YBR221W-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR221W-A / YBR221W-A

Click on Significant Values for Screen Details ID:SGTC_172|Compound:1112-0046|FD-Score:-3.89|P-value:1.69E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.81|P-value:1.84E-7 ID:SGTC_292|Compound:k038-0015|FD-Score:4.20|P-value:4.70E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:4.38|P-value:1.88E-6 ID:SGTC_297|Compound:0986-0032|FD-Score:4.65|P-value:4.43E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.12|P-value:6.79E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:3.10|P-value:5.34E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:5.45|P-value:4.19E-9 ID:SGTC_734|Compound:2023-0417|FD-Score:3.12|P-value:5.08E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:2.98|P-value:8.29E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.55|P-value:8.97E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.73|P-value:4.09E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.54|P-value:9.43E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.94|P-value:9.74E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-2.97|P-value:7.68E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.14|P-value:4.70E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.53|P-value:2.00E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.74|P-value:2.30E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.73|P-value:4.23E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.32|P-value:2.28E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.07|P-value:6.02E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.58|P-value:7.83E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.38|P-value:1.82E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.82|P-value:2.75E-5 ID:SGTC_1903|Compound:st060211|FD-Score:2.97|P-value:8.64E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.73|P-value:4.06E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.74|P-value:4.01E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-2.94|P-value:8.46E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.12|P-value:5.06E-4 ID:SGTC_1979|Compound:st071809|FD-Score:4.08|P-value:8.39E-6 ID:SGTC_1992|Compound:st073643|FD-Score:-3.58|P-value:6.89E-5 ID:SGTC_1993|Compound:st073995|FD-Score:-3.36|P-value:1.71E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.26|P-value:3.40E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-3.32|P-value:1.97E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.18|P-value:3.54E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.73|P-value:4.23E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.53|P-value:9.69E-5 ID:SGTC_2139|Compound:5578692|FD-Score:4.18|P-value:5.10E-6 ID:SGTC_2141|Compound:5621638|FD-Score:3.43|P-value:1.46E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.42|P-value:1.53E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.10|P-value:4.66E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.08|P-value:5.13E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.61|P-value:5.49E-7 ID:SGTC_2428|Compound:5615643|FD-Score:-3.00|P-value:6.96E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.25|P-value:3.55E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-3.69|P-value:4.18E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-4.47|P-value:9.90E-7 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.89|P-value:1.69E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.81|P-value:1.84E-7 ID:SGTC_292|Compound:k038-0015|FD-Score:4.20|P-value:4.70E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:4.38|P-value:1.88E-6 ID:SGTC_297|Compound:0986-0032|FD-Score:4.65|P-value:4.43E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.12|P-value:6.79E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:3.10|P-value:5.34E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:5.45|P-value:4.19E-9 ID:SGTC_734|Compound:2023-0417|FD-Score:3.12|P-value:5.08E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:2.98|P-value:8.29E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.55|P-value:8.97E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.73|P-value:4.09E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.54|P-value:9.43E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.94|P-value:9.74E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-2.97|P-value:7.68E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.14|P-value:4.70E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.53|P-value:2.00E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.74|P-value:2.30E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.73|P-value:4.23E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.32|P-value:2.28E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.07|P-value:6.02E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.58|P-value:7.83E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.38|P-value:1.82E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.82|P-value:2.75E-5 ID:SGTC_1903|Compound:st060211|FD-Score:2.97|P-value:8.64E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.73|P-value:4.06E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.74|P-value:4.01E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-2.94|P-value:8.46E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.12|P-value:5.06E-4 ID:SGTC_1979|Compound:st071809|FD-Score:4.08|P-value:8.39E-6 ID:SGTC_1992|Compound:st073643|FD-Score:-3.58|P-value:6.89E-5 ID:SGTC_1993|Compound:st073995|FD-Score:-3.36|P-value:1.71E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.26|P-value:3.40E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-3.32|P-value:1.97E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.18|P-value:3.54E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.73|P-value:4.23E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.53|P-value:9.69E-5 ID:SGTC_2139|Compound:5578692|FD-Score:4.18|P-value:5.10E-6 ID:SGTC_2141|Compound:5621638|FD-Score:3.43|P-value:1.46E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.42|P-value:1.53E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.10|P-value:4.66E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.08|P-value:5.13E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.61|P-value:5.49E-7 ID:SGTC_2428|Compound:5615643|FD-Score:-3.00|P-value:6.96E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.25|P-value:3.55E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-3.69|P-value:4.18E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-4.47|P-value:9.90E-7

Top fitness defect scores for YBR221W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_522 1273-0010 5.45 11.6 µM 4.19E-9 60S ribosome export 6 2.50E-8
2 SGTC_236 1509-0011 4.81 5.3 µM 1.84E-7 336 7.42E-7
3 SGTC_297 0986-0032 4.65 24.0 µM 4.43E-7 60S ribosome export 2 1.63E-6
4 SGTC_2424 5537928 4.61 59.2 µM 5.49E-7 23 1.97E-6
5 SGTC_294 k038-0071 4.38 157.0 µM 1.88E-6 ubiquinone biosynthesis & proteasome 43 5.94E-6
6 SGTC_1996 st072960 4.26 66.8 µM 3.40E-6 9 1.01E-5
7 SGTC_2809 7964133 4.25 13.0 µM 3.55E-6 60S ribosome export 26 1.05E-5
8 SGTC_292 k038-0015 4.20 474.0 µM 4.70E-6 3 1.36E-5
9 SGTC_2139 5578692 4.18 56.5 µM 5.10E-6 superoxide 13 1.46E-5
10 SGTC_402 epigallocatechin gallate 4.12 10.0 µM 6.79E-6 21 1.88E-5
11 SGTC_1979 st071809 4.08 45.3 µM 8.39E-6 RPP1 & pyrimidine depletion 10 2.28E-5
12 SGTC_1823 3-hydroxy-2-naphthoic acid 3.82 106.0 µM 2.75E-5 18 6.63E-5
13 SGTC_1938 st074717 3.74 56.4 µM 4.01E-5 16 9.28E-5
14 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.73 70.1 µM 4.06E-5 35 9.39E-5
15 SGTC_938 3126-1755 3.73 342.0 µM 4.09E-5 16 9.46E-5
16 SGTC_2088 5278280 3.73 127.4 µM 4.23E-5 31 9.74E-5
17 SGTC_1525 8-methoxypsoralen 3.73 92.5 µM 4.23E-5 DNA damage response 38 9.75E-5
18 SGTC_1670 st016595 3.58 4.0 µM 7.83E-5 16 1.70E-4
19 SGTC_933 2914-0560 3.55 114.0 µM 8.97E-5 35 1.92E-4
20 SGTC_1191 1487-1166 3.54 10.6 µM 9.43E-5 azole & statin 44 2.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 8.17E-44 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.224 1.68E-39 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.208 3.22E-34 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.204 8.01E-33 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.202 4.47E-32 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.192 3.20E-29 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.188 4.28E-28 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.188 7.92E-28 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.183 1.23E-26 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.174 3.38E-24 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.172 7.80E-24 YLR400W_d YLR400W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.170 2.75E-23 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.168 1.13E-22 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.163 1.94E-21 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.162 4.04E-21 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity