YBR130C / SHE3

Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR130C / SHE3

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.83|P-value:7.70E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:4.18|P-value:1.84E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.15|P-value:9.52E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.16|P-value:9.07E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:-3.21|P-value:7.34E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-4.37|P-value:7.73E-6 ID:SGTC_444|Compound:curcumin|FD-Score:3.80|P-value:8.67E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.44|P-value:3.24E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:4.05|P-value:3.17E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:5.05|P-value:3.03E-7 ID:SGTC_684|Compound:1140-0066|FD-Score:3.36|P-value:4.50E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:4.03|P-value:3.42E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.15|P-value:9.05E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.56|P-value:2.18E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.19|P-value:1.53E-7 ID:SGTC_1526|Compound:st051518|FD-Score:-3.55|P-value:2.16E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.26|P-value:6.24E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.16|P-value:8.83E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.21|P-value:7.66E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.18|P-value:8.67E-4 ID:SGTC_1948|Compound:st076329|FD-Score:5.23|P-value:1.20E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.93|P-value:5.17E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-4.28|P-value:1.14E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.33|P-value:5.18E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.96|P-value:4.33E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.36|P-value:7.74E-6 ID:SGTC_2954|Compound:9074818|FD-Score:3.79|P-value:9.23E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.18|P-value:8.26E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.51|P-value:4.25E-6 ID:SGTC_3324|Compound:9138759|FD-Score:-5.02|P-value:3.36E-7 ID:SGTC_3331|Compound:9141060|FD-Score:-5.63|P-value:1.25E-8 ID:SGTC_3343|Compound:9148379|FD-Score:3.18|P-value:8.41E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:3.83|P-value:7.70E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:4.18|P-value:1.84E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.15|P-value:9.52E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.16|P-value:9.07E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:-3.21|P-value:7.34E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-4.37|P-value:7.73E-6 ID:SGTC_444|Compound:curcumin|FD-Score:3.80|P-value:8.67E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.44|P-value:3.24E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:4.05|P-value:3.17E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:5.05|P-value:3.03E-7 ID:SGTC_684|Compound:1140-0066|FD-Score:3.36|P-value:4.50E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:4.03|P-value:3.42E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.15|P-value:9.05E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.56|P-value:2.18E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.19|P-value:1.53E-7 ID:SGTC_1526|Compound:st051518|FD-Score:-3.55|P-value:2.16E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.26|P-value:6.24E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.16|P-value:8.83E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.21|P-value:7.66E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.18|P-value:8.67E-4 ID:SGTC_1948|Compound:st076329|FD-Score:5.23|P-value:1.20E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.93|P-value:5.17E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-4.28|P-value:1.14E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.33|P-value:5.18E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.96|P-value:4.33E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.36|P-value:7.74E-6 ID:SGTC_2954|Compound:9074818|FD-Score:3.79|P-value:9.23E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.18|P-value:8.26E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.51|P-value:4.25E-6 ID:SGTC_3324|Compound:9138759|FD-Score:-5.02|P-value:3.36E-7 ID:SGTC_3331|Compound:9141060|FD-Score:-5.63|P-value:1.25E-8 ID:SGTC_3343|Compound:9148379|FD-Score:3.18|P-value:8.41E-4

Top fitness defect scores for YBR130C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1948 st076329 5.23 66.6 µM 1.20E-7 9 8.40E-8
2 SGTC_1453 4237-0541 5.19 195.0 µM 1.53E-7 heme biosynthesis & mitochondrial translocase 9 1.08E-7
3 SGTC_636 0kpi-0074 5.05 126.0 µM 3.03E-7 9 2.16E-7
4 SGTC_3205 9113483 4.51 49.5 µM 4.25E-6 14 3.24E-6
5 SGTC_3 0833-0587 4.18 95.6 µM 1.84E-5 redox potentiating 17 1.45E-5
6 SGTC_633 0437-0093 4.05 97.7 µM 3.17E-5 DNA intercalators 10 2.54E-5
7 SGTC_727 3032-0951 4.03 202.0 µM 3.42E-5 27 2.74E-5
8 SGTC_2129 girgensonine 3.93 121.0 µM 5.17E-5 heme biosynthesis & mitochondrial translocase 31 4.18E-5
9 SGTC_2 0422-0095 3.83 29.0 µM 7.70E-5 redox potentiating 6 6.28E-5
10 SGTC_444 curcumin 3.80 90.4 µM 8.67E-5 iron homeostasis 31 7.09E-5
11 SGTC_2954 9074818 3.79 52.7 µM 9.23E-5 40 7.56E-5
12 SGTC_278 4092-0821 3.64 23.9 µM 1.67E-4 plasma membrane duress 52 1.39E-4
13 SGTC_1176 0848-0131 3.56 83.3 µM 2.18E-4 Golgi 31 1.82E-4
14 SGTC_684 1140-0066 3.36 328.0 µM 4.50E-4 Golgi 58 3.83E-4
15 SGTC_2426 5582046 3.33 32.2 µM 5.18E-4 52 4.42E-4
16 SGTC_1938 st074717 3.21 56.4 µM 7.66E-4 31 6.59E-4
17 SGTC_3343 9148379 3.18 19.0 µM 8.41E-4 23 7.25E-4
18 SGTC_1941 st076221 3.18 61.8 µM 8.67E-4 sphingolipid biosynthesis & PDR1 122 7.49E-4
19 SGTC_219 mitoxanthrone 3.16 164.4 µM 9.07E-4 DNA intercalators 76 7.84E-4
20 SGTC_135 0933-0004 3.15 26.4 µM 9.52E-4 60S ribosome export 56 8.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.08E-11 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
0.102 2.66E-9 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.102 3.08E-9 YPR185W ATG13 hom Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
0.090 1.56E-7 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.089 2.22E-7 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.085 7.39E-7 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.084 9.53E-7 YJL151C SNA3 hom Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles
0.082 1.81E-6 YDR183W PLP1 hom Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators
0.082 1.98E-6 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.079 4.27E-6 YMR155W_p YMR155W_p hom Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
0.079 4.71E-6 YML009C MRPL39 hom Mitochondrial ribosomal protein of the large subunit
0.078 5.54E-6 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.077 7.06E-6 YOR095C RKI1 het Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
0.075 1.29E-5 YGR091W PRP31 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.075 1.29E-5 YNL247W YNL247W het Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments