YBR135W / CKS1

Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR135W / CKS1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.36|P-value:1.30E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.44|P-value:9.00E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.04|P-value:4.83E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.62|P-value:4.16E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.23|P-value:1.90E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:4.90|P-value:4.64E-8 ID:SGTC_338|Compound:4055-0136|FD-Score:3.14|P-value:3.23E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.18|P-value:2.15E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-2.89|P-value:7.18E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.17|P-value:2.20E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:4.18|P-value:2.73E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:3.33|P-value:1.47E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:2.95|P-value:6.69E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.28|P-value:1.77E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.37|P-value:1.24E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.44|P-value:1.56E-9 ID:SGTC_916|Compound:4466-0038|FD-Score:2.89|P-value:8.50E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:2.94|P-value:7.06E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.49|P-value:5.07E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.53|P-value:6.22E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.13|P-value:2.80E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:5.71|P-value:2.37E-10 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.26|P-value:1.63E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.89|P-value:8.50E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-2.81|P-value:9.62E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.40|P-value:1.11E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.20|P-value:2.47E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.51|P-value:4.48E-7 ID:SGTC_1591|Compound:genipin|FD-Score:-3.52|P-value:5.38E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.60|P-value:4.57E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.06|P-value:4.42E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.02|P-value:4.43E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-2.85|P-value:8.40E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.08|P-value:3.43E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-2.86|P-value:8.12E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.56|P-value:4.40E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.37|P-value:1.26E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.16|P-value:2.45E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.23|P-value:2.21E-4 ID:SGTC_2396|Compound:5342950|FD-Score:7.28|P-value:1.01E-15 ID:SGTC_2402|Compound:5553605|FD-Score:4.26|P-value:1.76E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.95|P-value:6.65E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.31|P-value:3.68E-9 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.62|P-value:4.19E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:7.84|P-value:5.90E-18 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.37|P-value:1.03E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.39|P-value:1.15E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:3.02|P-value:5.12E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:2.95|P-value:6.74E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.41|P-value:1.02E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-4.05|P-value:4.26E-6 ID:SGTC_2984|Compound:9022109|FD-Score:-2.96|P-value:5.43E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-3.19|P-value:2.16E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.27|P-value:1.90E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.24|P-value:2.15E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.36|P-value:1.30E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.44|P-value:9.00E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.04|P-value:4.83E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.62|P-value:4.16E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.23|P-value:1.90E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:4.90|P-value:4.64E-8 ID:SGTC_338|Compound:4055-0136|FD-Score:3.14|P-value:3.23E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.18|P-value:2.15E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-2.89|P-value:7.18E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.17|P-value:2.20E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:4.18|P-value:2.73E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:3.33|P-value:1.47E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:2.95|P-value:6.69E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.28|P-value:1.77E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.37|P-value:1.24E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.44|P-value:1.56E-9 ID:SGTC_916|Compound:4466-0038|FD-Score:2.89|P-value:8.50E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:2.94|P-value:7.06E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.49|P-value:5.07E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.53|P-value:6.22E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.13|P-value:2.80E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:5.71|P-value:2.37E-10 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.26|P-value:1.63E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.89|P-value:8.50E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-2.81|P-value:9.62E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.40|P-value:1.11E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.20|P-value:2.47E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.51|P-value:4.48E-7 ID:SGTC_1591|Compound:genipin|FD-Score:-3.52|P-value:5.38E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.60|P-value:4.57E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.06|P-value:4.42E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.02|P-value:4.43E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-2.85|P-value:8.40E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.08|P-value:3.43E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-2.86|P-value:8.12E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.56|P-value:4.40E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.37|P-value:1.26E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.16|P-value:2.45E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.23|P-value:2.21E-4 ID:SGTC_2396|Compound:5342950|FD-Score:7.28|P-value:1.01E-15 ID:SGTC_2402|Compound:5553605|FD-Score:4.26|P-value:1.76E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.95|P-value:6.65E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.31|P-value:3.68E-9 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.62|P-value:4.19E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:7.84|P-value:5.90E-18 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.37|P-value:1.03E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.39|P-value:1.15E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:3.02|P-value:5.12E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:2.95|P-value:6.74E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.41|P-value:1.02E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-4.05|P-value:4.26E-6 ID:SGTC_2984|Compound:9022109|FD-Score:-2.96|P-value:5.43E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-3.19|P-value:2.16E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.27|P-value:1.90E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.24|P-value:2.15E-4

Top fitness defect scores for YBR135W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2636 apigenin dimethyl ether 7.84 100.0 µM 5.90E-18 1 2.29E-15 2.67
2 SGTC_2396 5342950 7.28 42.8 µM 1.01E-15 RSC complex & mRNA processing 11 1.71E-13 0.28
3 SGTC_1284 0929-0043 5.71 16.0 µM 2.37E-10 1 5.61E-9 0.82
4 SGTC_829 1635-0120 5.44 117.0 µM 1.56E-9 DNA damage response 30 2.73E-8 0.10
5 SGTC_2619 obliquin 5.31 87.9 µM 3.68E-9 cell wall 21 5.63E-8 0.08
6 SGTC_332 4112-0506 4.90 40.9 µM 4.64E-8 15 4.78E-7 0.21
7 SGTC_1568 digitonin 4.51 820.0 nM 4.48E-7 sphingolipid biosynthesis & PDR1 11 3.23E-6 0.32
8 SGTC_1270 0831-1170 4.49 17.3 µM 5.07E-7 2 3.59E-6 1.21
9 SGTC_2402 5553605 4.26 200.0 µM 1.76E-6 4 1.03E-5 0.17
10 SGTC_514 4466-0038 4.18 2.6 nM 2.73E-6 cell wall 35 1.49E-5 0.02
11 SGTC_266 formosanin C 3.62 406.0 nM 4.16E-5 sphingolipid biosynthesis & PDR1 27 1.49E-4 0.21
12 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 3.62 100.0 µM 4.19E-5 4 1.50E-4 0.15
13 SGTC_1707 st032323 3.60 6.3 µM 4.57E-5 DNA damage response 37 1.61E-4 0.20
14 SGTC_1280 0880-0253 3.53 10.1 µM 6.22E-5 3 2.10E-4 0.23
15 SGTC_147 4466-0538 3.44 29.2 µM 9.00E-5 ergosterol biosynthesis 17 2.87E-4 0.03
16 SGTC_2795 7780010 3.41 54.5 µM 1.02E-4 9 3.20E-4 0.09
17 SGTC_1379 2144-0755 3.40 36.5 µM 1.11E-4 9 3.43E-4 0.00
18 SGTC_2648 atorvastatin 3.39 78.7 µM 1.15E-4 azole & statin 10 3.54E-4 0.06
19 SGTC_807 1315-0151 3.37 48.0 µM 1.24E-4 14 3.78E-4 0.07
20 SGTC_2311 7694451 3.37 200.0 µM 1.26E-4 20 3.81E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.239 6.06E-45 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.189 2.50E-28 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.176 7.32E-25 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.169 8.12E-23 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.164 1.40E-21 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.163 2.53E-21 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.142 1.09E-16 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.135 3.80E-15 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.131 2.37E-14 YGR113W DAM1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments
0.130 4.08E-14 YML048W GSF2 hom ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
0.129 6.51E-14 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.123 7.52E-13 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.123 1.02E-12 YIL106W MOB1 het Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.121 2.16E-12 YHR058C MED6 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress
0.119 4.32E-12 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress