YBR149W / ARA1

NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR149W / ARA1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:-3.23|P-value:4.14E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:3.02|P-value:8.06E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:5.27|P-value:2.05E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.22|P-value:4.41E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-4.15|P-value:8.53E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:6.34|P-value:2.15E-11 ID:SGTC_213|Compound:1246-0773|FD-Score:3.35|P-value:2.42E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:-3.18|P-value:4.95E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.19|P-value:4.46E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:6.75|P-value:1.11E-12 ID:SGTC_364|Compound:0083-0097|FD-Score:-5.68|P-value:1.97E-9 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.37|P-value:2.46E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.77|P-value:4.33E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.08|P-value:6.60E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.28|P-value:3.20E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.02|P-value:8.90E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.15|P-value:5.03E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.53|P-value:1.18E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.84|P-value:3.10E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.03|P-value:8.65E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:-4.52|P-value:1.45E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.10|P-value:6.78E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.75|P-value:5.17E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-5.45|P-value:8.16E-9 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.00|P-value:8.75E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.04|P-value:7.55E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.28|P-value:3.44E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.04|P-value:7.62E-4 ID:SGTC_1621|Compound:st003705|FD-Score:2.98|P-value:9.49E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.72|P-value:5.39E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.22|P-value:4.00E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-3.27|P-value:3.60E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.21|P-value:4.58E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.02|P-value:9.02E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-7.20|P-value:4.11E-14 ID:SGTC_1931|Compound:st074438|FD-Score:-3.62|P-value:8.83E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.55|P-value:1.22E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.66|P-value:7.49E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-3.10|P-value:6.63E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.03|P-value:8.70E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.86|P-value:2.89E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.00|P-value:9.64E-4 ID:SGTC_2337|Compound:9009472|FD-Score:6.75|P-value:1.12E-12 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.10|P-value:9.67E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.97|P-value:1.35E-7 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.82|P-value:3.52E-5 ID:SGTC_2811|Compound:7967822|FD-Score:-3.07|P-value:7.49E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.35|P-value:2.43E-4 ID:SGTC_2873|Compound:9040596|FD-Score:6.10|P-value:1.07E-10 ID:SGTC_2949|Compound:9072542|FD-Score:3.51|P-value:1.28E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.77|P-value:4.29E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:-3.23|P-value:4.14E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:3.02|P-value:8.06E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:5.27|P-value:2.05E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.22|P-value:4.41E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-4.15|P-value:8.53E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:6.34|P-value:2.15E-11 ID:SGTC_213|Compound:1246-0773|FD-Score:3.35|P-value:2.42E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:-3.18|P-value:4.95E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.19|P-value:4.46E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:6.75|P-value:1.11E-12 ID:SGTC_364|Compound:0083-0097|FD-Score:-5.68|P-value:1.97E-9 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.37|P-value:2.46E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.77|P-value:4.33E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.08|P-value:6.60E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.28|P-value:3.20E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.02|P-value:8.90E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.15|P-value:5.03E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.53|P-value:1.18E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.84|P-value:3.10E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.03|P-value:8.65E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:-4.52|P-value:1.45E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.10|P-value:6.78E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.75|P-value:5.17E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-5.45|P-value:8.16E-9 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.00|P-value:8.75E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.04|P-value:7.55E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.28|P-value:3.44E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.04|P-value:7.62E-4 ID:SGTC_1621|Compound:st003705|FD-Score:2.98|P-value:9.49E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.72|P-value:5.39E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.22|P-value:4.00E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-3.27|P-value:3.60E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.21|P-value:4.58E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.02|P-value:9.02E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-7.20|P-value:4.11E-14 ID:SGTC_1931|Compound:st074438|FD-Score:-3.62|P-value:8.83E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.55|P-value:1.22E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.66|P-value:7.49E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-3.10|P-value:6.63E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.03|P-value:8.70E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.86|P-value:2.89E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.00|P-value:9.64E-4 ID:SGTC_2337|Compound:9009472|FD-Score:6.75|P-value:1.12E-12 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.10|P-value:9.67E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.97|P-value:1.35E-7 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.82|P-value:3.52E-5 ID:SGTC_2811|Compound:7967822|FD-Score:-3.07|P-value:7.49E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.35|P-value:2.43E-4 ID:SGTC_2873|Compound:9040596|FD-Score:6.10|P-value:1.07E-10 ID:SGTC_2949|Compound:9072542|FD-Score:3.51|P-value:1.28E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.77|P-value:4.29E-5

Top fitness defect scores for YBR149W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_358 0075-0058 6.75 9.4 µM 1.11E-12 13 7.47E-12
2 SGTC_2337 9009472 6.75 200.0 µM 1.12E-12 2 7.50E-12
3 SGTC_182 3448-4371 6.34 550.5 µM 2.15E-11 3 1.17E-10
4 SGTC_2873 9040596 6.10 71.4 µM 1.07E-10 13 5.18E-10
5 SGTC_52 0329-0193 5.27 875.0 nM 2.05E-8 TSC3-RPN4 13 6.75E-8
6 SGTC_2592 piperlongumine 4.10 83.3 µM 9.67E-6 TSC3-RPN4 34 2.05E-5
7 SGTC_2027 5150920 3.86 200.0 µM 2.89E-5 12 5.65E-5
8 SGTC_882 0843-0131 3.84 351.0 µM 3.10E-5 18 6.04E-5
9 SGTC_2749 bexarotene 3.82 57.4 µM 3.52E-5 28 6.78E-5
10 SGTC_2999 9069765 3.77 71.4 µM 4.29E-5 amide catabolism 34 8.15E-5
11 SGTC_372 0155-0182 3.77 15.9 µM 4.33E-5 mitochondrial response to ROS 34 8.22E-5
12 SGTC_1704 st028805 3.72 70.8 µM 5.39E-5 13 1.01E-4
13 SGTC_881 0833-0569 3.53 170.0 µM 1.18E-4 49 2.09E-4
14 SGTC_2949 9072542 3.51 2.2 µM 1.28E-4 TSC3-RPN4 53 2.26E-4
15 SGTC_213 1246-0773 3.35 967.0 nM 2.42E-4 46 4.07E-4
16 SGTC_2819 7996655 3.35 46.4 µM 2.43E-4 40 4.08E-4
17 SGTC_563 tetrahydrosecaminediol 3.28 614.0 µM 3.20E-4 amide catabolism 35 5.27E-4
18 SGTC_1718 roemerine 3.22 11.9 µM 4.00E-4 redox potentiating 99 6.49E-4
19 SGTC_346 4513-0042 3.19 7.2 µM 4.46E-4 azole & statin 71 7.18E-4
20 SGTC_876 0720-0963 3.15 56.8 µM 5.03E-4 44 8.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 9.45E-16 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.130 4.79E-14 YKL018C-A_p YKL018C-A_p hom Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.114 3.08E-11 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.104 1.75E-9 YGR169C PUS6 hom tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
0.103 2.04E-9 YEL017W GTT3 hom Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
0.101 5.14E-9 YDL010W GRX6 hom Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
0.098 1.51E-8 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.097 2.12E-8 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.093 6.14E-8 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.088 3.04E-7 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.088 3.32E-7 YER113C TMN3 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation
0.087 4.57E-7 YJR131W MNS1 hom Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation
0.087 5.13E-7 YGR050C_p YGR050C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.086 5.30E-7 YIL074C SER33 hom 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication
0.086 6.47E-7 YJR149W_p YJR149W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm