YBR185C / MBA1

Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR185C / MBA1

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:3.79|P-value:3.96E-5 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.08|P-value:6.97E-4 ID:SGTC_229|Compound:benomyl|FD-Score:6.16|P-value:5.91E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:5.82|P-value:5.98E-10 ID:SGTC_277|Compound:nystatin|FD-Score:3.01|P-value:8.83E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.33|P-value:2.20E-6 ID:SGTC_349|Compound:k015-0014|FD-Score:4.33|P-value:3.16E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:3.14|P-value:5.53E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.69|P-value:1.42E-9 ID:SGTC_518|Compound:1021-0119|FD-Score:3.09|P-value:6.64E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:2.98|P-value:9.86E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.22|P-value:4.14E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.93|P-value:2.14E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.50|P-value:1.38E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.41|P-value:1.98E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.21|P-value:4.31E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.53|P-value:1.21E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.21|P-value:4.23E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.41|P-value:1.99E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.62|P-value:8.40E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.53|P-value:1.20E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.20|P-value:4.49E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-6.33|P-value:1.04E-11 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.94|P-value:1.29E-7 ID:SGTC_1994|Compound:st072947|FD-Score:3.17|P-value:4.89E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.49|P-value:1.41E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.62|P-value:5.89E-5 ID:SGTC_2157|Compound:5649910|FD-Score:-3.08|P-value:5.17E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.12|P-value:6.08E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.92|P-value:2.25E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.27|P-value:2.48E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.68|P-value:6.42E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.19|P-value:4.67E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.08|P-value:6.84E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.27|P-value:2.50E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.82|P-value:2.49E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.10|P-value:6.73E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-2.92|P-value:9.29E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.22|P-value:5.54E-6 ID:SGTC_2785|Compound:7756463|FD-Score:-3.13|P-value:4.35E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.08|P-value:5.08E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.33|P-value:2.69E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.23|P-value:3.95E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-2.99|P-value:7.15E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.79|P-value:3.96E-5 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.08|P-value:6.97E-4 ID:SGTC_229|Compound:benomyl|FD-Score:6.16|P-value:5.91E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:5.82|P-value:5.98E-10 ID:SGTC_277|Compound:nystatin|FD-Score:3.01|P-value:8.83E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.33|P-value:2.20E-6 ID:SGTC_349|Compound:k015-0014|FD-Score:4.33|P-value:3.16E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:3.14|P-value:5.53E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.69|P-value:1.42E-9 ID:SGTC_518|Compound:1021-0119|FD-Score:3.09|P-value:6.64E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:2.98|P-value:9.86E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.22|P-value:4.14E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.93|P-value:2.14E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.50|P-value:1.38E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.41|P-value:1.98E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.21|P-value:4.31E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.53|P-value:1.21E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.21|P-value:4.23E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.41|P-value:1.99E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.62|P-value:8.40E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.53|P-value:1.20E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.20|P-value:4.49E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-6.33|P-value:1.04E-11 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.94|P-value:1.29E-7 ID:SGTC_1994|Compound:st072947|FD-Score:3.17|P-value:4.89E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.49|P-value:1.41E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.62|P-value:5.89E-5 ID:SGTC_2157|Compound:5649910|FD-Score:-3.08|P-value:5.17E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.12|P-value:6.08E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.92|P-value:2.25E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.27|P-value:2.48E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.68|P-value:6.42E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.19|P-value:4.67E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.08|P-value:6.84E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.27|P-value:2.50E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.82|P-value:2.49E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.10|P-value:6.73E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-2.92|P-value:9.29E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.22|P-value:5.54E-6 ID:SGTC_2785|Compound:7756463|FD-Score:-3.13|P-value:4.35E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.08|P-value:5.08E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.33|P-value:2.69E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.23|P-value:3.95E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-2.99|P-value:7.15E-4

Top fitness defect scores for YBR185C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_229 benomyl 6.16 22.9 µM 5.91E-11 tubulin folding & SWR complex 16 3.53E-10
2 SGTC_236 1509-0011 5.82 5.3 µM 5.98E-10 297 2.92E-9
3 SGTC_436 n,n-dimethylsphingosine 5.69 3.3 µM 1.42E-9 5 6.42E-9
4 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.94 70.1 µM 1.29E-7 7 3.93E-7
5 SGTC_349 k015-0014 4.33 24.0 µM 3.16E-6 12 7.35E-6
6 SGTC_2780 5215298 4.22 71.4 µM 5.54E-6 30 1.23E-5
7 SGTC_1041 0206-0046 3.93 107.0 µM 2.14E-5 36 4.24E-5
8 SGTC_2335 9018011 3.92 154.2 µM 2.25E-5 27 4.44E-5
9 SGTC_66 0109-0187 3.79 42.4 µM 3.96E-5 44 7.46E-5
10 SGTC_2415 st077333 3.68 57.7 µM 6.42E-5 62 1.16E-4
11 SGTC_1688 st021091 3.62 57.6 µM 8.40E-5 11 1.49E-4
12 SGTC_1702 st027038 3.53 51.0 µM 1.20E-4 24 2.07E-4
13 SGTC_1357 1503-1303 3.53 39.5 µM 1.21E-4 47 2.09E-4
14 SGTC_1056 3448-1962 3.50 115.0 µM 1.38E-4 amide catabolism 30 2.35E-4
15 SGTC_1999 st074831 3.49 12.5 µM 1.41E-4 plasma membrane duress 48 2.40E-4
16 SGTC_1145 3546-0597 3.41 10.2 µM 1.98E-4 mitochondrial processes 34 3.27E-4
17 SGTC_1635 st007035 3.41 42.4 µM 1.99E-4 255 3.28E-4
18 SGTC_2927 9011802 3.33 47.9 µM 2.69E-4 45 4.33E-4
19 SGTC_3217 9129673 3.23 49.5 µM 3.95E-4 74 6.17E-4
20 SGTC_775 4577-0580 3.22 57.3 µM 4.14E-4 26 6.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 3.85E-45 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.239 9.54E-45 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.229 3.01E-41 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.225 7.78E-40 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.224 2.78E-39 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.223 4.48E-39 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.217 4.66E-37 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.217 6.29E-37 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.214 4.62E-36 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.211 4.56E-35 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.210 7.82E-35 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.209 2.15E-34 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.208 3.52E-34 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.203 1.43E-32 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.201 8.90E-32 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs