YBR219C_p

Putative protein of unknown function; YBR219C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR219C / YBR219C

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-4.29|P-value:3.92E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:3.37|P-value:2.50E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.54|P-value:1.29E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:4.59|P-value:1.05E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:3.65|P-value:8.29E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.00|P-value:9.85E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.31|P-value:3.12E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.21|P-value:4.69E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.50|P-value:1.34E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.28|P-value:3.49E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.56|P-value:1.20E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-4.54|P-value:1.19E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.00|P-value:8.69E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.66|P-value:8.01E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.09|P-value:7.23E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.67|P-value:6.74E-5 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.46|P-value:1.77E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.14|P-value:5.94E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.47|P-value:1.72E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.72|P-value:5.38E-5 ID:SGTC_1998|Compound:st075797|FD-Score:4.74|P-value:4.84E-7 ID:SGTC_2142|Compound:5622915|FD-Score:3.05|P-value:8.15E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.14|P-value:5.96E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.24|P-value:3.63E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.67|P-value:7.44E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.35|P-value:2.70E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.30|P-value:3.28E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.11|P-value:1.07E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.05|P-value:1.27E-5 ID:SGTC_2412|Compound:st077135|FD-Score:4.66|P-value:7.31E-7 ID:SGTC_2415|Compound:st077333|FD-Score:3.28|P-value:3.54E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.71|P-value:6.28E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.35|P-value:2.68E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.10|P-value:6.79E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.17|P-value:5.27E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.30|P-value:2.99E-4 ID:SGTC_3172|Compound:9105863|FD-Score:3.21|P-value:4.63E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.60|P-value:9.98E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.54|P-value:1.31E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.29|P-value:3.06E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.51|P-value:1.44E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.37|P-value:2.50E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.16|P-value:4.99E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.09|P-value:6.50E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.09|P-value:1.19E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.29|P-value:3.92E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:3.37|P-value:2.50E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.54|P-value:1.29E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:4.59|P-value:1.05E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:3.65|P-value:8.29E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.00|P-value:9.85E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.31|P-value:3.12E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.21|P-value:4.69E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.50|P-value:1.34E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.28|P-value:3.49E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.56|P-value:1.20E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-4.54|P-value:1.19E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.00|P-value:8.69E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.66|P-value:8.01E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.09|P-value:7.23E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.67|P-value:6.74E-5 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.46|P-value:1.77E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.14|P-value:5.94E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.47|P-value:1.72E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.72|P-value:5.38E-5 ID:SGTC_1998|Compound:st075797|FD-Score:4.74|P-value:4.84E-7 ID:SGTC_2142|Compound:5622915|FD-Score:3.05|P-value:8.15E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.14|P-value:5.96E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.24|P-value:3.63E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.67|P-value:7.44E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.35|P-value:2.70E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.30|P-value:3.28E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.11|P-value:1.07E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.05|P-value:1.27E-5 ID:SGTC_2412|Compound:st077135|FD-Score:4.66|P-value:7.31E-7 ID:SGTC_2415|Compound:st077333|FD-Score:3.28|P-value:3.54E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.71|P-value:6.28E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.35|P-value:2.68E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.10|P-value:6.79E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.17|P-value:5.27E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.30|P-value:2.99E-4 ID:SGTC_3172|Compound:9105863|FD-Score:3.21|P-value:4.63E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.60|P-value:9.98E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.54|P-value:1.31E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.29|P-value:3.06E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.51|P-value:1.44E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.37|P-value:2.50E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.16|P-value:4.99E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.09|P-value:6.50E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.09|P-value:1.19E-5

Top fitness defect scores for YBR219C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1998 st075797 4.74 76.8 µM 4.84E-7 mitochondrial response to ROS 6 1.08E-6
2 SGTC_2412 st077135 4.66 33.4 µM 7.31E-7 10 1.58E-6
3 SGTC_213 1246-0773 4.59 967.0 nM 1.05E-6 12 2.22E-6
4 SGTC_2370 9071495 4.11 200.0 µM 1.07E-5 mitochondrial processes 25 1.96E-5
5 SGTC_3323 9138564 4.09 53.9 µM 1.19E-5 19 2.16E-5
6 SGTC_2416 tofa 3.71 880.0 nM 6.28E-5 sphingolipid biosynthesis & PDR1 60 1.02E-4
7 SGTC_2240 6690706 3.67 185.9 µM 7.44E-5 22 1.20E-4
8 SGTC_1236 0330-0013 3.66 258.0 µM 8.01E-5 20 1.29E-4
9 SGTC_377 3970-0964 3.65 33.1 µM 8.29E-5 50 1.33E-4
10 SGTC_3173 9105693 3.60 49.5 µM 9.98E-5 34 1.58E-4
11 SGTC_1018 4259-0013 3.56 28.1 µM 1.20E-4 36 1.88E-4
12 SGTC_163 1327-0036 3.54 7.5 µM 1.29E-4 138 2.01E-4
13 SGTC_3181 9108277 3.54 49.5 µM 1.31E-4 iron homeostasis 30 2.04E-4
14 SGTC_3282 9108498 3.51 15.5 µM 1.44E-4 43 2.22E-4
15 SGTC_1888 azatryptophan 3.47 97.5 µM 1.72E-4 30 2.63E-4
16 SGTC_1497 4476-2978 3.46 41.3 µM 1.77E-4 24 2.71E-4
17 SGTC_3305 9127027 3.37 53.8 µM 2.50E-4 35 3.74E-4
18 SGTC_68 0986-0284 3.37 82.8 µM 2.50E-4 100 3.74E-4
19 SGTC_2756 carbadox 3.35 75.1 µM 2.68E-4 81 3.99E-4
20 SGTC_2352 9027995 3.35 87.8 µM 2.70E-4 tubulin folding & SWR complex 46 4.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.87E-20 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.113 4.86E-11 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.098 1.46E-8 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.093 6.31E-8 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.092 8.77E-8 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.090 1.59E-7 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.090 1.60E-7 YAL067W-A_p YAL067W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.085 7.47E-7 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.080 3.17E-6 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.079 4.25E-6 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.079 4.29E-6 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.079 4.53E-6 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.079 4.83E-6 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.079 5.18E-6 YBR172C SMY2 hom Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication
0.078 6.94E-6 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity