YBR124W_d

Putative protein of unknown function

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR124W / YBR124W

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.31|P-value:2.19E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.50|P-value:1.00E-4 ID:SGTC_13|Compound:0199-0087|FD-Score:3.22|P-value:3.07E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:-3.03|P-value:9.24E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:-3.03|P-value:9.19E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:4.89|P-value:1.16E-7 ID:SGTC_130|Compound:0136-0219|FD-Score:4.76|P-value:2.42E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.51|P-value:1.49E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.23|P-value:6.11E-6 ID:SGTC_220|Compound:paclitaxel|FD-Score:5.46|P-value:3.97E-9 ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.57|P-value:1.14E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.20|P-value:3.30E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:2.94|P-value:8.64E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:8.26|P-value:1.67E-18 ID:SGTC_535|Compound:2293-4129|FD-Score:3.07|P-value:5.50E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.12|P-value:4.45E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.31|P-value:2.16E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.08|P-value:7.48E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.63|P-value:4.75E-7 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.21|P-value:4.64E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.20|P-value:3.31E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.11|P-value:3.21E-8 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.92|P-value:2.60E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:2.98|P-value:7.65E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:2.96|P-value:8.00E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:2.95|P-value:8.29E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:4.53|P-value:8.15E-7 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.41|P-value:2.18E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:2.95|P-value:8.27E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.30|P-value:2.29E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:-3.02|P-value:9.50E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.06|P-value:5.69E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.13|P-value:4.29E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.30|P-value:3.37E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.23|P-value:3.02E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.07|P-value:5.34E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.00|P-value:7.04E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.31|P-value:2.21E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.24|P-value:3.49E-6 ID:SGTC_2088|Compound:5278280|FD-Score:-3.59|P-value:1.04E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.68|P-value:4.76E-5 ID:SGTC_2102|Compound:5377816|FD-Score:-3.05|P-value:8.34E-4 ID:SGTC_2108|Compound:5365811|FD-Score:-3.06|P-value:8.15E-4 ID:SGTC_2117|Compound:5521686|FD-Score:5.49|P-value:3.29E-9 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.01|P-value:9.78E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.29|P-value:2.35E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.53|P-value:1.35E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.93|P-value:8.95E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.79|P-value:2.85E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.51|P-value:9.62E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-5.80|P-value:8.93E-10 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.48|P-value:1.66E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.87|P-value:2.06E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.92|P-value:1.63E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-3.59|P-value:1.04E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.40|P-value:2.30E-4 ID:SGTC_2893|Compound:9048488|FD-Score:6.11|P-value:5.55E-11 ID:SGTC_2896|Compound:9052656|FD-Score:4.75|P-value:2.53E-7 ID:SGTC_2921|Compound:7974240|FD-Score:-3.16|P-value:5.62E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.03|P-value:9.17E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.63|P-value:5.87E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-3.73|P-value:5.90E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.47|P-value:1.13E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.69|P-value:4.41E-5 ID:SGTC_3240|Compound:9133527|FD-Score:-3.21|P-value:4.69E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.89|P-value:1.83E-5 ID:SGTC_2|Compound:0422-0095|FD-Score:3.31|P-value:2.19E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.50|P-value:1.00E-4 ID:SGTC_13|Compound:0199-0087|FD-Score:3.22|P-value:3.07E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:-3.03|P-value:9.24E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:-3.03|P-value:9.19E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:4.89|P-value:1.16E-7 ID:SGTC_130|Compound:0136-0219|FD-Score:4.76|P-value:2.42E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.51|P-value:1.49E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.23|P-value:6.11E-6 ID:SGTC_220|Compound:paclitaxel|FD-Score:5.46|P-value:3.97E-9 ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.57|P-value:1.14E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.20|P-value:3.30E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:2.94|P-value:8.64E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:8.26|P-value:1.67E-18 ID:SGTC_535|Compound:2293-4129|FD-Score:3.07|P-value:5.50E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.12|P-value:4.45E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.31|P-value:2.16E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.08|P-value:7.48E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.63|P-value:4.75E-7 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.21|P-value:4.64E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.20|P-value:3.31E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.11|P-value:3.21E-8 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.92|P-value:2.60E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:2.98|P-value:7.65E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:2.96|P-value:8.00E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:2.95|P-value:8.29E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:4.53|P-value:8.15E-7 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.41|P-value:2.18E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:2.95|P-value:8.27E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.30|P-value:2.29E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:-3.02|P-value:9.50E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.06|P-value:5.69E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.13|P-value:4.29E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.30|P-value:3.37E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.23|P-value:3.02E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.07|P-value:5.34E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.00|P-value:7.04E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.31|P-value:2.21E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.24|P-value:3.49E-6 ID:SGTC_2088|Compound:5278280|FD-Score:-3.59|P-value:1.04E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.68|P-value:4.76E-5 ID:SGTC_2102|Compound:5377816|FD-Score:-3.05|P-value:8.34E-4 ID:SGTC_2108|Compound:5365811|FD-Score:-3.06|P-value:8.15E-4 ID:SGTC_2117|Compound:5521686|FD-Score:5.49|P-value:3.29E-9 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.01|P-value:9.78E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.29|P-value:2.35E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.53|P-value:1.35E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.93|P-value:8.95E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.79|P-value:2.85E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.51|P-value:9.62E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-5.80|P-value:8.93E-10 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.48|P-value:1.66E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.87|P-value:2.06E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.92|P-value:1.63E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-3.59|P-value:1.04E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.40|P-value:2.30E-4 ID:SGTC_2893|Compound:9048488|FD-Score:6.11|P-value:5.55E-11 ID:SGTC_2896|Compound:9052656|FD-Score:4.75|P-value:2.53E-7 ID:SGTC_2921|Compound:7974240|FD-Score:-3.16|P-value:5.62E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.03|P-value:9.17E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.63|P-value:5.87E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-3.73|P-value:5.90E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.47|P-value:1.13E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.69|P-value:4.41E-5 ID:SGTC_3240|Compound:9133527|FD-Score:-3.21|P-value:4.69E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.89|P-value:1.83E-5

Top fitness defect scores for YBR124W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_514 4466-0038 8.26 2.6 nM 1.67E-18 cell wall 6 7.34E-17 0.69
2 SGTC_2893 9048488 6.11 26.0 µM 5.55E-11 fatty acid desaturase (OLE1) 2 4.93E-10 0.79
3 SGTC_2117 5521686 5.49 200.0 µM 3.29E-9 1 2.00E-8 0.66
4 SGTC_220 paclitaxel 5.46 373.4 µM 3.97E-9 1 2.37E-8 1.05
5 SGTC_1132 3456-3614 5.11 2.5 µM 3.21E-8 tubulin folding & SWR complex 3 1.58E-7 0.17
6 SGTC_41 0478-0632 4.89 82.6 µM 1.16E-7 10 5.07E-7 0.08
7 SGTC_130 0136-0219 4.76 337.7 µM 2.42E-7 5 9.85E-7 0.31
8 SGTC_2896 9052656 4.75 71.4 µM 2.53E-7 endomembrane recycling 17 1.03E-6 0.15
9 SGTC_996 3970-0799 4.63 1.8 µM 4.75E-7 17 1.81E-6 0.08
10 SGTC_1185 1319-0113 4.53 81.3 µM 8.15E-7 DNA damage response 2 2.96E-6 0.42
11 SGTC_2087 5276107 4.24 200.0 µM 3.49E-6 4 1.11E-5 0.21
12 SGTC_2755 lomerizine 3.92 42.7 µM 1.63E-5 4 4.47E-5 0.59
13 SGTC_3266 9136860 3.89 49.5 µM 1.83E-5 cell wall 13 4.96E-5 0.09
14 SGTC_2619 obliquin 3.87 87.9 µM 2.06E-5 cell wall 31 5.52E-5 0.03
15 SGTC_2454 5-benzylidenerhodanine 3.79 10.4 µM 2.85E-5 TRP & mitochondrial translation 5 7.42E-5 0.10
16 SGTC_3180 9109287 3.69 49.5 µM 4.41E-5 9 1.10E-4 0.05
17 SGTC_2100 5377183 3.68 190.0 µM 4.76E-5 60S ribosome export 10 1.18E-4 0.07
18 SGTC_3085 9117376 3.63 49.5 µM 5.87E-5 11 1.43E-4 0.11
19 SGTC_2455 5377712 3.51 9.8 µM 9.62E-5 7 2.23E-4 0.02
20 SGTC_9 0092-0002 3.50 10.4 µM 1.00E-4 19 2.32E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 1.88E-29 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.174 2.46E-24 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.161 5.28E-21 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.160 1.05E-20 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.156 1.06E-19 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.154 2.55E-19 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.151 1.32E-18 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.144 4.92E-17 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.143 1.02E-16 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.138 1.04E-15 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.133 1.35E-14 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.131 2.94E-14 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.127 1.79E-13 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.127 1.83E-13 YOL054W PSH1 hom E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
0.126 2.30E-13 YNL273W TOF1 hom Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase