YBR161W / CSH1

Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR161W / CSH1

Click on Significant Values for Screen Details ID:SGTC_153|Compound:4077-0274|FD-Score:2.89|P-value:7.51E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.88|P-value:1.02E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.39|P-value:1.13E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.25|P-value:1.77E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:2.82|P-value:9.88E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:2.86|P-value:8.46E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.22|P-value:2.07E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:2.95|P-value:6.03E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-4.12|P-value:3.74E-6 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.32|P-value:1.33E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.09|P-value:3.62E-6 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.68|P-value:2.72E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.84|P-value:1.29E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.41|P-value:6.82E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:-2.94|P-value:7.08E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.97|P-value:6.80E-6 ID:SGTC_1443|Compound:4112-3303|FD-Score:2.96|P-value:5.71E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:2.92|P-value:6.59E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.02|P-value:4.58E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.16|P-value:2.66E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.18|P-value:2.39E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:2.87|P-value:8.19E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.14|P-value:2.83E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-2.98|P-value:5.93E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.01|P-value:4.83E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.48|P-value:6.77E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.14|P-value:3.22E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.18|P-value:2.37E-4 ID:SGTC_2097|Compound:5376186|FD-Score:5.75|P-value:1.55E-10 ID:SGTC_2102|Compound:5377816|FD-Score:4.11|P-value:3.30E-6 ID:SGTC_2182|Compound:6325192|FD-Score:3.62|P-value:3.58E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-3.01|P-value:5.40E-4 ID:SGTC_2339|Compound:9000433|FD-Score:5.01|P-value:2.01E-8 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.12|P-value:3.45E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.57|P-value:4.45E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.69|P-value:2.60E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.04|P-value:4.17E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.52|P-value:5.58E-5 ID:SGTC_2957|Compound:9076800|FD-Score:2.99|P-value:5.18E-4 ID:SGTC_2995|Compound:9067767|FD-Score:6.29|P-value:2.90E-12 ID:SGTC_3055|Compound:9094636|FD-Score:3.42|P-value:8.92E-5 ID:SGTC_3201|Compound:9113999|FD-Score:5.05|P-value:1.54E-8 ID:SGTC_3219|Compound:9131112|FD-Score:4.56|P-value:2.95E-7 ID:SGTC_3222|Compound:9128301|FD-Score:3.03|P-value:4.47E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-3.03|P-value:4.90E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.23|P-value:1.77E-6 ID:SGTC_3300|Compound:9124615|FD-Score:3.21|P-value:2.12E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.17|P-value:2.86E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.65|P-value:3.04E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:2.89|P-value:7.51E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.88|P-value:1.02E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.39|P-value:1.13E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.25|P-value:1.77E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:2.82|P-value:9.88E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:2.86|P-value:8.46E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.22|P-value:2.07E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:2.95|P-value:6.03E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-4.12|P-value:3.74E-6 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.32|P-value:1.33E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.09|P-value:3.62E-6 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.68|P-value:2.72E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.84|P-value:1.29E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.41|P-value:6.82E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:-2.94|P-value:7.08E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.97|P-value:6.80E-6 ID:SGTC_1443|Compound:4112-3303|FD-Score:2.96|P-value:5.71E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:2.92|P-value:6.59E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.02|P-value:4.58E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.16|P-value:2.66E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.18|P-value:2.39E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:2.87|P-value:8.19E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.14|P-value:2.83E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-2.98|P-value:5.93E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.01|P-value:4.83E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.48|P-value:6.77E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.14|P-value:3.22E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.18|P-value:2.37E-4 ID:SGTC_2097|Compound:5376186|FD-Score:5.75|P-value:1.55E-10 ID:SGTC_2102|Compound:5377816|FD-Score:4.11|P-value:3.30E-6 ID:SGTC_2182|Compound:6325192|FD-Score:3.62|P-value:3.58E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-3.01|P-value:5.40E-4 ID:SGTC_2339|Compound:9000433|FD-Score:5.01|P-value:2.01E-8 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.12|P-value:3.45E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.57|P-value:4.45E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.69|P-value:2.60E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.04|P-value:4.17E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.52|P-value:5.58E-5 ID:SGTC_2957|Compound:9076800|FD-Score:2.99|P-value:5.18E-4 ID:SGTC_2995|Compound:9067767|FD-Score:6.29|P-value:2.90E-12 ID:SGTC_3055|Compound:9094636|FD-Score:3.42|P-value:8.92E-5 ID:SGTC_3201|Compound:9113999|FD-Score:5.05|P-value:1.54E-8 ID:SGTC_3219|Compound:9131112|FD-Score:4.56|P-value:2.95E-7 ID:SGTC_3222|Compound:9128301|FD-Score:3.03|P-value:4.47E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-3.03|P-value:4.90E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.23|P-value:1.77E-6 ID:SGTC_3300|Compound:9124615|FD-Score:3.21|P-value:2.12E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.17|P-value:2.86E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.65|P-value:3.04E-5

Top fitness defect scores for YBR161W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2995 9067767 6.29 71.4 µM 2.90E-12 4 1.62E-10
2 SGTC_2097 5376186 5.75 200.0 µM 1.55E-10 5 4.58E-9
3 SGTC_3201 9113999 5.05 49.5 µM 1.54E-8 13 2.18E-7
4 SGTC_2339 9000433 5.01 200.0 µM 2.01E-8 12 2.72E-7
5 SGTC_3219 9131112 4.56 49.5 µM 2.95E-7 Golgi 28 2.61E-6
6 SGTC_1239 0337-0584 4.41 35.4 µM 6.82E-7 unfolded protein response 43 5.27E-6
7 SGTC_3224 9130643 4.23 49.5 µM 1.77E-6 RPP1 & pyrimidine depletion 19 1.18E-5
8 SGTC_2102 5377816 4.11 72.8 µM 3.30E-6 24 1.98E-5
9 SGTC_1145 3546-0597 4.09 10.2 µM 3.62E-6 mitochondrial processes 18 2.14E-5
10 SGTC_1342 1486-1464 3.97 234.0 µM 6.80E-6 16 3.65E-5
11 SGTC_163 1327-0036 3.88 7.5 µM 1.02E-5 109 5.14E-5
12 SGTC_1179 1021-1431 3.84 9.3 µM 1.29E-5 45 6.27E-5
13 SGTC_2916 7875993 3.69 68.8 µM 2.60E-5 37 1.13E-4
14 SGTC_1146 3579-1023 3.68 7.0 µM 2.72E-5 22 1.17E-4
15 SGTC_3346 9158254 3.65 43.6 µM 3.04E-5 27 1.29E-4
16 SGTC_2182 6325192 3.62 200.0 µM 3.58E-5 Golgi 20 1.48E-4
17 SGTC_2712 st079126 3.57 47.7 µM 4.45E-5 26 1.78E-4
18 SGTC_2919 7978188 3.52 46.4 µM 5.58E-5 36 2.15E-4
19 SGTC_1860 st056228 3.48 74.6 µM 6.77E-5 33 2.53E-4
20 SGTC_3055 9094636 3.42 49.5 µM 8.92E-5 20 3.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.81E-18 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.140 3.77E-16 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.136 3.25E-15 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.123 8.65E-13 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.110 1.92E-10 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.92E-9 YDR221W GTB1 hom Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress
0.100 7.45E-9 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.096 2.21E-8 YOR026W BUB3 hom Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
0.096 2.79E-8 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.096 2.85E-8 YOR135C_d IRC14_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci
0.093 7.22E-8 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.092 9.79E-8 YBR031W RPL4A hom Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication
0.092 1.05E-7 YHR105W YPT35 hom Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport
0.090 1.53E-7 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.086 5.43E-7 YLR147C SMD3 het Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3