YBR145W / ADH5

Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR145W / ADH5

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.67|P-value:1.38E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.12|P-value:8.65E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.11|P-value:8.96E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.15|P-value:7.79E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.57|P-value:1.70E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.12|P-value:8.76E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.36|P-value:3.82E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:4.17|P-value:1.41E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.24|P-value:5.75E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.55|P-value:1.83E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.05|P-value:2.40E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.32|P-value:7.19E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.73|P-value:9.27E-5 ID:SGTC_1526|Compound:st051518|FD-Score:-3.30|P-value:4.60E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.21|P-value:6.33E-4 ID:SGTC_1630|Compound:st005209|FD-Score:6.13|P-value:3.82E-10 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.40|P-value:3.24E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.55|P-value:1.86E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.17|P-value:7.23E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.54|P-value:1.89E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.34|P-value:4.07E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.11|P-value:8.88E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-5.24|P-value:7.06E-8 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-5.17|P-value:1.02E-7 ID:SGTC_2563|Compound:tomatine|FD-Score:6.04|P-value:6.89E-10 ID:SGTC_2761|Compound:levamisole|FD-Score:3.87|P-value:5.23E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.58|P-value:1.67E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.85|P-value:5.56E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.40|P-value:3.19E-4 ID:SGTC_3023|Compound:9089636|FD-Score:-3.68|P-value:1.10E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.25|P-value:5.59E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-4.18|P-value:1.32E-5 ID:SGTC_3173|Compound:9105693|FD-Score:4.70|P-value:1.23E-6 ID:SGTC_3200|Compound:9114385|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.21|P-value:6.48E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.67|P-value:1.38E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.12|P-value:8.65E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.11|P-value:8.96E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.15|P-value:7.79E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.57|P-value:1.70E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.12|P-value:8.76E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.36|P-value:3.82E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:4.17|P-value:1.41E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.24|P-value:5.75E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.55|P-value:1.83E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.05|P-value:2.40E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.32|P-value:7.19E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.73|P-value:9.27E-5 ID:SGTC_1526|Compound:st051518|FD-Score:-3.30|P-value:4.60E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.21|P-value:6.33E-4 ID:SGTC_1630|Compound:st005209|FD-Score:6.13|P-value:3.82E-10 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.40|P-value:3.24E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.55|P-value:1.86E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.17|P-value:7.23E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.54|P-value:1.89E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.34|P-value:4.07E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.11|P-value:8.88E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-5.24|P-value:7.06E-8 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-5.17|P-value:1.02E-7 ID:SGTC_2563|Compound:tomatine|FD-Score:6.04|P-value:6.89E-10 ID:SGTC_2761|Compound:levamisole|FD-Score:3.87|P-value:5.23E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.58|P-value:1.67E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.85|P-value:5.56E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.40|P-value:3.19E-4 ID:SGTC_3023|Compound:9089636|FD-Score:-3.68|P-value:1.10E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.25|P-value:5.59E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-4.18|P-value:1.32E-5 ID:SGTC_3173|Compound:9105693|FD-Score:4.70|P-value:1.23E-6 ID:SGTC_3200|Compound:9114385|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.21|P-value:6.48E-4

Top fitness defect scores for YBR145W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1630 st005209 6.13 31.3 µM 3.82E-10 3 4.34E-10
2 SGTC_2563 tomatine 6.04 8.5 µM 6.89E-10 8 7.80E-10
3 SGTC_3173 9105693 4.70 49.5 µM 1.23E-6 7 1.33E-6
4 SGTC_35 0133-0054 4.67 64.1 µM 1.38E-6 13 1.48E-6
5 SGTC_1134 3477-0009 4.32 42.5 µM 7.19E-6 36 7.65E-6
6 SGTC_697 0508-1955 4.17 564.0 µM 1.41E-5 27 1.50E-5
7 SGTC_1088 bifonazole 4.05 369.0 nM 2.40E-5 15 2.54E-5
8 SGTC_2761 levamisole 3.87 97.9 µM 5.23E-5 17 5.49E-5
9 SGTC_2965 9082772 3.85 38.6 µM 5.56E-5 mitochondrial response to ROS 44 5.84E-5
10 SGTC_1212 0520-0165 3.73 585.0 µM 9.27E-5 42 9.70E-5
11 SGTC_3200 9114385 3.70 49.5 µM 1.03E-4 44 1.08E-4
12 SGTC_2765 myclobutanil 3.58 7.7 µM 1.67E-4 azole & statin 65 1.74E-4
13 SGTC_293 4049-0273 3.57 38.5 µM 1.70E-4 23 1.77E-4
14 SGTC_943 3253-1379 3.55 105.0 µM 1.83E-4 39 1.90E-4
15 SGTC_1929 genistein trimethyl ether 3.55 50.5 µM 1.86E-4 26 1.94E-4
16 SGTC_2048 5246248 3.54 200.0 µM 1.89E-4 10 1.97E-4
17 SGTC_3004 9076122 3.40 71.4 µM 3.19E-4 30 3.32E-4
18 SGTC_414 piperonyl butoxide 3.36 100.0 µM 3.82E-4 22 3.96E-4
19 SGTC_2101 5377231 3.34 179.2 µM 4.07E-4 16 4.22E-4
20 SGTC_3025 9087895 3.25 49.5 µM 5.59E-4 PDR1 57 5.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 5.16E-21 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.115 2.38E-11 YER060W FCY21 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.109 2.58E-10 YPR048W TAH18 het Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance
0.103 2.31E-9 YGR244C LSC2 hom Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
0.102 2.81E-9 YJR149W_p YJR149W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.098 1.49E-8 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.097 1.71E-8 YIL018W RPL2B hom Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures
0.093 7.46E-8 YJL020C BBC1 hom Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
0.092 8.01E-8 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.091 1.32E-7 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.086 5.46E-7 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.086 6.82E-7 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.085 7.58E-7 YIR018W YAP5 hom Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication
0.082 2.16E-6 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.081 2.42E-6 YNL253W TEX1 hom Protein involved in mRNA export, component of the transcription export (TREX) complex