YBR167C / POP7

Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR167C / POP7

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-4.55|P-value:6.24E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:3.74|P-value:6.27E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:3.58|P-value:1.46E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.22|P-value:9.40E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:-3.20|P-value:1.01E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:4.64|P-value:3.10E-8 ID:SGTC_343|Compound:4130-2827|FD-Score:-2.76|P-value:6.93E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:4.65|P-value:2.94E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:3.20|P-value:9.33E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.59|P-value:1.41E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:9.51|P-value:7.14E-29 ID:SGTC_545|Compound:4218-0007|FD-Score:2.69|P-value:8.18E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.93|P-value:2.20E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:2.84|P-value:4.57E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.82|P-value:4.98E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.42|P-value:1.45E-7 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.07|P-value:1.12E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.96|P-value:2.65E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.86|P-value:4.21E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-2.70|P-value:8.64E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.03|P-value:1.25E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.70|P-value:8.68E-6 ID:SGTC_1691|Compound:st019933|FD-Score:2.85|P-value:4.33E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-2.99|P-value:2.65E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:17.30|P-value:2.62E-90 ID:SGTC_1912|Compound:st060209|FD-Score:-2.99|P-value:2.67E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.63|P-value:1.15E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.16|P-value:1.20E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.47|P-value:2.59E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:2.79|P-value:5.52E-4 ID:SGTC_2006|Compound:4011487|FD-Score:2.68|P-value:8.70E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.71|P-value:8.40E-6 ID:SGTC_2049|Compound:5262831|FD-Score:4.47|P-value:9.27E-8 ID:SGTC_2059|Compound:5238311|FD-Score:-3.16|P-value:1.24E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.52|P-value:2.01E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-3.03|P-value:2.16E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.11|P-value:1.38E-4 ID:SGTC_2207|Compound:7258803|FD-Score:2.66|P-value:9.22E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.01|P-value:2.19E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.05|P-value:1.83E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.27|P-value:6.56E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.37|P-value:1.68E-7 ID:SGTC_2442|Compound:5158906|FD-Score:2.90|P-value:3.45E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-4.59|P-value:4.85E-8 ID:SGTC_2491|Compound:paeonol|FD-Score:3.62|P-value:1.15E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.82|P-value:5.01E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.31|P-value:5.49E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-2.88|P-value:4.27E-4 ID:SGTC_2834|Compound:9001755|FD-Score:2.65|P-value:9.67E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-2.78|P-value:6.27E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-2.87|P-value:4.44E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.45|P-value:1.02E-7 ID:SGTC_2975|Compound:9084847|FD-Score:3.29|P-value:6.21E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-2.72|P-value:8.13E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-2.82|P-value:5.40E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-2.82|P-value:5.29E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.55|P-value:6.24E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:3.74|P-value:6.27E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:3.58|P-value:1.46E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.22|P-value:9.40E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:-3.20|P-value:1.01E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:4.64|P-value:3.10E-8 ID:SGTC_343|Compound:4130-2827|FD-Score:-2.76|P-value:6.93E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:4.65|P-value:2.94E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:3.20|P-value:9.33E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.59|P-value:1.41E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:9.51|P-value:7.14E-29 ID:SGTC_545|Compound:4218-0007|FD-Score:2.69|P-value:8.18E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.93|P-value:2.20E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:2.84|P-value:4.57E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.82|P-value:4.98E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.42|P-value:1.45E-7 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.07|P-value:1.12E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.96|P-value:2.65E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.86|P-value:4.21E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-2.70|P-value:8.64E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.03|P-value:1.25E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.70|P-value:8.68E-6 ID:SGTC_1691|Compound:st019933|FD-Score:2.85|P-value:4.33E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-2.99|P-value:2.65E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:17.30|P-value:2.62E-90 ID:SGTC_1912|Compound:st060209|FD-Score:-2.99|P-value:2.67E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.63|P-value:1.15E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.16|P-value:1.20E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.47|P-value:2.59E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:2.79|P-value:5.52E-4 ID:SGTC_2006|Compound:4011487|FD-Score:2.68|P-value:8.70E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.71|P-value:8.40E-6 ID:SGTC_2049|Compound:5262831|FD-Score:4.47|P-value:9.27E-8 ID:SGTC_2059|Compound:5238311|FD-Score:-3.16|P-value:1.24E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.52|P-value:2.01E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-3.03|P-value:2.16E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.11|P-value:1.38E-4 ID:SGTC_2207|Compound:7258803|FD-Score:2.66|P-value:9.22E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.01|P-value:2.19E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.05|P-value:1.83E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.27|P-value:6.56E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.37|P-value:1.68E-7 ID:SGTC_2442|Compound:5158906|FD-Score:2.90|P-value:3.45E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-4.59|P-value:4.85E-8 ID:SGTC_2491|Compound:paeonol|FD-Score:3.62|P-value:1.15E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.82|P-value:5.01E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.31|P-value:5.49E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-2.88|P-value:4.27E-4 ID:SGTC_2834|Compound:9001755|FD-Score:2.65|P-value:9.67E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-2.78|P-value:6.27E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-2.87|P-value:4.44E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.45|P-value:1.02E-7 ID:SGTC_2975|Compound:9084847|FD-Score:3.29|P-value:6.21E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-2.72|P-value:8.13E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-2.82|P-value:5.40E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-2.82|P-value:5.29E-4

Top fitness defect scores for YBR167C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1872 amphotericin b 17.30 148.0 nM 2.62E-90 RNA pol III & RNase P/MRP 3 4.17E-67 3.19
2 SGTC_539 4859-0462 9.51 2.5 µM 7.14E-29 RNA pol III & RNase P/MRP 5 9.29E-22 1.94
3 SGTC_382 3229-0966 4.65 23.2 µM 2.94E-8 3 1.69E-6 0.51
4 SGTC_334 1502-1024 4.64 68.5 µM 3.10E-8 1 1.76E-6 0.95
5 SGTC_2049 5262831 4.47 67.2 µM 9.27E-8 3 3.97E-6 0.09
6 SGTC_2967 9089538 4.45 49.9 µM 1.02E-7 10 4.25E-6 0.09
7 SGTC_2415 st077333 4.37 57.7 µM 1.68E-7 11 6.17E-6 0.00
8 SGTC_1348 1493-0373 4.03 93.8 µM 1.25E-6 4 2.76E-5 0.25
9 SGTC_622 1348-1566 3.93 26.3 µM 2.20E-6 3 4.20E-5 0.08
10 SGTC_116 0155-0182 3.74 31.8 µM 6.27E-6 mitochondrial response to ROS 4 9.17E-5 0.07
11 SGTC_1924 st058459 3.63 75.1 µM 1.15E-5 8 1.44E-4 0.14
12 SGTC_2491 paeonol 3.62 100.0 µM 1.15E-5 2 1.45E-4 0.47
13 SGTC_425 3825-7017 3.59 13.1 µM 1.41E-5 14 1.68E-4 0.11
14 SGTC_159 3970-0959 3.58 50.0 µM 1.46E-5 23 1.73E-4 0.02
15 SGTC_2107 5363541 3.52 170.2 µM 2.01E-5 12 2.19E-4 0.16
16 SGTC_1927 st060202 3.47 13.8 µM 2.59E-5 10 2.65E-4 0.11
17 SGTC_2583 asiatic acid 3.31 100.0 µM 5.49E-5 14 4.65E-4 0.03
18 SGTC_2975 9084847 3.29 53.7 µM 6.21E-5 15 5.09E-4 0.08
19 SGTC_2411 st077133 3.27 39.9 µM 6.56E-5 RNA pol III & RNase P/MRP 28 5.31E-4 0.03
20 SGTC_384 k007-0144 3.20 5.2 µM 9.33E-5 ERAD & cell cycle 25 6.91E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.397 4.73E-127 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.311 3.00E-76 YNL282W POP3 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.254 1.61E-50 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.244 1.44E-46 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.243 1.99E-46 YER048C CAJ1 hom Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
0.236 1.26E-43 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.212 3.32E-35 YDR276C PMP3 hom Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
0.192 2.87E-29 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.162 3.02E-21 YNR029C_p YNR029C_p hom Putative protein of unknown function, deletion confers reduced fitness in saline
0.157 7.25E-20 YOL124C TRM11 hom Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
0.145 2.98E-17 YIL164C NIT1 hom Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
0.140 3.43E-16 YOR287C RRP36 het Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
0.135 4.40E-15 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.129 6.96E-14 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.122 1.47E-12 YPL010W RET3 het Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER