YBR152W / SPP381

mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR152W / SPP381

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:4.16|P-value:3.96E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:4.87|P-value:1.97E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:3.29|P-value:9.29E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-5.24|P-value:2.89E-7 ID:SGTC_325|Compound:2810-4341|FD-Score:3.85|P-value:1.32E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:3.56|P-value:3.71E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.59|P-value:3.41E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.42|P-value:5.40E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.77|P-value:1.55E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.88|P-value:1.86E-6 ID:SGTC_703|Compound:3875-0075|FD-Score:3.65|P-value:2.76E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.54|P-value:4.01E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:4.57|P-value:7.45E-6 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.37|P-value:7.10E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.40|P-value:6.46E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.62|P-value:3.06E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-4.36|P-value:1.53E-5 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.34|P-value:6.99E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.27|P-value:2.59E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.46|P-value:5.33E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.26|P-value:9.99E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.63|P-value:2.90E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.92|P-value:1.50E-6 ID:SGTC_1889|Compound:st059080|FD-Score:-4.00|P-value:6.52E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.98|P-value:8.19E-5 ID:SGTC_1912|Compound:st060209|FD-Score:4.15|P-value:4.25E-5 ID:SGTC_1915|Compound:st067105|FD-Score:7.75|P-value:9.05E-14 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.08|P-value:5.58E-5 ID:SGTC_1919|Compound:st067113|FD-Score:7.25|P-value:2.87E-12 ID:SGTC_2009|Compound:4012297|FD-Score:3.98|P-value:7.96E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.96|P-value:8.60E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.31|P-value:8.58E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.61|P-value:3.09E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.29|P-value:9.04E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.59|P-value:2.97E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.67|P-value:2.49E-4 ID:SGTC_2481|Compound:5478948|FD-Score:8.85|P-value:2.12E-17 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.91|P-value:9.38E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.99|P-value:7.68E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.42|P-value:1.38E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:-4.64|P-value:4.71E-6 ID:SGTC_2681|Compound:menadione|FD-Score:3.29|P-value:9.26E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.75|P-value:3.31E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.99|P-value:6.76E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:4.45|P-value:1.20E-5 ID:SGTC_2842|Compound:9000675|FD-Score:9.16|P-value:1.61E-18 ID:SGTC_2894|Compound:9048625|FD-Score:-4.07|P-value:5.11E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.66|P-value:2.36E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-4.03|P-value:5.84E-5 ID:SGTC_3070|Compound:9117005|FD-Score:3.51|P-value:4.35E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-4.53|P-value:7.44E-6 ID:SGTC_3090|Compound:9117696|FD-Score:-3.29|P-value:8.33E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.44|P-value:5.58E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:4.16|P-value:3.96E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:4.87|P-value:1.97E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:3.29|P-value:9.29E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-5.24|P-value:2.89E-7 ID:SGTC_325|Compound:2810-4341|FD-Score:3.85|P-value:1.32E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:3.56|P-value:3.71E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.59|P-value:3.41E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.42|P-value:5.40E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.77|P-value:1.55E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.88|P-value:1.86E-6 ID:SGTC_703|Compound:3875-0075|FD-Score:3.65|P-value:2.76E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.54|P-value:4.01E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:4.57|P-value:7.45E-6 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.37|P-value:7.10E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.40|P-value:6.46E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.62|P-value:3.06E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-4.36|P-value:1.53E-5 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.34|P-value:6.99E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.27|P-value:2.59E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.46|P-value:5.33E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.26|P-value:9.99E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.63|P-value:2.90E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.92|P-value:1.50E-6 ID:SGTC_1889|Compound:st059080|FD-Score:-4.00|P-value:6.52E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.98|P-value:8.19E-5 ID:SGTC_1912|Compound:st060209|FD-Score:4.15|P-value:4.25E-5 ID:SGTC_1915|Compound:st067105|FD-Score:7.75|P-value:9.05E-14 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.08|P-value:5.58E-5 ID:SGTC_1919|Compound:st067113|FD-Score:7.25|P-value:2.87E-12 ID:SGTC_2009|Compound:4012297|FD-Score:3.98|P-value:7.96E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.96|P-value:8.60E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.31|P-value:8.58E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.61|P-value:3.09E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.29|P-value:9.04E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.59|P-value:2.97E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.67|P-value:2.49E-4 ID:SGTC_2481|Compound:5478948|FD-Score:8.85|P-value:2.12E-17 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.91|P-value:9.38E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.99|P-value:7.68E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.42|P-value:1.38E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:-4.64|P-value:4.71E-6 ID:SGTC_2681|Compound:menadione|FD-Score:3.29|P-value:9.26E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.75|P-value:3.31E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.99|P-value:6.76E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:4.45|P-value:1.20E-5 ID:SGTC_2842|Compound:9000675|FD-Score:9.16|P-value:1.61E-18 ID:SGTC_2894|Compound:9048625|FD-Score:-4.07|P-value:5.11E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.66|P-value:2.36E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-4.03|P-value:5.84E-5 ID:SGTC_3070|Compound:9117005|FD-Score:3.51|P-value:4.35E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-4.53|P-value:7.44E-6 ID:SGTC_3090|Compound:9117696|FD-Score:-3.29|P-value:8.33E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.44|P-value:5.58E-4

Top fitness defect scores for YBR152W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2842 9000675 9.16 19.5 µM 1.61E-18 1 2.56E-20 3.97
2 SGTC_2481 5478948 8.85 45.2 µM 2.12E-17 PDR1 1 4.42E-19 2.00
3 SGTC_1915 st067105 7.75 30.6 µM 9.05E-14 RNA pol III & RNase P/MRP 12 4.52E-15 0.23
4 SGTC_1919 st067113 7.25 52.3 µM 2.87E-12 TSC3-RPN4 1 2.06E-13 1.08
5 SGTC_1765 st044815 4.92 90.4 µM 1.50E-6 4 4.24E-7 0.28
6 SGTC_695 3505-6186 4.88 243.0 µM 1.86E-6 4 5.37E-7 0.53
7 SGTC_88 0180-0332 4.87 8.7 µM 1.97E-6 4 5.71E-7 0.72
8 SGTC_2691 st077356 4.75 60.2 µM 3.31E-6 6 1.02E-6 0.02
9 SGTC_985 1493-0307 4.57 8.7 µM 7.45E-6 TSC3-RPN4 1 2.48E-6 0.56
10 SGTC_2760 etidronate 4.45 98.0 µM 1.20E-5 4 4.20E-6 0.32
11 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.42 100.0 µM 1.38E-5 7 4.89E-6 0.34
12 SGTC_1345 1488-0192 4.27 31.4 µM 2.59E-5 1 9.83E-6 0.55
13 SGTC_82 0054-0107 4.16 293.8 µM 3.96E-5 4 1.57E-5 0.26
14 SGTC_1912 st060209 4.15 90.8 µM 4.25E-5 9 1.69E-5 0.19
15 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.08 70.1 µM 5.58E-5 4 2.29E-5 0.05
16 SGTC_2596 sinensetin 3.99 100.0 µM 7.68E-5 4 3.25E-5 0.09
17 SGTC_2009 4012297 3.98 12.1 µM 7.96E-5 cell wall signaling 9 3.39E-5 0.06
18 SGTC_1892 st058411 3.98 7.4 µM 8.19E-5 4 3.49E-5 0.11
19 SGTC_2053 5265679 3.96 138.0 µM 8.60E-5 6 3.69E-5 0.13
20 SGTC_325 2810-4341 3.85 181.0 µM 1.32E-4 amide catabolism 7 5.92E-5 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 6.52E-18 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.100 7.13E-9 YBR232C_d YBR232C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.095 3.39E-8 YAR029W_p YAR029W_p hom Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.093 7.70E-8 YNL054W VAC7 hom Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock
0.092 8.96E-8 YCL030C HIS4 hom Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
0.089 2.89E-7 YDL214C PRR2 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
0.086 5.37E-7 YDL105W NSE4 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.086 5.88E-7 YIL136W OM45 hom Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress
0.083 1.28E-6 YAL033W POP5 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.081 2.71E-6 YMR002W MIC17 hom Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.081 2.81E-6 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.080 3.99E-6 YHR171W ATG7 hom Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation
0.077 7.13E-6 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.073 2.12E-5 YPR036W VMA13 hom Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
0.073 2.15E-5 YOL119C MCH4 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport