YBR203W / COS111

Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR203W / COS111

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:-3.47|P-value:4.66E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.82|P-value:2.57E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.67|P-value:4.25E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:4.54|P-value:1.68E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.72|P-value:3.57E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:5.62|P-value:1.29E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.29|P-value:8.35E-4 ID:SGTC_482|Compound:fipronil|FD-Score:4.06|P-value:1.08E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.42|P-value:9.38E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.01|P-value:1.31E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.43|P-value:9.13E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.43|P-value:9.16E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:5.76|P-value:6.42E-8 ID:SGTC_1277|Compound:0873-0036|FD-Score:5.50|P-value:2.28E-7 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.83|P-value:2.48E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.48|P-value:7.88E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.71|P-value:3.73E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:5.76|P-value:6.15E-8 ID:SGTC_1578|Compound:josamycin|FD-Score:3.42|P-value:9.39E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.65|P-value:4.53E-4 ID:SGTC_1677|Compound:st019204|FD-Score:4.32|P-value:3.97E-5 ID:SGTC_1695|Compound:st026914|FD-Score:-3.25|P-value:9.48E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.54|P-value:6.44E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.01|P-value:6.71E-5 ID:SGTC_1780|Compound:st038448|FD-Score:3.54|P-value:6.50E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.25|P-value:9.29E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.65|P-value:4.55E-4 ID:SGTC_2001|Compound:4023502|FD-Score:5.84|P-value:4.26E-8 ID:SGTC_2004|Compound:4023728|FD-Score:-4.34|P-value:1.83E-5 ID:SGTC_2007|Compound:4011539|FD-Score:4.99|P-value:2.49E-6 ID:SGTC_2017|Compound:5132927|FD-Score:6.91|P-value:1.04E-10 ID:SGTC_2168|Compound:5727979|FD-Score:4.51|P-value:1.87E-5 ID:SGTC_2237|Compound:6667747|FD-Score:-4.18|P-value:3.53E-5 ID:SGTC_2263|Compound:7948595|FD-Score:-3.36|P-value:6.52E-4 ID:SGTC_2264|Compound:7948757|FD-Score:4.53|P-value:1.71E-5 ID:SGTC_2346|Compound:9031566|FD-Score:-3.34|P-value:6.95E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.36|P-value:6.57E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.50|P-value:7.34E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.51|P-value:7.13E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.39|P-value:3.01E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.41|P-value:9.80E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:5.28|P-value:6.53E-7 ID:SGTC_2698|Compound:st077697|FD-Score:5.73|P-value:7.25E-8 ID:SGTC_2905|Compound:7799065|FD-Score:3.53|P-value:6.61E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.32|P-value:7.41E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.53|P-value:1.78E-5 ID:SGTC_3292|Compound:9120825|FD-Score:-3.28|P-value:8.59E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:-3.47|P-value:4.66E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.82|P-value:2.57E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.67|P-value:4.25E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:4.54|P-value:1.68E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.72|P-value:3.57E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:5.62|P-value:1.29E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.29|P-value:8.35E-4 ID:SGTC_482|Compound:fipronil|FD-Score:4.06|P-value:1.08E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.42|P-value:9.38E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.01|P-value:1.31E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.43|P-value:9.13E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.43|P-value:9.16E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:5.76|P-value:6.42E-8 ID:SGTC_1277|Compound:0873-0036|FD-Score:5.50|P-value:2.28E-7 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.83|P-value:2.48E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.48|P-value:7.88E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.71|P-value:3.73E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:5.76|P-value:6.15E-8 ID:SGTC_1578|Compound:josamycin|FD-Score:3.42|P-value:9.39E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.65|P-value:4.53E-4 ID:SGTC_1677|Compound:st019204|FD-Score:4.32|P-value:3.97E-5 ID:SGTC_1695|Compound:st026914|FD-Score:-3.25|P-value:9.48E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.54|P-value:6.44E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.01|P-value:6.71E-5 ID:SGTC_1780|Compound:st038448|FD-Score:3.54|P-value:6.50E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.25|P-value:9.29E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.65|P-value:4.55E-4 ID:SGTC_2001|Compound:4023502|FD-Score:5.84|P-value:4.26E-8 ID:SGTC_2004|Compound:4023728|FD-Score:-4.34|P-value:1.83E-5 ID:SGTC_2007|Compound:4011539|FD-Score:4.99|P-value:2.49E-6 ID:SGTC_2017|Compound:5132927|FD-Score:6.91|P-value:1.04E-10 ID:SGTC_2168|Compound:5727979|FD-Score:4.51|P-value:1.87E-5 ID:SGTC_2237|Compound:6667747|FD-Score:-4.18|P-value:3.53E-5 ID:SGTC_2263|Compound:7948595|FD-Score:-3.36|P-value:6.52E-4 ID:SGTC_2264|Compound:7948757|FD-Score:4.53|P-value:1.71E-5 ID:SGTC_2346|Compound:9031566|FD-Score:-3.34|P-value:6.95E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.36|P-value:6.57E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.50|P-value:7.34E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.51|P-value:7.13E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.39|P-value:3.01E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.41|P-value:9.80E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:5.28|P-value:6.53E-7 ID:SGTC_2698|Compound:st077697|FD-Score:5.73|P-value:7.25E-8 ID:SGTC_2905|Compound:7799065|FD-Score:3.53|P-value:6.61E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.32|P-value:7.41E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.53|P-value:1.78E-5 ID:SGTC_3292|Compound:9120825|FD-Score:-3.28|P-value:8.59E-4

Top fitness defect scores for YBR203W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2017 5132927 6.91 60.6 µM 1.04E-10 3 2.45E-12
2 SGTC_2001 4023502 5.84 57.7 µM 4.26E-8 mitochondrial processes 2 2.67E-9
3 SGTC_1529 apigenin 5.76 74.0 µM 6.15E-8 7 4.09E-9
4 SGTC_1156 4092-0367 5.76 4.9 µM 6.42E-8 3 4.30E-9
5 SGTC_2698 st077697 5.73 67.5 µM 7.25E-8 4 4.96E-9
6 SGTC_350 k064-0020 5.62 19.8 µM 1.29E-7 heme requiring 7 9.70E-9
7 SGTC_1277 0873-0036 5.50 22.0 µM 2.28E-7 PDR1 11 1.88E-8
8 SGTC_2677 mitomycin C 5.28 100.0 µM 6.53E-7 DNA damage response 7 6.41E-8
9 SGTC_2007 4011539 4.99 71.8 µM 2.49E-6 cell wall signaling 34 3.05E-7
10 SGTC_259 usnic acid 4.54 108.9 µM 1.68E-5 9 2.83E-6
11 SGTC_2264 7948757 4.53 110.8 µM 1.71E-5 7 2.89E-6
12 SGTC_2962 9082311 4.53 13.2 µM 1.78E-5 8 3.02E-6
13 SGTC_2168 5727979 4.51 200.0 µM 1.87E-5 10 3.20E-6
14 SGTC_2630 antimycin a 4.39 100.0 µM 3.01E-5 mitochondrial processes 26 5.56E-6
15 SGTC_1677 st019204 4.32 53.9 µM 3.97E-5 9 7.69E-6
16 SGTC_482 fipronil 4.06 114.0 µM 1.08E-4 2 2.48E-5
17 SGTC_786 4544-0069 4.01 423.0 µM 1.31E-4 22 3.10E-5
18 SGTC_1283 0922-0125 3.83 16.4 µM 2.48E-4 26 6.50E-5
19 SGTC_126 0417-1624 3.82 672.5 µM 2.57E-4 DNA intercalators 37 6.78E-5
20 SGTC_347 4534-1311 3.72 26.2 µM 3.57E-4 RPP1 & pyrimidine depletion 15 9.98E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.05E-12 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.106 8.09E-10 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.093 7.00E-8 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.092 8.63E-8 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.089 2.20E-7 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.089 2.80E-7 YBR047W_p FMP23_p hom Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.088 3.58E-7 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.087 4.21E-7 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.083 1.55E-6 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.082 1.93E-6 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.082 2.19E-6 YDR535C_d YDR535C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
0.081 2.47E-6 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.081 2.97E-6 YOR121C_d YOR121C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
0.080 3.49E-6 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 5.11E-6 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64