YBR157C / ICS2

Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR157C / ICS2

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-3.63|P-value:7.52E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.17|P-value:4.74E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.06|P-value:6.83E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-2.96|P-value:9.97E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-2.98|P-value:9.27E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.35|P-value:2.38E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:4.05|P-value:1.12E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.07|P-value:6.53E-4 ID:SGTC_490|Compound:phenamil|FD-Score:4.09|P-value:9.54E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.80|P-value:3.49E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:6.15|P-value:6.52E-11 ID:SGTC_662|Compound:k832-1615|FD-Score:3.49|P-value:1.31E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.41|P-value:1.83E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.91|P-value:2.17E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.05|P-value:7.16E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.85|P-value:2.85E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.05|P-value:7.08E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.82|P-value:3.24E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:5.58|P-value:2.77E-9 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.02|P-value:7.99E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:-3.96|P-value:1.80E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.61|P-value:8.10E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.10|P-value:5.90E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.70|P-value:5.52E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.34|P-value:2.50E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.04|P-value:7.44E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.37|P-value:2.12E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.04|P-value:7.45E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.16|P-value:4.86E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.26|P-value:3.21E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.48|P-value:1.43E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.24|P-value:3.53E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.49|P-value:1.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.40|P-value:1.14E-11 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.50|P-value:1.24E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:7.03|P-value:9.97E-14 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:8.57|P-value:1.61E-19 ID:SGTC_2616|Compound:abietic acid|FD-Score:-7.42|P-value:4.67E-15 ID:SGTC_2799|Compound:7812892|FD-Score:3.64|P-value:6.98E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-4.78|P-value:2.95E-7 ID:SGTC_2810|Compound:7959871|FD-Score:5.25|P-value:2.08E-8 ID:SGTC_2838|Compound:9002687|FD-Score:3.17|P-value:4.62E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.02|P-value:1.30E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.73|P-value:4.92E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.20|P-value:4.07E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.01|P-value:8.31E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.86|P-value:2.69E-5 ID:SGTC_3162|Compound:9099653|FD-Score:3.75|P-value:4.38E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-3.36|P-value:2.25E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.05|P-value:7.27E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.22|P-value:3.86E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.63|P-value:7.52E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.17|P-value:4.74E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.06|P-value:6.83E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-2.96|P-value:9.97E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-2.98|P-value:9.27E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.35|P-value:2.38E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:4.05|P-value:1.12E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.07|P-value:6.53E-4 ID:SGTC_490|Compound:phenamil|FD-Score:4.09|P-value:9.54E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.80|P-value:3.49E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:6.15|P-value:6.52E-11 ID:SGTC_662|Compound:k832-1615|FD-Score:3.49|P-value:1.31E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.41|P-value:1.83E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.91|P-value:2.17E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.05|P-value:7.16E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.85|P-value:2.85E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.05|P-value:7.08E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.82|P-value:3.24E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:5.58|P-value:2.77E-9 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.02|P-value:7.99E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:-3.96|P-value:1.80E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.61|P-value:8.10E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.10|P-value:5.90E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.70|P-value:5.52E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.34|P-value:2.50E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.04|P-value:7.44E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.37|P-value:2.12E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.04|P-value:7.45E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.16|P-value:4.86E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.26|P-value:3.21E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.48|P-value:1.43E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.24|P-value:3.53E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.49|P-value:1.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.40|P-value:1.14E-11 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.50|P-value:1.24E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:7.03|P-value:9.97E-14 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:8.57|P-value:1.61E-19 ID:SGTC_2616|Compound:abietic acid|FD-Score:-7.42|P-value:4.67E-15 ID:SGTC_2799|Compound:7812892|FD-Score:3.64|P-value:6.98E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-4.78|P-value:2.95E-7 ID:SGTC_2810|Compound:7959871|FD-Score:5.25|P-value:2.08E-8 ID:SGTC_2838|Compound:9002687|FD-Score:3.17|P-value:4.62E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.02|P-value:1.30E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.73|P-value:4.92E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.20|P-value:4.07E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.01|P-value:8.31E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.86|P-value:2.69E-5 ID:SGTC_3162|Compound:9099653|FD-Score:3.75|P-value:4.38E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-3.36|P-value:2.25E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.05|P-value:7.27E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.22|P-value:3.86E-4

Top fitness defect scores for YBR157C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2615 purpurogallin-4-carboxylic acid 8.57 100.0 µM 1.61E-19 redox potentiating 14 4.97E-18
2 SGTC_2610 ononetin 7.03 44.2 µM 9.97E-14 3 1.02E-12
3 SGTC_651 3253-0966 6.15 34.4 µM 6.52E-11 calcium & mitochondrial duress 7 3.90E-10
4 SGTC_1451 4152-0210 5.58 104.0 µM 2.77E-9 3 1.22E-8
5 SGTC_2810 7959871 5.25 45.5 µM 2.08E-8 copper-dependent oxidative stress 15 7.77E-8
6 SGTC_490 phenamil 4.09 164.0 µM 9.54E-6 heme requiring 8 2.16E-5
7 SGTC_292 k038-0015 4.05 474.0 µM 1.12E-5 6 2.51E-5
8 SGTC_2844 9010103 4.02 26.0 µM 1.30E-5 33 2.88E-5
9 SGTC_1066 ketoconazole 3.91 628.0 nM 2.17E-5 25 4.61E-5
10 SGTC_2984 9022109 3.86 39.0 µM 2.69E-5 7 5.62E-5
11 SGTC_1320 1313-0481 3.85 95.3 µM 2.85E-5 24 5.92E-5
12 SGTC_1447 4239-0816 3.82 81.9 µM 3.24E-5 32 6.66E-5
13 SGTC_491 tetrandrine 3.80 80.3 µM 3.49E-5 15 7.13E-5
14 SGTC_3162 9099653 3.75 49.5 µM 4.38E-5 7 8.78E-5
15 SGTC_2857 9024691 3.73 58.4 µM 4.92E-5 29 9.76E-5
16 SGTC_2100 5377183 3.70 190.0 µM 5.52E-5 60S ribosome export 15 1.09E-4
17 SGTC_2799 7812892 3.64 81.8 µM 6.98E-5 superoxide 41 1.35E-4
18 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.50 70.0 µM 1.24E-4 redox potentiating 93 2.29E-4
19 SGTC_662 k832-1615 3.49 104.0 µM 1.31E-4 37 2.41E-4
20 SGTC_713 1488-1073 3.41 324.0 µM 1.83E-4 ERG2 24 3.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 6.81E-32 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.137 1.52E-15 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.133 8.78E-15 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.131 2.83E-14 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.128 8.52E-14 YGL180W ATG1 hom Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p
0.120 3.15E-12 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.113 5.02E-11 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.112 7.79E-11 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.110 1.94E-10 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.105 1.12E-9 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.097 2.12E-8 YIL006W YIA6 hom Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs
0.095 3.03E-8 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.094 5.71E-8 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.091 1.42E-7 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.091 1.50E-7 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly