YBR168W / PEX32

Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR168W / PEX32

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.59|P-value:3.61E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.58|P-value:7.57E-8 ID:SGTC_47|Compound:0149-0135|FD-Score:3.50|P-value:4.91E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.78|P-value:3.37E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:4.26|P-value:3.02E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.67|P-value:5.52E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:3.38|P-value:7.40E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.81|P-value:1.68E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.86|P-value:2.40E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:4.15|P-value:4.75E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.32|P-value:8.87E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.42|P-value:6.41E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.45|P-value:5.74E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.75|P-value:2.10E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.75|P-value:2.04E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:6.12|P-value:4.09E-9 ID:SGTC_800|Compound:3448-7362|FD-Score:4.01|P-value:8.12E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.33|P-value:8.68E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.91|P-value:1.17E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.10|P-value:5.67E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.56|P-value:3.98E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.41|P-value:6.66E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.29|P-value:9.88E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.45|P-value:1.40E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.83|P-value:1.55E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.69|P-value:2.58E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-8.01|P-value:2.33E-14 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.86|P-value:1.41E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.35|P-value:8.14E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.05|P-value:6.80E-5 ID:SGTC_1903|Compound:st060211|FD-Score:-3.29|P-value:9.68E-4 ID:SGTC_1944|Compound:st076371|FD-Score:6.67|P-value:1.69E-10 ID:SGTC_1969|Compound:st069479|FD-Score:3.94|P-value:1.04E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.72|P-value:2.29E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.74|P-value:2.18E-4 ID:SGTC_2324|Compound:6149169|FD-Score:4.61|P-value:7.07E-6 ID:SGTC_2472|Compound:5377652|FD-Score:3.85|P-value:1.47E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.56|P-value:8.64E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.22|P-value:3.59E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.29|P-value:2.68E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.40|P-value:1.76E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-4.50|P-value:1.12E-5 ID:SGTC_2927|Compound:9011802|FD-Score:4.91|P-value:1.94E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.51|P-value:4.79E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.57|P-value:3.85E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.89|P-value:1.27E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.29|P-value:9.73E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.29|P-value:9.66E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.71|P-value:2.39E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-4.17|P-value:4.26E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.44|P-value:5.93E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.12|P-value:5.36E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:3.59|P-value:3.61E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.58|P-value:7.57E-8 ID:SGTC_47|Compound:0149-0135|FD-Score:3.50|P-value:4.91E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.78|P-value:3.37E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:4.26|P-value:3.02E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.67|P-value:5.52E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:3.38|P-value:7.40E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.81|P-value:1.68E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.86|P-value:2.40E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:4.15|P-value:4.75E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.32|P-value:8.87E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.42|P-value:6.41E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.45|P-value:5.74E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.75|P-value:2.10E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.75|P-value:2.04E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:6.12|P-value:4.09E-9 ID:SGTC_800|Compound:3448-7362|FD-Score:4.01|P-value:8.12E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.33|P-value:8.68E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.91|P-value:1.17E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.10|P-value:5.67E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.56|P-value:3.98E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.41|P-value:6.66E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.29|P-value:9.88E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.45|P-value:1.40E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.83|P-value:1.55E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.69|P-value:2.58E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-8.01|P-value:2.33E-14 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.86|P-value:1.41E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.35|P-value:8.14E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.05|P-value:6.80E-5 ID:SGTC_1903|Compound:st060211|FD-Score:-3.29|P-value:9.68E-4 ID:SGTC_1944|Compound:st076371|FD-Score:6.67|P-value:1.69E-10 ID:SGTC_1969|Compound:st069479|FD-Score:3.94|P-value:1.04E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.72|P-value:2.29E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.74|P-value:2.18E-4 ID:SGTC_2324|Compound:6149169|FD-Score:4.61|P-value:7.07E-6 ID:SGTC_2472|Compound:5377652|FD-Score:3.85|P-value:1.47E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.56|P-value:8.64E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.22|P-value:3.59E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.29|P-value:2.68E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.40|P-value:1.76E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-4.50|P-value:1.12E-5 ID:SGTC_2927|Compound:9011802|FD-Score:4.91|P-value:1.94E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.51|P-value:4.79E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.57|P-value:3.85E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.89|P-value:1.27E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.29|P-value:9.73E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.29|P-value:9.66E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.71|P-value:2.39E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-4.17|P-value:4.26E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.44|P-value:5.93E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.12|P-value:5.36E-5

Top fitness defect scores for YBR168W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1944 st076371 6.67 56.9 µM 1.69E-10 1 1.27E-11
2 SGTC_625 k213-0058 6.12 121.0 µM 4.09E-9 translation 33 4.57E-10
3 SGTC_46 0329-0187a 5.58 2.2 µM 7.57E-8 31 1.22E-8
4 SGTC_2927 9011802 4.91 47.9 µM 1.94E-6 12 4.66E-7
5 SGTC_161 4065-0411 4.86 162.2 µM 2.40E-6 43 5.92E-7
6 SGTC_56 0957-0365 4.78 83.2 µM 3.37E-6 Golgi 29 8.67E-7
7 SGTC_2324 6149169 4.61 200.0 µM 7.07E-6 14 1.99E-6
8 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 4.45 15.5 µM 1.40E-5 15 4.29E-6
9 SGTC_2651 1327-0036 4.40 5.0 µM 1.76E-5 139 5.53E-6
10 SGTC_59 0330-0160 4.26 1.3 µM 3.02E-5 96 1.02E-5
11 SGTC_2611 pyromycin 4.22 23.9 µM 3.59E-5 20 1.24E-5
12 SGTC_163 1327-0036 4.15 7.5 µM 4.75E-5 97 1.69E-5
13 SGTC_3218 9131285 4.12 49.5 µM 5.36E-5 endomembrane recycling 36 1.93E-5
14 SGTC_800 3448-7362 4.01 155.0 µM 8.12E-5 translation 157 3.08E-5
15 SGTC_1969 st069479 3.94 40.1 µM 1.04E-4 12 4.08E-5
16 SGTC_3029 9088683 3.89 49.5 µM 1.27E-4 24 5.11E-5
17 SGTC_2472 5377652 3.85 49.4 µM 1.47E-4 TRP & mitochondrial translation 62 5.98E-5
18 SGTC_1106 tegaserod maleate 3.83 11.7 µM 1.55E-4 21 6.36E-5
19 SGTC_422 cantharidin 3.75 155.0 µM 2.10E-4 cell wall signaling 66 8.94E-5
20 SGTC_2176 5809774 3.74 34.0 µM 2.18E-4 mitochondrial processes 17 9.34E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.71E-22 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.144 5.28E-17 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.140 4.49E-16 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.124 4.95E-13 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.122 1.45E-12 YGL100W SEH1 hom Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1
0.118 6.68E-12 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.117 9.37E-12 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
0.117 1.31E-11 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.117 1.36E-11 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.116 1.76E-11 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.115 2.92E-11 YIR021W-A_p YIR021W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.114 3.66E-11 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.114 3.81E-11 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.113 6.25E-11 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.112 7.74E-11 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification