HIPHOP chemogenomics database
YBR221C / PDB1 
E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YBR221C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.285 | 1.69E-63 | YER052C | HOM3 | hom | Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis |
| 0.251 | 2.48E-49 | YCR053W | THR4 | hom | Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway |
| 0.245 | 3.72E-47 | YNL071W | LAT1 | hom | Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA |
| 0.245 | 5.24E-47 | YER061C | CEM1 | hom | Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration |
| 0.236 | 1.49E-43 | YBR068C | BAP2 | hom | High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication |
| 0.213 | 1.31E-35 | YFL018C | LPD1 | hom | Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes |
| 0.180 | 6.53E-26 | YPL160W | CDC60 | het | Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA |
| 0.178 | 3.56E-25 | YNL215W | IES2 | hom | Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress |
| 0.177 | 4.60E-25 | YHR067W | HTD2 | hom | Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology |
| 0.164 | 1.11E-21 | YHR025W | THR1 | hom | Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway |
| 0.161 | 9.19E-21 | YJR139C | HOM6 | hom | Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions |
| 0.158 | 3.84E-20 | YLR239C | LIP2 | hom | Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups |
| 0.154 | 3.32E-19 | YMR207C | HFA1 | hom | Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress |
| 0.144 | 5.35E-17 | YDL002C | NHP10 | hom | Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair |
| 0.128 | 1.20E-13 | YLR207W | HRD3 | hom | Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events |