YBR202W / MCM7

Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR202W / MCM7

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:-4.61|P-value:1.01E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.60|P-value:1.01E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.58|P-value:1.10E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-4.09|P-value:4.81E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-4.54|P-value:1.26E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-5.90|P-value:9.65E-7 ID:SGTC_302|Compound:1094-0063|FD-Score:-5.13|P-value:1.76E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:4.56|P-value:1.22E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-4.42|P-value:1.82E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.84|P-value:4.90E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.31|P-value:2.63E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.15|P-value:1.70E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.10|P-value:2.01E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.84|P-value:9.82E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:5.09|P-value:2.06E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:8.39|P-value:6.77E-12 ID:SGTC_582|Compound:0987-0078|FD-Score:4.23|P-value:3.32E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-4.55|P-value:1.21E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:9.12|P-value:1.02E-13 ID:SGTC_916|Compound:4466-0038|FD-Score:6.67|P-value:3.84E-8 ID:SGTC_925|Compound:2064-1272|FD-Score:4.60|P-value:1.07E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.25|P-value:3.08E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:5.57|P-value:3.61E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.02|P-value:6.12E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.26|P-value:2.93E-4 ID:SGTC_1665|Compound:st014639|FD-Score:5.81|P-value:1.45E-6 ID:SGTC_1666|Compound:st014829|FD-Score:5.07|P-value:2.23E-5 ID:SGTC_1668|Compound:st014914|FD-Score:5.02|P-value:2.62E-5 ID:SGTC_1671|Compound:st016596|FD-Score:4.77|P-value:6.07E-5 ID:SGTC_1719|Compound:st032227|FD-Score:4.38|P-value:2.12E-4 ID:SGTC_1745|Compound:st081495|FD-Score:8.43|P-value:5.66E-12 ID:SGTC_1838|Compound:st055369|FD-Score:5.35|P-value:8.26E-6 ID:SGTC_1866|Compound:st057638|FD-Score:4.65|P-value:9.08E-5 ID:SGTC_1915|Compound:st067105|FD-Score:8.22|P-value:1.73E-11 ID:SGTC_2008|Compound:4012253|FD-Score:4.14|P-value:4.30E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-4.17|P-value:3.88E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.00|P-value:6.17E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.03|P-value:5.85E-4 ID:SGTC_2136|Compound:5328288|FD-Score:5.36|P-value:7.88E-6 ID:SGTC_2179|Compound:6298986|FD-Score:-4.04|P-value:5.60E-4 ID:SGTC_2192|Compound:5915882|FD-Score:4.14|P-value:4.31E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-4.73|P-value:6.70E-5 ID:SGTC_2367|Compound:9070478|FD-Score:6.33|P-value:1.69E-7 ID:SGTC_2393|Compound:9031399|FD-Score:3.85|P-value:9.60E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.58|P-value:1.14E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.01|P-value:6.16E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:4.02|P-value:5.99E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.87|P-value:9.16E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:6.95|P-value:1.06E-8 ID:SGTC_2533|Compound:agelasine|FD-Score:9.10|P-value:1.11E-13 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:8.14|P-value:2.79E-11 ID:SGTC_2619|Compound:obliquin|FD-Score:13.00|P-value:6.41E-26 ID:SGTC_2671|Compound:danthron|FD-Score:4.24|P-value:3.15E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.30|P-value:2.64E-4 ID:SGTC_3003|Compound:9075612|FD-Score:5.91|P-value:9.79E-7 ID:SGTC_3026|Compound:9090633|FD-Score:6.05|P-value:5.41E-7 ID:SGTC_3086|Compound:9117350|FD-Score:4.53|P-value:1.33E-4 ID:SGTC_3109|Compound:9122853|FD-Score:-5.13|P-value:1.77E-5 ID:SGTC_3114|Compound:9122766|FD-Score:5.22|P-value:1.29E-5 ID:SGTC_3118|Compound:9124250|FD-Score:6.64|P-value:4.44E-8 ID:SGTC_3136|Compound:9095672|FD-Score:4.32|P-value:2.55E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.57|P-value:3.64E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.08|P-value:2.17E-5 ID:SGTC_3331|Compound:9141060|FD-Score:4.35|P-value:2.29E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-4.61|P-value:1.01E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.60|P-value:1.01E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.58|P-value:1.10E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-4.09|P-value:4.81E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-4.54|P-value:1.26E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-5.90|P-value:9.65E-7 ID:SGTC_302|Compound:1094-0063|FD-Score:-5.13|P-value:1.76E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:4.56|P-value:1.22E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-4.42|P-value:1.82E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.84|P-value:4.90E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.31|P-value:2.63E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.15|P-value:1.70E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.10|P-value:2.01E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.84|P-value:9.82E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:5.09|P-value:2.06E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:8.39|P-value:6.77E-12 ID:SGTC_582|Compound:0987-0078|FD-Score:4.23|P-value:3.32E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-4.55|P-value:1.21E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:9.12|P-value:1.02E-13 ID:SGTC_916|Compound:4466-0038|FD-Score:6.67|P-value:3.84E-8 ID:SGTC_925|Compound:2064-1272|FD-Score:4.60|P-value:1.07E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.25|P-value:3.08E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:5.57|P-value:3.61E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.02|P-value:6.12E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.26|P-value:2.93E-4 ID:SGTC_1665|Compound:st014639|FD-Score:5.81|P-value:1.45E-6 ID:SGTC_1666|Compound:st014829|FD-Score:5.07|P-value:2.23E-5 ID:SGTC_1668|Compound:st014914|FD-Score:5.02|P-value:2.62E-5 ID:SGTC_1671|Compound:st016596|FD-Score:4.77|P-value:6.07E-5 ID:SGTC_1719|Compound:st032227|FD-Score:4.38|P-value:2.12E-4 ID:SGTC_1745|Compound:st081495|FD-Score:8.43|P-value:5.66E-12 ID:SGTC_1838|Compound:st055369|FD-Score:5.35|P-value:8.26E-6 ID:SGTC_1866|Compound:st057638|FD-Score:4.65|P-value:9.08E-5 ID:SGTC_1915|Compound:st067105|FD-Score:8.22|P-value:1.73E-11 ID:SGTC_2008|Compound:4012253|FD-Score:4.14|P-value:4.30E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-4.17|P-value:3.88E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.00|P-value:6.17E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.03|P-value:5.85E-4 ID:SGTC_2136|Compound:5328288|FD-Score:5.36|P-value:7.88E-6 ID:SGTC_2179|Compound:6298986|FD-Score:-4.04|P-value:5.60E-4 ID:SGTC_2192|Compound:5915882|FD-Score:4.14|P-value:4.31E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-4.73|P-value:6.70E-5 ID:SGTC_2367|Compound:9070478|FD-Score:6.33|P-value:1.69E-7 ID:SGTC_2393|Compound:9031399|FD-Score:3.85|P-value:9.60E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.58|P-value:1.14E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.01|P-value:6.16E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:4.02|P-value:5.99E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.87|P-value:9.16E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:6.95|P-value:1.06E-8 ID:SGTC_2533|Compound:agelasine|FD-Score:9.10|P-value:1.11E-13 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:8.14|P-value:2.79E-11 ID:SGTC_2619|Compound:obliquin|FD-Score:13.00|P-value:6.41E-26 ID:SGTC_2671|Compound:danthron|FD-Score:4.24|P-value:3.15E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.30|P-value:2.64E-4 ID:SGTC_3003|Compound:9075612|FD-Score:5.91|P-value:9.79E-7 ID:SGTC_3026|Compound:9090633|FD-Score:6.05|P-value:5.41E-7 ID:SGTC_3086|Compound:9117350|FD-Score:4.53|P-value:1.33E-4 ID:SGTC_3109|Compound:9122853|FD-Score:-5.13|P-value:1.77E-5 ID:SGTC_3114|Compound:9122766|FD-Score:5.22|P-value:1.29E-5 ID:SGTC_3118|Compound:9124250|FD-Score:6.64|P-value:4.44E-8 ID:SGTC_3136|Compound:9095672|FD-Score:4.32|P-value:2.55E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.57|P-value:3.64E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.08|P-value:2.17E-5 ID:SGTC_3331|Compound:9141060|FD-Score:4.35|P-value:2.29E-4

Top fitness defect scores for YBR202W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2619 obliquin 13.00 87.9 µM 6.41E-26 cell wall 4 7.57E-39 4.57
2 SGTC_829 1635-0120 9.12 117.0 µM 1.02E-13 DNA damage response 9 3.86E-20 0.23
3 SGTC_2533 agelasine 9.10 13.7 µM 1.11E-13 ERG2 3 4.35E-20 0.56
4 SGTC_1745 st081495 8.43 74.0 µM 5.66E-12 RNA processing & uracil transport 6 1.79E-17 0.09
5 SGTC_580 1123-0028 8.39 41.0 µM 6.77E-12 DNA damage response 3 2.35E-17 1.75
6 SGTC_1915 st067105 8.22 30.6 µM 1.73E-11 RNA pol III & RNase P/MRP 10 9.84E-17 0.31
7 SGTC_2539 epi(13)torulosol 8.14 80.0 µM 2.79E-11 1 2.05E-16 2.48
8 SGTC_2532 xanthone 6.95 78.9 µM 1.06E-8 1 1.77E-12 1.79
9 SGTC_916 4466-0038 6.67 42.0 nM 3.84E-8 cell wall 12 1.27E-11 0.42
10 SGTC_3118 9124250 6.64 49.5 µM 4.44E-8 1 1.58E-11 0.95
11 SGTC_2367 9070478 6.33 135.4 µM 1.69E-7 cell wall 3 1.21E-10 1.37
12 SGTC_3026 9090633 6.05 49.5 µM 5.41E-7 1 7.09E-10 0.69
13 SGTC_3003 9075612 5.91 71.4 µM 9.79E-7 1 1.75E-9 0.69
14 SGTC_1665 st014639 5.81 11.4 µM 1.45E-6 NEO1 3 3.17E-9 1.19
15 SGTC_1363 1636-0063 5.57 10.4 µM 3.61E-6 Golgi 2 1.27E-8 0.64
16 SGTC_3266 9136860 5.57 49.5 µM 3.64E-6 cell wall 6 1.29E-8 0.36
17 SGTC_2136 5328288 5.36 199.3 µM 7.88E-6 4 4.14E-8 0.53
18 SGTC_1838 st055369 5.35 84.5 µM 8.26E-6 2 4.45E-8 0.98
19 SGTC_3114 9122766 5.22 49.5 µM 1.29E-5 1 8.72E-8 0.79
20 SGTC_453 enantio-paf c16 5.15 10.0 µM 1.70E-5 8 1.33E-7 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.245 6.10E-47 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.243 2.31E-46 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.224 2.33E-39 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.205 2.83E-33 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.201 5.82E-32 YBR196C PGI1 het Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation
0.185 3.04E-27 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.174 3.57E-24 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.173 5.03E-24 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.172 1.19E-23 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.170 4.27E-23 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.169 5.59E-23 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.167 2.64E-22 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.166 3.69E-22 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.166 4.20E-22 YPL066W RGL1 hom Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.164 1.43E-21 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes