YBR201W / DER1

Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR201W / DER1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-3.48|P-value:2.05E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.16|P-value:7.42E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.29|P-value:4.23E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.14|P-value:7.92E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.70|P-value:1.11E-6 ID:SGTC_592|Compound:k241-0073|FD-Score:3.28|P-value:4.90E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.36|P-value:3.71E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.19|P-value:1.26E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:3.79|P-value:7.04E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:3.17|P-value:7.15E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.37|P-value:3.56E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.24|P-value:5.58E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.44|P-value:2.41E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.14|P-value:7.05E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.68|P-value:1.06E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.52|P-value:1.79E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.44|P-value:2.76E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.96|P-value:3.44E-5 ID:SGTC_1761|Compound:st044296|FD-Score:-3.06|P-value:9.51E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.80|P-value:6.56E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.08|P-value:9.79E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-4.36|P-value:4.81E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.82|P-value:6.03E-5 ID:SGTC_2090|Compound:5301565|FD-Score:3.14|P-value:8.11E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.90|P-value:4.32E-5 ID:SGTC_2102|Compound:5377816|FD-Score:4.54|P-value:2.42E-6 ID:SGTC_2270|Compound:7924575|FD-Score:3.66|P-value:1.15E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.00|P-value:2.85E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:6.75|P-value:5.13E-12 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.99|P-value:2.94E-5 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:3.33|P-value:4.08E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-4.05|P-value:1.97E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.19|P-value:5.87E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.25|P-value:9.61E-6 ID:SGTC_2585|Compound:alliin|FD-Score:4.07|P-value:2.15E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.57|P-value:2.11E-6 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:-3.12|P-value:7.73E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.70|P-value:8.60E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.81|P-value:6.43E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.14|P-value:1.58E-5 ID:SGTC_3008|Compound:9078912|FD-Score:-3.22|P-value:5.31E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.11|P-value:8.82E-4 ID:SGTC_3233|Compound:9132340|FD-Score:4.00|P-value:2.87E-5 ID:SGTC_3234|Compound:9132280|FD-Score:3.26|P-value:5.21E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.48|P-value:2.05E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.16|P-value:7.42E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.29|P-value:4.23E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.14|P-value:7.92E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.70|P-value:1.11E-6 ID:SGTC_592|Compound:k241-0073|FD-Score:3.28|P-value:4.90E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.36|P-value:3.71E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.19|P-value:1.26E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:3.79|P-value:7.04E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:3.17|P-value:7.15E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.37|P-value:3.56E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.24|P-value:5.58E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.44|P-value:2.41E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.14|P-value:7.05E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.68|P-value:1.06E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.52|P-value:1.79E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.44|P-value:2.76E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.96|P-value:3.44E-5 ID:SGTC_1761|Compound:st044296|FD-Score:-3.06|P-value:9.51E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.80|P-value:6.56E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.08|P-value:9.79E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-4.36|P-value:4.81E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.82|P-value:6.03E-5 ID:SGTC_2090|Compound:5301565|FD-Score:3.14|P-value:8.11E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.90|P-value:4.32E-5 ID:SGTC_2102|Compound:5377816|FD-Score:4.54|P-value:2.42E-6 ID:SGTC_2270|Compound:7924575|FD-Score:3.66|P-value:1.15E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.00|P-value:2.85E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:6.75|P-value:5.13E-12 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.99|P-value:2.94E-5 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:3.33|P-value:4.08E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-4.05|P-value:1.97E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.19|P-value:5.87E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.25|P-value:9.61E-6 ID:SGTC_2585|Compound:alliin|FD-Score:4.07|P-value:2.15E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.57|P-value:2.11E-6 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:-3.12|P-value:7.73E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.70|P-value:8.60E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.81|P-value:6.43E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.14|P-value:1.58E-5 ID:SGTC_3008|Compound:9078912|FD-Score:-3.22|P-value:5.31E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.11|P-value:8.82E-4 ID:SGTC_3233|Compound:9132340|FD-Score:4.00|P-value:2.87E-5 ID:SGTC_3234|Compound:9132280|FD-Score:3.26|P-value:5.21E-4

Top fitness defect scores for YBR201W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2539 epi(13)torulosol 6.75 80.0 µM 5.13E-12 2 7.31E-12
2 SGTC_536 3852-0578 4.70 10.6 µM 1.11E-6 14 1.29E-6
3 SGTC_2663 amphotericin b 4.57 100.0 µM 2.11E-6 7 2.42E-6
4 SGTC_2102 5377816 4.54 72.8 µM 2.42E-6 12 2.78E-6
5 SGTC_2582 agaric acid 4.25 100.0 µM 9.61E-6 redox potentiating 288 1.08E-5
6 SGTC_823 0417-1665 4.19 178.0 µM 1.26E-5 33 1.40E-5
7 SGTC_2954 9074818 4.14 52.7 µM 1.58E-5 33 1.76E-5
8 SGTC_2585 alliin 4.07 100.0 µM 2.15E-5 21 2.38E-5
9 SGTC_2309 7664088 4.00 163.9 µM 2.85E-5 27 3.14E-5
10 SGTC_3233 9132340 4.00 49.5 µM 2.87E-5 15 3.17E-5
11 SGTC_2541 muurolladie-3-one 3.99 83.1 µM 2.94E-5 excess fatty acid 25 3.24E-5
12 SGTC_1717 st033143 3.96 58.0 µM 3.44E-5 39 3.78E-5
13 SGTC_2091 4-phenylthiadiazole 3.90 200.0 µM 4.32E-5 16 4.73E-5
14 SGTC_2088 5278280 3.82 127.4 µM 6.03E-5 26 6.57E-5
15 SGTC_2802 7925815 3.81 54.5 µM 6.43E-5 49 7.00E-5
16 SGTC_1903 st060211 3.80 78.3 µM 6.56E-5 33 7.14E-5
17 SGTC_860 0443-0016 3.79 25.1 µM 7.04E-5 36 7.66E-5
18 SGTC_1041 0206-0046 3.68 107.0 µM 1.06E-4 41 1.15E-4
19 SGTC_2270 7924575 3.66 90.9 µM 1.15E-4 RPP1 & pyrimidine depletion 20 1.24E-4
20 SGTC_1219 1469-0211 3.44 33.1 µM 2.76E-4 25 2.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 7.79E-11 YHL028W WSC4 hom ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
0.112 8.29E-11 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.108 3.07E-10 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.107 5.77E-10 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.105 1.26E-9 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.104 1.29E-9 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.103 2.06E-9 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.098 1.15E-8 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.098 1.47E-8 YER072W VTC1 hom Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.093 6.41E-8 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.090 1.92E-7 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.089 2.64E-7 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.089 2.73E-7 YOR304C-A_p YOR304C-A_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck
0.086 6.67E-7 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.085 8.64E-7 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth