YBR214W / SDS24

Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR214W / SDS24

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:3.26|P-value:5.55E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.71|P-value:9.94E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.85|P-value:6.05E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:4.61|P-value:1.95E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:3.52|P-value:2.08E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.25|P-value:5.62E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.37|P-value:3.66E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.15|P-value:8.09E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.57|P-value:1.71E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.79|P-value:7.29E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.44|P-value:2.94E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.11|P-value:9.28E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.47|P-value:3.78E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.27|P-value:5.31E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.95|P-value:3.63E-7 ID:SGTC_1770|Compound:st043884|FD-Score:3.71|P-value:1.01E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.27|P-value:5.35E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.18|P-value:1.43E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-3.66|P-value:1.27E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.72|P-value:9.67E-5 ID:SGTC_2345|Compound:9052315|FD-Score:6.45|P-value:5.11E-11 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.57|P-value:1.75E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.90|P-value:1.75E-9 ID:SGTC_2961|Compound:9083290|FD-Score:-4.28|P-value:9.18E-6 ID:SGTC_3010|Compound:9080089|FD-Score:3.16|P-value:7.86E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.28|P-value:5.14E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.19|P-value:7.06E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.26|P-value:5.55E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.71|P-value:9.94E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.85|P-value:6.05E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:4.61|P-value:1.95E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:3.52|P-value:2.08E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.25|P-value:5.62E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.37|P-value:3.66E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.15|P-value:8.09E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.57|P-value:1.71E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.79|P-value:7.29E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.44|P-value:2.94E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.11|P-value:9.28E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.47|P-value:3.78E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.27|P-value:5.31E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.95|P-value:3.63E-7 ID:SGTC_1770|Compound:st043884|FD-Score:3.71|P-value:1.01E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.27|P-value:5.35E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.18|P-value:1.43E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-3.66|P-value:1.27E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.72|P-value:9.67E-5 ID:SGTC_2345|Compound:9052315|FD-Score:6.45|P-value:5.11E-11 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.57|P-value:1.75E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.90|P-value:1.75E-9 ID:SGTC_2961|Compound:9083290|FD-Score:-4.28|P-value:9.18E-6 ID:SGTC_3010|Compound:9080089|FD-Score:3.16|P-value:7.86E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.28|P-value:5.14E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.19|P-value:7.06E-4

Top fitness defect scores for YBR214W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2345 9052315 6.45 157.4 µM 5.11E-11 4 5.42E-11
2 SGTC_2814 7977482 5.90 43.0 µM 1.75E-9 8 1.84E-9
3 SGTC_1738 st035555 4.95 74.0 µM 3.63E-7 TSC3-RPN4 15 3.77E-7
4 SGTC_143 4032-1194 4.85 15.7 µM 6.05E-7 34 6.28E-7
5 SGTC_145 3737-0113 4.61 38.4 µM 1.95E-6 DNA intercalators 54 2.02E-6
6 SGTC_2167 5876490 4.18 200.0 µM 1.43E-5 25 1.47E-5
7 SGTC_990 3985-0011 3.79 41.3 µM 7.29E-5 amide catabolism 25 7.47E-5
8 SGTC_2292 7671323 3.72 168.1 µM 9.67E-5 RNA processing & uracil transport 41 9.91E-5
9 SGTC_113 0099-0221 3.71 2.5 µM 9.94E-5 31 1.02E-4
10 SGTC_1770 st043884 3.71 66.3 µM 1.01E-4 17 1.04E-4
11 SGTC_2786 7743617 3.71 45.5 µM 1.02E-4 34 1.04E-4
12 SGTC_922 1866-0035 3.57 480.0 µM 1.71E-4 excess fatty acid 78 1.75E-4
13 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.57 63.6 µM 1.75E-4 57 1.79E-4
14 SGTC_535 2293-4129 3.52 48.2 µM 2.08E-4 NEO1 82 2.13E-4
15 SGTC_648 0375-0473 3.37 33.3 µM 3.66E-4 33 3.74E-4
16 SGTC_3225 9130819 3.28 49.5 µM 5.14E-4 amide catabolism 49 5.25E-4
17 SGTC_86 0417-1630 3.26 471.9 µM 5.55E-4 ubiquinone biosynthesis & proteasome 200 5.66E-4
18 SGTC_619 1652-1634 3.25 108.0 µM 5.62E-4 PDR1 47 5.74E-4
19 SGTC_3010 9080089 3.16 71.4 µM 7.86E-4 49 8.01E-4
20 SGTC_732 3970-1727 3.15 52.7 µM 8.09E-4 28 8.25E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 1.98E-26 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.161 5.06E-21 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.144 6.42E-17 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.142 1.61E-16 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.138 9.80E-16 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.130 5.12E-14 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.129 7.71E-14 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.123 8.45E-13 YDL095W PMT1 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.121 1.83E-12 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.121 2.16E-12 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.120 3.23E-12 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.119 4.07E-12 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.117 1.07E-11 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.112 9.31E-11 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.109 2.77E-10 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data