YBR173C / UMP1

Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR173C / UMP1

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:3.14|P-value:4.08E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.56|P-value:7.59E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:3.64|P-value:5.41E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:5.15|P-value:2.03E-8 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.34|P-value:1.81E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.87|P-value:1.81E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.65|P-value:4.95E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.09|P-value:4.94E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.28|P-value:2.43E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.67|P-value:3.34E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.98|P-value:9.34E-11 ID:SGTC_340|Compound:k038-0059|FD-Score:2.97|P-value:7.80E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.24|P-value:2.86E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:3.91|P-value:1.54E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.77|P-value:3.02E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.79|P-value:2.74E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:6.61|P-value:9.66E-13 ID:SGTC_685|Compound:1278-0033|FD-Score:3.32|P-value:2.03E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-2.90|P-value:9.87E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:2.93|P-value:9.12E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:7.89|P-value:2.16E-17 ID:SGTC_814|Compound:3342-0569|FD-Score:3.04|P-value:6.09E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:5.25|P-value:1.13E-8 ID:SGTC_964|Compound:1287-0107|FD-Score:3.31|P-value:2.10E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.04|P-value:6.04E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.16|P-value:4.72E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:4.14|P-value:5.21E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.07|P-value:3.43E-8 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.09|P-value:4.82E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.23|P-value:2.95E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-2.97|P-value:7.69E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.12|P-value:5.65E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.37|P-value:1.70E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.12|P-value:4.43E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.13|P-value:4.35E-4 ID:SGTC_1657|Compound:st012939|FD-Score:4.40|P-value:1.38E-6 ID:SGTC_1676|Compound:st018489|FD-Score:4.20|P-value:3.78E-6 ID:SGTC_1984|Compound:st072354|FD-Score:3.71|P-value:3.87E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.06|P-value:5.59E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.16|P-value:3.89E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.03|P-value:6.20E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.05|P-value:5.73E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.00|P-value:7.06E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-2.91|P-value:9.56E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.39|P-value:1.55E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.85|P-value:1.99E-5 ID:SGTC_2908|Compound:7930301|FD-Score:2.99|P-value:7.37E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.16|P-value:3.68E-4 ID:SGTC_2951|Compound:9072950|FD-Score:2.99|P-value:7.28E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.32|P-value:2.08E-4 ID:SGTC_3026|Compound:9090633|FD-Score:-4.26|P-value:2.72E-6 ID:SGTC_3179|Compound:9107801|FD-Score:3.16|P-value:3.88E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.92|P-value:1.50E-5 ID:SGTC_3236|Compound:9132701|FD-Score:-3.73|P-value:3.54E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.03|P-value:6.22E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.14|P-value:4.08E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.56|P-value:7.59E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:3.64|P-value:5.41E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:5.15|P-value:2.03E-8 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.34|P-value:1.81E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.87|P-value:1.81E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.65|P-value:4.95E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.09|P-value:4.94E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.28|P-value:2.43E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.67|P-value:3.34E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.98|P-value:9.34E-11 ID:SGTC_340|Compound:k038-0059|FD-Score:2.97|P-value:7.80E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.24|P-value:2.86E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:3.91|P-value:1.54E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.77|P-value:3.02E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.79|P-value:2.74E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:6.61|P-value:9.66E-13 ID:SGTC_685|Compound:1278-0033|FD-Score:3.32|P-value:2.03E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-2.90|P-value:9.87E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:2.93|P-value:9.12E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:7.89|P-value:2.16E-17 ID:SGTC_814|Compound:3342-0569|FD-Score:3.04|P-value:6.09E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:5.25|P-value:1.13E-8 ID:SGTC_964|Compound:1287-0107|FD-Score:3.31|P-value:2.10E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.04|P-value:6.04E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.16|P-value:4.72E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:4.14|P-value:5.21E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.07|P-value:3.43E-8 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.09|P-value:4.82E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.23|P-value:2.95E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-2.97|P-value:7.69E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.12|P-value:5.65E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.37|P-value:1.70E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.12|P-value:4.43E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.13|P-value:4.35E-4 ID:SGTC_1657|Compound:st012939|FD-Score:4.40|P-value:1.38E-6 ID:SGTC_1676|Compound:st018489|FD-Score:4.20|P-value:3.78E-6 ID:SGTC_1984|Compound:st072354|FD-Score:3.71|P-value:3.87E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.06|P-value:5.59E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.16|P-value:3.89E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.03|P-value:6.20E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.05|P-value:5.73E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.00|P-value:7.06E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-2.91|P-value:9.56E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.39|P-value:1.55E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.85|P-value:1.99E-5 ID:SGTC_2908|Compound:7930301|FD-Score:2.99|P-value:7.37E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.16|P-value:3.68E-4 ID:SGTC_2951|Compound:9072950|FD-Score:2.99|P-value:7.28E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.32|P-value:2.08E-4 ID:SGTC_3026|Compound:9090633|FD-Score:-4.26|P-value:2.72E-6 ID:SGTC_3179|Compound:9107801|FD-Score:3.16|P-value:3.88E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.92|P-value:1.50E-5 ID:SGTC_3236|Compound:9132701|FD-Score:-3.73|P-value:3.54E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.03|P-value:6.22E-4

Top fitness defect scores for YBR173C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_774 k060-0086 7.89 136.0 µM 2.16E-17 4 1.52E-15
2 SGTC_670 4204-0025 6.61 119.0 µM 9.66E-13 copper-dependent oxidative stress 7 1.94E-11
3 SGTC_923 1900-2434 5.25 73.3 µM 1.13E-8 RNA processing & uracil transport 13 7.62E-8
4 SGTC_145 3737-0113 5.15 38.4 µM 2.03E-8 DNA intercalators 38 1.28E-7
5 SGTC_1001 4048-4355 5.07 44.4 µM 3.43E-8 copper-dependent oxidative stress 19 2.03E-7
6 SGTC_264 promethazine 4.67 12.5 mM 3.34E-7 DNA intercalators 36 1.52E-6
7 SGTC_1657 st012939 4.40 43.4 µM 1.38E-6 7 5.36E-6
8 SGTC_1676 st018489 4.20 23.4 µM 3.78E-6 60S ribosome export 27 1.31E-5
9 SGTC_972 1319-0219 4.16 195.0 µM 4.72E-6 23 1.59E-5
10 SGTC_992 3909-8734 4.14 162.0 µM 5.21E-6 13 1.74E-5
11 SGTC_1243 0416-0003 4.12 5.7 µM 5.65E-6 PDR1 24 1.87E-5
12 SGTC_3225 9130819 3.92 49.5 µM 1.50E-5 amide catabolism 27 4.43E-5
13 SGTC_347 4534-1311 3.91 26.2 µM 1.54E-5 RPP1 & pyrimidine depletion 12 4.55E-5
14 SGTC_585 0kpi-0023 3.79 191.0 µM 2.74E-5 20 7.57E-5
15 SGTC_497 capsazepine 3.77 133.0 µM 3.02E-5 17 8.25E-5
16 SGTC_1984 st072354 3.71 53.1 µM 3.87E-5 20 1.03E-4
17 SGTC_144 4161-2749 3.64 112.4 µM 5.41E-5 DNA intercalators 29 1.38E-4
18 SGTC_137 0438-0332 3.56 85.4 µM 7.59E-5 ubiquinone biosynthesis & proteasome 148 1.87E-4
19 SGTC_2815 7968870 3.39 71.4 µM 1.55E-4 49 3.52E-4
20 SGTC_1251 0490-5699 3.37 265.0 µM 1.70E-4 64 3.82E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 6.22E-35 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.208 5.80E-34 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.202 4.19E-32 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.191 8.66E-29 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.187 7.85E-28 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.164 9.26E-22 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.163 2.18E-21 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.158 4.13E-20 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.141 2.72E-16 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.140 3.32E-16 YBR182C SMP1 hom Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication
0.140 3.45E-16 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.140 3.50E-16 YLR133W CKI1 hom Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication
0.138 9.45E-16 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.137 2.10E-15 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.136 2.55E-15 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication