NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YBR149W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.139 | 9.45E-16 | YOR092W | ECM3 | hom | Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication |
0.130 | 4.79E-14 | YKL018C-A_p | YKL018C-A_p | hom | Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
0.114 | 3.08E-11 | YLR237W | THI7 | hom | Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia |
0.104 | 1.75E-9 | YGR169C | PUS6 | hom | tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability |
0.103 | 2.04E-9 | YEL017W | GTT3 | hom | Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery |
0.101 | 5.14E-9 | YDL010W | GRX6 | hom | Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication |
0.098 | 1.51E-8 | YOR252W | TMA16 | hom | Protein of unknown function that associates with ribosomes |
0.097 | 2.12E-8 | YBR169C | SSE2 | hom | Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication |
0.093 | 6.14E-8 | YJR115W_p | YJR115W_p | hom | Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication |
0.088 | 3.04E-7 | YDR185C | UPS3 | hom | Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations |
0.088 | 3.32E-7 | YER113C | TMN3 | hom | Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation |
0.087 | 4.57E-7 | YJR131W | MNS1 | hom | Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation |
0.087 | 5.13E-7 | YGR050C_p | YGR050C_p | hom | Protein of unknown function; mRNA identified as translated by ribosome profiling data |
0.086 | 5.30E-7 | YIL074C | SER33 | hom | 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication |
0.086 | 6.47E-7 | YJR149W_p | YJR149W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |