YBR179C / FZO1

Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR179C / FZO1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.78|P-value:1.66E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.41|P-value:1.39E-7 ID:SGTC_38|Compound:0929-0051|FD-Score:3.65|P-value:2.58E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.58|P-value:3.31E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.65|P-value:5.08E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:3.56|P-value:3.63E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.15|P-value:5.02E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:3.75|P-value:1.82E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:6.24|P-value:1.62E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:3.63|P-value:2.86E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:10.20|P-value:2.50E-22 ID:SGTC_173|Compound:1273-0061|FD-Score:5.41|P-value:1.42E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:20.30|P-value:1.24E-82 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.57|P-value:2.16E-16 ID:SGTC_279|Compound:1273-0055|FD-Score:3.75|P-value:1.82E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:4.42|P-value:1.34E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:6.30|P-value:1.13E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:4.42|P-value:1.33E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:4.02|P-value:6.72E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:5.70|P-value:3.19E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:7.00|P-value:1.58E-11 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.95|P-value:9.48E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.47|P-value:5.20E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.41|P-value:6.33E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:5.11|P-value:6.18E-7 ID:SGTC_538|Compound:2922-0838|FD-Score:6.10|P-value:3.49E-9 ID:SGTC_539|Compound:4859-0462|FD-Score:3.66|P-value:2.57E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.61|P-value:3.03E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.02|P-value:6.84E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:4.72|P-value:3.63E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.93|P-value:1.00E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.30|P-value:8.68E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.40|P-value:6.28E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.82|P-value:4.71E-11 ID:SGTC_832|Compound:4083-0019|FD-Score:3.41|P-value:5.97E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.81|P-value:5.24E-11 ID:SGTC_908|Compound:3448-7491|FD-Score:5.42|P-value:1.36E-7 ID:SGTC_974|Compound:1326-0144|FD-Score:4.91|P-value:1.53E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.32|P-value:2.07E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.85|P-value:1.27E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.94|P-value:9.07E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.11|P-value:5.05E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.33|P-value:7.74E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.65|P-value:1.37E-10 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.92|P-value:9.37E-9 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.43|P-value:1.30E-7 ID:SGTC_1635|Compound:st007035|FD-Score:6.98|P-value:1.76E-11 ID:SGTC_1658|Compound:st012944|FD-Score:-3.34|P-value:7.98E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.81|P-value:1.58E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.59|P-value:1.99E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.93|P-value:1.52E-6 ID:SGTC_1800|Compound:st050079|FD-Score:-4.28|P-value:2.51E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.72|P-value:3.96E-6 ID:SGTC_2010|Compound:4012422|FD-Score:4.04|P-value:6.23E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-4.34|P-value:2.04E-5 ID:SGTC_2149|Compound:5554786|FD-Score:-3.45|P-value:5.46E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-4.18|P-value:3.84E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.16|P-value:5.51E-12 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.95|P-value:8.72E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-3.54|P-value:4.08E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.36|P-value:7.03E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:6.27|P-value:1.31E-9 ID:SGTC_2526|Compound:patulin|FD-Score:4.01|P-value:6.89E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.69|P-value:2.44E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.28|P-value:2.59E-5 ID:SGTC_2819|Compound:7996655|FD-Score:5.58|P-value:6.02E-8 ID:SGTC_2840|Compound:9008771|FD-Score:3.38|P-value:6.58E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.34|P-value:7.41E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.60|P-value:2.04E-10 ID:SGTC_2908|Compound:7930301|FD-Score:3.41|P-value:6.06E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.29|P-value:8.87E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.99|P-value:1.10E-6 ID:SGTC_3107|Compound:9121808|FD-Score:3.54|P-value:3.79E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.40|P-value:6.43E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.78|P-value:1.66E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.41|P-value:1.39E-7 ID:SGTC_38|Compound:0929-0051|FD-Score:3.65|P-value:2.58E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.58|P-value:3.31E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.65|P-value:5.08E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:3.56|P-value:3.63E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.15|P-value:5.02E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:3.75|P-value:1.82E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:6.24|P-value:1.62E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:3.63|P-value:2.86E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:10.20|P-value:2.50E-22 ID:SGTC_173|Compound:1273-0061|FD-Score:5.41|P-value:1.42E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:20.30|P-value:1.24E-82 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.57|P-value:2.16E-16 ID:SGTC_279|Compound:1273-0055|FD-Score:3.75|P-value:1.82E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:4.42|P-value:1.34E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:6.30|P-value:1.13E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:4.42|P-value:1.33E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:4.02|P-value:6.72E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:5.70|P-value:3.19E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:7.00|P-value:1.58E-11 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.95|P-value:9.48E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.47|P-value:5.20E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.41|P-value:6.33E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:5.11|P-value:6.18E-7 ID:SGTC_538|Compound:2922-0838|FD-Score:6.10|P-value:3.49E-9 ID:SGTC_539|Compound:4859-0462|FD-Score:3.66|P-value:2.57E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.61|P-value:3.03E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.02|P-value:6.84E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:4.72|P-value:3.63E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.93|P-value:1.00E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.30|P-value:8.68E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.40|P-value:6.28E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.82|P-value:4.71E-11 ID:SGTC_832|Compound:4083-0019|FD-Score:3.41|P-value:5.97E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.81|P-value:5.24E-11 ID:SGTC_908|Compound:3448-7491|FD-Score:5.42|P-value:1.36E-7 ID:SGTC_974|Compound:1326-0144|FD-Score:4.91|P-value:1.53E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.32|P-value:2.07E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.85|P-value:1.27E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.94|P-value:9.07E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.11|P-value:5.05E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.33|P-value:7.74E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.65|P-value:1.37E-10 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.92|P-value:9.37E-9 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.43|P-value:1.30E-7 ID:SGTC_1635|Compound:st007035|FD-Score:6.98|P-value:1.76E-11 ID:SGTC_1658|Compound:st012944|FD-Score:-3.34|P-value:7.98E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.81|P-value:1.58E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.59|P-value:1.99E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.93|P-value:1.52E-6 ID:SGTC_1800|Compound:st050079|FD-Score:-4.28|P-value:2.51E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.72|P-value:3.96E-6 ID:SGTC_2010|Compound:4012422|FD-Score:4.04|P-value:6.23E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-4.34|P-value:2.04E-5 ID:SGTC_2149|Compound:5554786|FD-Score:-3.45|P-value:5.46E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-4.18|P-value:3.84E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.16|P-value:5.51E-12 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.95|P-value:8.72E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-3.54|P-value:4.08E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.36|P-value:7.03E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:6.27|P-value:1.31E-9 ID:SGTC_2526|Compound:patulin|FD-Score:4.01|P-value:6.89E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.69|P-value:2.44E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.28|P-value:2.59E-5 ID:SGTC_2819|Compound:7996655|FD-Score:5.58|P-value:6.02E-8 ID:SGTC_2840|Compound:9008771|FD-Score:3.38|P-value:6.58E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.34|P-value:7.41E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.60|P-value:2.04E-10 ID:SGTC_2908|Compound:7930301|FD-Score:3.41|P-value:6.06E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.29|P-value:8.87E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.99|P-value:1.10E-6 ID:SGTC_3107|Compound:9121808|FD-Score:3.54|P-value:3.79E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.40|P-value:6.43E-4

Top fitness defect scores for YBR179C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 20.30 5.3 µM 1.24E-82 53 1.26E-91
2 SGTC_168 3970-0862 10.20 530.5 µM 2.50E-22 10 1.35E-24
3 SGTC_275 trichlorophene 8.57 5.7 µM 2.16E-16 mitochondrial stress 62 5.30E-18
4 SGTC_2250 alverine citrate 7.16 130.0 µM 5.51E-12 32 4.11E-13
5 SGTC_386 1509-0011 7.00 3.1 µM 1.58E-11 77 1.32E-12
6 SGTC_1635 st007035 6.98 42.4 µM 1.76E-11 116 1.49E-12
7 SGTC_778 3456-2434 6.82 196.0 µM 4.71E-11 mitochondrial response to ROS 18 4.45E-12
8 SGTC_852 0418-0143 6.81 439.0 µM 5.24E-11 calcium & mitochondrial duress 17 5.00E-12
9 SGTC_1188 1403-0014 6.65 4.6 µM 1.37E-10 mitochondrial stress 13 1.45E-11
10 SGTC_1742 st038235 6.59 28.9 µM 1.99E-10 mitochondrial stress 32 2.20E-11
11 SGTC_310 1273-0058 6.30 1.1 µM 1.13E-9 mitochondrial stress 136 1.51E-10
12 SGTC_2513 baicalein 6.27 25.6 µM 1.31E-9 calcium & mitochondrial duress 8 1.78E-10
13 SGTC_134 0269-0018 6.24 6.9 µM 1.62E-9 78 2.25E-10
14 SGTC_538 2922-0838 6.10 53.3 µM 3.49E-9 Golgi 6 5.26E-10
15 SGTC_1260 0700-1617 5.92 7.8 µM 9.37E-9 calcium & mitochondrial duress 10 1.57E-9
16 SGTC_365 0121-0052 5.70 13.6 µM 3.19E-8 mitochondrial response to ROS 17 6.11E-9
17 SGTC_2819 7996655 5.58 46.4 µM 6.02E-8 5 1.23E-8
18 SGTC_1371 2421-0008 5.43 32.7 µM 1.30E-7 mitochondrial processes 9 2.89E-8
19 SGTC_908 3448-7491 5.42 47.7 µM 1.36E-7 mitochondrial stress 64 3.05E-8
20 SGTC_36 0335-0881 5.41 14.2 µM 1.39E-7 ubiquinone biosynthesis & proteasome 77 3.12E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.592 1.33E-316 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.590 3.36E-313 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.581 1.85E-301 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.557 2.40E-272 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.556 1.02E-271 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.553 5.46E-268 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.551 3.02E-265 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.543 1.20E-256 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.543 1.49E-255 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.513 1.40E-224 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.511 5.91E-223 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.507 7.36E-218 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.502 2.12E-213 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.490 4.19E-202 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.489 9.85E-201 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit