YBR164C / ARL1

Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR164C / ARL1

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:8.90|P-value:3.71E-11 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.37|P-value:7.19E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.84|P-value:1.97E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.86|P-value:1.87E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:6.32|P-value:1.89E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:4.25|P-value:9.33E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:4.62|P-value:3.54E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.29|P-value:8.43E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:4.63|P-value:3.45E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.67|P-value:3.14E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:5.32|P-value:4.85E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.38|P-value:6.73E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.18|P-value:7.78E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:6.90|P-value:2.21E-7 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:7.98|P-value:2.62E-9 ID:SGTC_562|Compound:3772-2733|FD-Score:5.18|P-value:7.35E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:6.99|P-value:1.54E-7 ID:SGTC_632|Compound:0781-2353|FD-Score:5.23|P-value:6.51E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.46|P-value:5.40E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.79|P-value:2.29E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:5.38|P-value:4.06E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:5.23|P-value:6.35E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:4.90|P-value:1.65E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:5.15|P-value:8.07E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.79|P-value:2.39E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:14.90|P-value:4.50E-28 ID:SGTC_1012|Compound:4112-3522|FD-Score:6.17|P-value:3.16E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.25|P-value:9.16E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.51|P-value:4.75E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:13.00|P-value:9.83E-22 ID:SGTC_1267|Compound:0828-0272|FD-Score:6.43|P-value:1.25E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:17.80|P-value:3.51E-39 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.30|P-value:8.27E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:7.39|P-value:3.24E-8 ID:SGTC_1540|Compound:guanosine|FD-Score:-4.51|P-value:4.99E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.78|P-value:2.33E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:11.60|P-value:9.06E-18 ID:SGTC_1658|Compound:st012944|FD-Score:5.39|P-value:3.98E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:9.66|P-value:7.91E-13 ID:SGTC_1687|Compound:st020778|FD-Score:7.56|P-value:1.56E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.93|P-value:1.59E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.13|P-value:8.68E-5 ID:SGTC_1765|Compound:st044815|FD-Score:5.44|P-value:3.38E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.32|P-value:8.15E-4 ID:SGTC_1850|Compound:st056238|FD-Score:4.43|P-value:5.85E-4 ID:SGTC_1897|Compound:st060201|FD-Score:4.50|P-value:4.98E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-4.90|P-value:1.74E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-5.99|P-value:6.21E-6 ID:SGTC_2009|Compound:4012297|FD-Score:4.45|P-value:5.62E-4 ID:SGTC_2041|Compound:5107442|FD-Score:6.99|P-value:1.57E-7 ID:SGTC_2168|Compound:5727979|FD-Score:5.10|P-value:9.51E-5 ID:SGTC_2185|Compound:6113692|FD-Score:-5.06|P-value:1.13E-4 ID:SGTC_2242|Compound:6630449|FD-Score:11.60|P-value:1.32E-17 ID:SGTC_2291|Compound:7917025|FD-Score:4.86|P-value:1.87E-4 ID:SGTC_2310|Compound:7668677|FD-Score:7.62|P-value:1.24E-8 ID:SGTC_2363|Compound:9053361|FD-Score:8.00|P-value:2.39E-9 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.55|P-value:4.45E-4 ID:SGTC_2411|Compound:st077133|FD-Score:4.27|P-value:8.71E-4 ID:SGTC_2413|Compound:inermin|FD-Score:12.60|P-value:1.46E-20 ID:SGTC_2414|Compound:st077232|FD-Score:4.96|P-value:1.40E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.41|P-value:6.16E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.25|P-value:9.35E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.25|P-value:9.26E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:16.30|P-value:4.57E-33 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.87|P-value:2.51E-7 ID:SGTC_2858|Compound:9025781|FD-Score:5.74|P-value:1.33E-5 ID:SGTC_2890|Compound:9046729|FD-Score:5.64|P-value:1.85E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-4.26|P-value:9.47E-4 ID:SGTC_2929|Compound:9013348|FD-Score:7.13|P-value:8.88E-8 ID:SGTC_2931|Compound:9014674|FD-Score:4.74|P-value:2.63E-4 ID:SGTC_3149|Compound:9097855|FD-Score:8.12|P-value:1.44E-9 ID:SGTC_3166|Compound:9102297|FD-Score:4.95|P-value:1.44E-4 ID:SGTC_3219|Compound:9131112|FD-Score:10.10|P-value:5.72E-14 ID:SGTC_3277|Compound:9138724|FD-Score:6.84|P-value:2.73E-7 ID:SGTC_3310|Compound:9130229|FD-Score:5.91|P-value:7.63E-6 ID:SGTC_3321|Compound:9137793|FD-Score:7.26|P-value:5.48E-8 ID:SGTC_3325|Compound:9138760|FD-Score:11.60|P-value:1.31E-17 ID:SGTC_3334|Compound:9142812|FD-Score:-7.11|P-value:1.06E-7 ID:SGTC_56|Compound:0957-0365|FD-Score:8.90|P-value:3.71E-11 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.37|P-value:7.19E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.84|P-value:1.97E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.86|P-value:1.87E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:6.32|P-value:1.89E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:4.25|P-value:9.33E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:4.62|P-value:3.54E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.29|P-value:8.43E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:4.63|P-value:3.45E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.67|P-value:3.14E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:5.32|P-value:4.85E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.38|P-value:6.73E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.18|P-value:7.78E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:6.90|P-value:2.21E-7 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:7.98|P-value:2.62E-9 ID:SGTC_562|Compound:3772-2733|FD-Score:5.18|P-value:7.35E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:6.99|P-value:1.54E-7 ID:SGTC_632|Compound:0781-2353|FD-Score:5.23|P-value:6.51E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.46|P-value:5.40E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.79|P-value:2.29E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:5.38|P-value:4.06E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:5.23|P-value:6.35E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:4.90|P-value:1.65E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:5.15|P-value:8.07E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.79|P-value:2.39E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:14.90|P-value:4.50E-28 ID:SGTC_1012|Compound:4112-3522|FD-Score:6.17|P-value:3.16E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.25|P-value:9.16E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.51|P-value:4.75E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:13.00|P-value:9.83E-22 ID:SGTC_1267|Compound:0828-0272|FD-Score:6.43|P-value:1.25E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:17.80|P-value:3.51E-39 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.30|P-value:8.27E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:7.39|P-value:3.24E-8 ID:SGTC_1540|Compound:guanosine|FD-Score:-4.51|P-value:4.99E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.78|P-value:2.33E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:11.60|P-value:9.06E-18 ID:SGTC_1658|Compound:st012944|FD-Score:5.39|P-value:3.98E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:9.66|P-value:7.91E-13 ID:SGTC_1687|Compound:st020778|FD-Score:7.56|P-value:1.56E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.93|P-value:1.59E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.13|P-value:8.68E-5 ID:SGTC_1765|Compound:st044815|FD-Score:5.44|P-value:3.38E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.32|P-value:8.15E-4 ID:SGTC_1850|Compound:st056238|FD-Score:4.43|P-value:5.85E-4 ID:SGTC_1897|Compound:st060201|FD-Score:4.50|P-value:4.98E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-4.90|P-value:1.74E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-5.99|P-value:6.21E-6 ID:SGTC_2009|Compound:4012297|FD-Score:4.45|P-value:5.62E-4 ID:SGTC_2041|Compound:5107442|FD-Score:6.99|P-value:1.57E-7 ID:SGTC_2168|Compound:5727979|FD-Score:5.10|P-value:9.51E-5 ID:SGTC_2185|Compound:6113692|FD-Score:-5.06|P-value:1.13E-4 ID:SGTC_2242|Compound:6630449|FD-Score:11.60|P-value:1.32E-17 ID:SGTC_2291|Compound:7917025|FD-Score:4.86|P-value:1.87E-4 ID:SGTC_2310|Compound:7668677|FD-Score:7.62|P-value:1.24E-8 ID:SGTC_2363|Compound:9053361|FD-Score:8.00|P-value:2.39E-9 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.55|P-value:4.45E-4 ID:SGTC_2411|Compound:st077133|FD-Score:4.27|P-value:8.71E-4 ID:SGTC_2413|Compound:inermin|FD-Score:12.60|P-value:1.46E-20 ID:SGTC_2414|Compound:st077232|FD-Score:4.96|P-value:1.40E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.41|P-value:6.16E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.25|P-value:9.35E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.25|P-value:9.26E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:16.30|P-value:4.57E-33 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.87|P-value:2.51E-7 ID:SGTC_2858|Compound:9025781|FD-Score:5.74|P-value:1.33E-5 ID:SGTC_2890|Compound:9046729|FD-Score:5.64|P-value:1.85E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-4.26|P-value:9.47E-4 ID:SGTC_2929|Compound:9013348|FD-Score:7.13|P-value:8.88E-8 ID:SGTC_2931|Compound:9014674|FD-Score:4.74|P-value:2.63E-4 ID:SGTC_3149|Compound:9097855|FD-Score:8.12|P-value:1.44E-9 ID:SGTC_3166|Compound:9102297|FD-Score:4.95|P-value:1.44E-4 ID:SGTC_3219|Compound:9131112|FD-Score:10.10|P-value:5.72E-14 ID:SGTC_3277|Compound:9138724|FD-Score:6.84|P-value:2.73E-7 ID:SGTC_3310|Compound:9130229|FD-Score:5.91|P-value:7.63E-6 ID:SGTC_3321|Compound:9137793|FD-Score:7.26|P-value:5.48E-8 ID:SGTC_3325|Compound:9138760|FD-Score:11.60|P-value:1.31E-17 ID:SGTC_3334|Compound:9142812|FD-Score:-7.11|P-value:1.06E-7

Top fitness defect scores for YBR164C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1306 1185-0270 17.80 9.0 µM 3.51E-39 Golgi 5 1.89E-71
2 SGTC_2737 bleomycin 16.30 30.5 nM 4.57E-33 Golgi 3 4.83E-60
3 SGTC_999 4022-0066 14.90 22.7 µM 4.50E-28 Golgi 1 9.81E-51
4 SGTC_1060 3448-7350 13.00 82.0 µM 9.83E-22 Golgi 5 6.31E-39
5 SGTC_2413 inermin 12.60 26.1 µM 1.46E-20 2 9.58E-37
6 SGTC_1581 himbacine 11.60 57.9 µM 9.06E-18 Golgi 4 1.49E-31
7 SGTC_3325 9138760 11.60 55.2 µM 1.31E-17 Golgi 1 2.96E-31
8 SGTC_2242 6630449 11.60 61.3 µM 1.32E-17 Golgi 6 3.00E-31
9 SGTC_3219 9131112 10.10 49.5 µM 5.72E-14 Golgi 3 1.71E-24
10 SGTC_1679 4130-1276 9.66 6.7 µM 7.91E-13 Golgi 13 2.23E-22
11 SGTC_56 0957-0365 8.90 83.2 µM 3.71E-11 Golgi 9 2.78E-19
12 SGTC_3149 9097855 8.12 49.5 µM 1.44E-9 Golgi 5 2.40E-16
13 SGTC_2363 9053361 8.00 176.0 µM 2.39E-9 Golgi 4 6.14E-16
14 SGTC_546 peri-Naphthalide 7.98 147.0 µM 2.62E-9 DNA damage response 2 7.32E-16
15 SGTC_2310 7668677 7.62 200.0 µM 1.24E-8 3 1.29E-14
16 SGTC_1687 st020778 7.56 55.4 µM 1.56E-8 75 1.95E-14
17 SGTC_1532 4',5'-dihydroxyflavone 7.39 78.7 µM 3.24E-8 Golgi 2 7.57E-14
18 SGTC_3321 9137793 7.26 26.8 µM 5.48E-8 cell wall 17 1.99E-13
19 SGTC_2929 9013348 7.13 24.6 µM 8.88E-8 3 4.85E-13
20 SGTC_605 1315-0399 6.99 119.0 µM 1.54E-7 Golgi 3 1.33E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.528 6.76E-240 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.466 8.36E-181 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.353 2.32E-99 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.316 7.64E-79 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.309 5.26E-75 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.278 1.21E-60 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.246 1.61E-47 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.243 4.30E-46 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.241 1.00E-45 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.229 4.53E-41 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.218 1.77E-37 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.200 1.74E-31 YEL053C MAK10 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
0.198 4.59E-31 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.189 2.38E-28 YOL018C TLG2 hom Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
0.188 5.71E-28 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment