YBR196C-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR196C-A / YBR196C-A

Click on Significant Values for Screen Details ID:SGTC_161|Compound:4065-0411|FD-Score:4.04|P-value:1.42E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.71|P-value:4.37E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.73|P-value:2.87E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:4.55|P-value:2.15E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.47|P-value:9.39E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-4.48|P-value:1.85E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:5.46|P-value:4.30E-7 ID:SGTC_758|Compound:0868-0029|FD-Score:6.15|P-value:1.48E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:5.11|P-value:2.07E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.59|P-value:6.46E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.57|P-value:6.88E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.86|P-value:2.65E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.97|P-value:1.83E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.77|P-value:3.58E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.88|P-value:2.50E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.48|P-value:2.81E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:-4.11|P-value:7.47E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.26|P-value:6.59E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.69|P-value:4.67E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.71|P-value:4.46E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.66|P-value:5.25E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:4.06|P-value:1.36E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.38|P-value:8.82E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.85|P-value:6.80E-8 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.59|P-value:6.50E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.61|P-value:1.72E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:-5.46|P-value:2.54E-7 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.98|P-value:1.75E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.72|P-value:4.21E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.65|P-value:3.65E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.61|P-value:6.17E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.99|P-value:1.14E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.61|P-value:6.03E-4 ID:SGTC_1814|Compound:st052110|FD-Score:4.07|P-value:1.30E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.99|P-value:1.15E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-3.62|P-value:4.14E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.75|P-value:9.49E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.08|P-value:1.25E-4 ID:SGTC_2088|Compound:5278280|FD-Score:4.01|P-value:1.59E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.51|P-value:8.40E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.52|P-value:7.96E-4 ID:SGTC_2254|Compound:7938975|FD-Score:4.00|P-value:1.64E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-5.58|P-value:1.41E-7 ID:SGTC_2281|Compound:7943571|FD-Score:3.96|P-value:1.89E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.13|P-value:1.93E-6 ID:SGTC_2395|Compound:5646831|FD-Score:3.57|P-value:7.00E-4 ID:SGTC_2585|Compound:alliin|FD-Score:4.36|P-value:4.41E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-20.10|P-value:2.71E-75 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.33|P-value:3.22E-5 ID:SGTC_2695|Compound:st077686|FD-Score:3.66|P-value:5.16E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.73|P-value:1.05E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-11.60|P-value:1.93E-26 ID:SGTC_2859|Compound:9028643|FD-Score:4.82|P-value:7.22E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-6.09|P-value:1.10E-8 ID:SGTC_2878|Compound:9043973|FD-Score:-6.84|P-value:1.69E-10 ID:SGTC_2936|Compound:9038235|FD-Score:-3.89|P-value:1.62E-4 ID:SGTC_2941|Compound:9056145|FD-Score:6.20|P-value:1.13E-8 ID:SGTC_2942|Compound:9052777|FD-Score:5.68|P-value:1.50E-7 ID:SGTC_2953|Compound:9074162|FD-Score:6.75|P-value:5.50E-10 ID:SGTC_2983|Compound:9022671|FD-Score:-4.64|P-value:9.56E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-3.59|P-value:4.53E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-5.72|P-value:7.42E-8 ID:SGTC_3293|Compound:9120939|FD-Score:-13.00|P-value:5.87E-33 ID:SGTC_161|Compound:4065-0411|FD-Score:4.04|P-value:1.42E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.71|P-value:4.37E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.73|P-value:2.87E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:4.55|P-value:2.15E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.47|P-value:9.39E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-4.48|P-value:1.85E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:5.46|P-value:4.30E-7 ID:SGTC_758|Compound:0868-0029|FD-Score:6.15|P-value:1.48E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:5.11|P-value:2.07E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.59|P-value:6.46E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.57|P-value:6.88E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.86|P-value:2.65E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.97|P-value:1.83E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.77|P-value:3.58E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.88|P-value:2.50E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.48|P-value:2.81E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:-4.11|P-value:7.47E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.26|P-value:6.59E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.69|P-value:4.67E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.71|P-value:4.46E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.66|P-value:5.25E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:4.06|P-value:1.36E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.38|P-value:8.82E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.85|P-value:6.80E-8 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.59|P-value:6.50E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.61|P-value:1.72E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:-5.46|P-value:2.54E-7 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.98|P-value:1.75E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.72|P-value:4.21E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.65|P-value:3.65E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.61|P-value:6.17E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.99|P-value:1.14E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.61|P-value:6.03E-4 ID:SGTC_1814|Compound:st052110|FD-Score:4.07|P-value:1.30E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.99|P-value:1.15E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-3.62|P-value:4.14E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.75|P-value:9.49E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.08|P-value:1.25E-4 ID:SGTC_2088|Compound:5278280|FD-Score:4.01|P-value:1.59E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.51|P-value:8.40E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.52|P-value:7.96E-4 ID:SGTC_2254|Compound:7938975|FD-Score:4.00|P-value:1.64E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-5.58|P-value:1.41E-7 ID:SGTC_2281|Compound:7943571|FD-Score:3.96|P-value:1.89E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.13|P-value:1.93E-6 ID:SGTC_2395|Compound:5646831|FD-Score:3.57|P-value:7.00E-4 ID:SGTC_2585|Compound:alliin|FD-Score:4.36|P-value:4.41E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-20.10|P-value:2.71E-75 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.33|P-value:3.22E-5 ID:SGTC_2695|Compound:st077686|FD-Score:3.66|P-value:5.16E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.73|P-value:1.05E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-11.60|P-value:1.93E-26 ID:SGTC_2859|Compound:9028643|FD-Score:4.82|P-value:7.22E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-6.09|P-value:1.10E-8 ID:SGTC_2878|Compound:9043973|FD-Score:-6.84|P-value:1.69E-10 ID:SGTC_2936|Compound:9038235|FD-Score:-3.89|P-value:1.62E-4 ID:SGTC_2941|Compound:9056145|FD-Score:6.20|P-value:1.13E-8 ID:SGTC_2942|Compound:9052777|FD-Score:5.68|P-value:1.50E-7 ID:SGTC_2953|Compound:9074162|FD-Score:6.75|P-value:5.50E-10 ID:SGTC_2983|Compound:9022671|FD-Score:-4.64|P-value:9.56E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-3.59|P-value:4.53E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-5.72|P-value:7.42E-8 ID:SGTC_3293|Compound:9120939|FD-Score:-13.00|P-value:5.87E-33

Top fitness defect scores for YBR196C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2953 9074162 6.75 66.5 µM 5.50E-10 3 7.39E-12
2 SGTC_2941 9056145 6.20 11.2 µM 1.13E-8 5 2.86E-10
3 SGTC_758 0868-0029 6.15 16.0 µM 1.48E-8 2 3.97E-10
4 SGTC_1375 2910-0797 5.85 186.0 µM 6.80E-8 6 2.53E-9
5 SGTC_2942 9052777 5.68 62.2 µM 1.50E-7 5 6.57E-9
6 SGTC_668 1682-0499 5.46 62.6 µM 4.30E-7 4 2.36E-8
7 SGTC_2282 7944268 5.13 200.0 µM 1.93E-6 RPP1 & pyrimidine depletion 11 1.45E-7
8 SGTC_767 0929-0023 5.11 86.0 µM 2.07E-6 TRP & mitochondrial translation 33 1.58E-7
9 SGTC_2859 9028643 4.82 45.5 µM 7.22E-6 5 7.17E-7
10 SGTC_1932 st074806 4.75 40.9 µM 9.49E-6 8 9.99E-7
11 SGTC_2852 9023854 4.73 52.0 µM 1.05E-5 18 1.13E-6
12 SGTC_1445 4239-0156 4.61 97.7 µM 1.72E-5 15 2.06E-6
13 SGTC_383 2324-0395 4.55 7.4 µM 2.15E-5 azole & statin 25 2.69E-6
14 SGTC_1040 k898-0338 4.48 155.0 µM 2.81E-5 15 3.72E-6
15 SGTC_2585 alliin 4.36 100.0 µM 4.41E-5 17 6.41E-6
16 SGTC_1051 3253-3903 4.26 78.0 µM 6.59E-5 16 1.04E-5
17 SGTC_2042 p-Dimethylaminoacetophenone 4.08 200.0 µM 1.25E-4 13 2.25E-5
18 SGTC_1814 st052110 4.07 31.5 µM 1.30E-4 RNA processing & uracil transport 10 2.38E-5
19 SGTC_1372 2752-0194 4.06 270.0 µM 1.36E-4 16 2.50E-5
20 SGTC_161 4065-0411 4.04 162.2 µM 1.42E-4 59 2.64E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 2.62E-34 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.196 2.53E-30 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.179 1.56E-25 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.134 7.70E-15 YKL119C VPH2 hom Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
0.130 3.42E-14 YBL013W FMT1 hom Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
0.112 9.06E-11 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.108 3.00E-10 YER147C SCC4 het Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.105 1.25E-9 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.103 2.04E-9 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.100 6.20E-9 YLR244C MAP1 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
0.097 1.68E-8 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
0.097 2.14E-8 YGL229C SAP4 hom Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
0.095 4.31E-8 YDR322W MRPL35 hom Mitochondrial ribosomal protein of the large subunit
0.090 1.59E-7 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.090 2.02E-7 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function