YBR155W / CNS1

TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR155W / CNS1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.10|P-value:2.31E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.04|P-value:3.08E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-9.31|P-value:4.17E-26 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.64|P-value:2.01E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.46|P-value:4.77E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.21|P-value:1.43E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.27|P-value:1.11E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.16|P-value:1.81E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:4.09|P-value:1.97E-6 ID:SGTC_336|Compound:4111-0029|FD-Score:2.89|P-value:5.65E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.54|P-value:3.21E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:3.45|P-value:5.06E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-2.87|P-value:6.01E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:2.80|P-value:7.97E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-2.86|P-value:6.18E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.93|P-value:4.64E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:2.89|P-value:5.61E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.84|P-value:6.71E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:2.79|P-value:8.36E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:2.99|P-value:3.75E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-2.78|P-value:8.33E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.43|P-value:5.34E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.14|P-value:1.52E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.43|P-value:5.50E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.20|P-value:1.55E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.15|P-value:1.95E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.00|P-value:3.55E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:2.80|P-value:8.00E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-2.83|P-value:6.94E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.16|P-value:1.85E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-5.24|P-value:1.67E-9 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.01|P-value:3.37E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.37|P-value:7.14E-5 ID:SGTC_1774|Compound:st048371|FD-Score:3.23|P-value:1.33E-4 ID:SGTC_1791|Compound:st048313|FD-Score:4.70|P-value:5.86E-8 ID:SGTC_1796|Compound:st049173|FD-Score:4.88|P-value:1.81E-8 ID:SGTC_1983|Compound:st071813|FD-Score:3.07|P-value:2.72E-4 ID:SGTC_1989|Compound:st071868|FD-Score:2.86|P-value:6.28E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-2.94|P-value:4.56E-4 ID:SGTC_2069|Compound:5228469|FD-Score:2.88|P-value:5.71E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.19|P-value:1.61E-4 ID:SGTC_2309|Compound:7664088|FD-Score:6.79|P-value:9.62E-15 ID:SGTC_2312|Compound:7706453|FD-Score:3.99|P-value:3.34E-6 ID:SGTC_2806|Compound:7952793|FD-Score:-2.94|P-value:4.56E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-2.89|P-value:5.40E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.75|P-value:1.16E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.49|P-value:4.21E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-4.69|P-value:5.82E-8 ID:SGTC_3211|Compound:9128781|FD-Score:2.91|P-value:5.08E-4 ID:SGTC_3278|Compound:9139605|FD-Score:2.95|P-value:4.36E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.10|P-value:2.31E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.04|P-value:3.08E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-9.31|P-value:4.17E-26 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.64|P-value:2.01E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.46|P-value:4.77E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.21|P-value:1.43E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.27|P-value:1.11E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.16|P-value:1.81E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:4.09|P-value:1.97E-6 ID:SGTC_336|Compound:4111-0029|FD-Score:2.89|P-value:5.65E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.54|P-value:3.21E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:3.45|P-value:5.06E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-2.87|P-value:6.01E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:2.80|P-value:7.97E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-2.86|P-value:6.18E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.93|P-value:4.64E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:2.89|P-value:5.61E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.84|P-value:6.71E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:2.79|P-value:8.36E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:2.99|P-value:3.75E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-2.78|P-value:8.33E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.43|P-value:5.34E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.14|P-value:1.52E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.43|P-value:5.50E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.20|P-value:1.55E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.15|P-value:1.95E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.00|P-value:3.55E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:2.80|P-value:8.00E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-2.83|P-value:6.94E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.16|P-value:1.85E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-5.24|P-value:1.67E-9 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.01|P-value:3.37E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.37|P-value:7.14E-5 ID:SGTC_1774|Compound:st048371|FD-Score:3.23|P-value:1.33E-4 ID:SGTC_1791|Compound:st048313|FD-Score:4.70|P-value:5.86E-8 ID:SGTC_1796|Compound:st049173|FD-Score:4.88|P-value:1.81E-8 ID:SGTC_1983|Compound:st071813|FD-Score:3.07|P-value:2.72E-4 ID:SGTC_1989|Compound:st071868|FD-Score:2.86|P-value:6.28E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-2.94|P-value:4.56E-4 ID:SGTC_2069|Compound:5228469|FD-Score:2.88|P-value:5.71E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.19|P-value:1.61E-4 ID:SGTC_2309|Compound:7664088|FD-Score:6.79|P-value:9.62E-15 ID:SGTC_2312|Compound:7706453|FD-Score:3.99|P-value:3.34E-6 ID:SGTC_2806|Compound:7952793|FD-Score:-2.94|P-value:4.56E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-2.89|P-value:5.40E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.75|P-value:1.16E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.49|P-value:4.21E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-4.69|P-value:5.82E-8 ID:SGTC_3211|Compound:9128781|FD-Score:2.91|P-value:5.08E-4 ID:SGTC_3278|Compound:9139605|FD-Score:2.95|P-value:4.36E-4

Top fitness defect scores for YBR155W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2309 7664088 6.79 163.9 µM 9.62E-15 2 5.78E-12 1.36
2 SGTC_1796 st049173 4.88 110.4 µM 1.81E-8 3 5.23E-7 1.17
3 SGTC_1791 st048313 4.70 56.1 µM 5.86E-8 3 1.33E-6 1.01
4 SGTC_1119 parthenolide 4.14 318.5 nM 1.52E-6 TSC3-RPN4 8 1.75E-5 0.01
5 SGTC_321 4534-3890 4.09 65.3 µM 1.97E-6 RPP1 & pyrimidine depletion 6 2.15E-5 0.25
6 SGTC_2312 7706453 3.99 155.7 µM 3.34E-6 9 3.27E-5 0.01
7 SGTC_423 5-fluorouracil 3.54 457.0 µM 3.21E-5 exosome 36 1.98E-4 0.01
8 SGTC_2926 9010726 3.49 65.2 µM 4.21E-5 11 2.45E-4 0.19
9 SGTC_428 3448-4153 3.45 16.5 µM 5.06E-5 TSC3-RPN4 13 2.84E-4 0.06
10 SGTC_1074 carmofur 3.43 3.8 µM 5.34E-5 exosome 37 2.96E-4 0.11
11 SGTC_1137 ixabepilone 3.43 100.0 µM 5.50E-5 10 3.03E-4 0.16
12 SGTC_1635 st007035 3.37 42.4 µM 7.14E-5 27 3.73E-4 0.03
13 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 3.27 4.6 µM 1.11E-4 heat shock/prefoldin 31 5.30E-4 0.04
14 SGTC_1774 st048371 3.23 48.5 µM 1.33E-4 RNA processing & uracil transport 12 6.13E-4 0.04
15 SGTC_1216 1165-0504 3.20 9.7 µM 1.55E-4 10 6.91E-4 0.09
16 SGTC_247 mechlorethamine 3.16 29.7 µM 1.81E-4 DNA damage response 5 7.83E-4 0.26
17 SGTC_1373 2887-0003 3.16 58.5 µM 1.85E-4 Golgi 26 7.97E-4 5.56E-4
18 SGTC_1222 0366-0074 3.15 1.2 µM 1.95E-4 TSC3-RPN4 10 8.30E-4 0.04
19 SGTC_38 0929-0051 3.10 58.3 µM 2.31E-4 14 9.51E-4 0.03
20 SGTC_1983 st071813 3.07 46.9 µM 2.72E-4 RPP1 & pyrimidine depletion 12 0.00109 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 1.95E-35 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.195 3.73E-30 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.193 2.10E-29 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.175 1.66E-24 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.170 3.71E-23 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.169 7.69E-23 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.166 4.30E-22 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.165 6.11E-22 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.162 3.79E-21 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.146 1.43E-17 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.144 4.46E-17 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.142 1.60E-16 YNL163C RIA1 het Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.140 3.77E-16 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.138 8.26E-16 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.134 5.89E-15 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition