YBR141C_p

Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR141C / YBR141C

Click on Significant Values for Screen Details ID:SGTC_297|Compound:0986-0032|FD-Score:3.55|P-value:1.23E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.06|P-value:1.96E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.61|P-value:9.61E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.80|P-value:4.40E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:5.03|P-value:1.15E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:4.24|P-value:6.13E-6 ID:SGTC_776|Compound:4476-4378|FD-Score:3.01|P-value:9.18E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.74|P-value:5.62E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.59|P-value:1.04E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.60|P-value:1.08E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:3.65|P-value:8.42E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.99|P-value:1.37E-7 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.09|P-value:6.90E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.47|P-value:1.70E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.49|P-value:1.58E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:5.96|P-value:4.43E-10 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.98|P-value:2.05E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.36|P-value:2.55E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.51|P-value:7.24E-9 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.22|P-value:4.44E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.17|P-value:5.26E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:4.49|P-value:1.85E-6 ID:SGTC_1760|Compound:st045453|FD-Score:4.53|P-value:1.51E-6 ID:SGTC_1761|Compound:st044296|FD-Score:-3.70|P-value:9.35E-5 ID:SGTC_1764|Compound:st044502|FD-Score:-4.09|P-value:1.75E-5 ID:SGTC_1766|Compound:st045414|FD-Score:-7.27|P-value:7.53E-14 ID:SGTC_1822|Compound:st052468|FD-Score:3.11|P-value:6.41E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.59|P-value:1.05E-4 ID:SGTC_1839|Compound:st053978|FD-Score:-4.97|P-value:2.32E-7 ID:SGTC_1916|Compound:st067606|FD-Score:-3.28|P-value:4.68E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.73|P-value:8.04E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.60|P-value:1.37E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.44|P-value:2.58E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.57|P-value:1.14E-4 ID:SGTC_1973|Compound:st070275|FD-Score:4.34|P-value:3.85E-6 ID:SGTC_1988|Compound:st071872|FD-Score:4.22|P-value:6.81E-6 ID:SGTC_1996|Compound:st072960|FD-Score:4.35|P-value:3.73E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-3.54|P-value:1.72E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.08|P-value:9.53E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.07|P-value:1.34E-5 ID:SGTC_2134|Compound:5324836|FD-Score:3.50|P-value:1.53E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.36|P-value:3.46E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.16|P-value:7.05E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-4.75|P-value:7.34E-7 ID:SGTC_2517|Compound:totarol|FD-Score:3.47|P-value:1.72E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.84|P-value:3.81E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-5.18|P-value:7.61E-8 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.69|P-value:6.92E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-5.33|P-value:3.19E-8 ID:SGTC_2704|Compound:st078022|FD-Score:5.11|P-value:7.47E-8 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.17|P-value:7.01E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.97|P-value:1.55E-7 ID:SGTC_2828|Compound:7998861|FD-Score:3.71|P-value:6.46E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.29|P-value:3.38E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.55|P-value:1.67E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.24|P-value:8.85E-6 ID:SGTC_3071|Compound:9117417|FD-Score:3.69|P-value:6.98E-5 ID:SGTC_3155|Compound:9099265|FD-Score:-3.15|P-value:7.46E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.33|P-value:3.88E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-4.06|P-value:2.02E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:3.55|P-value:1.23E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.06|P-value:1.96E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.61|P-value:9.61E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.80|P-value:4.40E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:5.03|P-value:1.15E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:4.24|P-value:6.13E-6 ID:SGTC_776|Compound:4476-4378|FD-Score:3.01|P-value:9.18E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.74|P-value:5.62E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.59|P-value:1.04E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.60|P-value:1.08E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:3.65|P-value:8.42E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.99|P-value:1.37E-7 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.09|P-value:6.90E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.47|P-value:1.70E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.49|P-value:1.58E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:5.96|P-value:4.43E-10 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.98|P-value:2.05E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.36|P-value:2.55E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.51|P-value:7.24E-9 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.22|P-value:4.44E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.17|P-value:5.26E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:4.49|P-value:1.85E-6 ID:SGTC_1760|Compound:st045453|FD-Score:4.53|P-value:1.51E-6 ID:SGTC_1761|Compound:st044296|FD-Score:-3.70|P-value:9.35E-5 ID:SGTC_1764|Compound:st044502|FD-Score:-4.09|P-value:1.75E-5 ID:SGTC_1766|Compound:st045414|FD-Score:-7.27|P-value:7.53E-14 ID:SGTC_1822|Compound:st052468|FD-Score:3.11|P-value:6.41E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.59|P-value:1.05E-4 ID:SGTC_1839|Compound:st053978|FD-Score:-4.97|P-value:2.32E-7 ID:SGTC_1916|Compound:st067606|FD-Score:-3.28|P-value:4.68E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.73|P-value:8.04E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.60|P-value:1.37E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.44|P-value:2.58E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.57|P-value:1.14E-4 ID:SGTC_1973|Compound:st070275|FD-Score:4.34|P-value:3.85E-6 ID:SGTC_1988|Compound:st071872|FD-Score:4.22|P-value:6.81E-6 ID:SGTC_1996|Compound:st072960|FD-Score:4.35|P-value:3.73E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-3.54|P-value:1.72E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.08|P-value:9.53E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.07|P-value:1.34E-5 ID:SGTC_2134|Compound:5324836|FD-Score:3.50|P-value:1.53E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.36|P-value:3.46E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.16|P-value:7.05E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-4.75|P-value:7.34E-7 ID:SGTC_2517|Compound:totarol|FD-Score:3.47|P-value:1.72E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.84|P-value:3.81E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-5.18|P-value:7.61E-8 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.69|P-value:6.92E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-5.33|P-value:3.19E-8 ID:SGTC_2704|Compound:st078022|FD-Score:5.11|P-value:7.47E-8 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.17|P-value:7.01E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.97|P-value:1.55E-7 ID:SGTC_2828|Compound:7998861|FD-Score:3.71|P-value:6.46E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.29|P-value:3.38E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.55|P-value:1.67E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.24|P-value:8.85E-6 ID:SGTC_3071|Compound:9117417|FD-Score:3.69|P-value:6.98E-5 ID:SGTC_3155|Compound:9099265|FD-Score:-3.15|P-value:7.46E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.33|P-value:3.88E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-4.06|P-value:2.02E-5

Top fitness defect scores for YBR141C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1219 1469-0211 5.96 33.1 µM 4.43E-10 11 1.24E-9
2 SGTC_1252 0493-0875 5.51 34.8 µM 7.24E-9 8 1.78E-8
3 SGTC_2704 st078022 5.11 71.1 µM 7.47E-8 8 1.65E-7
4 SGTC_599 1935-0052 5.03 86.5 µM 1.15E-7 3 2.48E-7
5 SGTC_1137 ixabepilone 4.99 100.0 µM 1.37E-7 12 2.95E-7
6 SGTC_2827 7993847 4.97 71.4 µM 1.55E-7 9 3.32E-7
7 SGTC_934 2950-0684 4.60 338.0 µM 1.08E-6 11 2.10E-6
8 SGTC_1760 st045453 4.53 10.4 µM 1.51E-6 NEO1-PIK1 123 2.90E-6
9 SGTC_1561 5-methoxyflavone 4.49 52.9 µM 1.85E-6 3 3.52E-6
10 SGTC_2391 6285546 4.36 200.0 µM 3.46E-6 7 6.39E-6
11 SGTC_1996 st072960 4.35 66.8 µM 3.73E-6 8 6.86E-6
12 SGTC_1973 st070275 4.34 50.2 µM 3.85E-6 7 7.08E-6
13 SGTC_669 0108-0021 4.24 26.2 µM 6.13E-6 fatty acid desaturase (OLE1) 68 1.10E-5
14 SGTC_1988 st071872 4.22 53.4 µM 6.81E-6 6 1.22E-5
15 SGTC_2125 5246583 4.07 200.0 µM 1.34E-5 tubulin folding & SWR complex 39 2.32E-5
16 SGTC_1235 benzylparaben 3.98 21.5 µM 2.05E-5 12 3.47E-5
17 SGTC_2593 nobiletin 3.84 86.2 µM 3.81E-5 32 6.27E-5
18 SGTC_432 NS 1619 3.80 61.3 µM 4.40E-5 35 7.20E-5
19 SGTC_876 0720-0963 3.74 56.8 µM 5.62E-5 22 9.08E-5
20 SGTC_2828 7998861 3.71 71.4 µM 6.46E-5 21 1.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.54E-9 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.089 2.43E-7 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.085 7.62E-7 YGL082W_p YGL082W_p hom Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
0.083 1.51E-6 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.080 3.09E-6 YOR375C GDH1 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication
0.080 3.70E-6 YML104C MDM1 hom Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.075 1.49E-5 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.074 1.59E-5 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.074 1.88E-5 YPL053C KTR6 hom Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication
0.074 2.00E-5 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.073 2.44E-5 YPR112C MRD1 het Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region
0.073 2.44E-5 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
0.071 4.29E-5 YGL139W FLC3 hom Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
0.069 6.95E-5 YKR049C FMP46 hom Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.068 8.11E-5 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination