YBR198C / TAF5

Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR198C / TAF5

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-3.84|P-value:1.19E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:8.69|P-value:1.13E-16 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.40|P-value:5.60E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.69|P-value:4.90E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:4.98|P-value:1.33E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:4.26|P-value:3.04E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:4.32|P-value:2.35E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:5.90|P-value:1.30E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:-4.57|P-value:6.22E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.99|P-value:6.70E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:3.69|P-value:2.62E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.12|P-value:5.35E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.40|P-value:7.07E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.79|P-value:2.31E-6 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.45|P-value:4.69E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:11.50|P-value:7.06E-28 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.72|P-value:1.86E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:6.11|P-value:4.05E-9 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-5.14|P-value:4.44E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.76|P-value:1.58E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.58|P-value:8.22E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-5.99|P-value:5.45E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.23|P-value:9.60E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:5.26|P-value:3.55E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.62|P-value:2.63E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.15|P-value:4.68E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:3.82|P-value:1.66E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.43|P-value:5.01E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.27|P-value:2.94E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:4.75|P-value:3.90E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:3.31|P-value:9.43E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:6.95|P-value:2.67E-11 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.59|P-value:6.85E-8 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.64|P-value:3.17E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.14|P-value:4.95E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:6.04|P-value:5.98E-9 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.33|P-value:7.00E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.43|P-value:6.41E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.67|P-value:2.79E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.44|P-value:4.81E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.40|P-value:5.50E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.23|P-value:9.67E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.72|P-value:1.86E-4 ID:SGTC_1729|Compound:st035615|FD-Score:5.56|P-value:8.06E-8 ID:SGTC_1799|Compound:st045822|FD-Score:3.84|P-value:1.53E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.47|P-value:5.66E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.66|P-value:2.88E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-8.55|P-value:1.92E-16 ID:SGTC_2009|Compound:4012297|FD-Score:-8.39|P-value:6.32E-16 ID:SGTC_2016|Compound:5121758|FD-Score:3.57|P-value:3.91E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.62|P-value:3.02E-13 ID:SGTC_2377|Compound:9073351|FD-Score:4.03|P-value:7.45E-5 ID:SGTC_2411|Compound:st077133|FD-Score:-4.75|P-value:2.83E-6 ID:SGTC_2426|Compound:5582046|FD-Score:4.04|P-value:7.13E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.76|P-value:2.08E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.30|P-value:2.57E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-3.76|P-value:1.59E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.47|P-value:4.48E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.29|P-value:3.02E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.71|P-value:2.43E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.07|P-value:8.76E-7 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.22|P-value:4.36E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.03|P-value:7.62E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.34|P-value:8.50E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.55|P-value:3.40E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.00|P-value:8.38E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:6.91|P-value:3.49E-11 ID:SGTC_2950|Compound:9072895|FD-Score:4.22|P-value:3.57E-5 ID:SGTC_2974|Compound:9094440|FD-Score:4.04|P-value:7.16E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.04|P-value:5.63E-5 ID:SGTC_3351|Compound:9150312|FD-Score:3.66|P-value:2.93E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.84|P-value:1.19E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:8.69|P-value:1.13E-16 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.40|P-value:5.60E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.69|P-value:4.90E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:4.98|P-value:1.33E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:4.26|P-value:3.04E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:4.32|P-value:2.35E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:5.90|P-value:1.30E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:-4.57|P-value:6.22E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.99|P-value:6.70E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:3.69|P-value:2.62E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.12|P-value:5.35E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.40|P-value:7.07E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.79|P-value:2.31E-6 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.45|P-value:4.69E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:11.50|P-value:7.06E-28 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.72|P-value:1.86E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:6.11|P-value:4.05E-9 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-5.14|P-value:4.44E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.76|P-value:1.58E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.58|P-value:8.22E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-5.99|P-value:5.45E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.23|P-value:9.60E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:5.26|P-value:3.55E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.62|P-value:2.63E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.15|P-value:4.68E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:3.82|P-value:1.66E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.43|P-value:5.01E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.27|P-value:2.94E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:4.75|P-value:3.90E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:3.31|P-value:9.43E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:6.95|P-value:2.67E-11 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.59|P-value:6.85E-8 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.64|P-value:3.17E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.14|P-value:4.95E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:6.04|P-value:5.98E-9 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.33|P-value:7.00E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.43|P-value:6.41E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.67|P-value:2.79E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.44|P-value:4.81E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.40|P-value:5.50E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.23|P-value:9.67E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.72|P-value:1.86E-4 ID:SGTC_1729|Compound:st035615|FD-Score:5.56|P-value:8.06E-8 ID:SGTC_1799|Compound:st045822|FD-Score:3.84|P-value:1.53E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.47|P-value:5.66E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.66|P-value:2.88E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-8.55|P-value:1.92E-16 ID:SGTC_2009|Compound:4012297|FD-Score:-8.39|P-value:6.32E-16 ID:SGTC_2016|Compound:5121758|FD-Score:3.57|P-value:3.91E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.62|P-value:3.02E-13 ID:SGTC_2377|Compound:9073351|FD-Score:4.03|P-value:7.45E-5 ID:SGTC_2411|Compound:st077133|FD-Score:-4.75|P-value:2.83E-6 ID:SGTC_2426|Compound:5582046|FD-Score:4.04|P-value:7.13E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.76|P-value:2.08E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.30|P-value:2.57E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-3.76|P-value:1.59E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.47|P-value:4.48E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.29|P-value:3.02E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.71|P-value:2.43E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.07|P-value:8.76E-7 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.22|P-value:4.36E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.03|P-value:7.62E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.34|P-value:8.50E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.55|P-value:3.40E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.00|P-value:8.38E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:6.91|P-value:3.49E-11 ID:SGTC_2950|Compound:9072895|FD-Score:4.22|P-value:3.57E-5 ID:SGTC_2974|Compound:9094440|FD-Score:4.04|P-value:7.16E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.04|P-value:5.63E-5 ID:SGTC_3351|Compound:9150312|FD-Score:3.66|P-value:2.93E-4

Top fitness defect scores for YBR198C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_350 k064-0020 11.50 19.8 µM 7.06E-28 heme requiring 1 6.34E-31 4.10
2 SGTC_69 0096-0274 8.69 206.7 µM 1.13E-16 mitochondrial processes 9 1.89E-18 0.47
3 SGTC_2248 tofa 7.62 1.1 µM 3.02E-13 sphingolipid biosynthesis & PDR1 9 1.24E-14 0.41
4 SGTC_922 1866-0035 6.95 480.0 µM 2.67E-11 excess fatty acid 2 1.83E-12 1.29
5 SGTC_2753 fluvastatin 6.91 17.1 µM 3.49E-11 azole & statin 2 2.46E-12 1.24
6 SGTC_377 3970-0964 6.11 33.1 µM 4.05E-9 3 4.91E-10 1.34
7 SGTC_1157 4092-0394 6.04 27.6 µM 5.98E-9 1 7.58E-10 1.19
8 SGTC_227 fluconazole 5.90 33.5 µM 1.30E-8 azole & statin 31 1.80E-9 0.26
9 SGTC_1019 4262-0212 5.59 3.4 µM 6.85E-8 ergosterol depletion effects on membrane 6 1.15E-8 0.63
10 SGTC_1729 st035615 5.56 46.0 µM 8.06E-8 3 1.37E-8 0.82
11 SGTC_2533 agelasine 5.29 13.7 µM 3.02E-7 ERG2 7 5.98E-8 0.86
12 SGTC_584 0986-0246 5.26 15.4 µM 3.55E-7 heme requiring 11 7.16E-8 0.29
13 SGTC_2594 a-mangostin 5.22 100.0 µM 4.36E-7 2 9.02E-8 0.90
14 SGTC_2584 androsterone 5.07 48.7 µM 8.76E-7 cell wall 19 1.96E-7 0.11
15 SGTC_168 3970-0862 4.98 530.5 µM 1.33E-6 30 3.12E-7 0.30
16 SGTC_863 0466-0191 4.75 129.0 µM 3.90E-6 cell wall 16 1.03E-6 0.03
17 SGTC_150 3970-0969 4.69 77.2 µM 4.90E-6 10 1.33E-6 0.11
18 SGTC_432 NS 1619 4.58 61.3 µM 8.22E-6 5 2.37E-6 0.24
19 SGTC_178 4092-0806 4.32 87.5 µM 2.35E-5 ergosterol depletion effects on membrane 18 7.65E-6 0.60
20 SGTC_2444 5485484 4.30 36.4 µM 2.57E-5 5 8.44E-6 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.253 5.90E-50 YDR145W TAF12 het Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
0.195 6.18E-30 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.176 1.36E-24 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.159 2.06E-20 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.150 2.00E-18 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.143 1.03E-16 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.141 2.23E-16 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.139 5.75E-16 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.137 1.62E-15 YKL028W TFA1 het TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
0.135 3.63E-15 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.128 1.32E-13 YMR227C TAF7 het TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.127 2.03E-13 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.115 2.94E-11 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
0.111 1.06E-10 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.111 1.17E-10 YOR194C TOA1 het TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA