YBR182C-A_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR182C-A / YBR182C-A

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.92|P-value:7.52E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.90|P-value:8.15E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:-4.38|P-value:1.00E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.74|P-value:2.24E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:4.25|P-value:1.95E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:3.77|P-value:1.33E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:6.14|P-value:1.33E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:6.03|P-value:2.58E-9 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.23|P-value:8.21E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.30|P-value:7.12E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.21|P-value:9.45E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.67|P-value:1.91E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-4.02|P-value:4.51E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:3.75|P-value:1.43E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.72|P-value:1.56E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.50|P-value:3.49E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.71|P-value:1.64E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.27|P-value:7.80E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.21|P-value:2.26E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.44|P-value:4.45E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.49|P-value:3.67E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.49|P-value:3.32E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.12|P-value:3.63E-7 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.63|P-value:2.23E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.44|P-value:4.34E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.21|P-value:9.66E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.60|P-value:2.51E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.91|P-value:7.59E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.45|P-value:3.88E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.73|P-value:1.53E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.71|P-value:1.64E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.89|P-value:8.26E-5 ID:SGTC_1859|Compound:st055998|FD-Score:4.01|P-value:5.23E-5 ID:SGTC_1867|Compound:st057372|FD-Score:3.36|P-value:5.83E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.83|P-value:1.07E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.75|P-value:2.15E-6 ID:SGTC_1981|Compound:st071826|FD-Score:4.22|P-value:2.18E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-4.53|P-value:5.28E-6 ID:SGTC_2191|Compound:5911152|FD-Score:4.07|P-value:4.06E-5 ID:SGTC_2248|Compound:tofa|FD-Score:-3.45|P-value:3.85E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.79|P-value:1.20E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.00|P-value:5.45E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.27|P-value:1.78E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.19|P-value:9.36E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.31|P-value:6.91E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.64|P-value:2.10E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.57|P-value:2.72E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.31|P-value:6.24E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.92|P-value:7.52E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.90|P-value:8.15E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:-4.38|P-value:1.00E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.74|P-value:2.24E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:4.25|P-value:1.95E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:3.77|P-value:1.33E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:6.14|P-value:1.33E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:6.03|P-value:2.58E-9 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.23|P-value:8.21E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.30|P-value:7.12E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.21|P-value:9.45E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.67|P-value:1.91E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-4.02|P-value:4.51E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:3.75|P-value:1.43E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.72|P-value:1.56E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.50|P-value:3.49E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.71|P-value:1.64E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.27|P-value:7.80E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.21|P-value:2.26E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.44|P-value:4.45E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.49|P-value:3.67E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.49|P-value:3.32E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.12|P-value:3.63E-7 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.63|P-value:2.23E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.44|P-value:4.34E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.21|P-value:9.66E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.60|P-value:2.51E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.91|P-value:7.59E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.45|P-value:3.88E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.73|P-value:1.53E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.71|P-value:1.64E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.89|P-value:8.26E-5 ID:SGTC_1859|Compound:st055998|FD-Score:4.01|P-value:5.23E-5 ID:SGTC_1867|Compound:st057372|FD-Score:3.36|P-value:5.83E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.83|P-value:1.07E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.75|P-value:2.15E-6 ID:SGTC_1981|Compound:st071826|FD-Score:4.22|P-value:2.18E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-4.53|P-value:5.28E-6 ID:SGTC_2191|Compound:5911152|FD-Score:4.07|P-value:4.06E-5 ID:SGTC_2248|Compound:tofa|FD-Score:-3.45|P-value:3.85E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.79|P-value:1.20E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.00|P-value:5.45E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.27|P-value:1.78E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.19|P-value:9.36E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.31|P-value:6.91E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.64|P-value:2.10E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.57|P-value:2.72E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.31|P-value:6.24E-4

Top fitness defect scores for YBR182C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_145 3737-0113 6.14 38.4 µM 1.33E-9 DNA intercalators 27 4.07E-10
2 SGTC_184 1494-0393 6.03 24.7 µM 2.58E-9 18 8.23E-10
3 SGTC_1357 1503-1303 5.12 39.5 µM 3.63E-7 10 1.57E-7
4 SGTC_1926 methyl fluorone black 4.75 53.6 µM 2.15E-6 DNA intercalators 39 1.03E-6
5 SGTC_58 0957-0393 4.74 9.0 µM 2.24E-6 cell wall 314 1.08E-6
6 SGTC_2314 7727897 4.27 200.0 µM 1.78E-5 13 9.73E-6
7 SGTC_143 4032-1194 4.25 15.7 µM 1.95E-5 53 1.08E-5
8 SGTC_1981 st071826 4.22 47.0 µM 2.18E-5 11 1.21E-5
9 SGTC_1033 k072-0102 4.21 21.3 µM 2.26E-5 60S ribosome export 15 1.26E-5
10 SGTC_2191 5911152 4.07 200.0 µM 4.06E-5 11 2.33E-5
11 SGTC_1859 st055998 4.01 20.0 µM 5.23E-5 22 3.06E-5
12 SGTC_2305 7443522 4.00 69.2 µM 5.45E-5 14 3.19E-5
13 SGTC_9 0092-0002 3.92 10.4 µM 7.52E-5 27 4.50E-5
14 SGTC_1493 4348-0038 3.91 111.0 µM 7.59E-5 RSC complex & mRNA processing 28 4.54E-5
15 SGTC_35 0133-0054 3.90 64.1 µM 8.15E-5 36 4.89E-5
16 SGTC_1857 st056007 3.89 79.3 µM 8.26E-5 7 4.97E-5
17 SGTC_1889 st059080 3.83 5.2 µM 1.07E-4 21 6.51E-5
18 SGTC_2270 7924575 3.79 90.9 µM 1.20E-4 RPP1 & pyrimidine depletion 17 7.39E-5
19 SGTC_144 4161-2749 3.77 112.4 µM 1.33E-4 DNA intercalators 27 8.23E-5
20 SGTC_663 1486-0733 3.75 13.9 µM 1.43E-4 cell wall signaling 57 8.86E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.216 9.11E-37 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.201 6.72E-32 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.184 7.25E-27 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.183 1.61E-26 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.176 1.08E-24 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.175 1.42E-24 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.175 1.80E-24 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.170 4.29E-23 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.166 3.17E-22 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.164 1.06E-21 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.158 4.10E-20 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.157 6.78E-20 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.155 1.97E-19 YBL008W-A_p YBL008W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.151 1.25E-18 YNL151C RPC31 het RNA polymerase III subunit C31
0.149 4.87E-18 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm