HIPHOP chemogenomics database

YBR221W-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR221W-A / YBR221W-A

Click on Significant Values for Screen Details

Top fitness defect scores for YBR221W-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_522	1273-0010	5.45	11.6 µM	4.19E-9	60S ribosome export	6	2.50E-8
2	SGTC_236	1509-0011	4.81	5.3 µM	1.84E-7		336	7.42E-7
3	SGTC_297	0986-0032	4.65	24.0 µM	4.43E-7	60S ribosome export	2	1.63E-6
4	SGTC_2424	5537928	4.61	59.2 µM	5.49E-7		23	1.97E-6
5	SGTC_294	k038-0071	4.38	157.0 µM	1.88E-6	ubiquinone biosynthesis & proteasome	43	5.94E-6
6	SGTC_1996	st072960	4.26	66.8 µM	3.40E-6		9	1.01E-5
7	SGTC_2809	7964133	4.25	13.0 µM	3.55E-6	60S ribosome export	26	1.05E-5
8	SGTC_292	k038-0015	4.20	474.0 µM	4.70E-6		3	1.36E-5
9	SGTC_2139	5578692	4.18	56.5 µM	5.10E-6	superoxide	13	1.46E-5
10	SGTC_402	epigallocatechin gallate	4.12	10.0 µM	6.79E-6		21	1.88E-5
11	SGTC_1979	st071809	4.08	45.3 µM	8.39E-6	RPP1 & pyrimidine depletion	10	2.28E-5
12	SGTC_1823	3-hydroxy-2-naphthoic acid	3.82	106.0 µM	2.75E-5		18	6.63E-5
13	SGTC_1938	st074717	3.74	56.4 µM	4.01E-5		16	9.28E-5
14	SGTC_1918	oxolan-2-ylmethyl 3-bromobenzoate	3.73	70.1 µM	4.06E-5		35	9.39E-5
15	SGTC_938	3126-1755	3.73	342.0 µM	4.09E-5		16	9.46E-5
16	SGTC_2088	5278280	3.73	127.4 µM	4.23E-5		31	9.74E-5
17	SGTC_1525	8-methoxypsoralen	3.73	92.5 µM	4.23E-5	DNA damage response	38	9.75E-5
18	SGTC_1670	st016595	3.58	4.0 µM	7.83E-5		16	1.70E-4
19	SGTC_933	2914-0560	3.55	114.0 µM	8.97E-5		35	1.92E-4
20	SGTC_1191	1487-1166	3.54	10.6 µM	9.43E-5	azole & statin	44	2.00E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.236	8.17E-44	YDL157C_p	YDL157C_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.224	1.68E-39	YGR072W	UPF3	hom	Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.208	3.22E-34	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.204	8.01E-33	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.202	4.47E-32	YGR022C_d	YGR022C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.192	3.20E-29	YNL166C	BNI5	hom	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.188	4.28E-28	YJR137C	MET5	hom	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.188	7.92E-28	YPR180W	AOS1	het	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.183	1.23E-26	YDR521W_d	YDR521W_d	hom	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.174	3.38E-24	YGR077C	PEX8	hom	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.172	7.80E-24	YLR400W_d	YLR400W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.170	2.75E-23	YLR213C	CRR1	hom	Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.168	1.13E-22	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.163	1.94E-21	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.162	4.04E-21	YOR094W	ARF3	hom	Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity