YBR183W / YPC1

Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR183W / YPC1

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.21|P-value:9.43E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.56|P-value:2.69E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.40|P-value:4.76E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.70|P-value:1.69E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.60|P-value:2.49E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:5.21|P-value:2.25E-7 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.59|P-value:2.41E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-6.21|P-value:7.89E-10 ID:SGTC_470|Compound:aa-861|FD-Score:4.35|P-value:1.29E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:-3.23|P-value:8.22E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.40|P-value:5.11E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.46|P-value:3.81E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.74|P-value:1.36E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:4.37|P-value:1.16E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:3.65|P-value:2.04E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.42|P-value:4.78E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.53|P-value:5.76E-6 ID:SGTC_1784|Compound:st039334|FD-Score:3.63|P-value:2.24E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.97|P-value:6.10E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.83|P-value:1.46E-6 ID:SGTC_1925|Compound:st057770|FD-Score:4.71|P-value:2.62E-6 ID:SGTC_1941|Compound:st076221|FD-Score:4.12|P-value:3.33E-5 ID:SGTC_2100|Compound:5377183|FD-Score:5.80|P-value:9.60E-9 ID:SGTC_2315|Compound:7733312|FD-Score:-3.87|P-value:8.32E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.43|P-value:8.92E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.24|P-value:8.78E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.51|P-value:3.20E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.24|P-value:8.11E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.49|P-value:3.41E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.62|P-value:3.94E-6 ID:SGTC_2954|Compound:9074818|FD-Score:3.39|P-value:5.22E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.34|P-value:5.76E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.32|P-value:6.24E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.20|P-value:9.18E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.21|P-value:9.43E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.56|P-value:2.69E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.40|P-value:4.76E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.70|P-value:1.69E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.60|P-value:2.49E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:5.21|P-value:2.25E-7 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.59|P-value:2.41E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-6.21|P-value:7.89E-10 ID:SGTC_470|Compound:aa-861|FD-Score:4.35|P-value:1.29E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:-3.23|P-value:8.22E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.40|P-value:5.11E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.46|P-value:3.81E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.74|P-value:1.36E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:4.37|P-value:1.16E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:3.65|P-value:2.04E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.42|P-value:4.78E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.53|P-value:5.76E-6 ID:SGTC_1784|Compound:st039334|FD-Score:3.63|P-value:2.24E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.97|P-value:6.10E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.83|P-value:1.46E-6 ID:SGTC_1925|Compound:st057770|FD-Score:4.71|P-value:2.62E-6 ID:SGTC_1941|Compound:st076221|FD-Score:4.12|P-value:3.33E-5 ID:SGTC_2100|Compound:5377183|FD-Score:5.80|P-value:9.60E-9 ID:SGTC_2315|Compound:7733312|FD-Score:-3.87|P-value:8.32E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.43|P-value:8.92E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.24|P-value:8.78E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.51|P-value:3.20E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.24|P-value:8.11E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.49|P-value:3.41E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.62|P-value:3.94E-6 ID:SGTC_2954|Compound:9074818|FD-Score:3.39|P-value:5.22E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.34|P-value:5.76E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.32|P-value:6.24E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.20|P-value:9.18E-4

Top fitness defect scores for YBR183W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2100 5377183 5.80 190.0 µM 9.60E-9 60S ribosome export 2 3.26E-9
2 SGTC_317 4495-0002 5.21 170.0 µM 2.25E-7 4 9.31E-8
3 SGTC_1922 5578187 4.83 25.0 µM 1.46E-6 TRP & mitochondrial translation 11 6.81E-7
4 SGTC_1925 st057770 4.71 10.1 µM 2.62E-6 TSC3-RPN4 11 1.26E-6
5 SGTC_2798 7813637 4.62 45.5 µM 3.94E-6 19 1.95E-6
6 SGTC_1300 1094-0077 4.53 113.0 µM 5.76E-6 7 2.92E-6
7 SGTC_2497 7-hydroxyflavone 4.43 100.0 µM 8.92E-6 13 4.65E-6
8 SGTC_642 0335-0876 4.37 158.0 µM 1.16E-5 ubiquinone biosynthesis & proteasome 31 6.14E-6
9 SGTC_470 aa-861 4.35 153.0 µM 1.29E-5 sphingolipid biosynthesis & PDR1 41 6.88E-6
10 SGTC_1941 st076221 4.12 61.8 µM 3.33E-5 sphingolipid biosynthesis & PDR1 70 1.88E-5
11 SGTC_1916 st067606 3.97 49.2 µM 6.10E-5 38 3.58E-5
12 SGTC_213 1246-0773 3.70 967.0 nM 1.69E-4 29 1.06E-4
13 SGTC_689 0833-0039 3.65 98.0 µM 2.04E-4 ergosterol depletion effects on membrane 39 1.29E-4
14 SGTC_1784 st039334 3.63 36.3 µM 2.24E-4 27 1.42E-4
15 SGTC_302 1094-0063 3.60 18.9 µM 2.49E-4 18 1.59E-4
16 SGTC_1017 4239-0030 3.42 168.0 µM 4.78E-4 46 3.19E-4
17 SGTC_556 4058-0063 3.40 51.5 µM 5.11E-4 42 3.42E-4
18 SGTC_2954 9074818 3.39 52.7 µM 5.22E-4 54 3.50E-4
19 SGTC_2552 juarezic acid 3.24 87.0 µM 8.78E-4 TSC3-RPN4 68 6.07E-4
20 SGTC_12 0849-0099 3.21 9.3 µM 9.43E-4 38 6.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.80E-13 YOR353C SOG2 het Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
0.094 5.48E-8 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.088 2.88E-7 YJR009C TDH2 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication
0.088 3.29E-7 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.082 1.78E-6 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.081 2.45E-6 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.078 5.34E-6 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.077 7.93E-6 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.077 8.96E-6 YLR126C YLR126C hom Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.072 2.70E-5 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.071 3.61E-5 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.070 4.75E-5 YNL138W SRV2 hom CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
0.067 1.04E-4 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.066 1.30E-4 YBR176W ECM31 hom Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
0.066 1.40E-4 YPR073C LTP1 hom Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine