YBR160W / CDC28

Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR160W / CDC28

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:-4.08|P-value:3.54E-6 ID:SGTC_85|Compound:0868-0259|FD-Score:2.87|P-value:8.10E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.19|P-value:2.24E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.10|P-value:3.12E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.77|P-value:1.75E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.02|P-value:4.47E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.78|P-value:1.63E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.16|P-value:2.62E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.08|P-value:3.52E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.17|P-value:2.44E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.20|P-value:2.16E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.41|P-value:6.42E-7 ID:SGTC_770|Compound:0389-1121|FD-Score:-2.85|P-value:8.32E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-4.12|P-value:2.87E-6 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.37|P-value:1.02E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:2.82|P-value:9.63E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:5.33|P-value:2.31E-9 ID:SGTC_924|Compound:2046-0044|FD-Score:3.04|P-value:4.18E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.15|P-value:2.66E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.88|P-value:1.01E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.16|P-value:2.55E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.33|P-value:9.53E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.35|P-value:1.16E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.47|P-value:7.01E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.22|P-value:2.05E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.00|P-value:4.63E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.18|P-value:2.42E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.34|P-value:1.19E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.60|P-value:2.16E-7 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.12|P-value:3.04E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-4.64|P-value:1.59E-7 ID:SGTC_1479|Compound:0549-0158|FD-Score:-2.98|P-value:5.01E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.28|P-value:1.49E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:2.95|P-value:5.87E-4 ID:SGTC_1626|Compound:st003712|FD-Score:2.91|P-value:6.83E-4 ID:SGTC_1697|Compound:st025554|FD-Score:2.87|P-value:8.03E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-5.34|P-value:2.06E-9 ID:SGTC_1794|Compound:st048918|FD-Score:3.11|P-value:3.11E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-6.57|P-value:2.42E-13 ID:SGTC_1871|Compound:st057448|FD-Score:2.94|P-value:6.22E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.51|P-value:3.53E-7 ID:SGTC_1884|Compound:5633444|FD-Score:-7.23|P-value:8.29E-16 ID:SGTC_1916|Compound:st067606|FD-Score:3.75|P-value:1.84E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-2.93|P-value:6.21E-4 ID:SGTC_2108|Compound:5365811|FD-Score:2.82|P-value:9.85E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.00|P-value:4.69E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.90|P-value:9.15E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-2.91|P-value:6.63E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.91|P-value:6.91E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.01|P-value:4.58E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.97|P-value:6.41E-6 ID:SGTC_2717|Compound:st081029|FD-Score:2.90|P-value:7.32E-4 ID:SGTC_2836|Compound:9010338|FD-Score:2.99|P-value:5.19E-4 ID:SGTC_3013|Compound:9080133|FD-Score:2.88|P-value:7.87E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.78|P-value:1.65E-5 ID:SGTC_3128|Compound:9127691|FD-Score:3.35|P-value:1.15E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.29|P-value:1.48E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.65|P-value:3.08E-5 ID:SGTC_3285|Compound:9112818|FD-Score:3.65|P-value:3.09E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.03|P-value:4.41E-4 ID:SGTC_3334|Compound:9142812|FD-Score:2.84|P-value:9.05E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:-4.08|P-value:3.54E-6 ID:SGTC_85|Compound:0868-0259|FD-Score:2.87|P-value:8.10E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.19|P-value:2.24E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.10|P-value:3.12E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.77|P-value:1.75E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.02|P-value:4.47E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.78|P-value:1.63E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.16|P-value:2.62E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.08|P-value:3.52E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.17|P-value:2.44E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.20|P-value:2.16E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.41|P-value:6.42E-7 ID:SGTC_770|Compound:0389-1121|FD-Score:-2.85|P-value:8.32E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-4.12|P-value:2.87E-6 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.37|P-value:1.02E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:2.82|P-value:9.63E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:5.33|P-value:2.31E-9 ID:SGTC_924|Compound:2046-0044|FD-Score:3.04|P-value:4.18E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.15|P-value:2.66E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.88|P-value:1.01E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.16|P-value:2.55E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.33|P-value:9.53E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.35|P-value:1.16E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.47|P-value:7.01E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.22|P-value:2.05E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.00|P-value:4.63E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.18|P-value:2.42E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.34|P-value:1.19E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.60|P-value:2.16E-7 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.12|P-value:3.04E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-4.64|P-value:1.59E-7 ID:SGTC_1479|Compound:0549-0158|FD-Score:-2.98|P-value:5.01E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.28|P-value:1.49E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:2.95|P-value:5.87E-4 ID:SGTC_1626|Compound:st003712|FD-Score:2.91|P-value:6.83E-4 ID:SGTC_1697|Compound:st025554|FD-Score:2.87|P-value:8.03E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-5.34|P-value:2.06E-9 ID:SGTC_1794|Compound:st048918|FD-Score:3.11|P-value:3.11E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-6.57|P-value:2.42E-13 ID:SGTC_1871|Compound:st057448|FD-Score:2.94|P-value:6.22E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.51|P-value:3.53E-7 ID:SGTC_1884|Compound:5633444|FD-Score:-7.23|P-value:8.29E-16 ID:SGTC_1916|Compound:st067606|FD-Score:3.75|P-value:1.84E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-2.93|P-value:6.21E-4 ID:SGTC_2108|Compound:5365811|FD-Score:2.82|P-value:9.85E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.00|P-value:4.69E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.90|P-value:9.15E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-2.91|P-value:6.63E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.91|P-value:6.91E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.01|P-value:4.58E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.97|P-value:6.41E-6 ID:SGTC_2717|Compound:st081029|FD-Score:2.90|P-value:7.32E-4 ID:SGTC_2836|Compound:9010338|FD-Score:2.99|P-value:5.19E-4 ID:SGTC_3013|Compound:9080133|FD-Score:2.88|P-value:7.87E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.78|P-value:1.65E-5 ID:SGTC_3128|Compound:9127691|FD-Score:3.35|P-value:1.15E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.29|P-value:1.48E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.65|P-value:3.08E-5 ID:SGTC_3285|Compound:9112818|FD-Score:3.65|P-value:3.09E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.03|P-value:4.41E-4 ID:SGTC_3334|Compound:9142812|FD-Score:2.84|P-value:9.05E-4

Top fitness defect scores for YBR160W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_822 1487-0950 5.33 154.0 µM 2.31E-9 1 4.90E-8 1.10
2 SGTC_1383 3049-0032 4.60 20.7 µM 2.16E-7 60S ribosome export 6 2.13E-6 0.16
3 SGTC_1873 rapamycin 4.51 2.0 nM 3.53E-7 12 3.21E-6 0.07
4 SGTC_761 k216-0224 4.41 480.0 µM 6.42E-7 3 5.28E-6 0.30
5 SGTC_1064 honokiol 4.33 6.8 µM 9.53E-7 7 7.34E-6 0.08
6 SGTC_2676 harmalol 3.97 100.0 µM 6.41E-6 mitochondrial processes 8 3.59E-5 0.02
7 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.90 200.0 µM 9.15E-6 3 4.84E-5 0.02
8 SGTC_1015 4130-4525 3.88 82.0 µM 1.01E-5 60S ribosome export 9 5.26E-5 0.22
9 SGTC_427 1354-0053 3.78 47.3 µM 1.63E-5 3 7.82E-5 0.09
10 SGTC_3044 9093193 3.78 49.5 µM 1.65E-5 5 7.90E-5 0.07
11 SGTC_379 3970-0972 3.77 5.9 µM 1.75E-5 tubulin folding & SWR complex 8 8.31E-5 0.02
12 SGTC_1916 st067606 3.75 49.2 µM 1.84E-5 7 8.67E-5 0.04
13 SGTC_3180 9109287 3.65 49.5 µM 3.08E-5 10 1.33E-4 0.10
14 SGTC_3285 9112818 3.65 20.9 µM 3.09E-5 cell wall 19 1.34E-4 0.13
15 SGTC_1082 camptothecin 3.47 424.9 nM 7.01E-5 DNA damage response 25 2.65E-4 0.07
16 SGTC_3128 9127691 3.35 49.5 µM 1.15E-4 7 4.00E-4 0.07
17 SGTC_1072 oxiconazole 3.35 14.9 nM 1.16E-4 ergosterol depletion effects on membrane 30 4.03E-4 0.09
18 SGTC_1362 1611-0397 3.34 101.0 µM 1.19E-4 9 4.13E-4 0.12
19 SGTC_3145 9085516 3.29 49.5 µM 1.48E-4 fatty acid desaturase (OLE1) 20 4.96E-4 0.04
20 SGTC_1116 jasmonic acid 3.22 1.6 µM 2.05E-4 7 6.51E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.97E-15 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.086 5.47E-7 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.085 7.83E-7 YOL066C RIB2 het Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs
0.080 3.66E-6 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.079 5.13E-6 YML077W BET5 het Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
0.078 5.46E-6 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.078 6.59E-6 YNL013C_d YNL013C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
0.077 8.85E-6 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.076 1.12E-5 YPR058W YMC1 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication
0.074 1.57E-5 YAL032C PRP45 het Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
0.074 2.03E-5 YDR391C_p YDR391C_p hom Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.073 2.33E-5 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.073 2.47E-5 YJR045C SSC1 het Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication
0.072 3.09E-5 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.071 3.85E-5 YGL069C_d YGL069C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance