YBR136W / MEC1

Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR136W / MEC1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:5.90|P-value:2.22E-10 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.06|P-value:5.04E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.36|P-value:2.03E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:4.62|P-value:5.34E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:-2.92|P-value:8.58E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.95|P-value:8.31E-8 ID:SGTC_211|Compound:3455-0679|FD-Score:3.11|P-value:5.33E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.44|P-value:1.46E-4 ID:SGTC_446|Compound:go6976|FD-Score:4.08|P-value:8.39E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:3.04|P-value:6.89E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.53|P-value:9.77E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:6.48|P-value:3.50E-12 ID:SGTC_644|Compound:1498-1197|FD-Score:5.30|P-value:1.03E-8 ID:SGTC_669|Compound:0108-0021|FD-Score:3.92|P-value:1.75E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:4.09|P-value:7.80E-6 ID:SGTC_693|Compound:4161-2696|FD-Score:3.79|P-value:3.14E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.01|P-value:7.65E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-2.98|P-value:6.93E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.04|P-value:6.75E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:6.60|P-value:1.47E-12 ID:SGTC_948|Compound:3448-0295|FD-Score:3.31|P-value:2.47E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.13|P-value:6.56E-6 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.59|P-value:7.64E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.24|P-value:3.24E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.33|P-value:2.25E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-2.93|P-value:8.30E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.05|P-value:5.29E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.00|P-value:7.87E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.16|P-value:4.38E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-2.99|P-value:6.55E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.09|P-value:4.50E-4 ID:SGTC_1653|Compound:st012112|FD-Score:6.06|P-value:7.23E-11 ID:SGTC_1654|Compound:st012436|FD-Score:3.26|P-value:2.98E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.18|P-value:5.01E-6 ID:SGTC_1683|Compound:st010134|FD-Score:-3.15|P-value:3.56E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.72|P-value:3.07E-7 ID:SGTC_1860|Compound:st056228|FD-Score:3.41|P-value:1.66E-4 ID:SGTC_1862|Compound:st057513|FD-Score:5.29|P-value:1.11E-8 ID:SGTC_1895|Compound:st058434|FD-Score:5.22|P-value:1.70E-8 ID:SGTC_1988|Compound:st071872|FD-Score:-3.88|P-value:1.61E-5 ID:SGTC_2068|Compound:5226020|FD-Score:3.16|P-value:4.33E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.23|P-value:3.36E-4 ID:SGTC_2113|Compound:5491891|FD-Score:6.39|P-value:6.78E-12 ID:SGTC_2163|Compound:5671233|FD-Score:5.96|P-value:1.48E-10 ID:SGTC_2258|Compound:7960471|FD-Score:3.34|P-value:2.13E-4 ID:SGTC_2279|Compound:7948423|FD-Score:4.33|P-value:2.46E-6 ID:SGTC_2351|Compound:9026858|FD-Score:3.96|P-value:1.48E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.86|P-value:2.35E-5 ID:SGTC_2457|Compound:5731572|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.11|P-value:5.22E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.71|P-value:4.60E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.10|P-value:5.51E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.89|P-value:1.99E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.04|P-value:1.01E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.34|P-value:2.28E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.50|P-value:1.01E-6 ID:SGTC_2676|Compound:harmalol|FD-Score:3.42|P-value:1.56E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.20|P-value:3.81E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.38|P-value:1.86E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.53|P-value:9.75E-5 ID:SGTC_2899|Compound:9053889|FD-Score:3.54|P-value:9.68E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.95|P-value:1.52E-5 ID:SGTC_3024|Compound:9090631|FD-Score:3.93|P-value:1.73E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.35|P-value:2.12E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.95|P-value:1.57E-5 ID:SGTC_3043|Compound:9092303|FD-Score:5.42|P-value:4.98E-9 ID:SGTC_3075|Compound:9116269|FD-Score:5.97|P-value:1.39E-10 ID:SGTC_3105|Compound:9121040|FD-Score:2.95|P-value:9.46E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.70|P-value:4.82E-5 ID:SGTC_3148|Compound:9097893|FD-Score:4.77|P-value:2.33E-7 ID:SGTC_3221|Compound:9128209|FD-Score:4.70|P-value:3.38E-7 ID:SGTC_3286|Compound:9117135|FD-Score:2.99|P-value:8.26E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:5.90|P-value:2.22E-10 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.06|P-value:5.04E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.36|P-value:2.03E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:4.62|P-value:5.34E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:-2.92|P-value:8.58E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.95|P-value:8.31E-8 ID:SGTC_211|Compound:3455-0679|FD-Score:3.11|P-value:5.33E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.44|P-value:1.46E-4 ID:SGTC_446|Compound:go6976|FD-Score:4.08|P-value:8.39E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:3.04|P-value:6.89E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.53|P-value:9.77E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:6.48|P-value:3.50E-12 ID:SGTC_644|Compound:1498-1197|FD-Score:5.30|P-value:1.03E-8 ID:SGTC_669|Compound:0108-0021|FD-Score:3.92|P-value:1.75E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:4.09|P-value:7.80E-6 ID:SGTC_693|Compound:4161-2696|FD-Score:3.79|P-value:3.14E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.01|P-value:7.65E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-2.98|P-value:6.93E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.04|P-value:6.75E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:6.60|P-value:1.47E-12 ID:SGTC_948|Compound:3448-0295|FD-Score:3.31|P-value:2.47E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.13|P-value:6.56E-6 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.59|P-value:7.64E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.24|P-value:3.24E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.33|P-value:2.25E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-2.93|P-value:8.30E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.05|P-value:5.29E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.00|P-value:7.87E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.16|P-value:4.38E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-2.99|P-value:6.55E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.09|P-value:4.50E-4 ID:SGTC_1653|Compound:st012112|FD-Score:6.06|P-value:7.23E-11 ID:SGTC_1654|Compound:st012436|FD-Score:3.26|P-value:2.98E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.18|P-value:5.01E-6 ID:SGTC_1683|Compound:st010134|FD-Score:-3.15|P-value:3.56E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.72|P-value:3.07E-7 ID:SGTC_1860|Compound:st056228|FD-Score:3.41|P-value:1.66E-4 ID:SGTC_1862|Compound:st057513|FD-Score:5.29|P-value:1.11E-8 ID:SGTC_1895|Compound:st058434|FD-Score:5.22|P-value:1.70E-8 ID:SGTC_1988|Compound:st071872|FD-Score:-3.88|P-value:1.61E-5 ID:SGTC_2068|Compound:5226020|FD-Score:3.16|P-value:4.33E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.23|P-value:3.36E-4 ID:SGTC_2113|Compound:5491891|FD-Score:6.39|P-value:6.78E-12 ID:SGTC_2163|Compound:5671233|FD-Score:5.96|P-value:1.48E-10 ID:SGTC_2258|Compound:7960471|FD-Score:3.34|P-value:2.13E-4 ID:SGTC_2279|Compound:7948423|FD-Score:4.33|P-value:2.46E-6 ID:SGTC_2351|Compound:9026858|FD-Score:3.96|P-value:1.48E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.86|P-value:2.35E-5 ID:SGTC_2457|Compound:5731572|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.11|P-value:5.22E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.71|P-value:4.60E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.10|P-value:5.51E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.89|P-value:1.99E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.04|P-value:1.01E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.34|P-value:2.28E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.50|P-value:1.01E-6 ID:SGTC_2676|Compound:harmalol|FD-Score:3.42|P-value:1.56E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.20|P-value:3.81E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.38|P-value:1.86E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.53|P-value:9.75E-5 ID:SGTC_2899|Compound:9053889|FD-Score:3.54|P-value:9.68E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.95|P-value:1.52E-5 ID:SGTC_3024|Compound:9090631|FD-Score:3.93|P-value:1.73E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.35|P-value:2.12E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.95|P-value:1.57E-5 ID:SGTC_3043|Compound:9092303|FD-Score:5.42|P-value:4.98E-9 ID:SGTC_3075|Compound:9116269|FD-Score:5.97|P-value:1.39E-10 ID:SGTC_3105|Compound:9121040|FD-Score:2.95|P-value:9.46E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.70|P-value:4.82E-5 ID:SGTC_3148|Compound:9097893|FD-Score:4.77|P-value:2.33E-7 ID:SGTC_3221|Compound:9128209|FD-Score:4.70|P-value:3.38E-7 ID:SGTC_3286|Compound:9117135|FD-Score:2.99|P-value:8.26E-4

Top fitness defect scores for YBR136W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_882 0843-0131 6.60 351.0 µM 1.47E-12 2 2.12E-11 1.32
2 SGTC_566 0958-0068 6.48 16.5 µM 3.50E-12 RSC & ERG11 4 4.59E-11 0.53
3 SGTC_2113 5491891 6.39 107.0 µM 6.78E-12 TSC3-RPN4 2 8.28E-11 0.31
4 SGTC_1653 st012112 6.06 65.0 µM 7.23E-11 1 6.82E-10 1.62
5 SGTC_3075 9116269 5.97 49.5 µM 1.39E-10 3 1.22E-9 0.15
6 SGTC_2163 5671233 5.96 125.0 µM 1.48E-10 3 1.29E-9 0.47
7 SGTC_41 0478-0632 5.90 82.6 µM 2.22E-10 4 1.85E-9 0.68
8 SGTC_3043 9092303 5.42 49.5 µM 4.98E-9 2 2.97E-8 0.99
9 SGTC_644 1498-1197 5.30 63.3 µM 1.03E-8 2 5.69E-8 0.05
10 SGTC_1862 st057513 5.29 3.8 µM 1.11E-8 1 6.06E-8 0.52
11 SGTC_1895 st058434 5.22 18.3 µM 1.70E-8 1 8.87E-8 1.26
12 SGTC_181 1447-1644 4.95 8.1 µM 8.31E-8 endomembrane recycling 8 3.66E-7 0.39
13 SGTC_3148 9097893 4.77 49.5 µM 2.33E-7 1 9.20E-7 0.38
14 SGTC_1755 st041960 4.72 45.2 µM 3.07E-7 5 1.18E-6 0.02
15 SGTC_3221 9128209 4.70 49.5 µM 3.38E-7 4 1.28E-6 0.07
16 SGTC_154 3389-1638 4.62 511.1 µM 5.34E-7 2 1.93E-6 0.34
17 SGTC_2591 skatole 4.50 100.0 µM 1.01E-6 3 3.41E-6 0.40
18 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 4.34 100.0 µM 2.28E-6 60S ribosome export 8 7.08E-6 0.22
19 SGTC_2279 7948423 4.33 32.9 µM 2.46E-6 5 7.56E-6 0.20
20 SGTC_1672 st016598 4.18 6.5 µM 5.01E-6 endomembrane recycling 17 1.43E-5 0.20

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.78E-11 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.106 6.49E-10 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.088 3.21E-7 YIL091C UTP25 het Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis
0.085 8.36E-7 YHR023W MYO1 het Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
0.084 1.00E-6 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.081 2.50E-6 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.078 6.58E-6 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.077 7.27E-6 YKL193C SDS22 het Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
0.077 7.22E-6 YLR219W MSC3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress
0.075 1.21E-5 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.074 1.64E-5 YBR175W SWD3 hom Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
0.073 2.39E-5 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.073 2.58E-5 YFR054C_d YFR054C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 2.78E-5 YEL057C_p YEL057C_p hom Protein of unknown function involved in telomere maintenance; target of UME6 regulation
0.072 2.87E-5 YLR416C_d YLR416C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data