YBR200W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR200W-A / YBR200W-A

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-3.49|P-value:6.61E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.32|P-value:3.55E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.53|P-value:5.71E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.02|P-value:1.06E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.96|P-value:2.56E-6 ID:SGTC_183|Compound:3914-0051|FD-Score:4.26|P-value:4.51E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:5.19|P-value:9.24E-7 ID:SGTC_230|Compound:MPP+|FD-Score:3.85|P-value:2.02E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.00|P-value:2.48E-38 ID:SGTC_657|Compound:3534-0529|FD-Score:3.57|P-value:5.17E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.46|P-value:7.42E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:4.08|P-value:8.69E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.56|P-value:1.36E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.14|P-value:7.09E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-4.40|P-value:2.50E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.62|P-value:4.44E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.14|P-value:7.00E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.46|P-value:7.42E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.88|P-value:3.57E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.86|P-value:1.94E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.09|P-value:8.48E-5 ID:SGTC_1516|Compound:st013856|FD-Score:-4.85|P-value:3.98E-6 ID:SGTC_1526|Compound:st051518|FD-Score:-10.60|P-value:6.91E-23 ID:SGTC_1531|Compound:st059297|FD-Score:4.01|P-value:1.15E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.83|P-value:2.13E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-4.20|P-value:5.57E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.49|P-value:2.81E-12 ID:SGTC_1655|Compound:st012546|FD-Score:3.64|P-value:4.14E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.40|P-value:8.86E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.96|P-value:1.34E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.65|P-value:9.48E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-4.84|P-value:4.21E-6 ID:SGTC_1752|Compound:st044819|FD-Score:3.73|P-value:2.97E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-5.65|P-value:1.01E-7 ID:SGTC_1762|Compound:st045503|FD-Score:4.34|P-value:3.29E-5 ID:SGTC_1765|Compound:st044815|FD-Score:5.18|P-value:9.34E-7 ID:SGTC_1772|Compound:st048439|FD-Score:4.14|P-value:7.01E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.93|P-value:1.51E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.60|P-value:4.64E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.70|P-value:7.58E-6 ID:SGTC_2363|Compound:9053361|FD-Score:4.53|P-value:1.57E-5 ID:SGTC_2367|Compound:9070478|FD-Score:-3.91|P-value:1.60E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.06|P-value:9.25E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:4.27|P-value:4.31E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-3.89|P-value:1.71E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-5.28|P-value:5.90E-7 ID:SGTC_2912|Compound:7964298|FD-Score:4.22|P-value:5.31E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.86|P-value:1.91E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.55|P-value:5.48E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.85|P-value:1.99E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.89|P-value:1.73E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.49|P-value:6.61E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.32|P-value:3.55E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.53|P-value:5.71E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.02|P-value:1.06E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.96|P-value:2.56E-6 ID:SGTC_183|Compound:3914-0051|FD-Score:4.26|P-value:4.51E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:5.19|P-value:9.24E-7 ID:SGTC_230|Compound:MPP+|FD-Score:3.85|P-value:2.02E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.00|P-value:2.48E-38 ID:SGTC_657|Compound:3534-0529|FD-Score:3.57|P-value:5.17E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.46|P-value:7.42E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:4.08|P-value:8.69E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.56|P-value:1.36E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.14|P-value:7.09E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-4.40|P-value:2.50E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.62|P-value:4.44E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.14|P-value:7.00E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.46|P-value:7.42E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.88|P-value:3.57E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.86|P-value:1.94E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.09|P-value:8.48E-5 ID:SGTC_1516|Compound:st013856|FD-Score:-4.85|P-value:3.98E-6 ID:SGTC_1526|Compound:st051518|FD-Score:-10.60|P-value:6.91E-23 ID:SGTC_1531|Compound:st059297|FD-Score:4.01|P-value:1.15E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.83|P-value:2.13E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-4.20|P-value:5.57E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.49|P-value:2.81E-12 ID:SGTC_1655|Compound:st012546|FD-Score:3.64|P-value:4.14E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.40|P-value:8.86E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.96|P-value:1.34E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.65|P-value:9.48E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-4.84|P-value:4.21E-6 ID:SGTC_1752|Compound:st044819|FD-Score:3.73|P-value:2.97E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-5.65|P-value:1.01E-7 ID:SGTC_1762|Compound:st045503|FD-Score:4.34|P-value:3.29E-5 ID:SGTC_1765|Compound:st044815|FD-Score:5.18|P-value:9.34E-7 ID:SGTC_1772|Compound:st048439|FD-Score:4.14|P-value:7.01E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.93|P-value:1.51E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.60|P-value:4.64E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.70|P-value:7.58E-6 ID:SGTC_2363|Compound:9053361|FD-Score:4.53|P-value:1.57E-5 ID:SGTC_2367|Compound:9070478|FD-Score:-3.91|P-value:1.60E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.06|P-value:9.25E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:4.27|P-value:4.31E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-3.89|P-value:1.71E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-5.28|P-value:5.90E-7 ID:SGTC_2912|Compound:7964298|FD-Score:4.22|P-value:5.31E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.86|P-value:1.91E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.55|P-value:5.48E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.85|P-value:1.99E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.89|P-value:1.73E-4

Top fitness defect scores for YBR200W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 14.00 5.3 µM 2.48E-38 117 6.44E-45
2 SGTC_1635 st007035 7.49 42.4 µM 2.81E-12 104 3.46E-14
3 SGTC_184 1494-0393 5.19 24.7 µM 9.24E-7 26 1.08E-7
4 SGTC_1765 st044815 5.18 90.4 µM 9.34E-7 8 1.09E-7
5 SGTC_179 1273-0063 4.96 6.8 µM 2.56E-6 10 3.56E-7
6 SGTC_1428 4049-0204 4.88 61.7 µM 3.57E-6 3 5.27E-7
7 SGTC_2053 5265679 4.70 138.0 µM 7.58E-6 9 1.27E-6
8 SGTC_1746 st038117 4.65 42.0 µM 9.48E-6 19 1.66E-6
9 SGTC_1032 k061-1018 4.56 98.7 µM 1.36E-5 8 2.53E-6
10 SGTC_2363 9053361 4.53 176.0 µM 1.57E-5 Golgi 23 3.00E-6
11 SGTC_1762 st045503 4.34 25.5 µM 3.29E-5 20 7.13E-6
12 SGTC_100 0086-0128 4.32 49.6 µM 3.55E-5 copper-dependent oxidative stress 36 7.80E-6
13 SGTC_2760 etidronate 4.27 98.0 µM 4.31E-5 19 9.78E-6
14 SGTC_183 3914-0051 4.26 30.6 µM 4.51E-5 60S ribosome export 16 1.03E-5
15 SGTC_2912 7964298 4.22 10.9 µM 5.31E-5 cell wall 86 1.25E-5
16 SGTC_1202 1988-0068 4.14 29.6 µM 7.00E-5 RNA processing & uracil transport 20 1.73E-5
17 SGTC_1772 st048439 4.14 82.2 µM 7.01E-5 33 1.73E-5
18 SGTC_1037 k284-1091 4.14 78.7 µM 7.09E-5 11 1.75E-5
19 SGTC_1515 3460-0031 4.09 42.1 µM 8.48E-5 DNA intercalators 17 2.16E-5
20 SGTC_935 2996-0153 4.08 430.0 µM 8.69E-5 PDR1 17 2.22E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.354 1.87E-99 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.352 1.94E-98 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.347 2.20E-95 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.331 1.23E-86 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.314 1.67E-77 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.313 6.53E-77 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.310 8.18E-76 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.308 1.28E-74 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.301 2.19E-71 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.301 3.74E-71 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.300 5.12E-71 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.298 8.56E-70 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.294 5.75E-68 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.292 6.83E-67 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.292 9.12E-67 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies