value:4.72E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.50|P-value:5.04E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.81|P-value:1.17E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.07|P-value:4.29E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.56|P-value:3.78E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.51|P-value:4.72E-5 ID:SGTC_2791|Compound:5663188|FD-Score:4.89|P-value:2.89E-8 ID:SGTC_2853|Compound:9015042|FD-Score:3.63|P-value:2.71E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.18|P-value:2.72E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.36|P-value:9.16E-5 ID:SGTC_3038|Compound:9091290|FD-Score:3.02|P-value:3.87E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.10|P-value:2.75E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.15|P-value:2.29E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.07|P-value:4.21E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.23|P-value:1.61E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:-3.25|P-value:2.03E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.64|P-value:1.30E-7 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.15|P-value:3.17E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:2.79|P-value:9.30E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.94|P-value:6.01E-6 ID:SGTC_385|Compound:1494-0393|FD-Score:2.92|P-value:5.73E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.21|P-value:2.46E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.20|P-value:1.83E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.08|P-value:4.32E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.08|P-value:4.15E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-2.94|P-value:7.18E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.24|P-value:2.12E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.11|P-value:3.64E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.78|P-value:9.73E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:-2.91|P-value:7.95E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-2.89|P-value:8.54E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:2.92|P-value:5.67E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.09|P-value:4.00E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.16|P-value:2.16E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:2.81|P-value:8.47E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.08|P-value:3.04E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.20|P-value:2.54E-4 ID:SGTC_1765|Compound:st044815|FD-Score:5.61|P-value:2.51E-10 ID:SGTC_1767|Compound:st044992|FD-Score:-3.07|P-value:4.30E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.45|P-value:6.08E-5 ID:SGTC_1830|Compound:st055982|FD-Score:3.72|P-value:1.79E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.07|P-value:3.11E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.29|P-value:9.66E-7 ID:SGTC_1895|Compound:st058434|FD-Score:3.47|P-value:5.71E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.38|P-value:8.37E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.29|P-value:1.25E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-3.05|P-value:4.69E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.80|P-value:9.08E-4 ID:SGTC_2188|Compound:6126565|FD-Score:2.83|P-value:7.92E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.56|P-value:3.58E-10 ID:SGTC_2447|Compound:5741742|FD-Score:3.39|P-value:7.98E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.97|P-value:4.72E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.50|P-value:5.04E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.81|P-value:1.17E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.07|P-value:4.29E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.56|P-value:3.78E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.51|P-value:4.72E-5 ID:SGTC_2791|Compound:5663188|FD-Score:4.89|P-value:2.89E-8 ID:SGTC_2853|Compound:9015042|FD-Score:3.63|P-value:2.71E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.18|P-value:2.72E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.36|P-value:9.16E-5 ID:SGTC_3038|Compound:9091290|FD-Score:3.02|P-value:3.87E-4

Top fitness defect scores for YBR113W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1765 st044815 5.61 90.4 µM 2.51E-10 4 9.83E-9
2 SGTC_2397 5161689 5.56 200.0 µM 3.58E-10 8 1.32E-8
3 SGTC_2791 5663188 4.89 71.4 µM 2.89E-8 RPP1 & pyrimidine depletion 6 4.95E-7
4 SGTC_271 rotenone 4.64 740.0 µM 1.30E-7 13 1.71E-6
5 SGTC_1891 st059073 4.29 26.2 µM 9.66E-7 TSC3-RPN4 16 8.98E-6
6 SGTC_376 3970-0862 3.94 59.1 µM 6.01E-6 19 4.06E-5
7 SGTC_2752 diclazuril 3.81 33.1 µM 1.17E-5 133 7.04E-5
8 SGTC_1830 st055982 3.72 50.3 µM 1.79E-5 25 1.00E-4
9 SGTC_2853 9015042 3.63 58.4 µM 2.71E-5 35 1.41E-4
10 SGTC_2757 clomiphene 3.56 4.2 µM 3.78E-5 fatty acid desaturase (OLE1) 55 1.86E-4
11 SGTC_2768 sulfasalazine 3.51 50.2 µM 4.72E-5 28 2.23E-4
12 SGTC_2742 clothiapine 3.50 36.3 µM 5.04E-5 NEO1 23 2.36E-4
13 SGTC_1895 st058434 3.47 18.3 µM 5.71E-5 22 2.62E-4
14 SGTC_1811 st050069 3.45 61.5 µM 6.08E-5 12 2.76E-4
15 SGTC_2447 5741742 3.39 33.8 µM 7.98E-5 43 3.45E-4
16 SGTC_2015 5119600 3.38 184.0 µM 8.37E-5 46 3.59E-4
17 SGTC_3010 9080089 3.36 71.4 µM 9.16E-5 34 3.87E-4
18 SGTC_2069 5228469 3.29 200.0 µM 1.25E-4 37 4.99E-4
19 SGTC_258 haloperidol 3.23 50.8 µM 1.61E-4 fatty acid desaturase (OLE1) 55 6.17E-4
20 SGTC_704 1310-0270 3.20 142.0 µM 1.83E-4 62 6.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.48E-10 YIR019C FLO11 hom GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain
0.107 6.33E-10 YDR218C SPR28 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
0.090 1.59E-7 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.084 1.01E-6 YNR001C CIT1 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
0.082 2.05E-6 YIL149C MLP2 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
0.080 3.29E-6 YIL139C REV7 hom Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.079 4.97E-6 YIR011C STS1 het Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.077 7.44E-6 YOR230W WTM1 hom Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
0.077 7.48E-6 YNL023C FAP1 hom Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1
0.076 1.13E-5 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.075 1.32E-5 YMR240C CUS1 het Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
0.074 1.76E-5 YBR094W PBY1 hom Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress
0.074 1.81E-5 YOR081C TGL5 hom Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate
0.074 1.87E-5 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
0.074 1.99E-5 YOL044W PEX15 hom Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly