YBR196C / PGI1

Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR196C / PGI1

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:4.83|P-value:1.32E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:4.13|P-value:2.79E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.64|P-value:3.12E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:5.37|P-value:9.00E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:3.31|P-value:5.73E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.32|P-value:5.66E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:4.41|P-value:8.62E-6 ID:SGTC_228|Compound:caffeine|FD-Score:3.85|P-value:8.43E-5 ID:SGTC_230|Compound:MPP+|FD-Score:4.86|P-value:1.11E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.57|P-value:4.42E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.66|P-value:1.98E-8 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.11|P-value:6.00E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.84|P-value:8.63E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.61|P-value:3.87E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.66|P-value:3.26E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.74|P-value:1.26E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.94|P-value:1.15E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:4.49|P-value:6.20E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:3.15|P-value:9.71E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.11|P-value:2.98E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.29|P-value:6.21E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.25|P-value:7.05E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.83|P-value:9.16E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.29|P-value:6.19E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.46|P-value:6.39E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.30|P-value:1.40E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.05|P-value:3.89E-5 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.28|P-value:6.46E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.28|P-value:6.52E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.00|P-value:4.75E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:5.96|P-value:3.67E-9 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.54|P-value:2.65E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.85|P-value:1.66E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.64|P-value:1.81E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-3.86|P-value:1.55E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.20|P-value:8.44E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.02|P-value:4.31E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:5.43|P-value:6.71E-8 ID:SGTC_1959|Compound:st077091|FD-Score:3.31|P-value:5.79E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.15|P-value:5.30E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.16|P-value:2.45E-5 ID:SGTC_2061|Compound:5245884|FD-Score:4.66|P-value:2.86E-6 ID:SGTC_2064|Compound:5220758|FD-Score:5.68|P-value:1.81E-8 ID:SGTC_2210|Compound:7115885|FD-Score:3.17|P-value:9.27E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.45|P-value:3.61E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.96|P-value:7.12E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:3.32|P-value:5.62E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.30|P-value:6.08E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:5.43|P-value:6.80E-8 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.56|P-value:4.41E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.17|P-value:9.19E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.01|P-value:6.01E-12 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.72|P-value:1.38E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.86|P-value:8.04E-5 ID:SGTC_2821|Compound:7996764|FD-Score:4.85|P-value:1.21E-6 ID:SGTC_2845|Compound:9003024|FD-Score:3.23|P-value:7.54E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.54|P-value:4.94E-6 ID:SGTC_3032|Compound:9089427|FD-Score:-3.51|P-value:5.49E-4 ID:SGTC_3033|Compound:9090887|FD-Score:5.28|P-value:1.42E-7 ID:SGTC_3075|Compound:9116269|FD-Score:-3.42|P-value:7.43E-4 ID:SGTC_3112|Compound:9123419|FD-Score:5.37|P-value:9.15E-8 ID:SGTC_3114|Compound:9122766|FD-Score:3.79|P-value:1.05E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.13|P-value:2.78E-5 ID:SGTC_3311|Compound:9131146|FD-Score:8.83|P-value:7.57E-18 ID:SGTC_3322|Compound:9139058|FD-Score:5.19|P-value:2.32E-7 ID:SGTC_3350|Compound:9150499|FD-Score:4.22|P-value:1.89E-5 ID:SGTC_3351|Compound:9150312|FD-Score:3.88|P-value:7.42E-5 ID:SGTC_5|Compound:0352-0601|FD-Score:4.83|P-value:1.32E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:4.13|P-value:2.79E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.64|P-value:3.12E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:5.37|P-value:9.00E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:3.31|P-value:5.73E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.32|P-value:5.66E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:4.41|P-value:8.62E-6 ID:SGTC_228|Compound:caffeine|FD-Score:3.85|P-value:8.43E-5 ID:SGTC_230|Compound:MPP+|FD-Score:4.86|P-value:1.11E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.57|P-value:4.42E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.66|P-value:1.98E-8 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.11|P-value:6.00E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.84|P-value:8.63E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.61|P-value:3.87E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.66|P-value:3.26E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.74|P-value:1.26E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.94|P-value:1.15E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:4.49|P-value:6.20E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:3.15|P-value:9.71E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.11|P-value:2.98E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.29|P-value:6.21E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.25|P-value:7.05E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.83|P-value:9.16E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.29|P-value:6.19E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.46|P-value:6.39E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.30|P-value:1.40E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.05|P-value:3.89E-5 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.28|P-value:6.46E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.28|P-value:6.52E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.00|P-value:4.75E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:5.96|P-value:3.67E-9 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.54|P-value:2.65E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.85|P-value:1.66E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.64|P-value:1.81E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-3.86|P-value:1.55E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.20|P-value:8.44E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.02|P-value:4.31E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:5.43|P-value:6.71E-8 ID:SGTC_1959|Compound:st077091|FD-Score:3.31|P-value:5.79E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.15|P-value:5.30E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.16|P-value:2.45E-5 ID:SGTC_2061|Compound:5245884|FD-Score:4.66|P-value:2.86E-6 ID:SGTC_2064|Compound:5220758|FD-Score:5.68|P-value:1.81E-8 ID:SGTC_2210|Compound:7115885|FD-Score:3.17|P-value:9.27E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.45|P-value:3.61E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.96|P-value:7.12E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:3.32|P-value:5.62E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.30|P-value:6.08E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:5.43|P-value:6.80E-8 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.56|P-value:4.41E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.17|P-value:9.19E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.01|P-value:6.01E-12 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.72|P-value:1.38E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.86|P-value:8.04E-5 ID:SGTC_2821|Compound:7996764|FD-Score:4.85|P-value:1.21E-6 ID:SGTC_2845|Compound:9003024|FD-Score:3.23|P-value:7.54E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.54|P-value:4.94E-6 ID:SGTC_3032|Compound:9089427|FD-Score:-3.51|P-value:5.49E-4 ID:SGTC_3033|Compound:9090887|FD-Score:5.28|P-value:1.42E-7 ID:SGTC_3075|Compound:9116269|FD-Score:-3.42|P-value:7.43E-4 ID:SGTC_3112|Compound:9123419|FD-Score:5.37|P-value:9.15E-8 ID:SGTC_3114|Compound:9122766|FD-Score:3.79|P-value:1.05E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.13|P-value:2.78E-5 ID:SGTC_3311|Compound:9131146|FD-Score:8.83|P-value:7.57E-18 ID:SGTC_3322|Compound:9139058|FD-Score:5.19|P-value:2.32E-7 ID:SGTC_3350|Compound:9150499|FD-Score:4.22|P-value:1.89E-5 ID:SGTC_3351|Compound:9150312|FD-Score:3.88|P-value:7.42E-5

Top fitness defect scores for YBR196C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3311 9131146 8.83 2.9 µM 7.57E-18 cell wall 4 5.01E-19 0.86
2 SGTC_2619 obliquin 7.01 87.9 µM 6.01E-12 cell wall 11 1.21E-12 0.29
3 SGTC_1363 1636-0063 5.96 10.4 µM 3.67E-9 Golgi 1 1.23E-9 0.64
4 SGTC_2064 5220758 5.68 200.0 µM 1.81E-8 1 6.88E-9 0.76
5 SGTC_241 5hr heat shock (37°C) + cantharidin 5.66 155.4 µM 1.98E-8 cell wall signaling 7 7.59E-9 0.06
6 SGTC_1880 MG-132 5.43 525.0 µM 6.71E-8 13 2.82E-8 0.09
7 SGTC_2549 cedrol 5.43 20.9 µM 6.80E-8 3 2.86E-8 0.66
8 SGTC_144 4161-2749 5.37 112.4 µM 9.00E-8 DNA intercalators 5 3.86E-8 0.25
9 SGTC_3112 9123419 5.37 49.5 µM 9.15E-8 RPP1 & pyrimidine depletion 1 3.93E-8 0.65
10 SGTC_3033 9090887 5.28 49.5 µM 1.42E-7 fatty acid desaturase (OLE1) 4 6.31E-8 0.03
11 SGTC_3322 9139058 5.19 2.1 µM 2.32E-7 cell wall 5 1.07E-7 0.08
12 SGTC_2367 9070478 4.96 135.4 µM 7.12E-7 cell wall 4 3.57E-7 0.11
13 SGTC_230 MPP+ 4.86 141.7 µM 1.11E-6 2 5.77E-7 0.13
14 SGTC_2821 7996764 4.85 71.4 µM 1.21E-6 5 6.30E-7 0.05
15 SGTC_5 0352-0601 4.83 109.9 µM 1.32E-6 ERG2 1 6.91E-7 1.05
16 SGTC_2061 5245884 4.66 81.0 µM 2.86E-6 tubulin folding & SWR complex 3 1.59E-6 0.30
17 SGTC_143 4032-1194 4.64 15.7 µM 3.12E-6 9 1.74E-6 0.02
18 SGTC_2567 aureobasidin a 4.56 60.0 nM 4.41E-6 35 2.53E-6 8.57E-4
19 SGTC_2950 9072895 4.54 21.5 µM 4.94E-6 8 2.86E-6 0.32
20 SGTC_569 4130-2812 4.49 160.0 µM 6.20E-6 amide catabolism 2 3.64E-6 0.37

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.247 1.19E-47 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.228 1.33E-40 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.225 1.16E-39 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.203 1.13E-32 YNL126W SPC98 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.201 5.82E-32 YBR202W MCM7 het Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex
0.191 6.35E-29 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.184 7.02E-27 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.179 1.54E-25 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.176 1.00E-24 YDR318W MCM21 hom Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2
0.162 2.92E-21 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.161 5.86E-21 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.159 2.49E-20 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.156 8.65E-20 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.153 6.06E-19 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.151 1.83E-18 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan