HIPHOP chemogenomics database
YBR196C-B_p 
Putative protein of unknown function; identified by expression profiling and mass spectrometry
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YBR196C-B deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.315 | 2.50E-78 | YMR168C | CEP3 | het | Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain |
| 0.294 | 8.59E-68 | YHL039W | EFM1 | hom | Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
| 0.274 | 7.20E-59 | YMR166C_p | YMR166C_p | hom | Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene |
| 0.261 | 2.78E-53 | YGL118C_d | YGL118C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.260 | 5.14E-53 | YMR289W | ABZ2 | hom | Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis |
| 0.223 | 7.27E-39 | YGR065C | VHT1 | het | High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin |
| 0.222 | 1.31E-38 | YDR401W_d | YDR401W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.208 | 6.43E-34 | YDL223C | HBT1 | hom | Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis |
| 0.205 | 4.34E-33 | YKL087C | CYT2 | hom | Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 |
| 0.204 | 9.18E-33 | YMR262W_p | YMR262W_p | hom | Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene |
| 0.193 | 2.31E-29 | YMR151W_d | YIM2_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 |
| 0.192 | 3.18E-29 | YNL264C | PDR17 | hom | Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition |
| 0.184 | 5.40E-27 | YHR050W-A_p | YHR050W-A_p | hom | Protein of unknown function; identified by expression profiling and mass spectrometry |
| 0.177 | 4.15E-25 | YJL166W | QCR8 | hom | Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p |
| 0.171 | 1.72E-23 | YLL009C | COX17 | hom | Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs |