YBR184W_p

Putative protein of unknown function; YBR184W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR184W / YBR184W

Click on Significant Values for Screen Details ID:SGTC_213|Compound:1246-0773|FD-Score:4.80|P-value:7.42E-7 ID:SGTC_277|Compound:nystatin|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.51|P-value:2.17E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.30|P-value:4.70E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.47|P-value:2.53E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.24|P-value:6.49E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.48|P-value:2.67E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.35|P-value:3.84E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.83|P-value:6.86E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.64|P-value:1.49E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.77|P-value:8.93E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.66|P-value:1.39E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.29|P-value:5.33E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.99|P-value:3.10E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.25|P-value:1.03E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.10|P-value:9.34E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.36|P-value:4.24E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.75|P-value:8.49E-5 ID:SGTC_2135|Compound:5326629|FD-Score:-3.12|P-value:9.65E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.23|P-value:5.98E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.18|P-value:7.10E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.28|P-value:5.69E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.95|P-value:4.22E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-3.82|P-value:7.35E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.23|P-value:1.13E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.34|P-value:3.97E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.40|P-value:3.26E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.22|P-value:6.79E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.54|P-value:1.93E-4 ID:SGTC_2933|Compound:9026794|FD-Score:4.41|P-value:4.94E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-4.22|P-value:1.37E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.71|P-value:9.85E-5 ID:SGTC_2959|Compound:9079155|FD-Score:4.18|P-value:1.37E-5 ID:SGTC_2965|Compound:9082772|FD-Score:3.21|P-value:6.36E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.67|P-value:1.16E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.36|P-value:3.70E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.55|P-value:2.11E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.86|P-value:5.37E-5 ID:SGTC_3253|Compound:9135987|FD-Score:3.22|P-value:6.11E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:4.80|P-value:7.42E-7 ID:SGTC_277|Compound:nystatin|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.51|P-value:2.17E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.30|P-value:4.70E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.47|P-value:2.53E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.24|P-value:6.49E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.48|P-value:2.67E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.35|P-value:3.84E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.83|P-value:6.86E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.64|P-value:1.49E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.77|P-value:8.93E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.66|P-value:1.39E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.29|P-value:5.33E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.99|P-value:3.10E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.25|P-value:1.03E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.10|P-value:9.34E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.36|P-value:4.24E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.75|P-value:8.49E-5 ID:SGTC_2135|Compound:5326629|FD-Score:-3.12|P-value:9.65E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.23|P-value:5.98E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.18|P-value:7.10E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.28|P-value:5.69E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.95|P-value:4.22E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-3.82|P-value:7.35E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.23|P-value:1.13E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.34|P-value:3.97E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.40|P-value:3.26E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.22|P-value:6.79E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.54|P-value:1.93E-4 ID:SGTC_2933|Compound:9026794|FD-Score:4.41|P-value:4.94E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-4.22|P-value:1.37E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.71|P-value:9.85E-5 ID:SGTC_2959|Compound:9079155|FD-Score:4.18|P-value:1.37E-5 ID:SGTC_2965|Compound:9082772|FD-Score:3.21|P-value:6.36E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.67|P-value:1.16E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.36|P-value:3.70E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.55|P-value:2.11E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.86|P-value:5.37E-5 ID:SGTC_3253|Compound:9135987|FD-Score:3.22|P-value:6.11E-4

Top fitness defect scores for YBR184W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_213 1246-0773 4.80 967.0 nM 7.42E-7 9 7.80E-7
2 SGTC_2933 9026794 4.41 32.5 µM 4.94E-6 9 5.19E-6
3 SGTC_1552 6-methylflavone 4.25 10.6 µM 1.03E-5 superoxide 11 1.08E-5
4 SGTC_2809 7964133 4.23 13.0 µM 1.13E-5 60S ribosome export 28 1.19E-5
5 SGTC_2959 9079155 4.18 11.0 µM 1.37E-5 22 1.44E-5
6 SGTC_1523 st012844 3.99 44.7 µM 3.10E-5 60S ribosome export 20 3.25E-5
7 SGTC_3228 9131799 3.86 49.5 µM 5.37E-5 amide catabolism 5 5.63E-5
8 SGTC_2050 5263056 3.75 171.0 µM 8.49E-5 fatty acid desaturase (OLE1) 50 8.89E-5
9 SGTC_2955 9076254 3.71 12.2 µM 9.85E-5 20 1.03E-4
10 SGTC_3098 9119039 3.67 49.5 µM 1.16E-4 Golgi 46 1.22E-4
11 SGTC_277 nystatin 3.58 15.5 µM 1.62E-4 21 1.69E-4
12 SGTC_2928 9011484 3.54 9.8 µM 1.93E-4 heme biosynthesis & mitochondrial translocase 50 2.02E-4
13 SGTC_552 k242-0005 3.51 476.0 µM 2.17E-4 32 2.27E-4
14 SGTC_772 k072-0172 3.47 35.3 µM 2.53E-4 33 2.65E-4
15 SGTC_2835 9006588 3.40 71.4 µM 3.26E-4 70 3.40E-4
16 SGTC_3103 9120822 3.36 49.5 µM 3.70E-4 34 3.86E-4
17 SGTC_898 1000-0849 3.35 28.3 µM 3.84E-4 15 4.01E-4
18 SGTC_2811 7967822 3.34 32.5 µM 3.97E-4 34 4.14E-4
19 SGTC_739 1486-1183 3.30 203.0 µM 4.70E-4 37 4.91E-4
20 SGTC_2225 6654152 3.23 15.4 µM 5.98E-4 27 6.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 7.29E-9 YGL067W NPY1 hom NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member
0.098 1.45E-8 YGL010W_p YGL010W_p hom Putative protein of unknown function; YGL010W is not an essential gene
0.090 1.74E-7 YJL210W PEX2 hom RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
0.085 9.48E-7 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.077 8.89E-6 YLR002C NOC3 het Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing
0.076 1.02E-5 YDR026C NSI1 hom RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
0.075 1.23E-5 YER045C ACA1 hom ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication
0.073 2.18E-5 YBL018C POP8 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.072 2.96E-5 YGR029W ERV1 het Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
0.070 5.26E-5 YDL146W LDB17 hom Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
0.067 1.00E-4 YBR187W_p GDT1_p hom Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis
0.067 1.00E-4 YDR321W ASP1 hom Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively
0.066 1.20E-4 YOR370C MRS6 het Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress
0.066 1.21E-4 YER109C FLO8 hom Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
0.066 1.28E-4 YGR284C ERV29 hom Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress