HIPHOP chemogenomics database

YBR124W_d

Putative protein of unknown function

Zygosity: Heterozygous strain

fixedexpanded
Profile for YBR124W / YBR124W

Click on Significant Values for Screen Details

Top fitness defect scores for YBR124W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_514	4466-0038	8.26	2.6 nM	1.67E-18	cell wall	6	7.34E-17	0.69
2	SGTC_2893	9048488	6.11	26.0 µM	5.55E-11	fatty acid desaturase (OLE1)	2	4.93E-10	0.79
3	SGTC_2117	5521686	5.49	200.0 µM	3.29E-9		1	2.00E-8	0.66
4	SGTC_220	paclitaxel	5.46	373.4 µM	3.97E-9		1	2.37E-8	1.05
5	SGTC_1132	3456-3614	5.11	2.5 µM	3.21E-8	tubulin folding & SWR complex	3	1.58E-7	0.17
6	SGTC_41	0478-0632	4.89	82.6 µM	1.16E-7		10	5.07E-7	0.08
7	SGTC_130	0136-0219	4.76	337.7 µM	2.42E-7		5	9.85E-7	0.31
8	SGTC_2896	9052656	4.75	71.4 µM	2.53E-7	endomembrane recycling	17	1.03E-6	0.15
9	SGTC_996	3970-0799	4.63	1.8 µM	4.75E-7		17	1.81E-6	0.08
10	SGTC_1185	1319-0113	4.53	81.3 µM	8.15E-7	DNA damage response	2	2.96E-6	0.42
11	SGTC_2087	5276107	4.24	200.0 µM	3.49E-6		4	1.11E-5	0.21
12	SGTC_2755	lomerizine	3.92	42.7 µM	1.63E-5		4	4.47E-5	0.59
13	SGTC_3266	9136860	3.89	49.5 µM	1.83E-5	cell wall	13	4.96E-5	0.09
14	SGTC_2619	obliquin	3.87	87.9 µM	2.06E-5	cell wall	31	5.52E-5	0.03
15	SGTC_2454	5-benzylidenerhodanine	3.79	10.4 µM	2.85E-5	TRP & mitochondrial translation	5	7.42E-5	0.10
16	SGTC_3180	9109287	3.69	49.5 µM	4.41E-5		9	1.10E-4	0.05
17	SGTC_2100	5377183	3.68	190.0 µM	4.76E-5	60S ribosome export	10	1.18E-4	0.07
18	SGTC_3085	9117376	3.63	49.5 µM	5.87E-5		11	1.43E-4	0.11
19	SGTC_2455	5377712	3.51	9.8 µM	9.62E-5		7	2.23E-4	0.02
20	SGTC_9	0092-0002	3.50	10.4 µM	1.00E-4		19	2.32E-4	0.11

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.193	1.88E-29	YGL033W	HOP2	hom	Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.174	2.46E-24	YBL085W	BOI1	hom	Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.161	5.28E-21	YMR036C	MIH1	hom	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.160	1.05E-20	YOL003C	PFA4	hom	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.156	1.06E-19	YMR121C	RPL15B	hom	Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.154	2.55E-19	YLR102C	APC9	hom	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.151	1.32E-18	YDR121W	DPB4	hom	Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.144	4.92E-17	YJL159W	HSP150	hom	O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.143	1.02E-16	YML118W	NGL3	hom	3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.138	1.04E-15	YPR061C	JID1	hom	Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.133	1.35E-14	YLL032C	YLL032C	hom	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.131	2.94E-14	YGR035C_p	YGR035C_p	hom	Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.127	1.79E-13	YGL222C	EDC1	hom	RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.127	1.83E-13	YOL054W	PSH1	hom	E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
0.126	2.30E-13	YNL273W	TOF1	hom	Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase