YBR133C / HSL7

Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR133C / HSL7

Click on Significant Values for Screen Details ID:SGTC_211|Compound:3455-0679|FD-Score:4.15|P-value:8.00E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:6.38|P-value:3.52E-9 ID:SGTC_335|Compound:4077-0256|FD-Score:-6.49|P-value:2.32E-9 ID:SGTC_338|Compound:4055-0136|FD-Score:-4.29|P-value:5.53E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.69|P-value:4.53E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.14|P-value:9.79E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.95|P-value:1.89E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-4.25|P-value:6.46E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.79|P-value:2.81E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.94|P-value:1.68E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.55|P-value:6.10E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.57|P-value:6.56E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:4.85|P-value:5.14E-6 ID:SGTC_1064|Compound:honokiol|FD-Score:4.10|P-value:9.69E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.41|P-value:9.62E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.06|P-value:1.11E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.46|P-value:8.15E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.26|P-value:5.46E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.24|P-value:5.87E-5 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.83|P-value:2.48E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.33|P-value:4.09E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.00|P-value:1.56E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.75|P-value:3.24E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.59|P-value:6.24E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.75|P-value:3.70E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.51|P-value:6.96E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.98|P-value:1.45E-4 ID:SGTC_1694|Compound:st024011|FD-Score:-3.51|P-value:7.96E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.89|P-value:2.01E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.65|P-value:4.41E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.04|P-value:1.17E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.50|P-value:7.13E-4 ID:SGTC_1852|Compound:st056254|FD-Score:4.24|P-value:5.85E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.51|P-value:7.04E-4 ID:SGTC_1957|Compound:st077035|FD-Score:4.91|P-value:4.11E-6 ID:SGTC_1971|Compound:st069429|FD-Score:3.67|P-value:4.13E-4 ID:SGTC_1984|Compound:st072354|FD-Score:4.44|P-value:2.67E-5 ID:SGTC_1985|Compound:st071382|FD-Score:5.58|P-value:2.04E-7 ID:SGTC_1987|Compound:st072290|FD-Score:4.30|P-value:4.70E-5 ID:SGTC_2014|Compound:4013930|FD-Score:4.79|P-value:6.72E-6 ID:SGTC_2027|Compound:5150920|FD-Score:3.40|P-value:9.90E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.64|P-value:4.59E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.53|P-value:6.58E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.61|P-value:5.08E-4 ID:SGTC_2457|Compound:5731572|FD-Score:4.10|P-value:9.52E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.94|P-value:1.97E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.00|P-value:1.37E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-4.73|P-value:1.02E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.60|P-value:5.28E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.73|P-value:3.98E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.55|P-value:2.07E-5 ID:SGTC_2692|Compound:st077426|FD-Score:8.64|P-value:2.30E-15 ID:SGTC_2833|Compound:9001315|FD-Score:6.45|P-value:2.40E-9 ID:SGTC_2989|Compound:9073649|FD-Score:-3.91|P-value:2.12E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.47|P-value:8.98E-4 ID:SGTC_2996|Compound:9066192|FD-Score:5.40|P-value:4.77E-7 ID:SGTC_3090|Compound:9117696|FD-Score:4.39|P-value:3.26E-5 ID:SGTC_3097|Compound:9117246|FD-Score:3.83|P-value:2.48E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.80|P-value:2.71E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.45|P-value:8.46E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.42|P-value:9.27E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.99|P-value:1.43E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.15|P-value:8.00E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:6.38|P-value:3.52E-9 ID:SGTC_335|Compound:4077-0256|FD-Score:-6.49|P-value:2.32E-9 ID:SGTC_338|Compound:4055-0136|FD-Score:-4.29|P-value:5.53E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.69|P-value:4.53E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.14|P-value:9.79E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.95|P-value:1.89E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-4.25|P-value:6.46E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.79|P-value:2.81E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.94|P-value:1.68E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.55|P-value:6.10E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.57|P-value:6.56E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:4.85|P-value:5.14E-6 ID:SGTC_1064|Compound:honokiol|FD-Score:4.10|P-value:9.69E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.41|P-value:9.62E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.06|P-value:1.11E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.46|P-value:8.15E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.26|P-value:5.46E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.24|P-value:5.87E-5 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.83|P-value:2.48E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.33|P-value:4.09E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.00|P-value:1.56E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.75|P-value:3.24E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.59|P-value:6.24E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.75|P-value:3.70E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.51|P-value:6.96E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.98|P-value:1.45E-4 ID:SGTC_1694|Compound:st024011|FD-Score:-3.51|P-value:7.96E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.89|P-value:2.01E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.65|P-value:4.41E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.04|P-value:1.17E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.50|P-value:7.13E-4 ID:SGTC_1852|Compound:st056254|FD-Score:4.24|P-value:5.85E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.51|P-value:7.04E-4 ID:SGTC_1957|Compound:st077035|FD-Score:4.91|P-value:4.11E-6 ID:SGTC_1971|Compound:st069429|FD-Score:3.67|P-value:4.13E-4 ID:SGTC_1984|Compound:st072354|FD-Score:4.44|P-value:2.67E-5 ID:SGTC_1985|Compound:st071382|FD-Score:5.58|P-value:2.04E-7 ID:SGTC_1987|Compound:st072290|FD-Score:4.30|P-value:4.70E-5 ID:SGTC_2014|Compound:4013930|FD-Score:4.79|P-value:6.72E-6 ID:SGTC_2027|Compound:5150920|FD-Score:3.40|P-value:9.90E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.64|P-value:4.59E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.53|P-value:6.58E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.61|P-value:5.08E-4 ID:SGTC_2457|Compound:5731572|FD-Score:4.10|P-value:9.52E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.94|P-value:1.97E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.00|P-value:1.37E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-4.73|P-value:1.02E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.60|P-value:5.28E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.73|P-value:3.98E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.55|P-value:2.07E-5 ID:SGTC_2692|Compound:st077426|FD-Score:8.64|P-value:2.30E-15 ID:SGTC_2833|Compound:9001315|FD-Score:6.45|P-value:2.40E-9 ID:SGTC_2989|Compound:9073649|FD-Score:-3.91|P-value:2.12E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.47|P-value:8.98E-4 ID:SGTC_2996|Compound:9066192|FD-Score:5.40|P-value:4.77E-7 ID:SGTC_3090|Compound:9117696|FD-Score:4.39|P-value:3.26E-5 ID:SGTC_3097|Compound:9117246|FD-Score:3.83|P-value:2.48E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.80|P-value:2.71E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.45|P-value:8.46E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.42|P-value:9.27E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.99|P-value:1.43E-4

Top fitness defect scores for YBR133C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2692 st077426 8.64 47.7 µM 2.30E-15 1 2.81E-18
2 SGTC_2833 9001315 6.45 45.5 µM 2.40E-9 amide catabolism 13 5.64E-11
3 SGTC_273 hydroxyurea 6.38 18.1 mM 3.52E-9 heme biosynthesis & mitochondrial translocase 9 9.00E-11
4 SGTC_1985 st071382 5.58 65.5 µM 2.04E-7 4 1.23E-8
5 SGTC_2996 9066192 5.40 71.4 µM 4.77E-7 7 3.42E-8
6 SGTC_1957 st077035 4.91 62.4 µM 4.11E-6 6 4.62E-7
7 SGTC_985 1493-0307 4.85 8.7 µM 5.14E-6 TSC3-RPN4 13 6.04E-7
8 SGTC_2014 4013930 4.79 200.0 µM 6.72E-6 12 8.36E-7
9 SGTC_1984 st072354 4.44 53.1 µM 2.67E-5 6 4.40E-6
10 SGTC_3090 9117696 4.39 49.5 µM 3.26E-5 12 5.61E-6
11 SGTC_1366 1683-0113 4.33 21.9 µM 4.09E-5 5 7.36E-6
12 SGTC_1987 st072290 4.30 61.9 µM 4.70E-5 10 8.72E-6
13 SGTC_1229 0139-0193 4.26 12.2 µM 5.46E-5 RSC complex & mRNA processing 6 1.04E-5
14 SGTC_1852 st056254 4.24 31.4 µM 5.85E-5 8 1.13E-5
15 SGTC_1232 0279-0259 4.24 161.0 µM 5.87E-5 10 1.14E-5
16 SGTC_211 3455-0679 4.15 143.5 µM 8.00E-5 14 1.65E-5
17 SGTC_2457 5731572 4.10 11.7 µM 9.52E-5 16 2.04E-5
18 SGTC_1064 honokiol 4.10 6.8 µM 9.69E-5 20 2.08E-5
19 SGTC_1166 k206-0078 4.06 225.0 µM 1.11E-4 18 2.46E-5
20 SGTC_1823 3-hydroxy-2-naphthoic acid 4.04 106.0 µM 1.17E-4 13 2.62E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.07E-13 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.089 2.29E-7 YDR246W TRS23 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.087 4.85E-7 YBR156C SLI15 hom Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.082 1.87E-6 YBR280C SAF1 hom F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
0.081 2.35E-6 YDL083C RPS16B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication
0.081 2.82E-6 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.080 3.77E-6 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.078 7.38E-6 YHR178W STB5 hom Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro
0.075 1.50E-5 YDR128W MTC5 hom Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress
0.072 3.31E-5 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.070 4.68E-5 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.070 5.47E-5 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.068 8.93E-5 YPR156C TPO3 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication
0.067 1.29E-4 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.067 1.15E-4 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation