YBR123C / TFC1

One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR123C / TFC1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.69|P-value:4.13E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.95|P-value:1.77E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.31|P-value:4.92E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.83|P-value:2.68E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.14|P-value:9.07E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.07|P-value:1.18E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.07|P-value:2.38E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:6.64|P-value:1.08E-9 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.49|P-value:7.79E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.63|P-value:1.97E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.59|P-value:1.67E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:3.68|P-value:4.29E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.46|P-value:2.84E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.06|P-value:3.52E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.01|P-value:1.92E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-4.39|P-value:4.88E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:-4.12|P-value:1.31E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:-4.77|P-value:1.13E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.86|P-value:2.39E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.97|P-value:1.65E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:6.69|P-value:8.62E-10 ID:SGTC_875|Compound:0709-0210|FD-Score:4.20|P-value:7.26E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.65|P-value:4.78E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.12|P-value:9.79E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:-4.68|P-value:1.61E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.92|P-value:1.97E-4 ID:SGTC_1629|Compound:st005085|FD-Score:8.89|P-value:6.50E-16 ID:SGTC_1630|Compound:st005209|FD-Score:5.02|P-value:3.00E-6 ID:SGTC_1632|Compound:st005650|FD-Score:-3.64|P-value:6.25E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.70|P-value:1.10E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-4.18|P-value:1.05E-4 ID:SGTC_1815|Compound:st051655|FD-Score:5.97|P-value:3.68E-8 ID:SGTC_1818|Compound:st052136|FD-Score:-3.94|P-value:2.36E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.79|P-value:2.98E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.92|P-value:1.94E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.42|P-value:9.73E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.45|P-value:8.83E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.60|P-value:5.53E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.71|P-value:5.06E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.84|P-value:2.56E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.51|P-value:7.37E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.98|P-value:1.59E-4 ID:SGTC_2425|Compound:5628681|FD-Score:5.04|P-value:2.65E-6 ID:SGTC_2434|Compound:5670830|FD-Score:3.63|P-value:5.09E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.53|P-value:7.03E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.57|P-value:7.95E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.13|P-value:1.86E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.56|P-value:8.10E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:5.48|P-value:3.88E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.89|P-value:5.42E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.77|P-value:1.42E-7 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.90|P-value:2.13E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.64|P-value:5.00E-4 ID:SGTC_2839|Compound:9003951|FD-Score:4.74|P-value:9.54E-6 ID:SGTC_2932|Compound:9016711|FD-Score:6.91|P-value:2.46E-10 ID:SGTC_2948|Compound:9070189|FD-Score:5.12|P-value:1.90E-6 ID:SGTC_2977|Compound:9011197|FD-Score:4.60|P-value:1.61E-5 ID:SGTC_3021|Compound:9087658|FD-Score:4.52|P-value:2.27E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:3.69|P-value:4.13E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.95|P-value:1.77E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.31|P-value:4.92E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.83|P-value:2.68E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.14|P-value:9.07E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.07|P-value:1.18E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.07|P-value:2.38E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:6.64|P-value:1.08E-9 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.49|P-value:7.79E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.63|P-value:1.97E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.59|P-value:1.67E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:3.68|P-value:4.29E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.46|P-value:2.84E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.06|P-value:3.52E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.01|P-value:1.92E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-4.39|P-value:4.88E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:-4.12|P-value:1.31E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:-4.77|P-value:1.13E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.86|P-value:2.39E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.97|P-value:1.65E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:6.69|P-value:8.62E-10 ID:SGTC_875|Compound:0709-0210|FD-Score:4.20|P-value:7.26E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.65|P-value:4.78E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.12|P-value:9.79E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:-4.68|P-value:1.61E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.92|P-value:1.97E-4 ID:SGTC_1629|Compound:st005085|FD-Score:8.89|P-value:6.50E-16 ID:SGTC_1630|Compound:st005209|FD-Score:5.02|P-value:3.00E-6 ID:SGTC_1632|Compound:st005650|FD-Score:-3.64|P-value:6.25E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.70|P-value:1.10E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-4.18|P-value:1.05E-4 ID:SGTC_1815|Compound:st051655|FD-Score:5.97|P-value:3.68E-8 ID:SGTC_1818|Compound:st052136|FD-Score:-3.94|P-value:2.36E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.79|P-value:2.98E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.92|P-value:1.94E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.42|P-value:9.73E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.45|P-value:8.83E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.60|P-value:5.53E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.71|P-value:5.06E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.84|P-value:2.56E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.51|P-value:7.37E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.98|P-value:1.59E-4 ID:SGTC_2425|Compound:5628681|FD-Score:5.04|P-value:2.65E-6 ID:SGTC_2434|Compound:5670830|FD-Score:3.63|P-value:5.09E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.53|P-value:7.03E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.57|P-value:7.95E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.13|P-value:1.86E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.56|P-value:8.10E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:5.48|P-value:3.88E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.89|P-value:5.42E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.77|P-value:1.42E-7 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.90|P-value:2.13E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.64|P-value:5.00E-4 ID:SGTC_2839|Compound:9003951|FD-Score:4.74|P-value:9.54E-6 ID:SGTC_2932|Compound:9016711|FD-Score:6.91|P-value:2.46E-10 ID:SGTC_2948|Compound:9070189|FD-Score:5.12|P-value:1.90E-6 ID:SGTC_2977|Compound:9011197|FD-Score:4.60|P-value:1.61E-5 ID:SGTC_3021|Compound:9087658|FD-Score:4.52|P-value:2.27E-5

Top fitness defect scores for YBR123C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1629 st005085 8.89 44.9 µM 6.50E-16 RPP1 & pyrimidine depletion 2 3.08E-19 1.72
2 SGTC_2932 9016711 6.91 44.5 µM 2.46E-10 1 2.44E-12 1.15
3 SGTC_825 1988-2224 6.69 89.6 µM 8.62E-10 cell wall signaling 3 1.15E-11 0.14
4 SGTC_236 1509-0011 6.64 5.3 µM 1.08E-9 8 1.52E-11 0.55
5 SGTC_1815 st051655 5.97 58.2 µM 3.68E-8 TSC3-RPN4 3 1.18E-9 0.03
6 SGTC_2651 1327-0036 5.89 5.0 µM 5.42E-8 33 1.90E-9 0.16
7 SGTC_2634 4'-methoxyflavone 5.48 100.0 µM 3.88E-7 1 2.14E-8 0.41
8 SGTC_2538 3',7'-epoxycaryophyllan-6-one 5.13 100.0 µM 1.86E-6 3 1.47E-7 0.41
9 SGTC_2948 9070189 5.12 9.4 µM 1.90E-6 plasma membrane duress 5 1.51E-7 0.25
10 SGTC_219 mitoxanthrone 5.07 164.4 µM 2.38E-6 DNA intercalators 7 1.99E-7 0.12
11 SGTC_2425 5628681 5.04 7.8 µM 2.65E-6 2 2.27E-7 0.59
12 SGTC_1630 st005209 5.02 31.3 µM 3.00E-6 2 2.65E-7 0.72
13 SGTC_2839 9003951 4.74 26.0 µM 9.54E-6 2 1.09E-6 0.88
14 SGTC_1675 st018485 4.70 24.5 µM 1.10E-5 60S ribosome export 5 1.31E-6 0.50
15 SGTC_2977 9011197 4.60 71.4 µM 1.61E-5 5 2.09E-6 0.03
16 SGTC_471 1-acyl-paf 4.59 4.0 µM 1.67E-5 DNA intercalators 13 2.18E-6 0.32
17 SGTC_3021 9087658 4.52 49.5 µM 2.27E-5 1 3.17E-6 0.53
18 SGTC_513 4245-1575 4.46 41.7 µM 2.84E-5 unfolded protein response 22 4.17E-6 0.15
19 SGTC_86 0417-1630 4.31 471.9 µM 4.92E-5 ubiquinone biosynthesis & proteasome 24 8.18E-6 0.09
20 SGTC_875 0709-0210 4.20 25.7 µM 7.26E-5 fatty acid desaturase (OLE1) 10 1.32E-5 0.31

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 5.14E-30 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.184 6.35E-27 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.180 1.00E-25 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.177 3.84E-25 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.175 2.07E-24 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.170 3.94E-23 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.165 1.04E-21 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.158 2.62E-20 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.157 4.56E-20 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.155 1.32E-19 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.155 1.54E-19 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.154 2.52E-19 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.153 4.77E-19 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.153 5.94E-19 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.153 6.60E-19 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit