YBR187W_p / GDT1

Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR187W / GDT1

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:4.23|P-value:1.89E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.42|P-value:4.29E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.34|P-value:5.73E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.56|P-value:2.85E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:-3.96|P-value:6.29E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:4.61|P-value:3.71E-6 ID:SGTC_277|Compound:nystatin|FD-Score:5.98|P-value:2.98E-9 ID:SGTC_318|Compound:1488-0629|FD-Score:7.76|P-value:2.28E-14 ID:SGTC_335|Compound:4077-0256|FD-Score:3.24|P-value:7.97E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-5.73|P-value:1.40E-8 ID:SGTC_349|Compound:k015-0014|FD-Score:4.20|P-value:2.19E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.31|P-value:6.88E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.76|P-value:1.26E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.46|P-value:7.19E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:7.70|P-value:3.58E-14 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.28|P-value:7.53E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:8.08|P-value:1.99E-15 ID:SGTC_589|Compound:1227-0070|FD-Score:4.30|P-value:1.41E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.33|P-value:5.84E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.44|P-value:4.06E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:5.55|P-value:3.43E-8 ID:SGTC_615|Compound:k087-0205|FD-Score:7.45|P-value:2.20E-13 ID:SGTC_619|Compound:1652-1634|FD-Score:3.55|P-value:2.69E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.74|P-value:1.34E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:7.03|P-value:4.01E-12 ID:SGTC_660|Compound:4031-1742|FD-Score:3.45|P-value:3.85E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.58|P-value:2.48E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.14|P-value:2.80E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.75|P-value:1.87E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:3.55|P-value:2.77E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.55|P-value:2.71E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.29|P-value:7.21E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.45|P-value:3.89E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.11|P-value:3.20E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.33|P-value:6.00E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.82|P-value:1.00E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.31|P-value:6.43E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.80|P-value:1.47E-6 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.20|P-value:9.18E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.92|P-value:6.83E-5 ID:SGTC_1640|Compound:st009078|FD-Score:3.24|P-value:8.07E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.72|P-value:1.48E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-4.39|P-value:1.07E-5 ID:SGTC_1772|Compound:st048439|FD-Score:3.46|P-value:3.75E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-4.22|P-value:2.16E-5 ID:SGTC_1814|Compound:st052110|FD-Score:4.90|P-value:9.52E-7 ID:SGTC_1836|Compound:st055642|FD-Score:3.17|P-value:9.97E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.42|P-value:4.39E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.28|P-value:7.59E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-3.21|P-value:9.33E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.18|P-value:9.68E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.20|P-value:9.06E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.58|P-value:2.42E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.86|P-value:8.49E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.69|P-value:1.66E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.99|P-value:5.09E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.60|P-value:2.25E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.57|P-value:2.57E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.27|P-value:7.19E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.79|P-value:1.11E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.47|P-value:6.83E-6 ID:SGTC_3136|Compound:9095672|FD-Score:4.02|P-value:4.55E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.65|P-value:1.92E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-4.70|P-value:2.62E-6 ID:SGTC_3340|Compound:9146634|FD-Score:3.21|P-value:8.80E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.23|P-value:1.89E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.42|P-value:4.29E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.34|P-value:5.73E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.56|P-value:2.85E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:-3.96|P-value:6.29E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:4.61|P-value:3.71E-6 ID:SGTC_277|Compound:nystatin|FD-Score:5.98|P-value:2.98E-9 ID:SGTC_318|Compound:1488-0629|FD-Score:7.76|P-value:2.28E-14 ID:SGTC_335|Compound:4077-0256|FD-Score:3.24|P-value:7.97E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-5.73|P-value:1.40E-8 ID:SGTC_349|Compound:k015-0014|FD-Score:4.20|P-value:2.19E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.31|P-value:6.88E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.76|P-value:1.26E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.46|P-value:7.19E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:7.70|P-value:3.58E-14 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.28|P-value:7.53E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:8.08|P-value:1.99E-15 ID:SGTC_589|Compound:1227-0070|FD-Score:4.30|P-value:1.41E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.33|P-value:5.84E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.44|P-value:4.06E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:5.55|P-value:3.43E-8 ID:SGTC_615|Compound:k087-0205|FD-Score:7.45|P-value:2.20E-13 ID:SGTC_619|Compound:1652-1634|FD-Score:3.55|P-value:2.69E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.74|P-value:1.34E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:7.03|P-value:4.01E-12 ID:SGTC_660|Compound:4031-1742|FD-Score:3.45|P-value:3.85E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.58|P-value:2.48E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.14|P-value:2.80E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.75|P-value:1.87E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:3.55|P-value:2.77E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.55|P-value:2.71E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.29|P-value:7.21E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.45|P-value:3.89E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.11|P-value:3.20E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.33|P-value:6.00E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.82|P-value:1.00E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.31|P-value:6.43E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.80|P-value:1.47E-6 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.20|P-value:9.18E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.92|P-value:6.83E-5 ID:SGTC_1640|Compound:st009078|FD-Score:3.24|P-value:8.07E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.72|P-value:1.48E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-4.39|P-value:1.07E-5 ID:SGTC_1772|Compound:st048439|FD-Score:3.46|P-value:3.75E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-4.22|P-value:2.16E-5 ID:SGTC_1814|Compound:st052110|FD-Score:4.90|P-value:9.52E-7 ID:SGTC_1836|Compound:st055642|FD-Score:3.17|P-value:9.97E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.42|P-value:4.39E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.28|P-value:7.59E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-3.21|P-value:9.33E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.18|P-value:9.68E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.20|P-value:9.06E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.58|P-value:2.42E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.86|P-value:8.49E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.69|P-value:1.66E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.99|P-value:5.09E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.60|P-value:2.25E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.57|P-value:2.57E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.27|P-value:7.19E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.79|P-value:1.11E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.47|P-value:6.83E-6 ID:SGTC_3136|Compound:9095672|FD-Score:4.02|P-value:4.55E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.65|P-value:1.92E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-4.70|P-value:2.62E-6 ID:SGTC_3340|Compound:9146634|FD-Score:3.21|P-value:8.80E-4

Top fitness defect scores for YBR187W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_568 1193-0097 8.08 7.5 µM 1.99E-15 ERAD & cell cycle 35 3.22E-16
2 SGTC_318 1488-0629 7.76 67.2 µM 2.28E-14 copper-dependent oxidative stress 7 4.24E-15
3 SGTC_457 grayanotoxin iii 7.70 135.0 µM 3.58E-14 11 6.85E-15
4 SGTC_615 k087-0205 7.45 167.0 µM 2.20E-13 2 4.69E-14
5 SGTC_637 1181-0519 7.03 7.3 µM 4.01E-12 fatty acid desaturase (OLE1) 40 1.01E-12
6 SGTC_277 nystatin 5.98 15.5 µM 2.98E-9 1 1.10E-9
7 SGTC_608 k048-0125 5.55 159.0 µM 3.43E-8 6 1.46E-8
8 SGTC_1814 st052110 4.90 31.5 µM 9.52E-7 RNA processing & uracil transport 7 4.89E-7
9 SGTC_1288 0973-0013 4.80 65.5 µM 1.47E-6 7 7.77E-7
10 SGTC_885 0865-0106 4.75 16.8 µM 1.87E-6 TSC3-RPN4 17 9.98E-7
11 SGTC_213 1246-0773 4.61 967.0 nM 3.71E-6 11 2.06E-6
12 SGTC_2831 7999036 4.47 19.5 µM 6.83E-6 31 3.92E-6
13 SGTC_439 amiodarone 4.46 34.4 µM 7.19E-6 NEO1-PIK1 76 4.14E-6
14 SGTC_589 1227-0070 4.30 34.1 µM 1.41E-5 23 8.46E-6
15 SGTC_100 0086-0128 4.23 49.6 µM 1.89E-5 copper-dependent oxidative stress 41 1.15E-5
16 SGTC_349 k015-0014 4.20 24.0 µM 2.19E-5 14 1.34E-5
17 SGTC_768 0384-0033 4.14 77.3 µM 2.80E-5 fatty acid desaturase (OLE1) 79 1.74E-5
18 SGTC_1071 trifluoperazine 4.11 6.3 µM 3.20E-5 22 2.00E-5
19 SGTC_3136 9095672 4.02 49.5 µM 4.55E-5 24 2.91E-5
20 SGTC_2398 5228213 3.99 48.8 µM 5.09E-5 iron homeostasis 37 3.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 5.77E-26 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.179 1.28E-25 YGR060W ERG25 het C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
0.170 5.04E-23 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.169 5.93E-23 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.159 1.82E-20 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.153 4.59E-19 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.147 1.37E-17 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.142 1.73E-16 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.142 1.79E-16 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.131 2.38E-14 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.125 3.72E-13 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.125 3.83E-13 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.122 1.54E-12 YOR104W PIN2 hom Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated
0.121 2.04E-12 YOR232W MGE1 het Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
0.121 2.06E-12 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3