YBR208C / DUR1,2

Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR208C / DUR1,2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:9.07|P-value:1.30E-22 ID:SGTC_68|Compound:0986-0284|FD-Score:4.84|P-value:1.09E-7 ID:SGTC_144|Compound:4161-2749|FD-Score:-2.92|P-value:8.41E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:2.89|P-value:9.99E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.14|P-value:3.64E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.31|P-value:1.88E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.35|P-value:1.47E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:3.05|P-value:5.45E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:2.90|P-value:9.54E-4 ID:SGTC_433|Compound:pimozide|FD-Score:2.91|P-value:9.39E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.55|P-value:7.41E-5 ID:SGTC_482|Compound:fipronil|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.60|P-value:5.98E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:-4.99|P-value:4.09E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:4.27|P-value:2.45E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:3.60|P-value:5.76E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.10|P-value:4.65E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:3.62|P-value:5.26E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.60|P-value:5.84E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.31|P-value:2.01E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.12|P-value:3.87E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.51|P-value:1.75E-9 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.59|P-value:6.14E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.14|P-value:4.30E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:-2.99|P-value:6.54E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.68|P-value:4.02E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-2.91|P-value:8.69E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.59|P-value:6.15E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.43|P-value:1.23E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.15|P-value:3.79E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.62|P-value:5.27E-5 ID:SGTC_2309|Compound:7664088|FD-Score:2.95|P-value:8.05E-4 ID:SGTC_2313|Compound:7726885|FD-Score:2.99|P-value:6.82E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.70|P-value:3.68E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.12|P-value:4.16E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.36|P-value:1.51E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:5.24|P-value:9.90E-9 ID:SGTC_2570|Compound:licareol|FD-Score:-5.64|P-value:6.71E-10 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.62|P-value:4.98E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.04|P-value:5.80E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.95|P-value:1.20E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.03|P-value:5.87E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.16|P-value:3.58E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.23|P-value:1.07E-8 ID:SGTC_2981|Compound:9013952|FD-Score:-3.22|P-value:2.67E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-4.21|P-value:3.00E-6 ID:SGTC_2993|Compound:9054257|FD-Score:5.73|P-value:4.17E-10 ID:SGTC_3018|Compound:9082602|FD-Score:-2.90|P-value:9.04E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.01|P-value:6.49E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-3.09|P-value:4.41E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.86|P-value:1.78E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-3.60|P-value:5.35E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.78|P-value:2.61E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.28|P-value:2.07E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.49|P-value:8.76E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.34|P-value:1.75E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.21|P-value:2.97E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.11|P-value:4.32E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.07|P-value:1.30E-22 ID:SGTC_68|Compound:0986-0284|FD-Score:4.84|P-value:1.09E-7 ID:SGTC_144|Compound:4161-2749|FD-Score:-2.92|P-value:8.41E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:2.89|P-value:9.99E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.14|P-value:3.64E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.31|P-value:1.88E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.35|P-value:1.47E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:3.05|P-value:5.45E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:2.90|P-value:9.54E-4 ID:SGTC_433|Compound:pimozide|FD-Score:2.91|P-value:9.39E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.55|P-value:7.41E-5 ID:SGTC_482|Compound:fipronil|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.60|P-value:5.98E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:-4.99|P-value:4.09E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:4.27|P-value:2.45E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:3.60|P-value:5.76E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.10|P-value:4.65E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:3.62|P-value:5.26E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.60|P-value:5.84E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.31|P-value:2.01E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.12|P-value:3.87E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.51|P-value:1.75E-9 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.59|P-value:6.14E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.14|P-value:4.30E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:-2.99|P-value:6.54E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.68|P-value:4.02E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-2.91|P-value:8.69E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.59|P-value:6.15E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.43|P-value:1.23E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.15|P-value:3.79E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.62|P-value:5.27E-5 ID:SGTC_2309|Compound:7664088|FD-Score:2.95|P-value:8.05E-4 ID:SGTC_2313|Compound:7726885|FD-Score:2.99|P-value:6.82E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.70|P-value:3.68E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.12|P-value:4.16E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.36|P-value:1.51E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:5.24|P-value:9.90E-9 ID:SGTC_2570|Compound:licareol|FD-Score:-5.64|P-value:6.71E-10 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.62|P-value:4.98E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.04|P-value:5.80E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.95|P-value:1.20E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.03|P-value:5.87E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.16|P-value:3.58E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.23|P-value:1.07E-8 ID:SGTC_2981|Compound:9013952|FD-Score:-3.22|P-value:2.67E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-4.21|P-value:3.00E-6 ID:SGTC_2993|Compound:9054257|FD-Score:5.73|P-value:4.17E-10 ID:SGTC_3018|Compound:9082602|FD-Score:-2.90|P-value:9.04E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.01|P-value:6.49E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-3.09|P-value:4.41E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.86|P-value:1.78E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-3.60|P-value:5.35E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.78|P-value:2.61E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.28|P-value:2.07E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.49|P-value:8.76E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.34|P-value:1.75E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.21|P-value:2.97E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.11|P-value:4.32E-4

Top fitness defect scores for YBR208C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 9.07 9.0 µM 1.30E-22 cell wall 94 6.21E-20
2 SGTC_2993 9054257 5.73 71.4 µM 4.17E-10 fatty acid desaturase (OLE1) 19 4.99E-9
3 SGTC_1133 3473-0247 5.51 50.0 µM 1.75E-9 RSC complex & mRNA processing 13 1.75E-8
4 SGTC_2568 diosmetin 5.24 100.0 µM 9.90E-9 6 7.94E-8
5 SGTC_2896 9052656 5.23 71.4 µM 1.07E-8 endomembrane recycling 50 8.48E-8
6 SGTC_68 0986-0284 4.84 82.8 µM 1.09E-7 38 6.45E-7
7 SGTC_528 3492-0019 4.27 172.0 µM 2.45E-6 calcium & mitochondrial duress 193 9.85E-6
8 SGTC_2801 7907800 3.95 81.8 µM 1.20E-5 27 3.97E-5
9 SGTC_3130 9127414 3.86 49.5 µM 1.78E-5 22 5.61E-5
10 SGTC_3146 9095609 3.78 49.5 µM 2.61E-5 18 7.84E-5
11 SGTC_2516 gossypol 3.70 71.5 µM 3.68E-5 16 1.06E-4
12 SGTC_1584 6-fluoro-dl-tryptophan 3.68 90.0 µM 4.02E-5 mitochondrial processes 21 1.14E-4
13 SGTC_714 4296-0578 3.62 26.1 µM 5.26E-5 4 1.45E-4
14 SGTC_2188 6126565 3.62 140.7 µM 5.27E-5 mitochondrial processes 17 1.45E-4
15 SGTC_539 4859-0462 3.60 2.5 µM 5.76E-5 RNA pol III & RNase P/MRP 37 1.57E-4
16 SGTC_827 3253-0474 3.60 693.0 µM 5.84E-5 28 1.59E-4
17 SGTC_486 niguldipine 3.60 82.0 µM 5.98E-5 amide catabolism 23 1.62E-4
18 SGTC_1427 4048-4900 3.59 550.0 nM 6.14E-5 35 1.66E-4
19 SGTC_1870 st057514 3.59 26.5 µM 6.15E-5 RSC & ERG11 36 1.66E-4
20 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.55 8.0 µM 7.41E-5 39 1.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.216 1.32E-36 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.199 2.11E-31 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.199 2.21E-31 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.192 3.58E-29 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.188 3.71E-28 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.187 8.00E-28 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.187 9.02E-28 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.184 5.34E-27 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.184 6.56E-27 YOR034C-A_p YOR034C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.179 1.49E-25 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.179 1.52E-25 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.176 7.89E-25 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.173 4.43E-24 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.172 9.64E-24 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.172 1.06E-23 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated