YBR196C-B_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR196C-B / YBR196C-B

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:-4.65|P-value:4.12E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.53|P-value:8.93E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.38|P-value:1.74E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.24|P-value:3.00E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.85|P-value:2.27E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:6.36|P-value:8.58E-12 ID:SGTC_164|Compound:4100-3994|FD-Score:4.00|P-value:1.14E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.81|P-value:1.76E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:3.24|P-value:3.00E-4 ID:SGTC_264|Compound:promethazine|FD-Score:5.77|P-value:4.94E-10 ID:SGTC_277|Compound:nystatin|FD-Score:3.28|P-value:2.63E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.71|P-value:4.29E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.53|P-value:9.34E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.10|P-value:5.31E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:2.99|P-value:7.89E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.29|P-value:2.48E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:2.98|P-value:8.19E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.43|P-value:1.39E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:4.23|P-value:3.79E-6 ID:SGTC_816|Compound:0325-0417|FD-Score:3.32|P-value:2.27E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.11|P-value:4.89E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:4.58|P-value:6.42E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.19|P-value:3.59E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.22|P-value:3.17E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.46|P-value:1.28E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.69|P-value:4.83E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.96|P-value:8.59E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:2.97|P-value:8.31E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.45|P-value:1.25E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.22|P-value:4.10E-6 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.44|P-value:1.32E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.15|P-value:4.24E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.06|P-value:6.13E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.42|P-value:1.47E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.72|P-value:2.92E-7 ID:SGTC_1635|Compound:st007035|FD-Score:5.42|P-value:4.78E-9 ID:SGTC_1686|Compound:st019653|FD-Score:4.59|P-value:6.01E-7 ID:SGTC_1748|Compound:st037455|FD-Score:4.75|P-value:2.53E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-2.94|P-value:9.03E-4 ID:SGTC_1838|Compound:st055369|FD-Score:2.95|P-value:9.18E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.85|P-value:2.30E-5 ID:SGTC_1943|Compound:st076331|FD-Score:4.47|P-value:1.10E-6 ID:SGTC_1946|Compound:st076057|FD-Score:3.73|P-value:3.90E-5 ID:SGTC_1971|Compound:st069429|FD-Score:3.02|P-value:7.14E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.23|P-value:3.20E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.83|P-value:2.59E-5 ID:SGTC_2089|Compound:5281248|FD-Score:-2.98|P-value:7.86E-4 ID:SGTC_2097|Compound:5376186|FD-Score:2.95|P-value:9.16E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.51|P-value:9.79E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-2.93|P-value:9.24E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.12|P-value:4.81E-4 ID:SGTC_2290|Compound:7904846|FD-Score:2.95|P-value:9.19E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-4.92|P-value:9.33E-8 ID:SGTC_2396|Compound:5342950|FD-Score:5.46|P-value:3.75E-9 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.06|P-value:5.78E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.30|P-value:2.40E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.13|P-value:6.15E-6 ID:SGTC_2796|Compound:7949634|FD-Score:3.27|P-value:2.71E-4 ID:SGTC_3040|Compound:9091894|FD-Score:2.97|P-value:8.46E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.65|P-value:4.12E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.53|P-value:8.93E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.38|P-value:1.74E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.24|P-value:3.00E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.85|P-value:2.27E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:6.36|P-value:8.58E-12 ID:SGTC_164|Compound:4100-3994|FD-Score:4.00|P-value:1.14E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.81|P-value:1.76E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:3.24|P-value:3.00E-4 ID:SGTC_264|Compound:promethazine|FD-Score:5.77|P-value:4.94E-10 ID:SGTC_277|Compound:nystatin|FD-Score:3.28|P-value:2.63E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.71|P-value:4.29E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.53|P-value:9.34E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.10|P-value:5.31E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:2.99|P-value:7.89E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.29|P-value:2.48E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:2.98|P-value:8.19E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.43|P-value:1.39E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:4.23|P-value:3.79E-6 ID:SGTC_816|Compound:0325-0417|FD-Score:3.32|P-value:2.27E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.11|P-value:4.89E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:4.58|P-value:6.42E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.19|P-value:3.59E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.22|P-value:3.17E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.46|P-value:1.28E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.69|P-value:4.83E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.96|P-value:8.59E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:2.97|P-value:8.31E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.45|P-value:1.25E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.22|P-value:4.10E-6 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.44|P-value:1.32E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.15|P-value:4.24E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.06|P-value:6.13E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.42|P-value:1.47E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.72|P-value:2.92E-7 ID:SGTC_1635|Compound:st007035|FD-Score:5.42|P-value:4.78E-9 ID:SGTC_1686|Compound:st019653|FD-Score:4.59|P-value:6.01E-7 ID:SGTC_1748|Compound:st037455|FD-Score:4.75|P-value:2.53E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-2.94|P-value:9.03E-4 ID:SGTC_1838|Compound:st055369|FD-Score:2.95|P-value:9.18E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.85|P-value:2.30E-5 ID:SGTC_1943|Compound:st076331|FD-Score:4.47|P-value:1.10E-6 ID:SGTC_1946|Compound:st076057|FD-Score:3.73|P-value:3.90E-5 ID:SGTC_1971|Compound:st069429|FD-Score:3.02|P-value:7.14E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.23|P-value:3.20E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.83|P-value:2.59E-5 ID:SGTC_2089|Compound:5281248|FD-Score:-2.98|P-value:7.86E-4 ID:SGTC_2097|Compound:5376186|FD-Score:2.95|P-value:9.16E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.51|P-value:9.79E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-2.93|P-value:9.24E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.12|P-value:4.81E-4 ID:SGTC_2290|Compound:7904846|FD-Score:2.95|P-value:9.19E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-4.92|P-value:9.33E-8 ID:SGTC_2396|Compound:5342950|FD-Score:5.46|P-value:3.75E-9 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.06|P-value:5.78E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.30|P-value:2.40E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.13|P-value:6.15E-6 ID:SGTC_2796|Compound:7949634|FD-Score:3.27|P-value:2.71E-4 ID:SGTC_3040|Compound:9091894|FD-Score:2.97|P-value:8.46E-4

Top fitness defect scores for YBR196C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_145 3737-0113 6.36 38.4 µM 8.58E-12 DNA intercalators 23 1.03E-10
2 SGTC_264 promethazine 5.77 12.5 mM 4.94E-10 DNA intercalators 22 3.86E-9
3 SGTC_2396 5342950 5.46 42.8 µM 3.75E-9 RSC complex & mRNA processing 17 2.37E-8
4 SGTC_1635 st007035 5.42 42.4 µM 4.78E-9 152 2.94E-8
5 SGTC_219 mitoxanthrone 4.81 164.4 µM 1.76E-7 DNA intercalators 31 7.42E-7
6 SGTC_1748 st037455 4.75 53.6 µM 2.53E-7 14 1.03E-6
7 SGTC_1584 6-fluoro-dl-tryptophan 4.72 90.0 µM 2.92E-7 mitochondrial processes 5 1.17E-6
8 SGTC_1686 st019653 4.59 115.5 µM 6.01E-7 mitochondrial processes 4 2.23E-6
9 SGTC_891 0929-0073 4.58 133.0 µM 6.42E-7 10 2.37E-6
10 SGTC_1943 st076331 4.47 65.2 µM 1.10E-6 10 3.83E-6
11 SGTC_1338 1486-1223 4.45 76.0 µM 1.25E-6 8 4.28E-6
12 SGTC_702 1488-0190 4.23 94.0 µM 3.79E-6 amide catabolism 12 1.16E-5
13 SGTC_1340 1486-1359 4.22 257.0 µM 4.10E-6 14 1.25E-5
14 SGTC_2771 fluoxetine 4.13 41.0 µM 6.15E-6 16 1.79E-5
15 SGTC_164 4100-3994 4.00 89.6 µM 1.14E-5 29 3.13E-5
16 SGTC_144 4161-2749 3.85 112.4 µM 2.27E-5 DNA intercalators 25 5.79E-5
17 SGTC_1860 st056228 3.85 74.6 µM 2.30E-5 25 5.86E-5
18 SGTC_2087 5276107 3.83 200.0 µM 2.59E-5 20 6.51E-5
19 SGTC_1946 st076057 3.73 65.1 µM 3.90E-5 6 9.42E-5
20 SGTC_362 0310-0100 3.71 9.0 µM 4.29E-5 RPP1 & pyrimidine depletion 41 1.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.315 2.50E-78 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.294 8.59E-68 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.274 7.20E-59 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.261 2.78E-53 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.260 5.14E-53 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.223 7.27E-39 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.222 1.31E-38 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.208 6.43E-34 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.205 4.34E-33 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.204 9.18E-33 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.193 2.31E-29 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.192 3.18E-29 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.184 5.40E-27 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.177 4.15E-25 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.171 1.72E-23 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs