YBR174C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR174C / YBR174C

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.49|P-value:3.57E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.24|P-value:8.30E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.21|P-value:9.13E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.52|P-value:3.20E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.23|P-value:8.51E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.34|P-value:5.94E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.95|P-value:6.16E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.81|P-value:1.09E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.02|P-value:4.70E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.68|P-value:1.82E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:7.49|P-value:1.84E-13 ID:SGTC_572|Compound:0960-0087|FD-Score:3.80|P-value:1.14E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.26|P-value:7.75E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.44|P-value:4.28E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.41|P-value:4.75E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.82|P-value:1.04E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.42|P-value:4.49E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.45|P-value:3.98E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.50|P-value:3.34E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:5.03|P-value:5.16E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.64|P-value:2.02E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.02|P-value:4.67E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.46|P-value:7.61E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.47|P-value:3.79E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.24|P-value:1.92E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.59|P-value:2.42E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:10.80|P-value:5.26E-26 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.59|P-value:2.45E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.22|P-value:8.97E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-4.13|P-value:3.06E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.68|P-value:1.82E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.29|P-value:7.02E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.35|P-value:5.74E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.90|P-value:7.70E-5 ID:SGTC_1891|Compound:st059073|FD-Score:3.64|P-value:2.03E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.40|P-value:4.87E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.80|P-value:1.14E-4 ID:SGTC_2164|Compound:5685496|FD-Score:5.68|P-value:1.77E-8 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.60|P-value:4.06E-6 ID:SGTC_2551|Compound:apiole|FD-Score:4.49|P-value:6.50E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.33|P-value:6.02E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.24|P-value:8.26E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.78|P-value:9.85E-9 ID:SGTC_2816|Compound:7982706|FD-Score:4.01|P-value:5.01E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.89|P-value:7.88E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.49|P-value:3.48E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.32|P-value:6.29E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.85|P-value:9.26E-5 ID:SGTC_2950|Compound:9072895|FD-Score:4.41|P-value:9.11E-6 ID:SGTC_3037|Compound:9091026|FD-Score:3.37|P-value:5.34E-4 ID:SGTC_3127|Compound:9126946|FD-Score:5.16|P-value:2.70E-7 ID:SGTC_3152|Compound:9099253|FD-Score:3.52|P-value:3.12E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.93|P-value:6.84E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.30|P-value:6.72E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.54|P-value:2.91E-4 ID:SGTC_3330|Compound:9141424|FD-Score:4.26|P-value:1.79E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.49|P-value:3.57E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.24|P-value:8.30E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.21|P-value:9.13E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.52|P-value:3.20E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.23|P-value:8.51E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.34|P-value:5.94E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.95|P-value:6.16E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.81|P-value:1.09E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.02|P-value:4.70E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.68|P-value:1.82E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:7.49|P-value:1.84E-13 ID:SGTC_572|Compound:0960-0087|FD-Score:3.80|P-value:1.14E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.26|P-value:7.75E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.44|P-value:4.28E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.41|P-value:4.75E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.82|P-value:1.04E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.42|P-value:4.49E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.45|P-value:3.98E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.50|P-value:3.34E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:5.03|P-value:5.16E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.64|P-value:2.02E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.02|P-value:4.67E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.46|P-value:7.61E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.47|P-value:3.79E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.24|P-value:1.92E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.59|P-value:2.42E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:10.80|P-value:5.26E-26 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.59|P-value:2.45E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.22|P-value:8.97E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-4.13|P-value:3.06E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.68|P-value:1.82E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.29|P-value:7.02E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.35|P-value:5.74E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.90|P-value:7.70E-5 ID:SGTC_1891|Compound:st059073|FD-Score:3.64|P-value:2.03E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.40|P-value:4.87E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.80|P-value:1.14E-4 ID:SGTC_2164|Compound:5685496|FD-Score:5.68|P-value:1.77E-8 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.60|P-value:4.06E-6 ID:SGTC_2551|Compound:apiole|FD-Score:4.49|P-value:6.50E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.33|P-value:6.02E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.24|P-value:8.26E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.78|P-value:9.85E-9 ID:SGTC_2816|Compound:7982706|FD-Score:4.01|P-value:5.01E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.89|P-value:7.88E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.49|P-value:3.48E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.32|P-value:6.29E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.85|P-value:9.26E-5 ID:SGTC_2950|Compound:9072895|FD-Score:4.41|P-value:9.11E-6 ID:SGTC_3037|Compound:9091026|FD-Score:3.37|P-value:5.34E-4 ID:SGTC_3127|Compound:9126946|FD-Score:5.16|P-value:2.70E-7 ID:SGTC_3152|Compound:9099253|FD-Score:3.52|P-value:3.12E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.93|P-value:6.84E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.30|P-value:6.72E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.54|P-value:2.91E-4 ID:SGTC_3330|Compound:9141424|FD-Score:4.26|P-value:1.79E-5

Top fitness defect scores for YBR174C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1427 4048-4900 10.80 550.0 nM 5.26E-26 4 1.72E-27
2 SGTC_517 1365-0151 7.49 113.0 µM 1.84E-13 5 3.53E-14
3 SGTC_2688 kanamycin b 5.78 96.7 µM 9.85E-9 calcium & mitochondrial duress 169 3.64E-9
4 SGTC_2164 5685496 5.68 200.0 µM 1.77E-8 5 6.75E-9
5 SGTC_3127 9126946 5.16 49.5 µM 2.70E-7 ERG2 5 1.22E-7
6 SGTC_1092 toremifene 5.03 6.3 µM 5.16E-7 6 2.42E-7
7 SGTC_2500 5-alpha-androstan-3,17-dione 4.60 61.4 µM 4.06E-6 27 2.15E-6
8 SGTC_2551 apiole 4.49 73.9 µM 6.50E-6 6 3.53E-6
9 SGTC_1218 1348-1416 4.46 30.7 µM 7.61E-6 SWF1 & branched chain AA biosynthesis 9 4.18E-6
10 SGTC_2950 9072895 4.41 21.5 µM 9.11E-6 26 5.05E-6
11 SGTC_3330 9141424 4.26 71.4 µM 1.79E-5 amide catabolism 12 1.03E-5
12 SGTC_1336 1486-0901 4.24 104.0 µM 1.92E-5 17 1.12E-5
13 SGTC_1193 1488-0126 4.02 41.5 µM 4.67E-5 24 2.85E-5
14 SGTC_513 4245-1575 4.02 41.7 µM 4.70E-5 unfolded protein response 112 2.87E-5
15 SGTC_2816 7982706 4.01 58.4 µM 5.01E-5 azole & statin 49 3.08E-5
16 SGTC_462 ag-879 3.95 158.0 µM 6.16E-5 29 3.83E-5
17 SGTC_3211 9128781 3.93 49.5 µM 6.84E-5 58 4.27E-5
18 SGTC_1818 st052136 3.90 56.3 µM 7.70E-5 NEO1-PIK1 54 4.85E-5
19 SGTC_2817 7995342 3.89 71.4 µM 7.88E-5 26 4.96E-5
20 SGTC_2942 9052777 3.85 62.2 µM 9.26E-5 35 5.89E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 6.96E-13 YKL156W RPS27A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.108 4.01E-10 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.106 7.21E-10 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.104 1.30E-9 YHR038W RRF1 hom Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
0.101 4.82E-9 YCR051W_p YCR051W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
0.098 1.09E-8 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.097 1.58E-8 YOL130W ALR1 het Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
0.097 1.67E-8 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.096 2.36E-8 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.093 5.92E-8 YLR253W_p YLR253W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene
0.093 6.21E-8 YGR086C PIL1 hom Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.093 7.86E-8 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.091 1.25E-7 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.091 1.38E-7 YBR175W SWD3 hom Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
0.090 1.71E-7 YBL067C UBP13 hom Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication