YBR146W / MRPS9

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR146W / MRPS9

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.28|P-value:6.28E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:4.69|P-value:1.86E-6 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.90|P-value:4.44E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.23|P-value:5.65E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.96|P-value:4.68E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.88|P-value:6.48E-5 ID:SGTC_276|Compound:colchicine|FD-Score:-3.21|P-value:6.13E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.77|P-value:7.47E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:4.76|P-value:1.33E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.98|P-value:4.38E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.13|P-value:8.12E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.44|P-value:3.54E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.77|P-value:1.01E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.29|P-value:4.55E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.40|P-value:4.05E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.51|P-value:2.73E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.38|P-value:4.37E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.61|P-value:2.72E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.86|P-value:7.28E-5 ID:SGTC_2017|Compound:5132927|FD-Score:4.74|P-value:1.43E-6 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.51|P-value:2.73E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.31|P-value:5.62E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.41|P-value:4.03E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.86|P-value:5.18E-5 ID:SGTC_2078|Compound:5212016|FD-Score:4.02|P-value:3.66E-5 ID:SGTC_2244|Compound:6635614|FD-Score:3.15|P-value:9.77E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.60|P-value:1.97E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.91|P-value:5.79E-5 ID:SGTC_2444|Compound:5485484|FD-Score:-3.92|P-value:3.97E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:6.67|P-value:2.08E-11 ID:SGTC_2817|Compound:7995342|FD-Score:4.81|P-value:1.04E-6 ID:SGTC_2822|Compound:7994718|FD-Score:3.79|P-value:9.60E-5 ID:SGTC_2869|Compound:9037858|FD-Score:3.84|P-value:7.85E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-4.94|P-value:3.59E-7 ID:SGTC_3109|Compound:9122853|FD-Score:3.26|P-value:6.85E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.66|P-value:1.60E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.22|P-value:1.58E-5 ID:SGTC_3222|Compound:9128301|FD-Score:4.09|P-value:2.75E-5 ID:SGTC_3292|Compound:9120825|FD-Score:3.53|P-value:2.60E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.44|P-value:6.04E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:3.28|P-value:6.28E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:4.69|P-value:1.86E-6 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.90|P-value:4.44E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.23|P-value:5.65E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.96|P-value:4.68E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.88|P-value:6.48E-5 ID:SGTC_276|Compound:colchicine|FD-Score:-3.21|P-value:6.13E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.77|P-value:7.47E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:4.76|P-value:1.33E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.98|P-value:4.38E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.13|P-value:8.12E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.44|P-value:3.54E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.77|P-value:1.01E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.29|P-value:4.55E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.40|P-value:4.05E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.51|P-value:2.73E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.38|P-value:4.37E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.61|P-value:2.72E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.86|P-value:7.28E-5 ID:SGTC_2017|Compound:5132927|FD-Score:4.74|P-value:1.43E-6 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.51|P-value:2.73E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.31|P-value:5.62E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.41|P-value:4.03E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.86|P-value:5.18E-5 ID:SGTC_2078|Compound:5212016|FD-Score:4.02|P-value:3.66E-5 ID:SGTC_2244|Compound:6635614|FD-Score:3.15|P-value:9.77E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.60|P-value:1.97E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.91|P-value:5.79E-5 ID:SGTC_2444|Compound:5485484|FD-Score:-3.92|P-value:3.97E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:6.67|P-value:2.08E-11 ID:SGTC_2817|Compound:7995342|FD-Score:4.81|P-value:1.04E-6 ID:SGTC_2822|Compound:7994718|FD-Score:3.79|P-value:9.60E-5 ID:SGTC_2869|Compound:9037858|FD-Score:3.84|P-value:7.85E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-4.94|P-value:3.59E-7 ID:SGTC_3109|Compound:9122853|FD-Score:3.26|P-value:6.85E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.66|P-value:1.60E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.22|P-value:1.58E-5 ID:SGTC_3222|Compound:9128301|FD-Score:4.09|P-value:2.75E-5 ID:SGTC_3292|Compound:9120825|FD-Score:3.53|P-value:2.60E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.44|P-value:6.04E-6

Top fitness defect scores for YBR146W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2610 ononetin 6.67 44.2 µM 2.08E-11 4 1.29E-11
2 SGTC_2817 7995342 4.81 71.4 µM 1.04E-6 12 7.67E-7
3 SGTC_953 1188-0045 4.76 9.7 µM 1.33E-6 60S ribosome export 11 9.86E-7
4 SGTC_2017 5132927 4.74 60.6 µM 1.43E-6 14 1.06E-6
5 SGTC_76 0433-0009 4.69 400.3 µM 1.86E-6 6 1.38E-6
6 SGTC_2013 4024628 4.61 200.0 µM 2.72E-6 30 2.04E-6
7 SGTC_3299 9121982 4.44 43.1 µM 6.04E-6 14 4.58E-6
8 SGTC_3198 9112019 4.22 49.5 µM 1.58E-5 mitochondrial processes 11 1.22E-5
9 SGTC_3222 9128301 4.09 49.5 µM 2.75E-5 60S ribosome export 25 2.14E-5
10 SGTC_2078 5212016 4.02 200.0 µM 3.66E-5 60S ribosome export 15 2.86E-5
11 SGTC_1099 5-nonyloxytryptamine 3.98 2.9 µM 4.38E-5 19 3.44E-5
12 SGTC_151 3013-0144 3.96 2.3 µM 4.68E-5 iron homeostasis 28 3.68E-5
13 SGTC_2391 6285546 3.91 200.0 µM 5.79E-5 21 4.56E-5
14 SGTC_270 tamoxifen 3.88 5.5 µM 6.48E-5 NEO1 32 5.12E-5
15 SGTC_2016 5121758 3.86 140.0 µM 7.28E-5 redox potentiating 57 5.76E-5
16 SGTC_2869 9037858 3.84 32.5 µM 7.85E-5 16 6.22E-5
17 SGTC_2822 7994718 3.79 71.4 µM 9.60E-5 23 7.64E-5
18 SGTC_1518 st038567 3.77 90.8 µM 1.01E-4 15 8.08E-5
19 SGTC_3192 9110362 3.66 49.5 µM 1.60E-4 mitochondrial processes 14 1.28E-4
20 SGTC_2339 9000433 3.60 200.0 µM 1.97E-4 48 1.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.45E-12 YIL159W BNR1 hom Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
0.118 7.48E-12 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.112 8.89E-11 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
0.110 1.59E-10 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.104 1.74E-9 YGL009C LEU1 hom Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
0.100 6.98E-9 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.089 2.58E-7 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.088 2.83E-7 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.088 3.43E-7 YDR515W SLF1 hom RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.088 3.73E-7 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.087 4.84E-7 YPR183W DPM1 het Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
0.086 6.54E-7 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.083 1.36E-6 YOR280C FSH3 hom Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2
0.082 2.25E-6 YER139C RTR1 hom CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication
0.080 3.55E-6 YIR003W AIM21 hom Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton