YBR175W / SWD3

Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR175W / SWD3

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:4.61|P-value:2.03E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:3.30|P-value:4.80E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:5.00|P-value:2.91E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.44|P-value:3.22E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.58|P-value:1.89E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.76|P-value:9.73E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:4.31|P-value:7.86E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:5.16|P-value:1.23E-7 ID:SGTC_305|Compound:1682-2595|FD-Score:4.80|P-value:7.79E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:3.54|P-value:1.93E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:4.29|P-value:8.67E-6 ID:SGTC_382|Compound:3229-0966|FD-Score:3.99|P-value:3.18E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.66|P-value:1.23E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.15|P-value:1.64E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:5.33|P-value:5.00E-8 ID:SGTC_539|Compound:4859-0462|FD-Score:3.65|P-value:1.26E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.31|P-value:5.08E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.30|P-value:5.24E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.42|P-value:3.07E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.07|P-value:2.35E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.18|P-value:7.10E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.12|P-value:9.75E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.39|P-value:3.41E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.36|P-value:3.83E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.17|P-value:7.56E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.80|P-value:6.98E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.25|P-value:5.71E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.68|P-value:1.14E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.73|P-value:9.29E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.36|P-value:6.44E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.74|P-value:9.04E-5 ID:SGTC_1608|Compound:st001473|FD-Score:4.46|P-value:4.11E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.87|P-value:5.25E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.86|P-value:6.28E-5 ID:SGTC_1754|Compound:st042065|FD-Score:6.89|P-value:2.93E-12 ID:SGTC_1755|Compound:st041960|FD-Score:14.70|P-value:8.95E-49 ID:SGTC_1781|Compound:st038725|FD-Score:3.84|P-value:6.11E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-3.86|P-value:6.20E-5 ID:SGTC_1846|Compound:st056244|FD-Score:5.06|P-value:2.11E-7 ID:SGTC_2220|Compound:6782180|FD-Score:4.05|P-value:2.55E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.71|P-value:1.24E-6 ID:SGTC_2293|Compound:7624732|FD-Score:-5.07|P-value:2.32E-7 ID:SGTC_2297|Compound:7971671|FD-Score:7.80|P-value:3.20E-15 ID:SGTC_2386|Compound:9075165|FD-Score:3.13|P-value:8.67E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.09|P-value:9.62E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.75|P-value:9.76E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.17|P-value:8.20E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.10|P-value:9.53E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.23|P-value:2.41E-10 ID:SGTC_2918|Compound:7977171|FD-Score:4.75|P-value:9.93E-7 ID:SGTC_2931|Compound:9014674|FD-Score:-3.26|P-value:6.09E-4 ID:SGTC_3014|Compound:9081533|FD-Score:5.31|P-value:5.54E-8 ID:SGTC_3031|Compound:9088762|FD-Score:-3.38|P-value:3.94E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.13|P-value:4.35E-10 ID:SGTC_3152|Compound:9099253|FD-Score:4.67|P-value:1.46E-6 ID:SGTC_3177|Compound:9107506|FD-Score:3.11|P-value:8.99E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.96|P-value:4.20E-5 ID:SGTC_3237|Compound:9133362|FD-Score:-3.12|P-value:9.71E-4 ID:SGTC_3254|Compound:9136651|FD-Score:4.08|P-value:2.20E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:4.61|P-value:2.03E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:3.30|P-value:4.80E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:5.00|P-value:2.91E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.44|P-value:3.22E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.58|P-value:1.89E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.76|P-value:9.73E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:4.31|P-value:7.86E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:5.16|P-value:1.23E-7 ID:SGTC_305|Compound:1682-2595|FD-Score:4.80|P-value:7.79E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:3.54|P-value:1.93E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:4.29|P-value:8.67E-6 ID:SGTC_382|Compound:3229-0966|FD-Score:3.99|P-value:3.18E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.66|P-value:1.23E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.15|P-value:1.64E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:5.33|P-value:5.00E-8 ID:SGTC_539|Compound:4859-0462|FD-Score:3.65|P-value:1.26E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.31|P-value:5.08E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.30|P-value:5.24E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.42|P-value:3.07E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.07|P-value:2.35E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.18|P-value:7.10E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.12|P-value:9.75E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.39|P-value:3.41E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.36|P-value:3.83E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.17|P-value:7.56E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.80|P-value:6.98E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.25|P-value:5.71E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.68|P-value:1.14E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.73|P-value:9.29E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.36|P-value:6.44E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.74|P-value:9.04E-5 ID:SGTC_1608|Compound:st001473|FD-Score:4.46|P-value:4.11E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.87|P-value:5.25E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.86|P-value:6.28E-5 ID:SGTC_1754|Compound:st042065|FD-Score:6.89|P-value:2.93E-12 ID:SGTC_1755|Compound:st041960|FD-Score:14.70|P-value:8.95E-49 ID:SGTC_1781|Compound:st038725|FD-Score:3.84|P-value:6.11E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-3.86|P-value:6.20E-5 ID:SGTC_1846|Compound:st056244|FD-Score:5.06|P-value:2.11E-7 ID:SGTC_2220|Compound:6782180|FD-Score:4.05|P-value:2.55E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.71|P-value:1.24E-6 ID:SGTC_2293|Compound:7624732|FD-Score:-5.07|P-value:2.32E-7 ID:SGTC_2297|Compound:7971671|FD-Score:7.80|P-value:3.20E-15 ID:SGTC_2386|Compound:9075165|FD-Score:3.13|P-value:8.67E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.09|P-value:9.62E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.75|P-value:9.76E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.17|P-value:8.20E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.10|P-value:9.53E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.23|P-value:2.41E-10 ID:SGTC_2918|Compound:7977171|FD-Score:4.75|P-value:9.93E-7 ID:SGTC_2931|Compound:9014674|FD-Score:-3.26|P-value:6.09E-4 ID:SGTC_3014|Compound:9081533|FD-Score:5.31|P-value:5.54E-8 ID:SGTC_3031|Compound:9088762|FD-Score:-3.38|P-value:3.94E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.13|P-value:4.35E-10 ID:SGTC_3152|Compound:9099253|FD-Score:4.67|P-value:1.46E-6 ID:SGTC_3177|Compound:9107506|FD-Score:3.11|P-value:8.99E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.96|P-value:4.20E-5 ID:SGTC_3237|Compound:9133362|FD-Score:-3.12|P-value:9.71E-4 ID:SGTC_3254|Compound:9136651|FD-Score:4.08|P-value:2.20E-5

Top fitness defect scores for YBR175W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1755 st041960 14.70 45.2 µM 8.95E-49 1 6.19E-49
2 SGTC_2297 7971671 7.80 152.3 µM 3.20E-15 RNA processing & uracil transport 2 3.05E-15
3 SGTC_1754 st042065 6.89 16.1 µM 2.93E-12 NEO1-PIK1 77 2.86E-12
4 SGTC_2688 kanamycin b 6.23 96.7 µM 2.41E-10 calcium & mitochondrial duress 143 2.39E-10
5 SGTC_3037 9091026 6.13 49.5 µM 4.35E-10 NEO1-PIK1 46 4.31E-10
6 SGTC_533 1222-0222 5.33 6.7 µM 5.00E-8 PDR1 7 5.03E-8
7 SGTC_3014 9081533 5.31 49.5 µM 5.54E-8 5 5.57E-8
8 SGTC_286 k060-0067 5.16 22.9 µM 1.23E-7 tubulin folding & SWR complex 12 1.24E-7
9 SGTC_1846 st056244 5.06 14.8 µM 2.11E-7 9 2.12E-7
10 SGTC_56 0957-0365 5.00 83.2 µM 2.91E-7 Golgi 28 2.93E-7
11 SGTC_305 1682-2595 4.80 20.8 µM 7.79E-7 RNA processing & uracil transport 12 7.88E-7
12 SGTC_137 0438-0332 4.76 85.4 µM 9.73E-7 ubiquinone biosynthesis & proteasome 84 9.84E-7
13 SGTC_2918 7977171 4.75 22.1 µM 9.93E-7 16 1.01E-6
14 SGTC_2250 alverine citrate 4.71 130.0 µM 1.24E-6 109 1.26E-6
15 SGTC_3152 9099253 4.67 49.5 µM 1.46E-6 NEO1-PIK1 91 1.48E-6
16 SGTC_53 0973-0023 4.61 40.0 µM 2.03E-6 RNA processing & uracil transport 8 2.06E-6
17 SGTC_1608 st001473 4.46 40.5 µM 4.11E-6 23 4.17E-6
18 SGTC_1189 1431-2119 4.36 7.3 µM 6.44E-6 16 6.54E-6
19 SGTC_142 0335-0849 4.31 62.7 µM 7.86E-6 ubiquinone biosynthesis & proteasome 107 7.99E-6
20 SGTC_356 1634-0012 4.29 32.5 µM 8.67E-6 18 8.82E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 5.63E-20 YML067C ERV41 hom Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
0.149 3.78E-18 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.135 4.41E-15 YGL043W DST1 hom General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress
0.132 2.04E-14 YNL079C TPM1 hom Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication
0.129 8.08E-14 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.127 1.37E-13 YGL100W SEH1 hom Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1
0.125 4.44E-13 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.123 7.74E-13 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.123 7.73E-13 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.119 4.07E-12 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.118 6.79E-12 YOL145C CTR9 hom Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats
0.116 1.63E-11 YGR086C PIL1 hom Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.115 2.12E-11 YLL036C PRP19 het Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain
0.113 4.95E-11 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.113 6.18E-11 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria