YBR140C / IRA1

GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR140C / IRA1

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:-4.84|P-value:4.00E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.73|P-value:5.35E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-5.22|P-value:1.49E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:6.05|P-value:1.41E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:5.27|P-value:1.32E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.67|P-value:6.13E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.27|P-value:1.33E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.57|P-value:7.83E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:7.26|P-value:2.54E-7 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.73|P-value:5.30E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.80|P-value:1.29E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:4.49|P-value:9.50E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:7.36|P-value:1.77E-7 ID:SGTC_280|Compound:3448-3607|FD-Score:-5.26|P-value:1.34E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-5.43|P-value:8.63E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-7.40|P-value:1.49E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:6.22|P-value:8.38E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:5.40|P-value:9.42E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.87|P-value:3.81E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:5.90|P-value:2.26E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:7.49|P-value:1.08E-7 ID:SGTC_602|Compound:3130-1533|FD-Score:4.54|P-value:8.41E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-5.15|P-value:1.82E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:9.11|P-value:1.45E-10 ID:SGTC_649|Compound:1123-0311|FD-Score:4.71|P-value:5.62E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.38|P-value:9.81E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.90|P-value:3.54E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-5.01|P-value:2.65E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:5.74|P-value:3.61E-5 ID:SGTC_694|Compound:1315-0438|FD-Score:4.56|P-value:8.02E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:6.31|P-value:6.46E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:5.35|P-value:1.09E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:7.00|P-value:6.35E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:5.07|P-value:2.25E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.66|P-value:4.53E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:5.10|P-value:2.08E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:6.51|P-value:3.40E-6 ID:SGTC_964|Compound:1287-0107|FD-Score:6.53|P-value:3.09E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.10|P-value:2.08E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.70|P-value:5.66E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.74|P-value:5.20E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.90|P-value:9.07E-7 ID:SGTC_1143|Compound:3454-2408|FD-Score:-5.26|P-value:1.34E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-4.75|P-value:5.05E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:9.14|P-value:1.30E-10 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.19|P-value:1.64E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.48|P-value:9.81E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.72|P-value:5.42E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:5.40|P-value:9.46E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:-5.53|P-value:6.41E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-5.16|P-value:1.77E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-8.46|P-value:2.38E-9 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.31|P-value:6.32E-6 ID:SGTC_1814|Compound:st052110|FD-Score:8.28|P-value:4.99E-9 ID:SGTC_1824|Compound:st053723|FD-Score:4.94|P-value:3.19E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-6.06|P-value:1.36E-5 ID:SGTC_1914|Compound:st062367|FD-Score:-7.59|P-value:7.51E-8 ID:SGTC_1919|Compound:st067113|FD-Score:-5.21|P-value:1.56E-4 ID:SGTC_1953|Compound:st076800|FD-Score:5.17|P-value:1.75E-4 ID:SGTC_1962|Compound:st076595|FD-Score:4.91|P-value:3.40E-4 ID:SGTC_2038|Compound:4100038|FD-Score:6.13|P-value:1.12E-5 ID:SGTC_2050|Compound:5263056|FD-Score:9.90|P-value:3.76E-12 ID:SGTC_2108|Compound:5365811|FD-Score:4.99|P-value:2.77E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.52|P-value:8.77E-4 ID:SGTC_2137|Compound:5261020|FD-Score:5.19|P-value:1.67E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:-5.07|P-value:2.26E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.80|P-value:3.06E-5 ID:SGTC_2293|Compound:7624732|FD-Score:5.06|P-value:2.32E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-5.11|P-value:2.04E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-5.72|P-value:3.78E-5 ID:SGTC_2429|Compound:5902844|FD-Score:5.69|P-value:4.14E-5 ID:SGTC_2432|Compound:5630864|FD-Score:10.00|P-value:2.11E-12 ID:SGTC_2612|Compound:dictamnine|FD-Score:8.21|P-value:6.89E-9 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.12|P-value:2.01E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:5.83|P-value:2.74E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:10.40|P-value:3.28E-13 ID:SGTC_2733|Compound:amorolfine|FD-Score:4.93|P-value:3.22E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.83|P-value:4.17E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:8.51|P-value:1.97E-9 ID:SGTC_2766|Compound:oltipraz|FD-Score:-7.19|P-value:3.27E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:5.75|P-value:3.45E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.73|P-value:3.65E-5 ID:SGTC_2851|Compound:9015922|FD-Score:10.50|P-value:2.17E-13 ID:SGTC_2912|Compound:7964298|FD-Score:5.53|P-value:6.45E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-4.92|P-value:3.29E-4 ID:SGTC_2948|Compound:9070189|FD-Score:8.08|P-value:1.12E-8 ID:SGTC_2970|Compound:9090938|FD-Score:7.28|P-value:2.42E-7 ID:SGTC_3067|Compound:9117431|FD-Score:-4.64|P-value:6.65E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.13|P-value:1.95E-4 ID:SGTC_3120|Compound:9124077|FD-Score:5.34|P-value:1.11E-4 ID:SGTC_3219|Compound:9131112|FD-Score:4.73|P-value:5.37E-4 ID:SGTC_3247|Compound:9135149|FD-Score:5.40|P-value:9.46E-5 ID:SGTC_3277|Compound:9138724|FD-Score:4.63|P-value:6.74E-4 ID:SGTC_3278|Compound:9139605|FD-Score:6.02|P-value:1.57E-5 ID:SGTC_3284|Compound:9108171|FD-Score:5.54|P-value:6.32E-5 ID:SGTC_3288|Compound:9119690|FD-Score:7.17|P-value:3.50E-7 ID:SGTC_3304|Compound:9125678|FD-Score:8.38|P-value:3.43E-9 ID:SGTC_3308|Compound:9128332|FD-Score:5.15|P-value:1.82E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-5.37|P-value:1.01E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-4.61|P-value:7.05E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-4.84|P-value:4.00E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.73|P-value:5.35E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-5.22|P-value:1.49E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:6.05|P-value:1.41E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:5.27|P-value:1.32E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.67|P-value:6.13E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.27|P-value:1.33E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.57|P-value:7.83E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:7.26|P-value:2.54E-7 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.73|P-value:5.30E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.80|P-value:1.29E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:4.49|P-value:9.50E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:7.36|P-value:1.77E-7 ID:SGTC_280|Compound:3448-3607|FD-Score:-5.26|P-value:1.34E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-5.43|P-value:8.63E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-7.40|P-value:1.49E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:6.22|P-value:8.38E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:5.40|P-value:9.42E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.87|P-value:3.81E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:5.90|P-value:2.26E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:7.49|P-value:1.08E-7 ID:SGTC_602|Compound:3130-1533|FD-Score:4.54|P-value:8.41E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-5.15|P-value:1.82E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:9.11|P-value:1.45E-10 ID:SGTC_649|Compound:1123-0311|FD-Score:4.71|P-value:5.62E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.38|P-value:9.81E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.90|P-value:3.54E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-5.01|P-value:2.65E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:5.74|P-value:3.61E-5 ID:SGTC_694|Compound:1315-0438|FD-Score:4.56|P-value:8.02E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:6.31|P-value:6.46E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:5.35|P-value:1.09E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:7.00|P-value:6.35E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:5.07|P-value:2.25E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.66|P-value:4.53E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:5.10|P-value:2.08E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:6.51|P-value:3.40E-6 ID:SGTC_964|Compound:1287-0107|FD-Score:6.53|P-value:3.09E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.10|P-value:2.08E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.70|P-value:5.66E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.74|P-value:5.20E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.90|P-value:9.07E-7 ID:SGTC_1143|Compound:3454-2408|FD-Score:-5.26|P-value:1.34E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-4.75|P-value:5.05E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:9.14|P-value:1.30E-10 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.19|P-value:1.64E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.48|P-value:9.81E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.72|P-value:5.42E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:5.40|P-value:9.46E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:-5.53|P-value:6.41E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-5.16|P-value:1.77E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-8.46|P-value:2.38E-9 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.31|P-value:6.32E-6 ID:SGTC_1814|Compound:st052110|FD-Score:8.28|P-value:4.99E-9 ID:SGTC_1824|Compound:st053723|FD-Score:4.94|P-value:3.19E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-6.06|P-value:1.36E-5 ID:SGTC_1914|Compound:st062367|FD-Score:-7.59|P-value:7.51E-8 ID:SGTC_1919|Compound:st067113|FD-Score:-5.21|P-value:1.56E-4 ID:SGTC_1953|Compound:st076800|FD-Score:5.17|P-value:1.75E-4 ID:SGTC_1962|Compound:st076595|FD-Score:4.91|P-value:3.40E-4 ID:SGTC_2038|Compound:4100038|FD-Score:6.13|P-value:1.12E-5 ID:SGTC_2050|Compound:5263056|FD-Score:9.90|P-value:3.76E-12 ID:SGTC_2108|Compound:5365811|FD-Score:4.99|P-value:2.77E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.52|P-value:8.77E-4 ID:SGTC_2137|Compound:5261020|FD-Score:5.19|P-value:1.67E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:-5.07|P-value:2.26E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.80|P-value:3.06E-5 ID:SGTC_2293|Compound:7624732|FD-Score:5.06|P-value:2.32E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-5.11|P-value:2.04E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-5.72|P-value:3.78E-5 ID:SGTC_2429|Compound:5902844|FD-Score:5.69|P-value:4.14E-5 ID:SGTC_2432|Compound:5630864|FD-Score:10.00|P-value:2.11E-12 ID:SGTC_2612|Compound:dictamnine|FD-Score:8.21|P-value:6.89E-9 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.12|P-value:2.01E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:5.83|P-value:2.74E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:10.40|P-value:3.28E-13 ID:SGTC_2733|Compound:amorolfine|FD-Score:4.93|P-value:3.22E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.83|P-value:4.17E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:8.51|P-value:1.97E-9 ID:SGTC_2766|Compound:oltipraz|FD-Score:-7.19|P-value:3.27E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:5.75|P-value:3.45E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.73|P-value:3.65E-5 ID:SGTC_2851|Compound:9015922|FD-Score:10.50|P-value:2.17E-13 ID:SGTC_2912|Compound:7964298|FD-Score:5.53|P-value:6.45E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-4.92|P-value:3.29E-4 ID:SGTC_2948|Compound:9070189|FD-Score:8.08|P-value:1.12E-8 ID:SGTC_2970|Compound:9090938|FD-Score:7.28|P-value:2.42E-7 ID:SGTC_3067|Compound:9117431|FD-Score:-4.64|P-value:6.65E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.13|P-value:1.95E-4 ID:SGTC_3120|Compound:9124077|FD-Score:5.34|P-value:1.11E-4 ID:SGTC_3219|Compound:9131112|FD-Score:4.73|P-value:5.37E-4 ID:SGTC_3247|Compound:9135149|FD-Score:5.40|P-value:9.46E-5 ID:SGTC_3277|Compound:9138724|FD-Score:4.63|P-value:6.74E-4 ID:SGTC_3278|Compound:9139605|FD-Score:6.02|P-value:1.57E-5 ID:SGTC_3284|Compound:9108171|FD-Score:5.54|P-value:6.32E-5 ID:SGTC_3288|Compound:9119690|FD-Score:7.17|P-value:3.50E-7 ID:SGTC_3304|Compound:9125678|FD-Score:8.38|P-value:3.43E-9 ID:SGTC_3308|Compound:9128332|FD-Score:5.15|P-value:1.82E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-5.37|P-value:1.01E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-4.61|P-value:7.05E-4

Top fitness defect scores for YBR140C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2851 9015922 10.50 71.4 µM 2.17E-13 1 5.83E-26 4.83
2 SGTC_2725 haloperidol 10.40 53.2 µM 3.28E-13 plasma membrane duress 3 1.37E-25 0.96
3 SGTC_2432 5630864 10.00 12.2 µM 2.11E-12 1 6.44E-24 5.10
4 SGTC_2050 5263056 9.90 171.0 µM 3.76E-12 fatty acid desaturase (OLE1) 3 2.12E-23 1.02
5 SGTC_1160 4092-0570 9.14 10.5 µM 1.30E-10 plasma membrane duress 2 3.23E-20 2.10
6 SGTC_609 0986-0026 9.11 86.3 µM 1.45E-10 calcium & mitochondrial duress 2 4.01E-20 1.13
7 SGTC_2756 carbadox 8.51 75.1 µM 1.97E-9 4 8.76E-18 0.80
8 SGTC_3304 9125678 8.38 46.1 µM 3.43E-9 13 2.74E-17 0.82
9 SGTC_1814 st052110 8.28 31.5 µM 4.99E-9 RNA processing & uracil transport 2 5.91E-17 2.02
10 SGTC_2612 dictamnine 8.21 15.5 µM 6.89E-9 RNA pol III & RNase P/MRP 12 1.15E-16 0.41
11 SGTC_2948 9070189 8.08 9.4 µM 1.12E-8 plasma membrane duress 2 3.12E-16 1.09
12 SGTC_601 0986-0029 7.49 62.9 µM 1.08E-7 calcium & mitochondrial duress 5 3.33E-14 0.60
13 SGTC_262 fenpropimorph 7.36 62.5 µM 1.77E-7 ergosterol depletion effects on membrane 3 9.10E-14 0.38
14 SGTC_2970 9090938 7.28 41.9 µM 2.42E-7 RNA processing & uracil transport 1 1.72E-13 1.26
15 SGTC_218 alverine citrate 7.26 93.8 µM 2.54E-7 fatty acid desaturase (OLE1) 3 1.91E-13 0.01
16 SGTC_3288 9119690 7.17 36.2 µM 3.50E-7 8 3.70E-13 0.27
17 SGTC_749 1000-0129 7.00 128.0 µM 6.35E-7 amide catabolism 1 1.25E-12 3.16
18 SGTC_1133 3473-0247 6.90 50.0 µM 9.07E-7 RSC complex & mRNA processing 16 2.60E-12 0.25
19 SGTC_255 tunicamycin 6.80 200.5 nM 1.29E-6 unfolded protein response 9 5.35E-12 0.23
20 SGTC_964 1287-0107 6.53 19.4 µM 3.09E-6 cell wall 6 3.20E-11 0.81

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 2.88E-39 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.200 1.64E-31 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.183 1.39E-26 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.181 3.38E-26 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.166 4.88E-22 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.161 6.78E-21 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.159 1.68E-20 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.152 7.25E-19 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.151 1.49E-18 YJR060W CBF1 hom Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress
0.150 2.00E-18 YBR029C CDS1 het Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
0.150 2.56E-18 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.147 1.12E-17 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.146 1.95E-17 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.145 3.63E-17 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.144 4.26E-17 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis