YBR206W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR206W / YBR206W

Click on Significant Values for Screen Details ID:SGTC_152|Compound:4469-0003|FD-Score:3.67|P-value:3.02E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.96|P-value:1.08E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.58|P-value:4.75E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:-3.44|P-value:7.41E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:6.00|P-value:1.07E-8 ID:SGTC_853|Compound:0419-0306|FD-Score:3.36|P-value:8.37E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.78|P-value:2.08E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.96|P-value:1.09E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.76|P-value:2.22E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.40|P-value:1.97E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.68|P-value:2.97E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.82|P-value:1.80E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.47|P-value:6.64E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.86|P-value:1.53E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.45|P-value:6.39E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.36|P-value:8.50E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.37|P-value:8.21E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.70|P-value:5.83E-6 ID:SGTC_1709|Compound:st033179|FD-Score:3.90|P-value:1.32E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.78|P-value:2.04E-4 ID:SGTC_1886|Compound:st057356|FD-Score:4.06|P-value:7.48E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.41|P-value:7.18E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.97|P-value:1.03E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.08|P-value:6.82E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.40|P-value:7.39E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.35|P-value:8.68E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-4.85|P-value:3.60E-6 ID:SGTC_2482|Compound:5981709|FD-Score:-5.06|P-value:1.43E-6 ID:SGTC_2484|Compound:5809818|FD-Score:-5.54|P-value:1.44E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.05|P-value:7.61E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.50|P-value:5.41E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:5.12|P-value:9.07E-7 ID:SGTC_2798|Compound:7813637|FD-Score:3.64|P-value:3.38E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.74|P-value:2.34E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.94|P-value:1.35E-4 ID:SGTC_2941|Compound:9056145|FD-Score:3.54|P-value:4.67E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.42|P-value:7.78E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.39|P-value:7.56E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.67|P-value:3.02E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.96|P-value:1.08E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.58|P-value:4.75E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:-3.44|P-value:7.41E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:6.00|P-value:1.07E-8 ID:SGTC_853|Compound:0419-0306|FD-Score:3.36|P-value:8.37E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.78|P-value:2.08E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.96|P-value:1.09E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.76|P-value:2.22E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.40|P-value:1.97E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.68|P-value:2.97E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.82|P-value:1.80E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.47|P-value:6.64E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.86|P-value:1.53E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.45|P-value:6.39E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.36|P-value:8.50E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.37|P-value:8.21E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.70|P-value:5.83E-6 ID:SGTC_1709|Compound:st033179|FD-Score:3.90|P-value:1.32E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.78|P-value:2.04E-4 ID:SGTC_1886|Compound:st057356|FD-Score:4.06|P-value:7.48E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.41|P-value:7.18E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.97|P-value:1.03E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.08|P-value:6.82E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.40|P-value:7.39E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.35|P-value:8.68E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-4.85|P-value:3.60E-6 ID:SGTC_2482|Compound:5981709|FD-Score:-5.06|P-value:1.43E-6 ID:SGTC_2484|Compound:5809818|FD-Score:-5.54|P-value:1.44E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.05|P-value:7.61E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.50|P-value:5.41E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:5.12|P-value:9.07E-7 ID:SGTC_2798|Compound:7813637|FD-Score:3.64|P-value:3.38E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.74|P-value:2.34E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.94|P-value:1.35E-4 ID:SGTC_2941|Compound:9056145|FD-Score:3.54|P-value:4.67E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.42|P-value:7.78E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.39|P-value:7.56E-4

Top fitness defect scores for YBR206W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_711 k292-0785 6.00 179.0 µM 1.07E-8 DNA intercalators 3 9.58E-10
2 SGTC_2588 indole-3-carbinol 5.12 100.0 µM 9.07E-7 16 1.57E-7
3 SGTC_1604 st002052 4.70 72.4 µM 5.83E-6 TSC3-RPN4 14 1.32E-6
4 SGTC_1167 k781-0610 4.40 148.0 µM 1.97E-5 RNA processing & uracil transport 16 5.33E-6
5 SGTC_2310 7668677 4.08 200.0 µM 6.82E-5 27 2.21E-5
6 SGTC_1886 st057356 4.06 49.9 µM 7.48E-5 60S ribosome export 17 2.46E-5
7 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.05 100.0 µM 7.61E-5 21 2.51E-5
8 SGTC_1901 st060216 3.97 58.6 µM 1.03E-4 23 3.55E-5
9 SGTC_271 rotenone 3.96 740.0 µM 1.08E-4 23 3.74E-5
10 SGTC_1017 4239-0030 3.96 168.0 µM 1.09E-4 26 3.77E-5
11 SGTC_1709 st033179 3.90 39.1 µM 1.32E-4 15 4.73E-5
12 SGTC_1327 1436-0082 3.86 2.2 µM 1.53E-4 23 5.58E-5
13 SGTC_1270 0831-1170 3.82 17.3 µM 1.80E-4 12 6.70E-5
14 SGTC_1762 st045503 3.78 25.5 µM 2.04E-4 31 7.74E-5
15 SGTC_914 3820-6779 3.78 408.0 µM 2.08E-4 30 7.93E-5
16 SGTC_1155 4088-0394 3.76 48.2 µM 2.22E-4 34 8.53E-5
17 SGTC_2805 7950783 3.74 58.4 µM 2.34E-4 37 9.05E-5
18 SGTC_1263 0774-1208 3.68 64.8 µM 2.97E-4 56 1.19E-4
19 SGTC_152 4469-0003 3.67 551.2 µM 3.02E-4 29 1.21E-4
20 SGTC_2798 7813637 3.64 45.5 µM 3.38E-4 43 1.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 1.74E-8 YDL064W UBC9 het SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
0.092 9.20E-8 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.082 1.76E-6 YJR107W_p YJR107W_p hom Putative lipase
0.082 1.94E-6 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.079 4.59E-6 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.078 5.96E-6 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.075 1.39E-5 YLR299W ECM38 hom Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
0.072 2.93E-5 YOL043C NTG2 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication
0.072 3.26E-5 YNL261W ORC5 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.071 3.76E-5 YNL087W TCB2 hom ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud
0.068 8.37E-5 YBR136W MEC1 het Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres
0.067 1.01E-4 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
0.066 1.23E-4 YJR083C ACF4 hom Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.065 1.68E-4 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.063 2.34E-4 YOR134W BAG7 hom Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p