Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YBR157C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.201 | 6.81E-32 | YGR197C | SNG1 | hom | Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance |
0.137 | 1.52E-15 | YOR162C | YRR1 | hom | Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication |
0.133 | 8.78E-15 | YLR367W | RPS22B | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication |
0.131 | 2.83E-14 | YBL059W_p | YBL059W_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication |
0.128 | 8.52E-14 | YGL180W | ATG1 | hom | Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p |
0.120 | 3.15E-12 | YOR382W | FIT2 | hom | Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall |
0.113 | 5.02E-11 | YBR151W | APD1 | hom | Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus |
0.112 | 7.79E-11 | YPL222W_p | FMP40_p | hom | Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.110 | 1.94E-10 | YDR315C | IPK1 | hom | Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable |
0.105 | 1.12E-9 | YJL051W | IRC8 | hom | Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc |
0.097 | 2.12E-8 | YIL006W | YIA6 | hom | Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs |
0.095 | 3.03E-8 | YGR159C | NSR1 | hom | Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis |
0.094 | 5.71E-8 | YDR279W | RNH202 | hom | Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome |
0.091 | 1.42E-7 | YEL060C | PRB1 | hom | Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress |
0.091 | 1.50E-7 | YJR046W | TAH11 | het | DNA replication licensing factor, required for pre-replication complex assembly |