YBR156C / SLI15

Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR156C / SLI15

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.13|P-value:7.37E-8 ID:SGTC_65|Compound:0798-0905|FD-Score:10.00|P-value:5.01E-25 ID:SGTC_138|Compound:0850-0259|FD-Score:5.82|P-value:1.26E-9 ID:SGTC_230|Compound:MPP+|FD-Score:-3.05|P-value:8.42E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.71|P-value:7.18E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.44|P-value:1.95E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.15|P-value:6.29E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.03|P-value:9.78E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.63|P-value:1.01E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.61|P-value:9.95E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.17|P-value:5.42E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.27|P-value:3.76E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-4.41|P-value:2.83E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:3.43|P-value:2.29E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.48|P-value:1.89E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.87|P-value:3.75E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.30|P-value:3.39E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:4.41|P-value:3.17E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.08|P-value:8.09E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.44|P-value:2.19E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.77|P-value:5.81E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.20|P-value:8.53E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.04|P-value:1.80E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.12|P-value:6.54E-4 ID:SGTC_1654|Compound:st012436|FD-Score:4.24|P-value:7.09E-6 ID:SGTC_1662|Compound:st014054|FD-Score:3.14|P-value:6.53E-4 ID:SGTC_1743|Compound:st037606|FD-Score:5.81|P-value:1.35E-9 ID:SGTC_1745|Compound:st081495|FD-Score:4.80|P-value:4.38E-7 ID:SGTC_1772|Compound:st048439|FD-Score:4.18|P-value:9.41E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:7.08|P-value:1.94E-13 ID:SGTC_1803|Compound:st050068|FD-Score:4.10|P-value:1.34E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.03|P-value:9.65E-4 ID:SGTC_1856|Compound:st057054|FD-Score:6.48|P-value:1.54E-11 ID:SGTC_1907|Compound:st060210|FD-Score:4.26|P-value:6.58E-6 ID:SGTC_1925|Compound:st057770|FD-Score:3.17|P-value:5.94E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.69|P-value:8.05E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.03|P-value:9.76E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.94|P-value:2.10E-7 ID:SGTC_1936|Compound:st074407|FD-Score:3.22|P-value:5.01E-4 ID:SGTC_1984|Compound:st072354|FD-Score:7.44|P-value:1.21E-14 ID:SGTC_1985|Compound:st071382|FD-Score:5.68|P-value:2.94E-9 ID:SGTC_1986|Compound:st071812|FD-Score:3.25|P-value:4.38E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.53|P-value:1.77E-6 ID:SGTC_2137|Compound:5261020|FD-Score:3.66|P-value:8.98E-5 ID:SGTC_2282|Compound:7944268|FD-Score:4.02|P-value:1.97E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.43|P-value:2.27E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.08|P-value:8.10E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.26|P-value:4.32E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.25|P-value:4.51E-4 ID:SGTC_2485|Compound:5633444|FD-Score:4.24|P-value:7.16E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.41|P-value:2.46E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.64|P-value:9.92E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.25|P-value:6.72E-6 ID:SGTC_2894|Compound:9048625|FD-Score:3.82|P-value:4.72E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.03|P-value:9.66E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.22|P-value:4.91E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.03|P-value:9.82E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.13|P-value:7.37E-8 ID:SGTC_65|Compound:0798-0905|FD-Score:10.00|P-value:5.01E-25 ID:SGTC_138|Compound:0850-0259|FD-Score:5.82|P-value:1.26E-9 ID:SGTC_230|Compound:MPP+|FD-Score:-3.05|P-value:8.42E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.71|P-value:7.18E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.44|P-value:1.95E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.15|P-value:6.29E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.03|P-value:9.78E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.63|P-value:1.01E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.61|P-value:9.95E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.17|P-value:5.42E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.27|P-value:3.76E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-4.41|P-value:2.83E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:3.43|P-value:2.29E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.48|P-value:1.89E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.87|P-value:3.75E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.30|P-value:3.39E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:4.41|P-value:3.17E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.08|P-value:8.09E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.44|P-value:2.19E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.77|P-value:5.81E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.20|P-value:8.53E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.04|P-value:1.80E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.12|P-value:6.54E-4 ID:SGTC_1654|Compound:st012436|FD-Score:4.24|P-value:7.09E-6 ID:SGTC_1662|Compound:st014054|FD-Score:3.14|P-value:6.53E-4 ID:SGTC_1743|Compound:st037606|FD-Score:5.81|P-value:1.35E-9 ID:SGTC_1745|Compound:st081495|FD-Score:4.80|P-value:4.38E-7 ID:SGTC_1772|Compound:st048439|FD-Score:4.18|P-value:9.41E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:7.08|P-value:1.94E-13 ID:SGTC_1803|Compound:st050068|FD-Score:4.10|P-value:1.34E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.03|P-value:9.65E-4 ID:SGTC_1856|Compound:st057054|FD-Score:6.48|P-value:1.54E-11 ID:SGTC_1907|Compound:st060210|FD-Score:4.26|P-value:6.58E-6 ID:SGTC_1925|Compound:st057770|FD-Score:3.17|P-value:5.94E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.69|P-value:8.05E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.03|P-value:9.76E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.94|P-value:2.10E-7 ID:SGTC_1936|Compound:st074407|FD-Score:3.22|P-value:5.01E-4 ID:SGTC_1984|Compound:st072354|FD-Score:7.44|P-value:1.21E-14 ID:SGTC_1985|Compound:st071382|FD-Score:5.68|P-value:2.94E-9 ID:SGTC_1986|Compound:st071812|FD-Score:3.25|P-value:4.38E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.53|P-value:1.77E-6 ID:SGTC_2137|Compound:5261020|FD-Score:3.66|P-value:8.98E-5 ID:SGTC_2282|Compound:7944268|FD-Score:4.02|P-value:1.97E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.43|P-value:2.27E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.08|P-value:8.10E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.26|P-value:4.32E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.25|P-value:4.51E-4 ID:SGTC_2485|Compound:5633444|FD-Score:4.24|P-value:7.16E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.41|P-value:2.46E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.64|P-value:9.92E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.25|P-value:6.72E-6 ID:SGTC_2894|Compound:9048625|FD-Score:3.82|P-value:4.72E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.03|P-value:9.66E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.22|P-value:4.91E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.03|P-value:9.82E-4

Top fitness defect scores for YBR156C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 10.00 35.0 µM 5.01E-25 calcium & mitochondrial duress 9 6.77E-24
2 SGTC_1984 st072354 7.44 53.1 µM 1.21E-14 1 5.01E-14
3 SGTC_1788 fluconazole 7.08 20.0 µM 1.94E-13 azole & statin 23 7.03E-13
4 SGTC_1856 st057054 6.48 55.7 µM 1.54E-11 6 4.50E-11
5 SGTC_138 0850-0259 5.82 40.9 µM 1.26E-9 cell wall 111 2.99E-9
6 SGTC_1743 st037606 5.81 46.4 µM 1.35E-9 5 3.20E-9
7 SGTC_1985 st071382 5.68 65.5 µM 2.94E-9 3 6.68E-9
8 SGTC_58 0957-0393 5.13 9.0 µM 7.37E-8 cell wall 270 1.44E-7
9 SGTC_1933 st074711 4.94 15.9 µM 2.10E-7 19 3.89E-7
10 SGTC_1745 st081495 4.80 74.0 µM 4.38E-7 RNA processing & uracil transport 45 7.84E-7
11 SGTC_245 methotrexate 4.71 289.6 µM 7.18E-7 24 1.25E-6
12 SGTC_2564 betulinic acid 4.64 100.0 µM 9.92E-7 19 1.71E-6
13 SGTC_1987 st072290 4.53 61.9 µM 1.77E-6 8 2.97E-6
14 SGTC_1343 1487-0095 4.41 224.0 µM 3.17E-6 6 5.16E-6
15 SGTC_1907 st060210 4.26 83.7 µM 6.58E-6 13 1.04E-5
16 SGTC_2571 chrysanthemic acid 4.25 100.0 µM 6.72E-6 9 1.06E-5
17 SGTC_1654 st012436 4.24 41.8 µM 7.09E-6 13 1.11E-5
18 SGTC_2485 5633444 4.24 17.8 µM 7.16E-6 redox potentiating 34 1.12E-5
19 SGTC_1451 4152-0210 4.20 104.0 µM 8.53E-6 18 1.33E-5
20 SGTC_1772 st048439 4.18 82.2 µM 9.41E-6 30 1.46E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.239 6.74E-45 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.203 1.69E-32 YHL013C OTU2 hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress
0.166 3.57E-22 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.162 4.07E-21 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.161 6.92E-21 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.157 5.31E-20 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.155 1.85E-19 YBR108W AIM3 hom Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.155 2.48E-19 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.154 2.47E-19 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.154 2.70E-19 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.152 8.20E-19 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.152 8.93E-19 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.150 2.28E-18 YPR095C SYT1 hom Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain
0.145 3.59E-17 YGR106C VOA1 hom Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
0.145 4.12E-17 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner