YBR180W / DTR1

Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR180W / DTR1

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:-3.54|P-value:1.48E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:5.11|P-value:8.94E-8 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.49|P-value:2.31E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.50|P-value:1.78E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.77|P-value:5.93E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.06|P-value:8.93E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.72|P-value:7.39E-5 ID:SGTC_917|Compound:harmaline|FD-Score:4.85|P-value:3.73E-7 ID:SGTC_919|Compound:tnp00227|FD-Score:3.74|P-value:6.77E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:3.55|P-value:1.44E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.09|P-value:1.52E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.61|P-value:1.26E-6 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.69|P-value:8.67E-7 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.35|P-value:3.20E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.11|P-value:7.41E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.29|P-value:3.87E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.82|P-value:4.90E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.12|P-value:7.33E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.05|P-value:9.17E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.71|P-value:7.53E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:4.07|P-value:1.67E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.56|P-value:1.41E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.31|P-value:3.67E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.57|P-value:1.59E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.09|P-value:7.99E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.17|P-value:6.05E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.03|P-value:9.98E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.36|P-value:3.03E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.89|P-value:3.54E-5 ID:SGTC_1911|Compound:st060208|FD-Score:4.30|P-value:5.79E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.15|P-value:6.48E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.22|P-value:5.13E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.17|P-value:6.18E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.34|P-value:3.30E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.44|P-value:2.23E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.06|P-value:8.97E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.14|P-value:6.74E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.07|P-value:1.62E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.72|P-value:7.32E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.73|P-value:6.78E-7 ID:SGTC_2802|Compound:7925815|FD-Score:-3.81|P-value:4.93E-5 ID:SGTC_3274|Compound:9138298|FD-Score:3.53|P-value:1.60E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.54|P-value:1.48E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:5.11|P-value:8.94E-8 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.49|P-value:2.31E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.50|P-value:1.78E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.77|P-value:5.93E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.06|P-value:8.93E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.72|P-value:7.39E-5 ID:SGTC_917|Compound:harmaline|FD-Score:4.85|P-value:3.73E-7 ID:SGTC_919|Compound:tnp00227|FD-Score:3.74|P-value:6.77E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:3.55|P-value:1.44E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.09|P-value:1.52E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.61|P-value:1.26E-6 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.69|P-value:8.67E-7 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.35|P-value:3.20E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.11|P-value:7.41E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.29|P-value:3.87E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.82|P-value:4.90E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.12|P-value:7.33E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.05|P-value:9.17E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.71|P-value:7.53E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:4.07|P-value:1.67E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.56|P-value:1.41E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.31|P-value:3.67E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.57|P-value:1.59E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.09|P-value:7.99E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.17|P-value:6.05E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.03|P-value:9.98E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.36|P-value:3.03E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.89|P-value:3.54E-5 ID:SGTC_1911|Compound:st060208|FD-Score:4.30|P-value:5.79E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.15|P-value:6.48E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.22|P-value:5.13E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.17|P-value:6.18E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.34|P-value:3.30E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.44|P-value:2.23E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.06|P-value:8.97E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.14|P-value:6.74E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.07|P-value:1.62E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.72|P-value:7.32E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.73|P-value:6.78E-7 ID:SGTC_2802|Compound:7925815|FD-Score:-3.81|P-value:4.93E-5 ID:SGTC_3274|Compound:9138298|FD-Score:3.53|P-value:1.60E-4

Top fitness defect scores for YBR180W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_366 0181-0206 5.11 4.3 µM 8.94E-8 Golgi 14 1.57E-7
2 SGTC_917 harmaline 4.85 728.1 nM 3.73E-7 ergosterol biosynthesis 11 6.19E-7
3 SGTC_2750 bromebric acid 4.73 70.2 µM 6.78E-7 14 1.10E-6
4 SGTC_1014 4130-3005 4.69 69.3 µM 8.67E-7 8 1.39E-6
5 SGTC_1011 4112-3381 4.61 17.4 µM 1.26E-6 22 2.00E-6
6 SGTC_1632 st005650 4.57 90.0 µM 1.59E-6 15 2.49E-6
7 SGTC_503 tyrphostin 8 4.49 294.0 µM 2.31E-6 TSC3-RPN4 14 3.58E-6
8 SGTC_1911 st060208 4.30 74.3 µM 5.79E-6 26 8.65E-6
9 SGTC_1008 4106-0037 4.09 6.0 µM 1.52E-5 PDR1 19 2.18E-5
10 SGTC_2397 5161689 4.07 200.0 µM 1.62E-5 30 2.33E-5
11 SGTC_1443 4112-3303 4.07 14.0 µM 1.67E-5 6 2.39E-5
12 SGTC_1907 st060210 3.89 83.7 µM 3.54E-5 25 4.93E-5
13 SGTC_1277 0873-0036 3.82 22.0 µM 4.90E-5 PDR1 29 6.75E-5
14 SGTC_662 k832-1615 3.77 104.0 µM 5.93E-5 20 8.10E-5
15 SGTC_919 tnp00227 3.74 403.6 nM 6.77E-5 RNA pol III & RNase P/MRP 43 9.20E-5
16 SGTC_1453 4237-0541 3.56 195.0 µM 1.41E-4 heme biosynthesis & mitochondrial translocase 37 1.86E-4
17 SGTC_999 4022-0066 3.55 22.7 µM 1.44E-4 Golgi 61 1.91E-4
18 SGTC_3274 9138298 3.53 49.5 µM 1.60E-4 31 2.11E-4
19 SGTC_506 n9-isopropylolomoucine 3.50 153.0 µM 1.78E-4 22 2.34E-4
20 SGTC_2251 lansoprazole 3.44 556.0 µM 2.23E-4 32 2.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 9.02E-11 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.108 3.41E-10 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.105 9.87E-10 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.104 1.73E-9 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.103 2.46E-9 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.099 1.00E-8 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.098 1.35E-8 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.098 1.49E-8 YLL060C GTT2 hom Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress
0.093 7.57E-8 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.091 1.20E-7 YDR099W BMH2 hom 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.089 2.53E-7 YPR045C THP3 hom Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
0.088 3.29E-7 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.086 5.69E-7 YKL064W MNR2 hom Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
0.086 6.99E-7 YDL031W DBP10 het Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
0.085 8.06E-7 YDL015C TSC13 het Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress