YBR163W / EXO5

Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR163W / EXO5

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.44|P-value:1.80E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.73|P-value:2.35E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.52|P-value:1.21E-7 ID:SGTC_38|Compound:0929-0051|FD-Score:3.72|P-value:2.37E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.35|P-value:8.18E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:4.94|P-value:1.88E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:4.95|P-value:1.84E-6 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.89|P-value:1.82E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.70|P-value:2.55E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.90|P-value:2.30E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.56|P-value:5.58E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:11.40|P-value:9.67E-27 ID:SGTC_236|Compound:1509-0011|FD-Score:6.91|P-value:5.65E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.81|P-value:3.32E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:5.58|P-value:8.92E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:3.78|P-value:1.94E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.92|P-value:3.13E-6 ID:SGTC_556|Compound:4058-0063|FD-Score:3.75|P-value:2.18E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:5.00|P-value:1.47E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:4.19|P-value:4.29E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.46|P-value:5.80E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:5.03|P-value:1.27E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.97|P-value:2.55E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:4.64|P-value:7.02E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.12|P-value:9.04E-9 ID:SGTC_933|Compound:2914-0560|FD-Score:3.48|P-value:5.29E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:5.21|P-value:5.59E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.38|P-value:7.35E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:7.33|P-value:4.02E-12 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.17|P-value:4.70E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.99|P-value:9.04E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.85|P-value:1.52E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.12|P-value:5.59E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:3.65|P-value:3.04E-4 ID:SGTC_1696|Compound:st025591|FD-Score:4.69|P-value:5.66E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.04|P-value:1.08E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.32|P-value:9.10E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.60|P-value:8.18E-6 ID:SGTC_1801|Compound:st050089|FD-Score:3.43|P-value:6.41E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.07|P-value:6.75E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.88|P-value:1.37E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.33|P-value:2.48E-5 ID:SGTC_1921|Compound:5740136|FD-Score:6.41|P-value:1.07E-9 ID:SGTC_1991|Compound:st073000|FD-Score:4.09|P-value:6.22E-5 ID:SGTC_1995|Compound:st072814|FD-Score:-4.14|P-value:7.44E-5 ID:SGTC_2086|Compound:5274770|FD-Score:3.66|P-value:2.97E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.00|P-value:8.67E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.39|P-value:7.20E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.50|P-value:5.07E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.83|P-value:3.02E-6 ID:SGTC_2312|Compound:7706453|FD-Score:4.45|P-value:1.52E-5 ID:SGTC_2464|Compound:5717415|FD-Score:3.70|P-value:2.53E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.63|P-value:4.45E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.58|P-value:8.96E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.53|P-value:1.60E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.45|P-value:2.26E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.53|P-value:4.60E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.57|P-value:3.96E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.64|P-value:3.10E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.06|P-value:1.01E-4 ID:SGTC_2704|Compound:st078022|FD-Score:5.67|P-value:5.71E-8 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.54|P-value:4.42E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:5.93|P-value:1.48E-8 ID:SGTC_2836|Compound:9010338|FD-Score:-5.96|P-value:2.07E-8 ID:SGTC_2921|Compound:7974240|FD-Score:4.94|P-value:1.85E-6 ID:SGTC_2985|Compound:9022375|FD-Score:4.16|P-value:4.77E-5 ID:SGTC_3047|Compound:9092122|FD-Score:4.41|P-value:1.83E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.37|P-value:7.59E-4 ID:SGTC_3054|Compound:9094397|FD-Score:8.41|P-value:2.30E-15 ID:SGTC_3148|Compound:9097893|FD-Score:4.53|P-value:1.10E-5 ID:SGTC_3150|Compound:9097574|FD-Score:5.19|P-value:6.12E-7 ID:SGTC_3194|Compound:9111903|FD-Score:4.08|P-value:6.50E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-3.99|P-value:1.27E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.58|P-value:3.90E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.85|P-value:1.49E-4 ID:SGTC_3238|Compound:9133470|FD-Score:5.78|P-value:3.28E-8 ID:SGTC_3263|Compound:9137018|FD-Score:-3.40|P-value:9.41E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.15|P-value:5.07E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-5.13|P-value:1.25E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:5.44|P-value:1.80E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.73|P-value:2.35E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.52|P-value:1.21E-7 ID:SGTC_38|Compound:0929-0051|FD-Score:3.72|P-value:2.37E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.35|P-value:8.18E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:4.94|P-value:1.88E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:4.95|P-value:1.84E-6 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.89|P-value:1.82E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.70|P-value:2.55E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.90|P-value:2.30E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.56|P-value:5.58E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:11.40|P-value:9.67E-27 ID:SGTC_236|Compound:1509-0011|FD-Score:6.91|P-value:5.65E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.81|P-value:3.32E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:5.58|P-value:8.92E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:3.78|P-value:1.94E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.92|P-value:3.13E-6 ID:SGTC_556|Compound:4058-0063|FD-Score:3.75|P-value:2.18E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:5.00|P-value:1.47E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:4.19|P-value:4.29E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.46|P-value:5.80E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:5.03|P-value:1.27E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.97|P-value:2.55E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:4.64|P-value:7.02E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.12|P-value:9.04E-9 ID:SGTC_933|Compound:2914-0560|FD-Score:3.48|P-value:5.29E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:5.21|P-value:5.59E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.38|P-value:7.35E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:7.33|P-value:4.02E-12 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.17|P-value:4.70E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.99|P-value:9.04E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.85|P-value:1.52E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.12|P-value:5.59E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:3.65|P-value:3.04E-4 ID:SGTC_1696|Compound:st025591|FD-Score:4.69|P-value:5.66E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.04|P-value:1.08E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.32|P-value:9.10E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.60|P-value:8.18E-6 ID:SGTC_1801|Compound:st050089|FD-Score:3.43|P-value:6.41E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.07|P-value:6.75E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.88|P-value:1.37E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.33|P-value:2.48E-5 ID:SGTC_1921|Compound:5740136|FD-Score:6.41|P-value:1.07E-9 ID:SGTC_1991|Compound:st073000|FD-Score:4.09|P-value:6.22E-5 ID:SGTC_1995|Compound:st072814|FD-Score:-4.14|P-value:7.44E-5 ID:SGTC_2086|Compound:5274770|FD-Score:3.66|P-value:2.97E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.00|P-value:8.67E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.39|P-value:7.20E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.50|P-value:5.07E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.83|P-value:3.02E-6 ID:SGTC_2312|Compound:7706453|FD-Score:4.45|P-value:1.52E-5 ID:SGTC_2464|Compound:5717415|FD-Score:3.70|P-value:2.53E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.63|P-value:4.45E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.58|P-value:8.96E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.53|P-value:1.60E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.45|P-value:2.26E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.53|P-value:4.60E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.57|P-value:3.96E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.64|P-value:3.10E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.06|P-value:1.01E-4 ID:SGTC_2704|Compound:st078022|FD-Score:5.67|P-value:5.71E-8 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.54|P-value:4.42E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:5.93|P-value:1.48E-8 ID:SGTC_2836|Compound:9010338|FD-Score:-5.96|P-value:2.07E-8 ID:SGTC_2921|Compound:7974240|FD-Score:4.94|P-value:1.85E-6 ID:SGTC_2985|Compound:9022375|FD-Score:4.16|P-value:4.77E-5 ID:SGTC_3047|Compound:9092122|FD-Score:4.41|P-value:1.83E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.37|P-value:7.59E-4 ID:SGTC_3054|Compound:9094397|FD-Score:8.41|P-value:2.30E-15 ID:SGTC_3148|Compound:9097893|FD-Score:4.53|P-value:1.10E-5 ID:SGTC_3150|Compound:9097574|FD-Score:5.19|P-value:6.12E-7 ID:SGTC_3194|Compound:9111903|FD-Score:4.08|P-value:6.50E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-3.99|P-value:1.27E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.58|P-value:3.90E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.85|P-value:1.49E-4 ID:SGTC_3238|Compound:9133470|FD-Score:5.78|P-value:3.28E-8 ID:SGTC_3263|Compound:9137018|FD-Score:-3.40|P-value:9.41E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.15|P-value:5.07E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-5.13|P-value:1.25E-6

Top fitness defect scores for YBR163W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 11.40 2.7 µM 9.67E-27 mitochondrial stress 29 1.48E-30
2 SGTC_3054 9094397 8.41 49.5 µM 2.30E-15 fatty acid desaturase (OLE1) 2 2.12E-17
3 SGTC_1022 4477-0945 7.33 21.3 µM 4.02E-12 2 1.17E-13
4 SGTC_236 1509-0011 6.91 5.3 µM 5.65E-11 269 2.45E-12
5 SGTC_1921 5740136 6.41 50.0 µM 1.07E-9 TRP & mitochondrial translation 12 7.22E-11
6 SGTC_2760 etidronate 5.93 98.0 µM 1.48E-8 3 1.49E-9
7 SGTC_3238 9133470 5.78 49.5 µM 3.28E-8 2 3.72E-9
8 SGTC_2704 st078022 5.67 71.1 µM 5.71E-8 5 7.05E-9
9 SGTC_310 1273-0058 5.58 1.1 µM 8.92E-8 mitochondrial stress 155 1.18E-8
10 SGTC_28 pentachloropyridine N-oxide 5.52 1.6 µM 1.21E-7 TSC3-RPN4 23 1.68E-8
11 SGTC_10 0279-0212 5.44 42.6 µM 1.80E-7 TRP & mitochondrial translation 41 2.63E-8
12 SGTC_997 3996-0078 5.21 137.0 µM 5.59E-7 5 9.67E-8
13 SGTC_3150 9097574 5.19 49.5 µM 6.12E-7 3 1.07E-7
14 SGTC_745 0469-0705 5.03 296.0 µM 1.27E-6 mitochondrial processes 8 2.47E-7
15 SGTC_581 0958-0271 5.00 211.0 µM 1.47E-6 26 2.93E-7
16 SGTC_100 0086-0128 4.95 49.6 µM 1.84E-6 copper-dependent oxidative stress 24 3.79E-7
17 SGTC_2921 7974240 4.94 10.7 µM 1.85E-6 27 3.83E-7
18 SGTC_99 0109-0120 4.94 622.8 µM 1.88E-6 2 3.89E-7
19 SGTC_118 0083-0097 4.90 135.3 µM 2.30E-6 translation 65 4.91E-7
20 SGTC_2250 alverine citrate 4.83 130.0 µM 3.02E-6 103 6.70E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 2.53E-71 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.295 1.93E-68 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.289 1.29E-65 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.287 9.24E-65 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.282 2.23E-62 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.276 1.73E-59 YMR267W PPA2 hom Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
0.274 5.42E-59 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.274 1.12E-58 YLR067C PET309 hom Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)
0.273 2.99E-58 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.264 1.26E-54 YHR120W MSH1 hom DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
0.264 1.67E-54 YDL202W MRPL11 hom Mitochondrial ribosomal protein of the large subunit
0.264 1.67E-54 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.263 2.49E-54 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.263 5.43E-54 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.262 6.19E-54 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies