YBR151W / APD1

Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR151W / APD1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:6.75|P-value:2.30E-12 ID:SGTC_3|Compound:0833-0587|FD-Score:3.65|P-value:9.24E-5 ID:SGTC_32|Compound:0928-0142|FD-Score:4.14|P-value:1.13E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:22.40|P-value:8.94E-117 ID:SGTC_122|Compound:0236-0016|FD-Score:5.18|P-value:5.59E-8 ID:SGTC_288|Compound:1315-0019|FD-Score:4.66|P-value:9.12E-7 ID:SGTC_333|Compound:3486-0131|FD-Score:3.53|P-value:1.50E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.63|P-value:9.99E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.16|P-value:6.06E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.19|P-value:5.36E-8 ID:SGTC_458|Compound:nppb|FD-Score:-3.13|P-value:6.76E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.34|P-value:3.15E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:4.12|P-value:1.21E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:4.07|P-value:1.53E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:5.84|P-value:1.08E-9 ID:SGTC_679|Compound:0422-0091|FD-Score:3.05|P-value:8.87E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.32|P-value:4.83E-6 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.10|P-value:7.53E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.61|P-value:1.15E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:3.79|P-value:5.21E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.72|P-value:6.86E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.35|P-value:3.02E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:5.32|P-value:2.53E-8 ID:SGTC_965|Compound:1291-5240|FD-Score:5.49|P-value:9.05E-9 ID:SGTC_981|Compound:1488-1094|FD-Score:3.28|P-value:3.81E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.64|P-value:9.48E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.17|P-value:5.78E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.87|P-value:3.61E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.36|P-value:2.85E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:8.64|P-value:4.41E-19 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.21|P-value:5.12E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:-3.15|P-value:6.25E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.57|P-value:1.27E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.70|P-value:7.25E-7 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.31|P-value:4.99E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.92|P-value:2.96E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.49|P-value:1.75E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.05|P-value:1.68E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.11|P-value:7.25E-4 ID:SGTC_1663|Compound:st014140|FD-Score:5.18|P-value:5.53E-8 ID:SGTC_1702|Compound:st027038|FD-Score:4.07|P-value:1.51E-5 ID:SGTC_1834|Compound:st055981|FD-Score:6.12|P-value:1.79E-10 ID:SGTC_1892|Compound:st058411|FD-Score:3.11|P-value:7.17E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.04|P-value:9.32E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.05|P-value:8.94E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.96|P-value:2.49E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.58|P-value:1.24E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.91|P-value:3.11E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-3.17|P-value:5.79E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.05|P-value:9.04E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.04|P-value:9.45E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.91|P-value:3.07E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.13|P-value:6.77E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-4.83|P-value:3.89E-7 ID:SGTC_2526|Compound:patulin|FD-Score:3.69|P-value:7.70E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.46|P-value:2.47E-6 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:7.62|P-value:2.87E-15 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.28|P-value:5.83E-6 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.42|P-value:2.29E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:13.00|P-value:5.51E-41 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:9.26|P-value:1.19E-21 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-4.70|P-value:7.29E-7 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.10|P-value:7.49E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-5.36|P-value:1.98E-8 ID:SGTC_2823|Compound:7987624|FD-Score:-3.53|P-value:1.53E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.24|P-value:4.50E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.20|P-value:5.15E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.84|P-value:4.20E-5 ID:SGTC_1|Compound:0258-0098|FD-Score:6.75|P-value:2.30E-12 ID:SGTC_3|Compound:0833-0587|FD-Score:3.65|P-value:9.24E-5 ID:SGTC_32|Compound:0928-0142|FD-Score:4.14|P-value:1.13E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:22.40|P-value:8.94E-117 ID:SGTC_122|Compound:0236-0016|FD-Score:5.18|P-value:5.59E-8 ID:SGTC_288|Compound:1315-0019|FD-Score:4.66|P-value:9.12E-7 ID:SGTC_333|Compound:3486-0131|FD-Score:3.53|P-value:1.50E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.63|P-value:9.99E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.16|P-value:6.06E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.19|P-value:5.36E-8 ID:SGTC_458|Compound:nppb|FD-Score:-3.13|P-value:6.76E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.34|P-value:3.15E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:4.12|P-value:1.21E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:4.07|P-value:1.53E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:5.84|P-value:1.08E-9 ID:SGTC_679|Compound:0422-0091|FD-Score:3.05|P-value:8.87E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.32|P-value:4.83E-6 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.10|P-value:7.53E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.61|P-value:1.15E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:3.79|P-value:5.21E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.72|P-value:6.86E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.35|P-value:3.02E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:5.32|P-value:2.53E-8 ID:SGTC_965|Compound:1291-5240|FD-Score:5.49|P-value:9.05E-9 ID:SGTC_981|Compound:1488-1094|FD-Score:3.28|P-value:3.81E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.64|P-value:9.48E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.17|P-value:5.78E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.87|P-value:3.61E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.36|P-value:2.85E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:8.64|P-value:4.41E-19 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.21|P-value:5.12E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:-3.15|P-value:6.25E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.57|P-value:1.27E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.70|P-value:7.25E-7 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.31|P-value:4.99E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.92|P-value:2.96E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.49|P-value:1.75E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.05|P-value:1.68E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.11|P-value:7.25E-4 ID:SGTC_1663|Compound:st014140|FD-Score:5.18|P-value:5.53E-8 ID:SGTC_1702|Compound:st027038|FD-Score:4.07|P-value:1.51E-5 ID:SGTC_1834|Compound:st055981|FD-Score:6.12|P-value:1.79E-10 ID:SGTC_1892|Compound:st058411|FD-Score:3.11|P-value:7.17E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.04|P-value:9.32E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.05|P-value:8.94E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.96|P-value:2.49E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.58|P-value:1.24E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.91|P-value:3.11E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-3.17|P-value:5.79E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.05|P-value:9.04E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.04|P-value:9.45E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.91|P-value:3.07E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.13|P-value:6.77E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-4.83|P-value:3.89E-7 ID:SGTC_2526|Compound:patulin|FD-Score:3.69|P-value:7.70E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.46|P-value:2.47E-6 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:7.62|P-value:2.87E-15 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.28|P-value:5.83E-6 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.42|P-value:2.29E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:13.00|P-value:5.51E-41 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:9.26|P-value:1.19E-21 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-4.70|P-value:7.29E-7 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.10|P-value:7.49E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-5.36|P-value:1.98E-8 ID:SGTC_2823|Compound:7987624|FD-Score:-3.53|P-value:1.53E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.24|P-value:4.50E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.20|P-value:5.15E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.84|P-value:4.20E-5

Top fitness defect scores for YBR151W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_102 gallobenzophenone 22.40 83.6 µM 8.94E-117 redox potentiating 1 2.16E-111
2 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 13.00 70.0 µM 5.51E-41 redox potentiating 3 3.78E-39
3 SGTC_2615 purpurogallin-4-carboxylic acid 9.26 100.0 µM 1.19E-21 redox potentiating 10 1.02E-20
4 SGTC_1174 0739-0097 8.64 51.1 µM 4.41E-19 redox potentiating 2 2.87E-18
5 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 7.62 19.9 µM 2.87E-15 redox potentiating 1 1.24E-14
6 SGTC_1 0258-0098 6.75 57.4 µM 2.30E-12 heme biosynthesis & mitochondrial translocase 3 7.30E-12
7 SGTC_1834 st055981 6.12 52.8 µM 1.79E-10 RPP1 & pyrimidine depletion 6 4.67E-10
8 SGTC_676 falcarinol 5.84 140.0 µM 1.08E-9 16 2.58E-9
9 SGTC_965 1291-5240 5.49 308.0 µM 9.05E-9 11 1.97E-8
10 SGTC_955 1216-0110 5.32 33.0 µM 2.53E-8 sphingolipid biosynthesis & PDR1 40 5.25E-8
11 SGTC_454 lyso-paf C-16 5.19 6.7 µM 5.36E-8 3 1.07E-7
12 SGTC_1663 st014140 5.18 55.4 µM 5.53E-8 60S ribosome export 5 1.11E-7
13 SGTC_122 0236-0016 5.18 402.4 µM 5.59E-8 RNA processing & uracil transport 13 1.12E-7
14 SGTC_1330 1469-0054 4.70 61.8 µM 7.25E-7 iron homeostasis 8 1.29E-6
15 SGTC_288 1315-0019 4.66 35.1 µM 9.12E-7 RSC & ERG11 12 1.60E-6
16 SGTC_769 0302-0231 4.61 76.0 µM 1.15E-6 23 2.00E-6
17 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 4.46 63.6 µM 2.47E-6 27 4.16E-6
18 SGTC_754 3474-0146 4.32 171.0 µM 4.83E-6 copper-dependent oxidative stress 16 7.87E-6
19 SGTC_1401 3807-4679 4.31 7.6 µM 4.99E-6 tubulin folding & SWR complex 15 8.12E-6
20 SGTC_2552 juarezic acid 4.28 87.0 µM 5.83E-6 TSC3-RPN4 28 9.43E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 4.78E-22 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.165 9.00E-22 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.144 3.95E-17 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.139 5.26E-16 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication
0.139 5.46E-16 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.138 1.13E-15 YEL051W VMA8 hom Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
0.136 3.01E-15 YDR006C SOK1 hom Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
0.135 4.01E-15 YKR052C MRS4 hom Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication
0.125 3.40E-13 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.124 4.95E-13 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.121 2.30E-12 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.113 5.02E-11 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.112 8.28E-11 YNL155W YNL155W hom Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress
0.111 1.05E-10 YDR034C LYS14 hom Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
0.110 1.55E-10 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress